DE60325946D1 - Modifizierter typ-1-plasminogenaktivatorinhibitor und darauf beruhende verfahren - Google Patents
Modifizierter typ-1-plasminogenaktivatorinhibitor und darauf beruhende verfahrenInfo
- Publication number
- DE60325946D1 DE60325946D1 DE60325946T DE60325946T DE60325946D1 DE 60325946 D1 DE60325946 D1 DE 60325946D1 DE 60325946 T DE60325946 T DE 60325946T DE 60325946 T DE60325946 T DE 60325946T DE 60325946 D1 DE60325946 D1 DE 60325946D1
- Authority
- DE
- Germany
- Prior art keywords
- pai
- modified
- angiogenesis
- analogs
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
- C07K14/8132—Plasminogen activator inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heart & Thoracic Surgery (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36167002P | 2002-03-04 | 2002-03-04 | |
PCT/US2003/006679 WO2003080646A2 (en) | 2002-03-04 | 2003-03-04 | Modified plasminogen activator inhibitor type-1 and methods based thereon |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60325946D1 true DE60325946D1 (de) | 2009-03-12 |
Family
ID=28454581
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60325946T Expired - Lifetime DE60325946D1 (de) | 2002-03-04 | 2003-03-04 | Modifizierter typ-1-plasminogenaktivatorinhibitor und darauf beruhende verfahren |
Country Status (7)
Country | Link |
---|---|
US (2) | US7592422B2 (de) |
EP (1) | EP1487867B1 (de) |
AT (1) | ATE421528T1 (de) |
AU (1) | AU2003243134A1 (de) |
CA (1) | CA2481556C (de) |
DE (1) | DE60325946D1 (de) |
WO (1) | WO2003080646A2 (de) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE421528T1 (de) * | 2002-03-04 | 2009-02-15 | Ohio Med College | Modifizierter typ-1-plasminogenaktivatorinhibitor und darauf beruhende verfahren |
US8106002B2 (en) | 2005-04-18 | 2012-01-31 | Chugai Seiyaku Kabushiki Kaisha | Anti-cancer agent comprising protein C inhibitor |
US20090041755A1 (en) * | 2005-05-10 | 2009-02-12 | Ludwig Institute For Cancer Research | Methods and Compositions For PDGF-D Activation and Inhibition |
WO2007047205A2 (en) * | 2005-10-11 | 2007-04-26 | Amano Enzyme Usa Co., Ltd. | Enzyme inhibitors of pai-1 |
WO2009014564A2 (en) * | 2007-04-27 | 2009-01-29 | The University Of Toledo | Modified plasminogen activator inhibitor type-1 molecule and methods based thereon |
WO2009045412A2 (en) * | 2007-10-01 | 2009-04-09 | American Diagnostica, Inc. | Methods of treatment using modified plasminogen activator inhibitor type-1 molecules |
WO2011086557A1 (en) * | 2010-01-13 | 2011-07-21 | Thrombotech Ltd. | Peptides for the treatment of respiratory diseases |
US9597379B1 (en) | 2010-02-09 | 2017-03-21 | David Gordon Bermudes | Protease inhibitor combination with therapeutic proteins including antibodies |
US8771669B1 (en) | 2010-02-09 | 2014-07-08 | David Gordon Bermudes | Immunization and/or treatment of parasites and infectious agents by live bacteria |
US8524220B1 (en) | 2010-02-09 | 2013-09-03 | David Gordon Bermudes | Protease inhibitor: protease sensitivity expression system composition and methods improving the therapeutic activity and specificity of proteins delivered by bacteria |
WO2011139974A2 (en) * | 2010-05-03 | 2011-11-10 | Abbott Laboratories | Anti-pai-1 antibodies and methods of use thereof |
US9737592B1 (en) | 2014-02-14 | 2017-08-22 | David Gordon Bermudes | Topical and orally administered protease inhibitors and bacterial vectors for the treatment of disorders and methods of treatment |
US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
EP4061956A4 (de) * | 2019-11-21 | 2023-11-01 | The Regents Of The University Of Michigan | Polypeptid-inhibitoren von neutrophiler elastase-aktivität und verwendungen davon |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4554101A (en) * | 1981-01-09 | 1985-11-19 | New York Blood Center, Inc. | Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity |
US4980286A (en) * | 1985-07-05 | 1990-12-25 | Whitehead Institute For Biomedical Research | In vivo introduction and expression of foreign genetic material in epithelial cells |
US4946778A (en) * | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
US5679350A (en) * | 1992-05-28 | 1997-10-21 | The University Of Toledo | Method of delivery of a medicament to a cancer cell using a pathway of plasminogen activator material |
US5635493A (en) * | 1993-12-01 | 1997-06-03 | Marine Polymer Technologies, Inc. | Methods and compositions for poly-β-1-4-N-acetylglucosamine chemotherapeutics |
US5639726A (en) * | 1994-09-30 | 1997-06-17 | The Regents Of The University Of Michigan | Peptide mediated enhancement of thrombolysis methods and compositions |
US6103498A (en) | 1996-04-12 | 2000-08-15 | American National Red Cross | Mutant plasminogen activator-inhibitor type 1 (PAI-1) and uses thereof |
US6303338B1 (en) | 1996-08-16 | 2001-10-16 | Human Genome Sciences, Inc. | Pancreas-derived plasminogen activator inhibitor |
ATE421528T1 (de) * | 2002-03-04 | 2009-02-15 | Ohio Med College | Modifizierter typ-1-plasminogenaktivatorinhibitor und darauf beruhende verfahren |
AU2005296064A1 (en) * | 2004-10-04 | 2006-04-27 | Trinity Biosystems, Inc. | Methods and compositions for needleless delivery of macromolecules |
WO2009014564A2 (en) * | 2007-04-27 | 2009-01-29 | The University Of Toledo | Modified plasminogen activator inhibitor type-1 molecule and methods based thereon |
-
2003
- 2003-03-04 AT AT03745086T patent/ATE421528T1/de not_active IP Right Cessation
- 2003-03-04 EP EP03745086A patent/EP1487867B1/de not_active Expired - Lifetime
- 2003-03-04 AU AU2003243134A patent/AU2003243134A1/en not_active Abandoned
- 2003-03-04 WO PCT/US2003/006679 patent/WO2003080646A2/en not_active Application Discontinuation
- 2003-03-04 CA CA2481556A patent/CA2481556C/en not_active Expired - Fee Related
- 2003-03-04 US US10/506,406 patent/US7592422B2/en not_active Expired - Fee Related
- 2003-03-04 DE DE60325946T patent/DE60325946D1/de not_active Expired - Lifetime
-
2009
- 2009-09-18 US US12/562,750 patent/US20100137209A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2481556C (en) | 2014-04-29 |
US20100137209A1 (en) | 2010-06-03 |
CA2481556A1 (en) | 2003-10-02 |
EP1487867A4 (de) | 2006-05-31 |
AU2003243134A1 (en) | 2003-10-08 |
WO2003080646A3 (en) | 2004-04-08 |
ATE421528T1 (de) | 2009-02-15 |
EP1487867B1 (de) | 2009-01-21 |
EP1487867A2 (de) | 2004-12-22 |
US20050158295A1 (en) | 2005-07-21 |
WO2003080646A2 (en) | 2003-10-02 |
US7592422B2 (en) | 2009-09-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE60325946D1 (de) | Modifizierter typ-1-plasminogenaktivatorinhibitor und darauf beruhende verfahren | |
Adler et al. | Crystal structures of two potent nonamidine inhibitors bound to factor Xa | |
EA200501017A1 (ru) | Астма и модуляторы аллергических воспалений | |
EA200400971A1 (ru) | Фторзамещенные циклоалканоиндолы, композиции, содержащие такие соединения, и способы лечения | |
EA200100992A1 (ru) | Ингибиторы фермента impdh | |
EA200500299A1 (ru) | Пиразольные композиции, используемые в качестве ингибиторов gsk-3 | |
DE69904511D1 (de) | Proteinmaterial mit verlangsamtem verdaungsablauf und deren verwendung | |
MEP53308A (en) | Novel peptides that bind to the erythropoietin receptor | |
ATE279430T1 (de) | Verfahren zur verbesserung der serum halbwertszeit von biologisch aktiven molekülen | |
EA200401541A1 (ru) | АМИДЫ ЗАМЕЩЁННЫХ 3-АМИНОТИЕНО [2,3-b]ПИРИДИН-2-КАРБОНОВЫХ КИСЛОТ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ | |
NO20052595L (no) | Sammensetninger anvendelige som inhibitorer av ROCK- og andre proteinkinaser. | |
TR200103336T2 (tr) | Amid türevleri. | |
CY1107342T1 (el) | Χρηση παραγωγων νιτριλιου ως φαρμακο | |
BRPI0814220A2 (pt) | Purificação de fator viii usando uma resina multimodal ou de modo misto | |
NO20051847L (no) | Eikosapentaensyre (EPA) for behandling av anoreksia nevrosa (AN) og bulimi. | |
Suzuki | Activated protein C inhibitor | |
De et al. | Ubiquitin-like protein from human placental extract exhibits collagenase activity | |
Taddese et al. | In vitro degradation of human tropoelastin by MMP-12 and the generation of matrikines from domain 24 | |
Yoshida et al. | Characterization of an apparently lower molecular weight gamma-chain variant in fibrinogen Kyoto I. The replacement of gamma-asparagine 308 by lysine which causes accelerated cleavage of fragment D1 by plasmin and the generation of a new plasmin cleavage site. | |
ES2113878T3 (es) | Proteina c hibrida. | |
Lee et al. | Crosslinking of α2‐Antiplasmin to Fibrin | |
Yamasaki et al. | Inhibition of membrane-type serine protease 1/matriptase by natural and synthetic protease inhibitors | |
He et al. | Mechanical stretch promotes the osteogenic differentiation of bone mesenchymal stem cells induced by erythropoietin | |
JP5053435B2 (ja) | Vwfプロペプチドから成熟vwfを産生するための方法。 | |
Banfield et al. | Evolution of prothrombin: isolation and characterization of the cDNAs encoding chicken and hagfish prothrombin |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: UNIVERSITY OF TOLEDO, TOLEDO, OHIO, US |