DE69218958T2 - Verfahren zur synthese von rns mit einem neuen schutzgruppenabspaltungsreagens - Google Patents

Verfahren zur synthese von rns mit einem neuen schutzgruppenabspaltungsreagens

Info

Publication number
DE69218958T2
DE69218958T2 DE69218958T DE69218958T DE69218958T2 DE 69218958 T2 DE69218958 T2 DE 69218958T2 DE 69218958 T DE69218958 T DE 69218958T DE 69218958 T DE69218958 T DE 69218958T DE 69218958 T2 DE69218958 T2 DE 69218958T2
Authority
DE
Germany
Prior art keywords
pct
reagent
radical
rna
rns
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69218958T
Other languages
English (en)
Other versions
DE69218958D1 (de
Inventor
Anne-Marie Duplaa
Didier Gasparutto
Thierry Livache
Didier Molko
Robert Teoule
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CIS Bio International SA
Commissariat a lEnergie Atomique et aux Energies Alternatives CEA
Original Assignee
Commissariat a lEnergie Atomique CEA
CIS Bio International SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Commissariat a lEnergie Atomique CEA, CIS Bio International SA filed Critical Commissariat a lEnergie Atomique CEA
Publication of DE69218958D1 publication Critical patent/DE69218958D1/de
Application granted granted Critical
Publication of DE69218958T2 publication Critical patent/DE69218958T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Fire-Extinguishing Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
DE69218958T 1991-10-08 1992-10-07 Verfahren zur synthese von rns mit einem neuen schutzgruppenabspaltungsreagens Expired - Lifetime DE69218958T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9112357A FR2682112B1 (fr) 1991-10-08 1991-10-08 Procede de synthese d'acide ribonucleique (arn) utilisant un nouveau reactif de deprotection.
PCT/FR1992/000929 WO1993007164A1 (fr) 1991-10-08 1992-10-07 Procede de synthese d'acide ribonucleique (arn) utilisant un nouveau reactif de deprotection

Publications (2)

Publication Number Publication Date
DE69218958D1 DE69218958D1 (de) 1997-05-15
DE69218958T2 true DE69218958T2 (de) 1997-10-30

Family

ID=9417692

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69218958T Expired - Lifetime DE69218958T2 (de) 1991-10-08 1992-10-07 Verfahren zur synthese von rns mit einem neuen schutzgruppenabspaltungsreagens

Country Status (7)

Country Link
US (1) US5552539A (de)
EP (1) EP0607337B1 (de)
JP (1) JP2836961B2 (de)
AT (1) ATE151434T1 (de)
DE (1) DE69218958T2 (de)
FR (1) FR2682112B1 (de)
WO (1) WO1993007164A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997014706A1 (en) * 1995-10-19 1997-04-24 Nexstar Pharmaceuticals, Inc. Method for solution phase synthesis of oligonucleotides
US7655790B2 (en) 2002-07-12 2010-02-02 Sirna Therapeutics, Inc. Deprotection and purification of oligonucleotides and their derivatives
US6989442B2 (en) * 2002-07-12 2006-01-24 Sirna Therapeutics, Inc. Deprotection and purification of oligonucleotides and their derivatives
CA2561741C (en) * 2004-04-05 2016-09-27 Alnylam Pharmaceuticals, Inc. Processes and reagents for oligonucleotide synthesis and purification
US7872121B2 (en) * 2004-04-19 2011-01-18 Avecia Biotechnology, Inc. Process for the removal of exocyclic base protecting groups
AU2007323809A1 (en) 2006-11-20 2008-05-29 Integrated Dna Technologies Inc. Methods for RNA desilylation
JO2778B1 (en) 2007-10-16 2014-03-15 ايساي انك Certain vehicles, installations and methods
WO2009117227A2 (en) * 2008-03-18 2009-09-24 Merck & Co., Inc. Deprotection of oligonucleotides that contain one or more ribonucleotides
US8252194B2 (en) * 2008-05-02 2012-08-28 Micron Technology, Inc. Methods of removing silicon oxide
US8609631B2 (en) 2009-04-06 2013-12-17 Eisai Inc. Compositions and methods for treating cancer
JP5730854B2 (ja) * 2009-04-06 2015-06-10 大塚製薬株式会社 デシタビンとシチジンデアミナーゼ阻害剤との組合せ、およびがんの治療におけるその使用
TWI477508B (zh) * 2009-04-06 2015-03-21 Otsuka Pharma Co Ltd 用以治療癌症之組成物及方法
EP2416781B1 (de) * 2009-04-06 2017-03-08 Otsuka Pharmaceutical Co., Ltd. Kombination von antineoplastischen arzneimitteln auf cytidin-basis mit cytidin-deaminase-inhibitor und ihre verwendung in der krebstherapie
RU2681939C2 (ru) 2013-10-29 2019-03-14 Оцука Фармасьютикал Ко., Лтд. Путь синтезирования 2'-дезокси-2'2'-дифтортетрагидроуридинов

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0155950B1 (de) * 1983-09-02 1990-01-17 Molecular Biosystems, Inc. Oligonukleotid-polymer-tragsystem
AU5931290A (en) * 1989-06-20 1991-01-08 Meiogenics, Inc. Nuclease resistant, single-stranded, non-naturally occurring nucleic acid molecules
JP2794461B2 (ja) * 1989-08-17 1998-09-03 有機合成薬品工業株式会社 ホスホアミダイト化合物及びそれを用いたオリゴリボヌクレオチドの固相合成法

Also Published As

Publication number Publication date
JPH07501794A (ja) 1995-02-23
WO1993007164A1 (fr) 1993-04-15
EP0607337A1 (de) 1994-07-27
DE69218958D1 (de) 1997-05-15
US5552539A (en) 1996-09-03
FR2682112A1 (fr) 1993-04-09
JP2836961B2 (ja) 1998-12-14
FR2682112B1 (fr) 1993-12-10
ATE151434T1 (de) 1997-04-15
EP0607337B1 (de) 1997-04-09

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