DE60315178D1 - cephem - Google Patents

cephem

Info

Publication number
DE60315178D1
DE60315178D1 DE60315178T DE60315178T DE60315178D1 DE 60315178 D1 DE60315178 D1 DE 60315178D1 DE 60315178 T DE60315178 T DE 60315178T DE 60315178 T DE60315178 T DE 60315178T DE 60315178 D1 DE60315178 D1 DE 60315178D1
Authority
DE
Germany
Prior art keywords
cephem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60315178T
Other languages
German (de)
Other versions
DE60315178T2 (en
DE60315178T3 (en
Inventor
Hidenori Ohki
Shinya Okuda
Toshio Yamanaka
Masaru Ohgaki
Ayako Toda
Kohji Kawabata
Satoshi Inoue
Keiji Misumi
Kenji Itoh
Kenji Satoh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wakunaga Pharmaceutical Co Ltd
Astellas Pharma Inc
Original Assignee
Wakunaga Pharmaceutical Co Ltd
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2002952355A external-priority patent/AU2002952355A0/en
Priority claimed from AU2003904813A external-priority patent/AU2003904813A0/en
Application filed by Wakunaga Pharmaceutical Co Ltd, Astellas Pharma Inc filed Critical Wakunaga Pharmaceutical Co Ltd
Publication of DE60315178D1 publication Critical patent/DE60315178D1/en
Publication of DE60315178T2 publication Critical patent/DE60315178T2/en
Application granted granted Critical
Publication of DE60315178T3 publication Critical patent/DE60315178T3/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
DE60315178.7T 2002-10-30 2003-10-27 cephem Expired - Lifetime DE60315178T3 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
AU2002952355 2002-10-30
AU2002952355A AU2002952355A0 (en) 2002-10-30 2002-10-30 Cephem compounds
AU2003904813A AU2003904813A0 (en) 2003-09-04 Cephem Compounds
AU2003904813 2003-09-04
PCT/JP2003/013684 WO2004039814A1 (en) 2002-10-30 2003-10-27 Cephem compounds
EP03758919.9A EP1556389B9 (en) 2002-10-30 2003-10-27 Cephem compounds

Publications (3)

Publication Number Publication Date
DE60315178D1 true DE60315178D1 (en) 2007-09-06
DE60315178T2 DE60315178T2 (en) 2008-04-30
DE60315178T3 DE60315178T3 (en) 2015-06-18

Family

ID=32231625

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60315178.7T Expired - Lifetime DE60315178T3 (en) 2002-10-30 2003-10-27 cephem

Country Status (20)

Country Link
US (2) US7129232B2 (en)
EP (1) EP1556389B9 (en)
JP (1) JP4448821B2 (en)
KR (1) KR101023035B1 (en)
AR (1) AR041729A1 (en)
AT (1) ATE368042T1 (en)
BE (1) BE2016C002I2 (en)
BR (1) BRPI0315188B8 (en)
CA (1) CA2504730C (en)
DE (1) DE60315178T3 (en)
DK (1) DK1556389T6 (en)
ES (1) ES2290498T7 (en)
FR (1) FR16C0004I2 (en)
HK (1) HK1086566A1 (en)
HU (1) HUS1600008I1 (en)
LU (1) LU92943I2 (en)
NL (1) NL300793I1 (en)
PT (1) PT1556389E (en)
TW (1) TWI319403B (en)
WO (1) WO2004039814A1 (en)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
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WO2002090364A1 (en) * 2001-05-01 2002-11-14 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
JP4448821B2 (en) * 2002-10-30 2010-04-14 アステラス製薬株式会社 Cephem compound
AU2003902380A0 (en) * 2003-05-16 2003-06-05 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
WO2005027909A1 (en) * 2003-09-18 2005-03-31 Astellas Pharma Inc. Cephem compounds
US7511159B2 (en) 2003-12-25 2009-03-31 Ono Pharmaceutical Co., Ltd. Azetidine ring compounds and drugs comprising the same
EP1994035A1 (en) * 2006-03-16 2008-11-26 Astellas Pharma Inc. Cephem compounds and use as antimicrobial agents
ITFE20060029A1 (en) * 2006-10-17 2008-04-18 Gruppo Kemon Spa PRIMARY HETEROCYCLIC INTERMEDIATES FOR THE OXIDATIVE COLORING OF PYRACTIONAL HAIR
JP5733856B2 (en) 2007-10-09 2015-06-10 ソファーミア，インコーポレイテッド Broadband β-lactamase inhibitor
CN103649076B (en) 2011-05-13 2015-09-09 阵列生物制药公司 As pyrrolidyl urea and the pyrrolidyl thiourea compound of TRKA kinase inhibitor
EP2753326A4 (en) 2011-09-09 2015-04-15 Cubist Pharm Inc Methods for treating intrapulmonary infections
EP2628730B1 (en) * 2012-02-16 2017-12-06 Noxell Corporation Telescoping synthesis of 5-amino-4-nitroso-1-alkyl-1h-pyrazole salts
US8809314B1 (en) 2012-09-07 2014-08-19 Cubist Pharmacueticals, Inc. Cephalosporin compound
US8476425B1 (en) 2012-09-27 2013-07-02 Cubist Pharmaceuticals, Inc. Tazobactam arginine compositions
AU2013323280A1 (en) 2012-09-27 2015-04-09 Merck Sharp & Dohme Corp. Tazobactam arginine antibiotic compositions
US20140274999A1 (en) * 2013-03-14 2014-09-18 Cubist Pharmaceuticals, Inc. Cephalosporin compositions and methods of manufacture
CN110279698B (en) 2013-03-15 2022-10-28 默沙东有限责任公司 Ceftolozane antibiotic compositions
US20140274993A1 (en) 2013-03-15 2014-09-18 Cubist Pharmaceuticals, Inc. Ceftolozane-tazobactam pharmaceutical compositions
US9872906B2 (en) 2013-03-15 2018-01-23 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
US10376496B2 (en) 2013-09-09 2019-08-13 Merck, Sharp & Dohme Corp. Treating infections with ceftolozane/tazobactam in subjects having impaired renal function
US20150094293A1 (en) * 2013-09-27 2015-04-02 Calixa Therapeutics, Inc. Solid forms of ceftolozane
US20160228448A1 (en) * 2013-09-27 2016-08-11 Merck Sharp & Dohme Corp. Solid Forms of Ceftolozane
US9120796B2 (en) 2013-10-02 2015-09-01 Cubist Pharmaceuticals, Inc. B-lactamase inhibitor picoline salt
NZ727418A (en) 2014-05-15 2023-03-31 Array Biopharma Inc 1-((3s,4r)-4-(3-fluorophenyl)-1-(2-methoxyethyl)pyrrolidin-3-yl)-3-(4-methyl-3-(2-methylpyrimidin-5-yl)-1-phenyl-1h-pyrazol-5-yl)urea as a trka kinase inhibitor
CN110204558B (en) 2014-08-15 2022-05-06 默沙东公司 Synthesis of cephalosporin compounds
WO2016025813A1 (en) 2014-08-15 2016-02-18 Merck Sharp & Dohme Corp. Intermediates in the synthesis of cephalosporin compounds
US10000510B2 (en) 2014-08-18 2018-06-19 Merck Sharp & Dohme Corp. Salt forms of ceftolozane
WO2016100897A1 (en) * 2014-12-18 2016-06-23 Merck Sharp & Dohme Corp. Thiadiazolyl-oximinoacetic acid derivative compounds
US10035774B2 (en) 2014-12-18 2018-07-31 Merck Sharp & Dohme Corp. Pyrazolyl carboxylic acid and pyrazolyl urea derivative compounds
US20160176897A1 (en) 2014-12-23 2016-06-23 Merck Sharp & Dohme Corp. 7-aminocephem derivative compounds
US10214543B2 (en) 2014-12-30 2019-02-26 Merck Sharp & Dohme Corp. Synthesis of cephalosporin compounds
CA2987158A1 (en) * 2015-06-29 2017-01-05 Sandoz Ag Process for the preparation of carbamoylamino pyrazole derivatives
EP3347362B1 (en) 2015-09-08 2019-10-23 Sandoz AG Process for preparing ceftolozane from 7-aminocephalosporanic acid (7-aca)
BR112018009725A8 (en) 2015-12-10 2019-02-26 Naeja Rgm Pharmaceuticals Ulc cefém compounds, their production and use
CN109195967A (en) 2016-06-06 2019-01-11 默沙东公司 The solid form and preparation method of cephalo Luozha
CN107586305A (en) * 2017-06-23 2018-01-16 浙江惠迪森药业有限公司 A kind of beta-lactam class compound carboxyl and hydroxyl protecting group removal methods
WO2019145784A2 (en) * 2018-01-26 2019-08-01 Legochem Biosciences, Inc. Combination therapies for multi-drug resistant pathogens
CN109369535A (en) * 2018-11-07 2019-02-22 浙江东邦药业有限公司 A kind of preparation method of carbamoylamino pyrazole derivative compounds

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR78245B (en) * 1980-09-12 1984-09-26 Ciba Geigy Ag
US5194432A (en) * 1985-11-22 1993-03-16 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
CA1293719C (en) * 1986-09-22 1991-12-31 Takao Takaya Cephem compounds and processes for preparation thereof
US5663163A (en) * 1987-09-07 1997-09-02 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds and processes for preparation thereof
US5210080A (en) * 1987-09-07 1993-05-11 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
IE63094B1 (en) * 1987-09-14 1995-03-22 Fujisawa Pharmaceutical Co Cephem compound and a process for preparation thereof
US5173485A (en) * 1988-03-09 1992-12-22 Fujisawa Pharmaceutical Company, Ltd. Cephem compounds
GB8905301D0 (en) * 1989-03-08 1989-04-19 Fujisawa Pharmaceutical Co New cephem compound and a process for preparation thereof
US5215982A (en) * 1989-11-10 1993-06-01 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
KR910015587A (en) * 1990-02-27 1991-09-30 후지사와 토모키치로 Cefem compound
GB9023479D0 (en) * 1990-10-29 1990-12-12 Fujisawa Pharmaceutical Co New cephem compounds and processes for preparation thereof
JPH09110877A (en) 1995-10-17 1997-04-28 Katayama Seiyakushiyo:Kk Cephem compound, its production and antibacterial agent containing the compound
AUPN955596A0 (en) 1996-04-30 1996-05-23 Fujisawa Pharmaceutical Co., Ltd. New compound
TW526202B (en) * 1998-11-27 2003-04-01 Shionogi & Amp Co Broad spectrum cephem having benzo[4,5-b]pyridium methyl group of antibiotic activity
WO2002090364A1 (en) * 2001-05-01 2002-11-14 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
JP4448821B2 (en) * 2002-10-30 2010-04-14 アステラス製薬株式会社 Cephem compound
AU2003902380A0 (en) * 2003-05-16 2003-06-05 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
WO2005027909A1 (en) * 2003-09-18 2005-03-31 Astellas Pharma Inc. Cephem compounds

Also Published As

Publication number Publication date
KR101023035B1 (en) 2011-03-24
EP1556389B3 (en) 2015-04-01
DE60315178T2 (en) 2008-04-30
US20040132994A1 (en) 2004-07-08
KR20050084897A (en) 2005-08-29
LU92943I2 (en) 2016-03-14
EP1556389A1 (en) 2005-07-27
JP4448821B2 (en) 2010-04-14
EP1556389B9 (en) 2015-09-09
NL300793I2 (en) 2016-03-15
HUS1600008I1 (en) 2016-03-29
HK1086566A1 (en) 2006-09-22
BRPI0315188B1 (en) 2017-04-25
EP1556389B1 (en) 2007-07-25
TW200410977A (en) 2004-07-01
DE60315178T3 (en) 2015-06-18
US20070037786A1 (en) 2007-02-15
FR16C0004I1 (en) 2016-03-25
US7129232B2 (en) 2006-10-31
BR0315188A (en) 2005-09-06
PT1556389E (en) 2007-11-08
CA2504730A1 (en) 2004-05-13
ES2290498T3 (en) 2008-02-16
DK1556389T3 (en) 2007-11-26
BRPI0315188B8 (en) 2021-05-25
WO2004039814A1 (en) 2004-05-13
DK1556389T6 (en) 2015-05-11
AR041729A1 (en) 2005-05-26
JP2006506459A (en) 2006-02-23
ATE368042T1 (en) 2007-08-15
BE2016C002I2 (en) 2023-03-07
NL300793I1 (en) 2016-03-15
FR16C0004I2 (en) 2017-01-06
ES2290498T7 (en) 2015-07-10
TWI319403B (en) 2010-01-11
CA2504730C (en) 2011-04-12

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
R065 Request for grant of supplementary protection certificate validly filed

Free format text: PRODUCT NAME: CEFTOLOZAN ODER EIN PHARMAZEUTISCH VERTRAEGLICHES SALZ DAVON, INSBESONDERE EIN SCHWEFELSAEURESALZ; REGISTRATION NO/DATE: EU/1/15/1032/001 20150918

Spc suppl protection certif: 122015000113

Filing date: 20151222

Expiry date: 20231028

Extension date: 20281027

R067 Examining division decision granting supplementary protection certificate

Free format text: PRODUCT NAME: CEFTOLOZAN ODER EIN PHARMAZEUTISCH VERTRAEGLICHES SALZ DAVON, INSBESONDERE EIN SCHWEFELSAEURESALZ; REGISTRATION NO/DATE: EU/1/15/1032/001 20150918

Spc suppl protection certif: 122015000113

Filing date: 20151222

Expiry date: 20231028

Extension date: 20281027

R069 Supplementary protection certificate granted

Free format text: PRODUCT NAME: CEFTOLOZAN ODER EIN PHARMAZEUTISCH VERTRAEGLICHES SALZ DAVON, INSBESONDERE EIN SCHWEFELSAEURESALZ; REGISTRATION NO/DATE: EU/1/15/1032/001 20150918

Spc suppl protection certif: 122015000113

Filing date: 20151222

Expiry date: 20231028

Extension date: 20281027