DE60214127D1 - HYBRIDOMY CELL LINE G250 AND ITS USE FOR THE PRODUCTION OF MONOCLONAL ANTIBODIES - Google Patents
HYBRIDOMY CELL LINE G250 AND ITS USE FOR THE PRODUCTION OF MONOCLONAL ANTIBODIESInfo
- Publication number
- DE60214127D1 DE60214127D1 DE60214127T DE60214127T DE60214127D1 DE 60214127 D1 DE60214127 D1 DE 60214127D1 DE 60214127 T DE60214127 T DE 60214127T DE 60214127 T DE60214127 T DE 60214127T DE 60214127 D1 DE60214127 D1 DE 60214127D1
- Authority
- DE
- Germany
- Prior art keywords
- hybridomy
- production
- cell line
- monoclonal antibodies
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3038—Kidney, bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
- A61K47/6861—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from kidney or bladder cancer cell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Urology & Nephrology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention relates to novel nucleic acid sequences which encode an antibody suitable in the field of tumor diagnostics and therapeutics. Further, a method of producing recombinant antibodies is provided, wherein the novel nucleic acid sequencs are employed.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26685301P | 2001-02-07 | 2001-02-07 | |
US266853P | 2001-02-07 | ||
US32700801P | 2001-10-05 | 2001-10-05 | |
US327008P | 2001-10-05 | ||
PCT/EP2002/001282 WO2002062972A2 (en) | 2001-02-07 | 2002-02-07 | Hybridoma cell line g250 and its use for producing monoclonal antibodies |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60214127D1 true DE60214127D1 (en) | 2006-10-05 |
DE60214127T2 DE60214127T2 (en) | 2007-01-11 |
Family
ID=26952068
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60214127T Expired - Lifetime DE60214127T2 (en) | 2001-02-07 | 2002-02-07 | HYBRIDOMY CELL LINE G250 AND ITS USE FOR THE PRODUCTION OF MONOCLONAL ANTIBODIES |
Country Status (13)
Country | Link |
---|---|
US (1) | US20040219633A1 (en) |
EP (2) | EP1358318B8 (en) |
JP (1) | JP4263485B2 (en) |
AT (1) | ATE337395T1 (en) |
AU (2) | AU2002238537B8 (en) |
CA (1) | CA2435683C (en) |
DE (1) | DE60214127T2 (en) |
DK (2) | DK1733736T3 (en) |
ES (2) | ES2266448T3 (en) |
HK (1) | HK1094876A1 (en) |
MX (1) | MXPA03006992A (en) |
PT (2) | PT1733736E (en) |
WO (2) | WO2002063010A2 (en) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040077081A1 (en) | 2001-02-07 | 2004-04-22 | Egbert Oosterwijk | Hybridoma cell line g250 and its use for producing monoclonal antibodies |
US20090162382A1 (en) * | 2002-03-01 | 2009-06-25 | Bernett Matthew J | Optimized ca9 antibodies and methods of using the same |
AU2003280442B2 (en) | 2002-07-01 | 2009-02-05 | Wilex Ag | Co-administration of CG250 and IL-2 or IFN-alpha for treating cancer such as renal cell carcinomas |
JP2008505143A (en) * | 2004-07-02 | 2008-02-21 | ヴィレックス アクチェンゲゼルシャフト | Improved adjuvant therapy for G250 expressing tumors |
US8466263B2 (en) | 2005-12-02 | 2013-06-18 | Dana-Farber Cancer Institute, Inc. | Carbonic anhydrase IX (G250) anitbodies |
DOP2006000277A (en) * | 2005-12-12 | 2007-08-31 | Bayer Pharmaceuticals Corp | ANTI MN ANTIBODIES AND METHODS FOR USE |
WO2008091798A2 (en) * | 2007-01-22 | 2008-07-31 | Xencor, Inc. | Optimized ca9 antibodies and methods of using the same |
GB0911569D0 (en) * | 2009-07-03 | 2009-08-12 | Ulive Entpr Ltd | Method for the detection of organ or tissue injury |
RU2536290C2 (en) * | 2009-09-15 | 2014-12-20 | Вилекс Аг | Selective detection of bone metastases in clear cell renal cell adenocarcinoma |
AU2014220705C1 (en) * | 2013-02-22 | 2018-10-18 | Wilex Ag | CAIX stratification based cancer treatment |
BR112021026651A2 (en) * | 2019-07-02 | 2022-03-03 | Telix Int Pty Ltd | Antibodies against coffin with reduced affinity for the neonatal fc receptor |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4816567A (en) * | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
AU6032786A (en) * | 1985-07-25 | 1987-01-29 | University Of Minnesota | Detection, imaging and therapy of renal cell carcinoma with monoclonal antibodies in vivo |
US5618920A (en) * | 1985-11-01 | 1997-04-08 | Xoma Corporation | Modular assembly of antibody genes, antibodies prepared thereby and use |
WO1988008854A1 (en) * | 1987-05-06 | 1988-11-17 | Egbert Oosterwijk | Monoclonal antibodies to renal cell carcinoma |
US5258498A (en) * | 1987-05-21 | 1993-11-02 | Creative Biomolecules, Inc. | Polypeptide linkers for production of biosynthetic proteins |
US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
GB9015198D0 (en) * | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
DE69616651D1 (en) * | 1995-05-26 | 2001-12-13 | Merck Patent Gmbh | Antiidiotypic antibodies that induce an immune response against the receptor for epidermal growth factor |
US6057098A (en) * | 1997-04-04 | 2000-05-02 | Biosite Diagnostics, Inc. | Polyvalent display libraries |
DK2180007T4 (en) * | 1998-04-20 | 2017-11-27 | Roche Glycart Ag | Glycosylation technique for antibodies to enhance antibody-dependent cell cytotoxicity |
FR2793497B1 (en) * | 1999-05-10 | 2003-04-18 | Centre Nat Rech Scient | MONOCLONAL ANTIBODIES DIRECTED AGAINST HUMAN RENAL CARCINOMA CELLS |
KR20020092886A (en) * | 1999-07-06 | 2002-12-12 | 고트-아-겐 에이비 | Recombinant adenovirus |
GB0017720D0 (en) * | 2000-07-19 | 2000-09-06 | Got A Gene Ab | Modified virus |
WO2003016909A1 (en) * | 2001-08-16 | 2003-02-27 | Ludwig Institute For Cancer Research | Method for determining protein component in a biological sample |
-
2002
- 2002-02-07 ES ES02704692T patent/ES2266448T3/en not_active Expired - Lifetime
- 2002-02-07 JP JP2002563309A patent/JP4263485B2/en not_active Expired - Lifetime
- 2002-02-07 DE DE60214127T patent/DE60214127T2/en not_active Expired - Lifetime
- 2002-02-07 WO PCT/EP2002/001283 patent/WO2002063010A2/en not_active Application Discontinuation
- 2002-02-07 WO PCT/EP2002/001282 patent/WO2002062972A2/en active IP Right Grant
- 2002-02-07 AT AT02704692T patent/ATE337395T1/en active
- 2002-02-07 DK DK06014768.3T patent/DK1733736T3/en active
- 2002-02-07 EP EP02704692A patent/EP1358318B8/en not_active Expired - Lifetime
- 2002-02-07 PT PT60147683T patent/PT1733736E/en unknown
- 2002-02-07 DK DK02704692T patent/DK1358318T3/en active
- 2002-02-07 AU AU2002238537A patent/AU2002238537B8/en not_active Expired
- 2002-02-07 PT PT02704692T patent/PT1358318E/en unknown
- 2002-02-07 MX MXPA03006992A patent/MXPA03006992A/en active IP Right Grant
- 2002-02-07 EP EP02722053A patent/EP1385959A2/en not_active Withdrawn
- 2002-02-07 CA CA2435683A patent/CA2435683C/en not_active Expired - Lifetime
- 2002-02-07 AU AU2002252999A patent/AU2002252999A1/en not_active Abandoned
- 2002-02-07 ES ES06014768.3T patent/ES2531909T3/en not_active Expired - Lifetime
-
2003
- 2003-08-07 US US10/635,908 patent/US20040219633A1/en not_active Abandoned
-
2007
- 2007-03-02 HK HK07102381.6A patent/HK1094876A1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AU2002252999A1 (en) | 2002-08-19 |
WO2002063010A2 (en) | 2002-08-15 |
WO2002062972A2 (en) | 2002-08-15 |
HK1094876A1 (en) | 2007-04-13 |
WO2002062972A3 (en) | 2002-12-12 |
US20040219633A1 (en) | 2004-11-04 |
ATE337395T1 (en) | 2006-09-15 |
MXPA03006992A (en) | 2003-11-18 |
AU2002238537B2 (en) | 2006-07-20 |
EP1358318A2 (en) | 2003-11-05 |
CA2435683A1 (en) | 2002-08-15 |
DE60214127T2 (en) | 2007-01-11 |
WO2002063010A9 (en) | 2002-09-12 |
ES2531909T3 (en) | 2015-03-20 |
AU2002238537B8 (en) | 2006-08-24 |
JP2004522447A (en) | 2004-07-29 |
DK1733736T3 (en) | 2015-06-01 |
JP4263485B2 (en) | 2009-05-13 |
EP1358318B8 (en) | 2006-11-15 |
EP1358318B1 (en) | 2006-08-23 |
WO2002063010A3 (en) | 2003-11-27 |
PT1358318E (en) | 2007-01-31 |
DK1358318T3 (en) | 2007-01-02 |
ES2266448T3 (en) | 2007-03-01 |
PT1733736E (en) | 2015-06-11 |
CA2435683C (en) | 2012-03-20 |
EP1385959A2 (en) | 2004-02-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8381 | Inventor (new situation) |
Inventor name: OOSTERWIJK, EGBERT, NL-6641 BEUNINGEN, NL Inventor name: WARNAAR, SVEN, NL-2334 LEIDEN, NL Inventor name: ULLRICH, STEFAN, DR., 82319 STARNBERG, DE |
|
8364 | No opposition during term of opposition |