DE60319354D1 - Mannose-6-Phosphat Rezeptor vermittelter Gentransfer zu Muskelzellen - Google Patents

Mannose-6-Phosphat Rezeptor vermittelter Gentransfer zu Muskelzellen

Info

Publication number
DE60319354D1
DE60319354D1 DE60319354T DE60319354T DE60319354D1 DE 60319354 D1 DE60319354 D1 DE 60319354D1 DE 60319354 T DE60319354 T DE 60319354T DE 60319354 T DE60319354 T DE 60319354T DE 60319354 D1 DE60319354 D1 DE 60319354D1
Authority
DE
Germany
Prior art keywords
mannose
muscle cells
phosphate receptor
gene transfer
mediated gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60319354T
Other languages
English (en)
Other versions
DE60319354T2 (de
Inventor
Gerard Johannes Platenburg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LBR MEDBIOTECH BV
Original Assignee
LBR MEDBIOTECH BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LBR MEDBIOTECH BV filed Critical LBR MEDBIOTECH BV
Application granted granted Critical
Publication of DE60319354D1 publication Critical patent/DE60319354D1/de
Publication of DE60319354T2 publication Critical patent/DE60319354T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
DE60319354T 2003-07-11 2003-07-11 Mannose-6-Phosphat Rezeptor vermittelter Gentransfer zu Muskelzellen Expired - Lifetime DE60319354T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03077205A EP1495769B1 (de) 2003-07-11 2003-07-11 Mannose-6-Phosphat Rezeptor vermittelter Gentransfer zu Muskelzellen

Publications (2)

Publication Number Publication Date
DE60319354D1 true DE60319354D1 (de) 2008-04-10
DE60319354T2 DE60319354T2 (de) 2009-03-26

Family

ID=33442814

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60319354T Expired - Lifetime DE60319354T2 (de) 2003-07-11 2003-07-11 Mannose-6-Phosphat Rezeptor vermittelter Gentransfer zu Muskelzellen

Country Status (5)

Country Link
EP (1) EP1495769B1 (de)
AT (1) ATE387217T1 (de)
DE (1) DE60319354T2 (de)
DK (1) DK1495769T3 (de)
ES (1) ES2302898T3 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2361325T3 (es) 2004-06-28 2011-06-16 The University Of Western Australia Oligonucleótidos antisentido para inducir la omisión de exón y métodos de uso de los mismos.
GB0524987D0 (en) 2005-12-08 2006-01-18 Ge Healthcare Ltd Novel imaging agents for fibrosis
WO2007123391A1 (en) 2006-04-20 2007-11-01 Academisch Ziekenhuis Leiden Therapeutic intervention in a genetic disease in an individual by modifying expression of an aberrantly expressed gene.
EP1857548A1 (de) 2006-05-19 2007-11-21 Academisch Ziekenhuis Leiden Mittel und Verfahren zur Induktion von Exon-skipping
WO2008018795A1 (en) 2006-08-11 2008-02-14 Prosensa Technologies B.V. Methods and means for treating dna repeat instability associated genetic disorders
DK2167136T3 (en) 2007-07-12 2016-07-25 Biomarin Tech Bv Molecules for targeting compounds at different selected organs or tissues
EP2167135A2 (de) 2007-07-12 2010-03-31 Prosensa Technologies B.V. Moleküle für targeting von verbindungen auf verschiedene ausgewählte organe, gewebe oder tumorzellen
USRE48468E1 (en) 2007-10-26 2021-03-16 Biomarin Technologies B.V. Means and methods for counteracting muscle disorders
NZ584793A (en) 2007-10-26 2012-05-25 Academisch Ziekenhuis Leiden Means and methods for counteracting muscle disorders
NZ587178A (en) 2008-02-08 2011-11-25 Prosensa Holding Bv Methods and means for treating dna repeat instability associated genetic disorders
EP2119783A1 (de) 2008-05-14 2009-11-18 Prosensa Technologies B.V. Verfahren für effizientes Exon (44)-Skipping bei Duchenne-Muskeldystrophie und entsprechende Mittel
EP4174178A1 (de) 2008-10-24 2023-05-03 Sarepta Therapeutics, Inc. Mehrere exon-skipping-zusammensetzungen für dmd
JP2012524540A (ja) 2009-04-24 2012-10-18 プロセンサ テクノロジーズ ビー.ブイ. Dmdを処置するためのイノシンを含むオリゴヌクレオチド
JP5837486B2 (ja) * 2009-07-03 2015-12-24 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル カチオン非依存性マンノース6−リン酸受容体を標的とする化合物
EP3431603A1 (de) 2009-11-12 2019-01-23 The University Of Western Australia Antisense-moleküle und verfahren zur krankheitsbehandlung damit
AU2010335039B2 (en) 2009-12-24 2015-03-26 Academisch Ziekenhuis Leiden H.O.D.N. Lumc Molecule for treating an inflammatory disorder
EP2806900B1 (de) 2012-01-27 2021-12-15 BioMarin Technologies B.V. Rna-modulierende oligonukleotide mit verbesserten eigenschaften zur behandlung der duchenne- und becker-muskeldystrophie
AU2013336237A1 (en) 2012-10-22 2015-06-11 Sabag-Rfa Ltd A system for delivering therapeutic agents into living cells and cells nuclei
KR102112892B1 (ko) 2012-11-15 2020-05-19 로슈 이노베이션 센터 코펜하겐 에이/에스 올리고뉴클레오티드 콘쥬게이트
MY177989A (en) 2013-01-30 2020-09-28 Hoffmann La Roche Lna oligonucleotide carbohydrate conjugates
WO2014118272A1 (en) 2013-01-30 2014-08-07 Santaris Pharma A/S Antimir-122 oligonucleotide carbohydrate conjugates
IL280443B (en) 2013-03-14 2022-07-01 Sarepta Therapeutics Inc Preparations that skip axon for the treatment of muscular dystrophy
EA201591792A1 (ru) 2013-03-15 2016-02-29 Сарепта Терапьютикс, Инк. Улучшенные композиции для лечения мышечной дистрофии
ES2770667T3 (es) 2013-06-27 2020-07-02 Roche Innovation Ct Copenhagen As Oligómeros antisentido y conjugados que se dirigen a PCSK9
GB201408623D0 (en) 2014-05-15 2014-07-02 Santaris Pharma As Oligomers and oligomer conjugates
TWI794662B (zh) 2016-03-14 2023-03-01 瑞士商赫孚孟拉羅股份公司 用於降低pd-l1表現之寡核苷酸
CN113474633A (zh) 2019-02-26 2021-10-01 罗氏创新中心哥本哈根有限公司 寡核苷酸配制方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6172208B1 (en) * 1992-07-06 2001-01-09 Genzyme Corporation Oligonucleotides modified with conjugate groups

Also Published As

Publication number Publication date
DK1495769T3 (da) 2008-06-23
ES2302898T3 (es) 2008-08-01
EP1495769A1 (de) 2005-01-12
DE60319354T2 (de) 2009-03-26
EP1495769B1 (de) 2008-02-27
ATE387217T1 (de) 2008-03-15

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