DE69120253D1 - Apparat zur fluoreszenzanalyse - Google Patents

Apparat zur fluoreszenzanalyse

Info

Publication number
DE69120253D1
DE69120253D1 DE69120253T DE69120253T DE69120253D1 DE 69120253 D1 DE69120253 D1 DE 69120253D1 DE 69120253 T DE69120253 T DE 69120253T DE 69120253 T DE69120253 T DE 69120253T DE 69120253 D1 DE69120253 D1 DE 69120253D1
Authority
DE
Germany
Prior art keywords
fluorescence analysis
fluorescence
analysis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69120253T
Other languages
English (en)
Other versions
DE69120253T2 (de
Inventor
Myron Block
Steve Lackie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of DE69120253D1 publication Critical patent/DE69120253D1/de
Application granted granted Critical
Publication of DE69120253T2 publication Critical patent/DE69120253T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G01N2021/7706—Reagent provision
    • G01N2021/7733—Reservoir, liquid reagent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7769—Measurement method of reaction-produced change in sensor
    • G01N2021/7786—Fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plasma & Fusion (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
DE69120253T 1990-11-13 1991-11-08 Apparat zur fluoreszenzanalyse Expired - Fee Related DE69120253T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61286990A 1990-11-13 1990-11-13
PCT/US1991/008390 WO1992008966A1 (en) 1990-11-13 1991-11-08 Fluorescence assay apparatus

Publications (2)

Publication Number Publication Date
DE69120253D1 true DE69120253D1 (de) 1996-07-18
DE69120253T2 DE69120253T2 (de) 1997-01-30

Family

ID=24454944

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69120253T Expired - Fee Related DE69120253T2 (de) 1990-11-13 1991-11-08 Apparat zur fluoreszenzanalyse

Country Status (5)

Country Link
EP (1) EP0510175B1 (de)
JP (1) JP3283876B2 (de)
CA (1) CA2073344C (de)
DE (1) DE69120253T2 (de)
WO (1) WO1992008966A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0957354A3 (de) * 1998-03-20 2000-03-22 IA Inc. Verfahren und Vorrichtung zum Messen der Bindung zwischen Biomolekülen
JP3429282B2 (ja) 2001-02-02 2003-07-22 リサーチ・インターナショナル・インコーポレーテッド 自動化されたシステム、及びサンプルの分析方法
US7496245B2 (en) 2004-08-20 2009-02-24 Research International, Inc. Misalignment compensating optical sensor and method

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3604927A (en) * 1966-11-16 1971-09-14 Block Engineering Total reflection fluorescence spectroscopy
US3975084A (en) * 1973-09-27 1976-08-17 Block Engineering, Inc. Particle detecting system
US4050895A (en) * 1975-09-26 1977-09-27 Monsanto Research Corporation Optical analytical device, waveguide and method
AU557816B2 (en) * 1981-09-18 1987-01-08 Prutec Ltd. Method for the determination of species in solution with an optical wave-guide
US4582809A (en) * 1982-06-14 1986-04-15 Myron J. Block Apparatus including optical fiber for fluorescence immunoassay
US4558014A (en) * 1983-06-13 1985-12-10 Myron J. Block Assay apparatus and methods
CA1231136A (en) * 1984-06-13 1988-01-05 Ian A. Shanks Capillary action chemical test device
DE3610940A1 (de) * 1986-03-04 1987-09-10 Escher Wyss Gmbh Hochtemperatur-hochkonsistenz-schnellbleiche
DK0429612T3 (da) * 1989-06-22 1994-03-07 Applied Research Systems Fremgangsmåde til optisk analyse

Also Published As

Publication number Publication date
EP0510175A1 (de) 1992-10-28
EP0510175B1 (de) 1996-06-12
CA2073344A1 (en) 1992-05-14
CA2073344C (en) 2001-08-21
JP3283876B2 (ja) 2002-05-20
WO1992008966A1 (en) 1992-05-29
EP0510175A4 (en) 1993-04-28
JPH05503584A (ja) 1993-06-10
DE69120253T2 (de) 1997-01-30

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: BOEHRINGER MANNHEIM CORP., INDIANAPOLIS, IND., US

8328 Change in the person/name/address of the agent

Free format text: MAYER, FRANK UND REINHARDT, 75173 PFORZHEIM

8327 Change in the person/name/address of the patent owner

Owner name: ROCHE DIAGNOSTICS CORP., INDIANAPOLIS, IND., US

8339 Ceased/non-payment of the annual fee