DE60308349D1 - Terephthalic derivatives, their preparation and compositions containing them - Google Patents

Terephthalic derivatives, their preparation and compositions containing them

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Publication number
DE60308349D1
DE60308349D1 DE60308349T DE60308349T DE60308349D1 DE 60308349 D1 DE60308349 D1 DE 60308349D1 DE 60308349 T DE60308349 T DE 60308349T DE 60308349 T DE60308349 T DE 60308349T DE 60308349 D1 DE60308349 D1 DE 60308349D1
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DE
Germany
Prior art keywords
preparation
derivatives
terephthalic
compositions containing
sub
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60308349T
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German (de)
Other versions
DE60308349T2 (en
Inventor
Francis Barth
Serge Martinez
Murielle Rinaldi-Carmona
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Sanofi Aventis France
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Sanofi Aventis France
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Publication of DE60308349D1 publication Critical patent/DE60308349D1/en
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Publication of DE60308349T2 publication Critical patent/DE60308349T2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/28—Nitrogen atoms
    • C07D295/32—Nitrogen atoms acylated with carboxylic or carbonic acids, or their nitrogen or sulfur analogues
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    • C07C233/68—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/69—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of an acyclic saturated carbon skeleton
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
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    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/16—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with acylated ring nitrogen atom
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    • C07D211/98—Nitrogen atom
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    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/22—All rings being cycloaliphatic the ring system containing eight carbon atoms, e.g. pentalene

Abstract

The invention relates to terphenyl derivatives of formula: and to their preparation and to the pharmaceutical compositions comprising them. These compounds exhibit an antagonist activity with respect to CB<SUB>1 </SUB>cannabinoid receptors.
DE60308349T 2002-04-11 2003-04-10 Terephthalic derivatives, their preparation and compositions containing them Expired - Lifetime DE60308349T2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0204567 2002-04-11
FR0204567A FR2838439B1 (en) 2002-04-11 2002-04-11 TERPHENYL DERIVATIVES, THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
PCT/FR2003/001134 WO2003084943A2 (en) 2002-04-11 2003-04-10 Terphenyl derivatives, preparation thereof, compositions containing same

Publications (2)

Publication Number Publication Date
DE60308349D1 true DE60308349D1 (en) 2006-10-26
DE60308349T2 DE60308349T2 (en) 2007-04-19

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
DE60308349T Expired - Lifetime DE60308349T2 (en) 2002-04-11 2003-04-10 Terephthalic derivatives, their preparation and compositions containing them

Country Status (13)

Country Link
US (1) US7390924B2 (en)
EP (1) EP1497274B1 (en)
JP (1) JP4634717B2 (en)
CN (1) CN100432062C (en)
AT (1) ATE339408T1 (en)
AU (1) AU2003246811A1 (en)
BR (1) BR0309106A (en)
CA (1) CA2481392A1 (en)
DE (1) DE60308349T2 (en)
FR (1) FR2838439B1 (en)
MX (1) MXPA04009981A (en)
PL (1) PL374024A1 (en)
WO (1) WO2003084943A2 (en)

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