DE60331934D1 - Mutierter androgenrezeptor, diesen exprimierende krebszellen, verfahren zur konstruktion davon und verwendung davon - Google Patents

Mutierter androgenrezeptor, diesen exprimierende krebszellen, verfahren zur konstruktion davon und verwendung davon

Info

Publication number
DE60331934D1
DE60331934D1 DE60331934T DE60331934T DE60331934D1 DE 60331934 D1 DE60331934 D1 DE 60331934D1 DE 60331934 T DE60331934 T DE 60331934T DE 60331934 T DE60331934 T DE 60331934T DE 60331934 D1 DE60331934 D1 DE 60331934D1
Authority
DE
Germany
Prior art keywords
expressing cancer
androgen receptor
constructing
cancer cells
androgen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60331934T
Other languages
English (en)
Inventor
Takahito Hara
Masami Kusaka
Junichi Miyazaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical Co Ltd filed Critical Takeda Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DE60331934D1 publication Critical patent/DE60331934D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0693—Tumour cells; Cancer cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57434—Specifically defined cancers of prostate
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • Hospice & Palliative Care (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
DE60331934T 2002-06-03 2003-06-02 Mutierter androgenrezeptor, diesen exprimierende krebszellen, verfahren zur konstruktion davon und verwendung davon Expired - Lifetime DE60331934D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2002162206 2002-06-03
JP2002255612A JP4447826B2 (ja) 2002-06-03 2002-08-30 変異アンドロゲン受容体、それを発現する癌細胞、それらの作出方法およびそれらの用途
PCT/JP2003/006942 WO2003102188A1 (fr) 2002-06-03 2003-06-02 Recepteur d'androgene mute, cellules cancereuses l'exprimant, procede de construction de ce recepteur et utilisations correspondantes

Publications (1)

Publication Number Publication Date
DE60331934D1 true DE60331934D1 (de) 2010-05-12

Family

ID=29714332

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60331934T Expired - Lifetime DE60331934D1 (de) 2002-06-03 2003-06-02 Mutierter androgenrezeptor, diesen exprimierende krebszellen, verfahren zur konstruktion davon und verwendung davon

Country Status (7)

Country Link
US (1) US20050181462A1 (de)
EP (2) EP1550720B1 (de)
JP (1) JP4447826B2 (de)
AT (1) ATE462724T1 (de)
AU (1) AU2003241738A1 (de)
DE (1) DE60331934D1 (de)
WO (1) WO2003102188A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0313405A (pt) 2002-08-12 2005-07-12 Takeda Pharmaceutical Compostos, métodos para preparar um composto e para prevenir e/ou tratar câncer, prodroga, medicamento, modulador do receptor de androgênio, agente para prevenir e/ou tratar hipogonadismo ou pertubação climatérica masculina, osteoporose e câncer, e, uso de um composto
US8841422B2 (en) 2008-09-17 2014-09-23 University Of Maryland, Baltimore Human androgen receptor alternative splice variants
US8133724B2 (en) * 2008-09-17 2012-03-13 University Of Maryland, Baltimore Human androgen receptor alternative splice variants as biomarkers and therapeutic targets
US20120283120A1 (en) 2009-09-29 2012-11-08 Takeda Pharmaceutical Company Limited Screening method
US10206911B2 (en) 2012-10-26 2019-02-19 Memorial Sloan-Kettering Cancer Center Androgen receptor variants and methods for making and using

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6994992B1 (en) * 1999-02-24 2006-02-07 Trustees Of Tufts College Androgen-induced suppressor of cell proliferation and uses thereof
GB0005689D0 (en) * 2000-03-09 2000-05-03 Schering Ag Crystal
US6291194B1 (en) * 2000-07-28 2001-09-18 Taneli Raivio Assay for determination of androgenic or anti-androgenic activity of a serum sample or a test compound
AU2002367424A1 (en) * 2001-12-28 2003-07-24 Takeda Chemical Industries, Ltd. Androgen receptor antagonists

Also Published As

Publication number Publication date
JP4447826B2 (ja) 2010-04-07
US20050181462A1 (en) 2005-08-18
EP1550720B1 (de) 2010-03-31
JP2004057180A (ja) 2004-02-26
ATE462724T1 (de) 2010-04-15
EP1550720A1 (de) 2005-07-06
AU2003241738A1 (en) 2003-12-19
WO2003102188A1 (fr) 2003-12-11
EP1550720A4 (de) 2006-07-26
EP2090656A1 (de) 2009-08-19

Similar Documents

Publication Publication Date Title
DE60314500D1 (de) Diaminopyrimidine und deren verwendung als angiogenesehemmer
WO2005016967A3 (en) Modified human igf-1r antibodies
PT1899334E (pt) Compostos de naftiridina
PT1928882E (pt) (s)-n-metilnaltrexona, processo para a sua síntese e sua utilização farmacêutica
MXPA05012832A (es) Punto terminal terapeutico sustituto para inmunoterapia de enfermedad basada en anti-ctla-4.
CY1112754T1 (el) Μεθοδοι και ενδιαμεσα για την παρασκευη παραγωγων ν4-φαινυλ-κιναζολιν-4-αμινης
MX2007001986A (es) Compuestos de aminoheteroarilo como inhibidores de proteina quinasa.
DE602004020538D1 (de) Verfahren und Vorrichtung zur Laserbestrahlung, sowie Verfahren zur Herstellung von Halbleiter.
DE50305049D1 (de) Galactosyl-isomalt, verfahren zu seiner herstellung und verwendung
DK1572106T3 (da) Fremgangsmåde til forebyggelse og behandling af cancermetastase og knogletab forbundet med cancermetastase
ATE497509T1 (de) Elektrosterisch stabilisierte wässrige polyurethan-harze, verfahren zu ihrer herstellung und deren verwendung
NO20055741D0 (no) Nye kjemiske forbindelser
ATE309331T1 (de) Transplant-akzeptanz induzierende zellen monocytären ursprungs, sowie deren herstellung und verwendung
WO2004098377A3 (en) Methods and compositions for diagnosis and therapy of parkin-associated disorders
DE60305200D1 (de) Aminocyclohexylether-verbindungen und deren verwendung
EP1749298B8 (de) Prozess zur herstellung eines stanzers für einen mehrwertigen rom-datenträger, herstellungsvorrichtung dafür und resultierender datenträger
WO2005089294A3 (en) Synthesis of indenoisoquinoliniums and methods of use
EP1586681A4 (de) Titanoxid-körner, verfahren und vorrichtung zu deren herstellung und behandlungsverfahren mit diesem titanoxid
ATE446299T1 (de) Verfahren zur herstellung von 7-ethyl-10- hydroxycamptothecin
EP1676132A4 (de) System und verfahren zur behandlung von krebs, einschliesslich krebserkrankungen des zentralen nervensystems
ATE516290T1 (de) Verfahren zur herstellung von buprenorphin und derivaten von buprenorphin
DE60331934D1 (de) Mutierter androgenrezeptor, diesen exprimierende krebszellen, verfahren zur konstruktion davon und verwendung davon
WO2005058251A3 (en) Hla-dr-specific antibodies, compositions and methods
DE602005015329D1 (de) Rutheniumkomplexe zur krebsbehandlung
AU2003294324A1 (en) Compositions and methods for the treatment of cancer, screening of putative anti-cancer compounds, and assessing cancer progression

Legal Events

Date Code Title Description
8364 No opposition during term of opposition