TR200003654T2 - 3- (2-oxo- (1,3 ') bipyrolidinyl-3-ylidenemethyl) -cephalo derivatives. - Google Patents

3- (2-oxo- (1,3 ') bipyrolidinyl-3-ylidenemethyl) -cephalo derivatives.

Info

Publication number
TR200003654T2
TR200003654T2 TR2000/03654T TR200003654T TR200003654T2 TR 200003654 T2 TR200003654 T2 TR 200003654T2 TR 2000/03654 T TR2000/03654 T TR 2000/03654T TR 200003654 T TR200003654 T TR 200003654T TR 200003654 T2 TR200003654 T2 TR 200003654T2
Authority
TR
Turkey
Prior art keywords
hydrogen
ocor
cooch
coor
alkyl
Prior art date
Application number
TR2000/03654T
Other languages
Turkish (tr)
Inventor
Hebeisen Paul
Hubschwerlen Christian
Specklin Jean-Luc
Original Assignee
Basilea Pharmaceutica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basilea Pharmaceutica Ag filed Critical Basilea Pharmaceutica Ag
Publication of TR200003654T2 publication Critical patent/TR200003654T2/en

Links

Abstract

Bulus formül I'e uygun bilesikler, farmasötik açidan kabul edilebilen tuzlari ve bunlarin hidratlari ve bu tür bilesiklerin farmasötik terkiplerin imalatinda kullanimina iliskindir. Burada R1 hidrojen, istege göre fluoro ile ikameli C1-6-alkil veya C3-6 sikloalkildir; R2 hidrojen veya asagidaki gruplardan biridir: -CH2C(=CHR)COOR,-CH2OCOR, -CH(R)OCOR, -CH(R)OCOOR, -CH(OCOR)OCOR, -CH2COCH2OCOR ve (II) R3 hidrojen veya asagidaki gruplardan biridir; -CH2C(=CH2)-COOR, -COOCH2C(=CHR)-COOR, -COOCH2OCOR, -COOCH(R)OCOR, -COOCH(R)OCOOR, -COOCH(OCOR)OCOR, -COOH2COCH2OCOR, ve (III), su sartla ki R2 veR3 ten biri hidrojendir ve R2 ve R3'ten digeri hidrojenden farklidir; R hidrojen veya C1-6-alkildir; R4 hidrojen veya hidroksidir, R5 hidrojen veya omega-hidroksi alkildir; ve XCH veya N'dir.The invention relates to compounds according to formula I, their pharmaceutically acceptable salts and their hydrates, and the use of such compounds in the manufacture of pharmaceutical compositions. R1 is hydrogen, C1-6-alkyl or C3-6 cycloalkyl optionally substituted with fluoro; R2 is hydrogen or one of the following groups: -CH2C (= CHR) COOR, -CH2OCOR, -CH (R) OCOR, -CH (R) OCOOR, -CH (OCOR) OCOR, -CH2COCH2OCOR and (II) R3 is hydrogen or it is one; -CH2C (= CH2) -COOR, -COOCH2C (= CHR) -COOR, -COOCH2OCOR, -COOCH (R) OCOR, -COOCH (R) OCOOR, -COOCH (OCOR) OCOR, -COOH2COCH2OCOR, and (III), provided that one of R2 and R3 is hydrogen and the other of R2 and R3 is different from hydrogen; R is hydrogen or C1-6-alkyl; R4 is hydrogen or hydroxy, R5 is hydrogen or omega-hydroxy alkyl; and XCH or N.

TR2000/03654T 1998-06-15 1999-06-07 3- (2-oxo- (1,3 ') bipyrolidinyl-3-ylidenemethyl) -cephalo derivatives. TR200003654T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98110888 1998-06-15

Publications (1)

Publication Number Publication Date
TR200003654T2 true TR200003654T2 (en) 2001-03-21

Family

ID=8232122

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/03654T TR200003654T2 (en) 1998-06-15 1999-06-07 3- (2-oxo- (1,3 ') bipyrolidinyl-3-ylidenemethyl) -cephalo derivatives.

Country Status (2)

Country Link
TR (1) TR200003654T2 (en)
ZA (1) ZA200006960B (en)

Also Published As

Publication number Publication date
ZA200006960B (en) 2002-02-27

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