DE69116187T2 - Use of a dihydropyridine to improve blood circulation in the inner ear - Google Patents

Use of a dihydropyridine to improve blood circulation in the inner ear

Info

Publication number
DE69116187T2
DE69116187T2 DE69116187T DE69116187T DE69116187T2 DE 69116187 T2 DE69116187 T2 DE 69116187T2 DE 69116187 T DE69116187 T DE 69116187T DE 69116187 T DE69116187 T DE 69116187T DE 69116187 T2 DE69116187 T2 DE 69116187T2
Authority
DE
Germany
Prior art keywords
inner ear
dihydropyridine
blood circulation
improve blood
medicament
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69116187T
Other languages
German (de)
Other versions
DE69116187D1 (en
Inventor
Mitsuyoshi Nakashima
Toshihiko Uematsu
Kazuo Umemura
Yutaka Kohno
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of DE69116187D1 publication Critical patent/DE69116187D1/en
Application granted granted Critical
Publication of DE69116187T2 publication Critical patent/DE69116187T2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof

Abstract

Use of a dihydropyridine compound of the general formula: <CHEM> wherein R<1> means a nitrophenyl group; and R<2>, R<3> and R<4> each means a lower alkyl group, or a pharmaceutically acceptable salt thereof for manufacturing a medicament for treating or preventing disorder of inner ear microcirculation.
DE69116187T 1990-02-21 1991-02-19 Use of a dihydropyridine to improve blood circulation in the inner ear Expired - Fee Related DE69116187T2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP4041390 1990-02-21
JP12211090 1990-05-10

Publications (2)

Publication Number Publication Date
DE69116187D1 DE69116187D1 (en) 1996-02-22
DE69116187T2 true DE69116187T2 (en) 1996-05-15

Family

ID=26379878

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69116187T Expired - Fee Related DE69116187T2 (en) 1990-02-21 1991-02-19 Use of a dihydropyridine to improve blood circulation in the inner ear

Country Status (5)

Country Link
EP (1) EP0447812B1 (en)
KR (1) KR0178273B1 (en)
AT (1) ATE132748T1 (en)
CA (1) CA2036708A1 (en)
DE (1) DE69116187T2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10025152A1 (en) * 2000-05-23 2001-12-06 Marlies Knipper Treatment of noise- or age-induced hearing deficiency, comprises using neurotrophin stimulating agents to counteract cochlear neurodegeneration

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0322747B1 (en) * 1987-12-29 1994-03-02 Fujisawa Pharmaceutical Co., Ltd. A brain neuron protecting agent containing a dihydropyridine compound
EP0323604B1 (en) * 1987-12-29 1994-05-11 Fujisawa Pharmaceutical Co., Ltd. A venous extensibility improving and cardiac hypertrophy suppressant agent containing a dihydropyridine compound

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10025152A1 (en) * 2000-05-23 2001-12-06 Marlies Knipper Treatment of noise- or age-induced hearing deficiency, comprises using neurotrophin stimulating agents to counteract cochlear neurodegeneration

Also Published As

Publication number Publication date
KR0178273B1 (en) 1999-03-20
CA2036708A1 (en) 1991-08-22
EP0447812A2 (en) 1991-09-25
DE69116187D1 (en) 1996-02-22
EP0447812A3 (en) 1992-07-08
KR910021377A (en) 1991-12-20
ATE132748T1 (en) 1996-01-15
EP0447812B1 (en) 1996-01-10

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee