DE69004368D1 - Mit Tritium markierte Verbindung, seine Herstellung und Verwendung, besonders bei der Lokalisierung von nuklearen Rezeptoren von Retinoiden. - Google Patents

Mit Tritium markierte Verbindung, seine Herstellung und Verwendung, besonders bei der Lokalisierung von nuklearen Rezeptoren von Retinoiden.

Info

Publication number
DE69004368D1
DE69004368D1 DE90402100T DE69004368T DE69004368D1 DE 69004368 D1 DE69004368 D1 DE 69004368D1 DE 90402100 T DE90402100 T DE 90402100T DE 69004368 T DE69004368 T DE 69004368T DE 69004368 D1 DE69004368 D1 DE 69004368D1
Authority
DE
Germany
Prior art keywords
retinoids
localization
manufacture
labeled compound
nuclear receptors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE90402100T
Other languages
English (en)
Other versions
DE69004368T2 (de
Inventor
Braham Villa Shroot
Michel Darmon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Galderma Research and Development SNC
Original Assignee
Centre International de Recherches Dermatologiques Galderma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre International de Recherches Dermatologiques Galderma filed Critical Centre International de Recherches Dermatologiques Galderma
Application granted granted Critical
Publication of DE69004368D1 publication Critical patent/DE69004368D1/de
Publication of DE69004368T2 publication Critical patent/DE69004368T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/534—Production of labelled immunochemicals with radioactive label
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0402—Organic compounds carboxylic acid carriers, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
    • C07C65/26—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic containing rings other than six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Optics & Photonics (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE90402100T 1989-07-20 1990-07-20 Mit Tritium markierte Verbindung, seine Herstellung und Verwendung, besonders bei der Lokalisierung von nuklearen Rezeptoren von Retinoiden. Expired - Fee Related DE69004368T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8909778A FR2649976B1 (fr) 1989-07-20 1989-07-20 Nouveau compose marque au tritium, sa preparation et son application notamment dans le reperage des recepteurs nucleaires des retinoides

Publications (2)

Publication Number Publication Date
DE69004368D1 true DE69004368D1 (de) 1993-12-09
DE69004368T2 DE69004368T2 (de) 1994-02-24

Family

ID=9383969

Family Applications (1)

Application Number Title Priority Date Filing Date
DE90402100T Expired - Fee Related DE69004368T2 (de) 1989-07-20 1990-07-20 Mit Tritium markierte Verbindung, seine Herstellung und Verwendung, besonders bei der Lokalisierung von nuklearen Rezeptoren von Retinoiden.

Country Status (6)

Country Link
US (1) US5073361A (de)
EP (1) EP0409740B1 (de)
JP (1) JP2833837B2 (de)
CA (1) CA2021550C (de)
DE (1) DE69004368T2 (de)
FR (1) FR2649976B1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5508456A (en) * 1993-07-30 1996-04-16 Ligand Pharmaceuticals Incorporated 9-cis tritium-labeled retinoids and intermediates, methods for their synthesis and methods for their use in discovering retinoid X receptor ligands
FR2733684B1 (fr) 1995-05-03 1997-05-30 Cird Galderma Utilisation de retinoides dans une composition cosmetique ou pour la fabrication d'une composition pharmaceutique
US6462064B1 (en) * 1996-07-08 2002-10-08 Galderma Research & Development S.N.C. Apoptosis inducing adamantyl derivatives and their usage as anti-cancer agents, especially for cervical cancers and dysplasias
CA2281523A1 (en) * 1997-02-25 1998-08-27 Braham Shroot Identification of a unique receptor specific for a particular retinoid inducing cellular apoptosis
US8039266B2 (en) * 2006-09-15 2011-10-18 Colorado School Of Mines Methods to radiolabel natural organic matter by reduction with hydrogen labeled reducing agents
FR2910320B1 (fr) 2006-12-21 2009-02-13 Galderma Res & Dev S N C Snc Emulsion comprenant au moins un retinoide et du peroxyde de benzole
FR2910321B1 (fr) 2006-12-21 2009-07-10 Galderma Res & Dev S N C Snc Gel creme comprenant au moins un retinoide et du peroxyde de benzole
FR2931661B1 (fr) 2008-05-30 2010-07-30 Galderma Res & Dev Nouvelles compositions depigmentantes sous forme d'une composition anhydre sans vaseline et sans elastomere comprenant un derive phenolique solubilise et un retinoide.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3142975A1 (de) * 1981-10-29 1983-05-11 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Verfahren zur herstellung von mit tritium markierterretinsaeure
LU85849A1 (fr) * 1985-04-11 1986-11-05 Cird Derives benzonaphtaleniques,leur procede de preparation et leur application dans les domaines pharmaceutiques et cosmetiques
FR2603280B1 (fr) * 1986-08-29 1988-10-28 Cird Nouveau compose marque au tritium, sa preparation et son application notamment dans la determination de l'affinite des retinoides pour leur recepteur cellulaire

Also Published As

Publication number Publication date
DE69004368T2 (de) 1994-02-24
EP0409740B1 (de) 1993-11-03
EP0409740A1 (de) 1991-01-23
CA2021550A1 (fr) 1991-01-21
CA2021550C (fr) 2001-09-04
FR2649976A1 (fr) 1991-01-25
JP2833837B2 (ja) 1998-12-09
US5073361A (en) 1991-12-17
FR2649976B1 (fr) 1991-09-27
JPH0363246A (ja) 1991-03-19

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee