DE60227408D1 - CONCERNING ORNAMENTAL CONNECTIONS - Google Patents

CONCERNING ORNAMENTAL CONNECTIONS

Info

Publication number
DE60227408D1
DE60227408D1 DE60227408T DE60227408T DE60227408D1 DE 60227408 D1 DE60227408 D1 DE 60227408D1 DE 60227408 T DE60227408 T DE 60227408T DE 60227408 T DE60227408 T DE 60227408T DE 60227408 D1 DE60227408 D1 DE 60227408D1
Authority
DE
Germany
Prior art keywords
ornamental
concerning
connections
heteroalkyl
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60227408T
Other languages
German (de)
Inventor
Keith Wood
Erika Hawkins
Mike Scurria
Dieter Klaubert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Promega Corp
Original Assignee
Promega Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Promega Corp filed Critical Promega Corp
Application granted granted Critical
Publication of DE60227408D1 publication Critical patent/DE60227408D1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/66—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving luciferase

Abstract

A compound of formula (XII) wherein R 7 is H, alkyl, heteroalkyl, aryl, or -CH 2 -C 6 H 4 OR 14 ; R 8 is H, alkyl, heteroalkyl, or aryl or combinations thereof; R 9 is H, alkyl, heteroalkyl, aryl, or combinations thereof or -C 6 H 4 OR 15 ; R 10 is-H, -CH 3 , or-CH (CH 3 ) 2 ; and R 11 , R 14 , and R 15 are independently enzyme-removable groups; wherein R 11 , R 14 , and R 15 together with the oxygen atom to which each is attached is an ether, ester, or combination thereof; with the proviso that R 11 , R 14 and R 15 are not all acetyl groups.
DE60227408T 2001-11-02 2002-11-01 CONCERNING ORNAMENTAL CONNECTIONS Expired - Lifetime DE60227408D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/053,482 US7268229B2 (en) 2001-11-02 2001-11-02 Compounds to co-localize luminophores with luminescent proteins
PCT/US2002/034972 WO2003040100A1 (en) 2001-11-02 2002-11-01 Compositions, methods and kits pertaining to luminescent compounds

Publications (1)

Publication Number Publication Date
DE60227408D1 true DE60227408D1 (en) 2008-08-14

Family

ID=21984572

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60227408T Expired - Lifetime DE60227408D1 (en) 2001-11-02 2002-11-01 CONCERNING ORNAMENTAL CONNECTIONS

Country Status (10)

Country Link
US (2) US7268229B2 (en)
EP (2) EP1894933B1 (en)
JP (1) JP4958388B2 (en)
CN (2) CN101440089A (en)
AT (1) ATE399784T1 (en)
CA (1) CA2462506C (en)
DE (1) DE60227408D1 (en)
DK (1) DK1451155T3 (en)
ES (1) ES2307829T3 (en)
WO (1) WO2003040100A1 (en)

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US8288559B2 (en) 2008-08-18 2012-10-16 Promega Corporation Luminogenic compounds and methods to detect cytochrome P450 3A enzymes
WO2010090319A1 (en) 2009-02-09 2010-08-12 チッソ株式会社 Coelenterazine analogs and manufacturing method thereof
BRPI1010019B1 (en) 2009-05-01 2019-02-05 Promega Corp modified luciferase polypeptide, vector and kit comprising the same
JP5605727B2 (en) 2010-04-06 2014-10-15 Ｊｎｃ株式会社 Coelenterazine analogs and coelenteramide analogs
KR101867359B1 (en) 2010-05-10 2018-07-23 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 Endoribonuclease compositions and methods of use thereof
US9487520B2 (en) * 2010-11-02 2016-11-08 Promega Corporation Coelenterazine derivatives and methods of using same
ES2567410T3 (en) * 2010-11-02 2016-04-22 Promega Corporation New coelenterazine substrates and methods of use
WO2013033515A1 (en) 2011-09-02 2013-03-07 Promega Corporation Compounds and methods for assaying redox state of metabolically active cells and methods for measuring nad(p)/nad(p)h
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JP6484987B2 (en) 2013-10-21 2019-03-20 Jnc株式会社 Evil luciferase catalytic protein mutant gene and its usage
JP6442825B2 (en) 2013-12-26 2018-12-26 Jnc株式会社 Evil luciferase catalytic protein mutant gene and its usage
WO2015116806A1 (en) 2014-01-29 2015-08-06 Promega Corporation Pro-substrates for live cell applications
US9790537B2 (en) 2014-01-29 2017-10-17 Promega Corporation Quinone-masked probes as labeling reagents for cell uptake measurements
JP6265020B2 (en) 2014-04-16 2018-01-24 Jnc株式会社 Evil luciferase catalytic protein mutant gene and its usage
WO2016040788A1 (en) * 2014-09-11 2016-03-17 Promega Corporation Luciferase sequences utilizing infrared-emitting substrates to produce enhanced luminescence
EP3191601B1 (en) 2014-09-12 2022-11-02 Promega Corporation Internal protein tags
WO2016057084A1 (en) 2014-10-08 2016-04-14 Promega Corporation Bioluminescent succinate detection assay
EP3313846B1 (en) 2015-06-25 2020-05-06 Promega Corporation Thienopyrrole compounds and uses thereof as inhibitors of oplophorus-derived luciferases
WO2017142852A1 (en) 2016-02-15 2017-08-24 Promega Corporation Coelenterazine analogues
JP6978492B2 (en) * 2016-09-09 2021-12-08 プロメガ コーポレイションPromega Corporation Double-protected proselenterazine substrate
EP3535270B1 (en) 2016-11-01 2022-07-27 Promega Corporation Coelenterazine analogues tethered to energy acceptors
US10577370B2 (en) 2016-12-01 2020-03-03 Promega Corporation Cell impermeable coelenterazine analogues
US10815247B2 (en) 2016-12-28 2020-10-27 Promega Corporation Functionalized NANOLUC inhibitors
US10836767B2 (en) 2017-07-06 2020-11-17 Promega Corporation Serum stable pro-coelenterazine analogues
US11655247B2 (en) 2018-05-01 2023-05-23 Promega Corporation Nanoluc suicide substrates
EP4140991A1 (en) 2018-06-01 2023-03-01 Promega Corporation Inhibitors of oplophorus luciferase-derived bioluminescent complexes
US11857638B2 (en) 2018-07-27 2024-01-02 Promega Corporation Quinone-containing conjugates
JP7447101B2 (en) 2018-10-03 2024-03-11 プロメガ コーポレイション Compositions and methods for stabilizing coelenterazine and its analogs and derivatives
BR112022010153A2 (en) 2019-11-27 2022-08-09 Promega Corp PEPTIDES, NUCLEIC ACID, POLYPEPTIDE, COMPOSITION, BIOLUMINESCENT COMPLEX, METHODS, DIPEPTIDE, SYSTEM AND KIT
EP4073512A1 (en) 2019-12-10 2022-10-19 Promega Corporation Compositions and methods for bioluminescent detection using multifunctional probes
EP4153770A2 (en) 2020-05-22 2023-03-29 Promega Corporation Enhancement of kinase target engagement
CN113683617B (en) * 2021-07-16 2022-08-30 山东大学 Coelenterazine-h-based deuterated compound as well as preparation method and application thereof
WO2023215497A1 (en) 2022-05-04 2023-11-09 Promega Corporation Photoactivatable compounds and uses thereof
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Also Published As

Publication number Publication date
EP1894933A2 (en) 2008-03-05
CA2462506C (en) 2010-04-06
EP1894933B1 (en) 2013-07-03
WO2003040100A1 (en) 2003-05-15
DK1451155T3 (en) 2008-11-10
CN101440089A (en) 2009-05-27
ATE399784T1 (en) 2008-07-15
JP4958388B2 (en) 2012-06-20
US7537912B2 (en) 2009-05-26
CA2462506A1 (en) 2003-05-15
CN100439338C (en) 2008-12-03
EP1451155A1 (en) 2004-09-01
US20030153090A1 (en) 2003-08-14
US20080050760A1 (en) 2008-02-28
EP1894933A3 (en) 2008-03-26
US7268229B2 (en) 2007-09-11
EP1451155B1 (en) 2008-07-02
JP2005515977A (en) 2005-06-02
ES2307829T3 (en) 2008-12-01
CN1612860A (en) 2005-05-04
EP1451155A4 (en) 2006-03-01

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