DE69102174T2 - Iontophoresezusammensetzung zur Erhöhung der Hautkonzentration aktiver Wirkstoffe. - Google Patents

Iontophoresezusammensetzung zur Erhöhung der Hautkonzentration aktiver Wirkstoffe.

Info

Publication number
DE69102174T2
DE69102174T2 DE69102174T DE69102174T DE69102174T2 DE 69102174 T2 DE69102174 T2 DE 69102174T2 DE 69102174 T DE69102174 T DE 69102174T DE 69102174 T DE69102174 T DE 69102174T DE 69102174 T2 DE69102174 T2 DE 69102174T2
Authority
DE
Germany
Prior art keywords
skin concentration
increasing
active ingredients
compositions
iontophoresis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69102174T
Other languages
English (en)
Other versions
DE69102174D1 (de
Inventor
Burton H Sage
James E Riviere
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vyteris Inc
Original Assignee
Becton Dickinson and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/653,204 external-priority patent/US5334138A/en
Application filed by Becton Dickinson and Co filed Critical Becton Dickinson and Co
Application granted granted Critical
Publication of DE69102174D1 publication Critical patent/DE69102174D1/de
Publication of DE69102174T2 publication Critical patent/DE69102174T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Electrotherapy Devices (AREA)
  • Control Of El Displays (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
DE69102174T 1990-03-15 1991-03-15 Iontophoresezusammensetzung zur Erhöhung der Hautkonzentration aktiver Wirkstoffe. Expired - Fee Related DE69102174T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49406290A 1990-03-15 1990-03-15
US07/653,204 US5334138A (en) 1990-03-15 1991-02-08 Method and composition for increased skin concentration of active agents by iontophoresis

Publications (2)

Publication Number Publication Date
DE69102174D1 DE69102174D1 (de) 1994-07-07
DE69102174T2 true DE69102174T2 (de) 1994-09-08

Family

ID=27051283

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69102174T Expired - Fee Related DE69102174T2 (de) 1990-03-15 1991-03-15 Iontophoresezusammensetzung zur Erhöhung der Hautkonzentration aktiver Wirkstoffe.

Country Status (11)

Country Link
EP (1) EP0448299B1 (de)
JP (1) JPH0761957B2 (de)
AT (1) ATE106244T1 (de)
AU (1) AU643760B2 (de)
DE (1) DE69102174T2 (de)
DK (1) DK0448299T3 (de)
ES (1) ES2057759T3 (de)
FI (1) FI911269A (de)
IE (1) IE64891B1 (de)
NO (1) NO911022L (de)
NZ (1) NZ237332A (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5750141A (en) * 1993-04-08 1998-05-12 The University Of Queensland Administration of vaso-active agent and therapeutic agent
US5505715A (en) * 1994-02-25 1996-04-09 Bristol-Myers Squibb Company Iontophoretic transdermal delivery of deoxyspergualin compounds
JPH09511927A (ja) * 1994-04-18 1997-12-02 ザ、プロクター、エンド、ギャンブル、カンパニー 歯槽骨へのビスホスホネート類のイオン導入デリバリー
WO1998009665A2 (en) * 1996-09-04 1998-03-12 Becton Dickinson And Company Iontophoretic method of using phenylephrine to improve the effect of local anesthetics
US20050220854A1 (en) 2004-04-01 2005-10-06 Yuh-Fun Maa Apparatus and method for transdermal delivery of influenza vaccine
WO2007041158A1 (en) * 2005-09-30 2007-04-12 Vyteris, Inc. Iontophoresis drug delivery device providing acceptable depth and duration of dermal anesthesia
FR2977493B1 (fr) * 2011-07-05 2014-02-14 Galderma Res & Dev Nouvelle composition anesthesique stable pour la reduction des reactions cutanees
JP6371073B2 (ja) * 2013-02-22 2018-08-08 帝國製薬株式会社 イオントフォレシスで麻酔剤（局所麻酔薬）を導入する際に使用するパッチ

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU609769B2 (en) 1987-02-10 1991-05-09 Drug Delivery Systems Inc. Electrolytic transdermal delivery of proteins
US5013293A (en) * 1987-05-28 1991-05-07 Drug Delivery Systems Inc. Pulsating transdermal drug delivery system
US5334138A (en) * 1990-03-15 1994-08-02 North Carolina State University Method and composition for increased skin concentration of active agents by iontophoresis

Also Published As

Publication number Publication date
EP0448299A2 (de) 1991-09-25
DK0448299T3 (da) 1994-06-20
EP0448299A3 (en) 1991-12-27
FI911269A0 (fi) 1991-03-14
AU643760B2 (en) 1993-11-25
FI911269A (fi) 1991-09-16
EP0448299B1 (de) 1994-06-01
JPH0597709A (ja) 1993-04-20
JPH0761957B2 (ja) 1995-07-05
NZ237332A (en) 1993-07-27
NO911022D0 (no) 1991-03-14
IE64891B1 (en) 1995-09-20
NO911022L (no) 1991-09-16
IE910716A1 (en) 1991-09-25
AU7280191A (en) 1991-09-19
ATE106244T1 (de) 1994-06-15
ES2057759T3 (es) 1994-10-16
DE69102174D1 (de) 1994-07-07

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: BECTON DICKINSON AND CO., FRANKLIN LAKES, N.J., US

8328 Change in the person/name/address of the agent

Free format text: JABBUSCH UND KOLLEGEN, 26135 OLDENBURG

8327 Change in the person/name/address of the patent owner

Owner name: DRUG DELIVERY TECHNOLOGIES, INC., FAIR LAWN, N.J.,

8327 Change in the person/name/address of the patent owner

Owner name: VYTERIS, INC. (N.D.GES.D. STAATES DELAWARE), FAIR

8339 Ceased/non-payment of the annual fee