DE69022778D1 - Zellkultursubstrat, Bioreaktor mit Zellkultursubstrat und therapeutische Vorrichtung vom extrakorporalen Umlauftyp. - Google Patents

Zellkultursubstrat, Bioreaktor mit Zellkultursubstrat und therapeutische Vorrichtung vom extrakorporalen Umlauftyp.

Info

Publication number
DE69022778D1
DE69022778D1 DE69022778T DE69022778T DE69022778D1 DE 69022778 D1 DE69022778 D1 DE 69022778D1 DE 69022778 T DE69022778 T DE 69022778T DE 69022778 T DE69022778 T DE 69022778T DE 69022778 D1 DE69022778 D1 DE 69022778D1
Authority
DE
Germany
Prior art keywords
cell culture
culture substrate
bioreactor
circulation type
therapeutic device
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69022778T
Other languages
English (en)
Other versions
DE69022778T2 (de
Inventor
Makoto Ohnishi
Ayako Makino
Kenichi Shimura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Terumo Corp
Original Assignee
Terumo Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP14733689A external-priority patent/JPH0310674A/ja
Priority claimed from JP1151133A external-priority patent/JPH0315382A/ja
Application filed by Terumo Corp filed Critical Terumo Corp
Publication of DE69022778D1 publication Critical patent/DE69022778D1/de
Application granted granted Critical
Publication of DE69022778T2 publication Critical patent/DE69022778T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068—General culture methods using substrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3687—Chemical treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3687—Chemical treatment
    • A61M1/3689—Chemical treatment by biological cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/10—Hollow fibers or tubes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/16—Hollow fibers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Vascular Medicine (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cell Biology (AREA)
  • Sustainable Development (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
DE69022778T 1989-06-09 1990-06-08 Zellkultursubstrat, Bioreaktor mit Zellkultursubstrat und therapeutische Vorrichtung vom extrakorporalen Umlauftyp. Expired - Lifetime DE69022778T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP14733689A JPH0310674A (ja) 1989-06-09 1989-06-09 細胞培養用多孔質膜およびそれを用いた細胞培養器
JP1151133A JPH0315382A (ja) 1989-06-14 1989-06-14 細胞培養用基材、細胞培養用基材ユニット、バイオリアクターおよび体外循環式治療器

Publications (2)

Publication Number Publication Date
DE69022778D1 true DE69022778D1 (de) 1995-11-09
DE69022778T2 DE69022778T2 (de) 1996-04-18

Family

ID=26477916

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69022778T Expired - Lifetime DE69022778T2 (de) 1989-06-09 1990-06-08 Zellkultursubstrat, Bioreaktor mit Zellkultursubstrat und therapeutische Vorrichtung vom extrakorporalen Umlauftyp.

Country Status (2)

Country Link
EP (1) EP0402272B1 (de)
DE (1) DE69022778T2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5270192A (en) * 1991-02-07 1993-12-14 Monsanto Company Biological artificial liver
EP1211309A4 (de) * 1999-08-20 2003-02-12 Verfahren und vorrichtung zur vermehrung von hepatitisviren
US20050153438A1 (en) * 2004-01-09 2005-07-14 Akio Shirasu Vessel for cell culture
JP5583312B2 (ja) * 2007-02-20 2014-09-03 富士フイルム株式会社 組織体形成用基材、組織体形成キット、それを用いた組織体形成法、及び該組織体形成法により形成された三次元組織体
CN101342099B (zh) * 2008-07-04 2012-03-14 南京大学医学院附属鼓楼医院 生物人工肝细胞反应器
CN101381678B (zh) * 2008-09-26 2011-05-18 浙江大学 多层膜片结构灌流型生物反应器及应用
DE102010005415B4 (de) * 2010-01-22 2015-07-16 Zellwerk Gmbh Verfahren und Vorrichtung zur dynamischen Expansion und/oder Differenzierung von suspendierten primären Zellen oder Stammzellen humanen und tierischen Ursprungs
NL2007734C2 (nl) * 2011-11-07 2013-05-08 Tulip Life Science Products B V Inrichting voor het kweken van cellen.
CN106232801A (zh) 2014-04-28 2016-12-14 维瓦生物细胞股份公司 自动化细胞培养和收获装置
WO2017183570A1 (ja) * 2016-04-18 2017-10-26 東洋製罐グループホールディングス株式会社 細胞培養用容器、及びその使用方法
JP6841282B2 (ja) 2016-07-25 2021-03-10 宇部興産株式会社 細胞培養モジュール
DE202019001093U1 (de) 2019-03-06 2019-04-11 Zellwerk Gmbh Zellkulturträger für Bioreaktoren
DE102019001604B4 (de) 2019-03-06 2020-12-24 Zellwerk Gmbh Zellkulturträger für Bioreaktoren
WO2020177789A1 (de) 2019-03-06 2020-09-10 Zellwerk Gmbh Zellkulturträger für bioreaktoren

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4007089A (en) * 1975-04-30 1977-02-08 Nelson Research & Development Company Method for binding biologically active compounds
CS183856B1 (en) * 1975-09-19 1978-07-31 Jiri Sulc Device for preserving or transport microorganisms
EP0135630A1 (de) * 1983-09-28 1985-04-03 Research Products Rehovot Ltd. Amidoxim-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendungen
GB8331865D0 (en) * 1983-11-29 1984-01-04 Univ Glasgow Microstructures
WO1988001279A1 (en) * 1986-08-15 1988-02-25 Commonwealth Scientific And Industrial Research Or Promoting cell adhesion and growth on a substrate
US5094749A (en) * 1987-05-29 1992-03-10 Terumo Kabushiki Kaisha Knurled sheetlike permeable membrane, for production thereof, and body fluid filtering apparatus

Also Published As

Publication number Publication date
EP0402272A2 (de) 1990-12-12
DE69022778T2 (de) 1996-04-18
EP0402272B1 (de) 1995-10-04
EP0402272A3 (de) 1992-05-27

Similar Documents

Publication Publication Date Title
DE68913962D1 (de) Bioreaktor und vorrichtung zur kultivierung von tierischen zellen.
DK490788D0 (da) Biologisk aktivt middel med kontrolleret, langvarig firgivelse
NO902188L (no) Kateter med tilbakestroemnings-innsnevring.
DE3686050D1 (de) Vorrichtung zur kultivierung von zellen in vitro.
DE3888642D1 (de) Rollflasche zur Züchtung von Zellengewebekulturen.
DE3884016D1 (de) Enzym-Immobilisierung und Bioaffinitätstrennungen mit Perfluorcarbon-Polymer-Trägern.
DE3888040D1 (de) Transformation von Sojabohnenpflanzen und Zellinien mit Hilfe von Partikeln.
NO871729D0 (no) Framgangsmaate for aa frambringe paasproeytede belegg, apparat for gjennomfoering av framgangsmaaten og gjenstander tilvirket i samsvar med framgangsmaaten.
DE3886980D1 (de) Vorrichtung mit Durchflusszelle.
DE69332851D1 (de) Implantierbare, medizinische Eingriffsvorrichtung mit verstellbaren Kriterien zur Erkennung von Tachykardien
DE3789876D1 (de) Knochenplatte mit konischen Löchern.
DE3853716D1 (de) Polycarbonsäure mit höherer Verdickungskapazität und besserer Klarheit.
DE3784064D1 (de) Einheitlicher, steriler fluessigkeitsverabreichungszusammenbau und herstellungsverfahren.
DE69022778D1 (de) Zellkultursubstrat, Bioreaktor mit Zellkultursubstrat und therapeutische Vorrichtung vom extrakorporalen Umlauftyp.
DE3880893D1 (de) Fluessige modifizierte statistische aethylencopolymere und ihre verwendung.
DK134187D0 (da) Pyrethroid-insecticidt og/eller -acaricidt middel til landbrugsmaessig anvendelse i form af mikrokapsler samt fremgangsmaade til dets fremstilling.
DE3850309D1 (de) Hochfrequenz-Bipolartransistor und dessen Herstellungsverfahren.
DE3683029D1 (de) Behandlungssystem mit koronaentladung.
NO903527D0 (no) Laboratorieanordning, samt fremgangsmaate for behandling av steinproever.
DE3877682D1 (de) Zellbehandlungsvorrichtung.
DE69002034D1 (de) Vorrichtung mit gesteuerter wirkstoffabgabe.
DE3787186D1 (de) Taktempfindliche Stimulierung mit Benutzung des ventrikulären Gradienten.
DE3889294D1 (de) Fermentation mit gesteuerter Wachstumsgeschwindigkeit.
FI880636A (fi) Foerfarande foer inaktivering av med hoelje foersedda virus i en medelst en cell in vitro framstaellda proteinprodukter.
DK191089A (da) Biologisk aktive forbindelser

Legal Events

Date Code Title Description
8364 No opposition during term of opposition