DE69013015D1 - Protein aus dem Cytosol, das FK-506 binden kann. - Google Patents

Protein aus dem Cytosol, das FK-506 binden kann.

Info

Publication number
DE69013015D1
DE69013015D1 DE69013015T DE69013015T DE69013015D1 DE 69013015 D1 DE69013015 D1 DE 69013015D1 DE 69013015 T DE69013015 T DE 69013015T DE 69013015 T DE69013015 T DE 69013015T DE 69013015 D1 DE69013015 D1 DE 69013015D1
Authority
DE
Germany
Prior art keywords
cytosol
bind
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69013015T
Other languages
English (en)
Other versions
DE69013015T2 (de
Inventor
John J Siekierka
Marie J Staruch
Nolan H Sigal
Richard A Mumford
Hsueh-Yun Hung
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE69013015D1 publication Critical patent/DE69013015D1/de
Publication of DE69013015T2 publication Critical patent/DE69013015T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Enzymes And Modification Thereof (AREA)
DE69013015T 1989-01-19 1990-01-17 Protein aus dem Cytosol, das FK-506 binden kann. Expired - Fee Related DE69013015T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30065989A 1989-01-19 1989-01-19
US36957689A 1989-06-21 1989-06-21

Publications (2)

Publication Number Publication Date
DE69013015D1 true DE69013015D1 (de) 1994-11-10
DE69013015T2 DE69013015T2 (de) 1995-05-11

Family

ID=26971891

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69013015T Expired - Fee Related DE69013015T2 (de) 1989-01-19 1990-01-17 Protein aus dem Cytosol, das FK-506 binden kann.

Country Status (4)

Country Link
EP (1) EP0379342B1 (de)
JP (1) JP2573707B2 (de)
CA (1) CA2008149C (de)
DE (1) DE69013015T2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2063580C (en) * 1990-05-09 2002-11-19 Steven J. Soldin Receptor assay for fk-506
JP2982908B2 (ja) * 1990-07-11 1999-11-29 東燃株式会社 ヒトｆｋ５０６結合蛋白質をコードするｄｎａ
CA2052928A1 (en) * 1990-10-15 1992-04-16 John J. Siekierka Genes encoding the human fk-506 binding protein and a.s. cerevisiae homolog, fkb1 and their expression
EP0584217A1 (de) * 1991-05-08 1994-03-02 Vertex Pharmaceuticals Incorporated RFKBP: eine neue Prolylisomerase und Rapamycin/FK506 bindendes Protein
US5164495A (en) * 1991-09-18 1992-11-17 Abbott Laboratories Method for preparing a dicarboxylic acid half-acid ester of FK506
WO1993007269A1 (en) * 1991-10-11 1993-04-15 Vertex Pharmaceuticals Incorporated ISOLATION OF AN Mr 52,000 FK506 BINDING PROTEIN AND MOLECULAR CLONING OF A CORRESPONDING HUMAN cDNA
US5763590A (en) * 1991-10-11 1998-06-09 Vertex Pharmaceuticals, Inc. Isolation of an Mr 52,000 FK506 binding protein and molecular cloning of a corresponding human cDNA
US5498597A (en) * 1992-01-17 1996-03-12 Dana-Farber Cancer Institute, Inc. FKBP-13, an FK506-binding immunophilin
IL112873A (en) 1994-03-08 2005-03-20 Wyeth Corp Rapamycin-fkbp12 binding proteins, their isolation and their use

Also Published As

Publication number Publication date
DE69013015T2 (de) 1995-05-11
JP2573707B2 (ja) 1997-01-22
CA2008149C (en) 1999-08-17
CA2008149A1 (en) 1990-07-19
EP0379342B1 (de) 1994-10-05
EP0379342A2 (de) 1990-07-25
EP0379342A3 (en) 1990-11-28
JPH02273181A (ja) 1990-11-07

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee