DE69018357T2 - Mutein von HST-1 und seine Herstellung. - Google Patents
Mutein von HST-1 und seine Herstellung.Info
- Publication number
- DE69018357T2 DE69018357T2 DE69018357T DE69018357T DE69018357T2 DE 69018357 T2 DE69018357 T2 DE 69018357T2 DE 69018357 T DE69018357 T DE 69018357T DE 69018357 T DE69018357 T DE 69018357T DE 69018357 T2 DE69018357 T2 DE 69018357T2
- Authority
- DE
- Germany
- Prior art keywords
- mutein
- hst
- production
- wounds
- heparin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 102100028072 Fibroblast growth factor 4 Human genes 0.000 title 1
- 101001060274 Homo sapiens Fibroblast growth factor 4 Proteins 0.000 title 1
- 101000993347 Gallus gallus Ciliary neurotrophic factor Proteins 0.000 abstract 1
- 101150101014 HST1 gene Proteins 0.000 abstract 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 1
- 208000032984 Intraoperative Complications Diseases 0.000 abstract 1
- 206010052428 Wound Diseases 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 230000010261 cell growth Effects 0.000 abstract 1
- 230000037430 deletion Effects 0.000 abstract 1
- 238000012217 deletion Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000035876 healing Effects 0.000 abstract 1
- 229960002897 heparin Drugs 0.000 abstract 1
- 229920000669 heparin Polymers 0.000 abstract 1
- 230000003248 secreting effect Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000001131 transforming effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/82—Translation products from oncogenes
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Oncology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Transducers For Ultrasonic Waves (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP26233189 | 1989-10-06 | ||
| JP27303689 | 1989-10-19 | ||
| JP30360789 | 1989-11-21 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69018357D1 DE69018357D1 (de) | 1995-05-11 |
| DE69018357T2 true DE69018357T2 (de) | 1995-09-21 |
Family
ID=27335120
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69018357T Expired - Fee Related DE69018357T2 (de) | 1989-10-06 | 1990-10-05 | Mutein von HST-1 und seine Herstellung. |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US5639862A (de) |
| EP (1) | EP0421455B1 (de) |
| AT (1) | ATE120799T1 (de) |
| CA (1) | CA2027075C (de) |
| DE (1) | DE69018357T2 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5459250A (en) * | 1987-06-16 | 1995-10-17 | New York University | Truncated mammalian growth factor DNA sequence |
| ATE139700T1 (de) * | 1991-02-15 | 1996-07-15 | Takeda Chemical Industries Ltd | Mit einem zellwachstumsfaktor bewirkte anregung von wachstum im knocheninneren |
| EP0585631A1 (de) * | 1992-08-05 | 1994-03-09 | Takeda Chemical Industries, Ltd. | Blutplättchen vermehrendes Agens |
| EP0613946B1 (de) * | 1993-02-12 | 2003-05-28 | Takeda Chemical Industries, Ltd. | HST-2 Mutein, dafür kodierende DNS und Herstellung |
| AU760664B2 (en) * | 1998-04-17 | 2003-05-22 | Angiogenix, Inc. | Therapeutic angiogenic factors and methods for their use |
| US6451303B1 (en) * | 1998-10-13 | 2002-09-17 | Chiron Corporation | Method of treating coronary artery disease by administering a recombinant FGF |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0326907A1 (de) * | 1988-01-26 | 1989-08-09 | Takeda Chemical Industries, Ltd. | Polypeptide, DNA und ihre Verwendung |
-
1990
- 1990-10-05 EP EP90119127A patent/EP0421455B1/de not_active Expired - Lifetime
- 1990-10-05 AT AT90119127T patent/ATE120799T1/de not_active IP Right Cessation
- 1990-10-05 DE DE69018357T patent/DE69018357T2/de not_active Expired - Fee Related
- 1990-10-05 CA CA002027075A patent/CA2027075C/en not_active Expired - Fee Related
-
1995
- 1995-05-19 US US08/446,198 patent/US5639862A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69018357D1 (de) | 1995-05-11 |
| EP0421455B1 (de) | 1995-04-05 |
| CA2027075A1 (en) | 1991-04-07 |
| ATE120799T1 (de) | 1995-04-15 |
| US5639862A (en) | 1997-06-17 |
| CA2027075C (en) | 2002-11-26 |
| EP0421455A1 (de) | 1991-04-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: TAKEDA PHARMACEUTICAL CO. LTD., OSAKA, JP Owner name: PRESIDENT OF NATIONAL CANCER CENTER, TOKIO/TOKYO, |
|
| 8339 | Ceased/non-payment of the annual fee |