DE602006020335D1 - Verwendung von parp-1-hemmern - Google Patents
Verwendung von parp-1-hemmernInfo
- Publication number
- DE602006020335D1 DE602006020335D1 DE602006020335T DE602006020335T DE602006020335D1 DE 602006020335 D1 DE602006020335 D1 DE 602006020335D1 DE 602006020335 T DE602006020335 T DE 602006020335T DE 602006020335 T DE602006020335 T DE 602006020335T DE 602006020335 D1 DE602006020335 D1 DE 602006020335D1
- Authority
- DE
- Germany
- Prior art keywords
- parp
- amount
- tumor
- patient
- increase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 108010064218 Poly (ADP-Ribose) Polymerase-1 Proteins 0.000 title abstract 3
- 102100023712 Poly [ADP-ribose] polymerase 1 Human genes 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title abstract 3
- XXPXYPLPSDPERN-UHFFFAOYSA-N Ecteinascidin 743 Natural products COc1cc2C(NCCc2cc1O)C(=O)OCC3N4C(O)C5Cc6cc(C)c(OC)c(O)c6C(C4C(S)c7c(OC(=O)C)c(C)c8OCOc8c37)N5C XXPXYPLPSDPERN-UHFFFAOYSA-N 0.000 abstract 6
- PKVRCIRHQMSYJX-AIFWHQITSA-N trabectedin Chemical compound C([C@@]1(C(OC2)=O)NCCC3=C1C=C(C(=C3)O)OC)S[C@@H]1C3=C(OC(C)=O)C(C)=C4OCOC4=C3[C@H]2N2[C@@H](O)[C@H](CC=3C4=C(O)C(OC)=C(C)C=3)N(C)[C@H]4[C@@H]21 PKVRCIRHQMSYJX-AIFWHQITSA-N 0.000 abstract 6
- 229960000977 trabectedin Drugs 0.000 abstract 6
- 239000000203 mixture Substances 0.000 abstract 3
- 231100000433 cytotoxic Toxicity 0.000 abstract 2
- 230000001472 cytotoxic effect Effects 0.000 abstract 2
- 210000004881 tumor cell Anatomy 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 230000003013 cytotoxicity Effects 0.000 abstract 1
- 231100000135 cytotoxicity Toxicity 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73953605P | 2005-11-25 | 2005-11-25 | |
| PCT/US2006/061254 WO2007062413A2 (en) | 2005-11-25 | 2006-11-27 | Use of parp-1 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602006020335D1 true DE602006020335D1 (de) | 2011-04-07 |
Family
ID=38068066
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602006020335T Active DE602006020335D1 (de) | 2005-11-25 | 2006-11-27 | Verwendung von parp-1-hemmern |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20090170860A1 (https=) |
| EP (1) | EP1962843B1 (https=) |
| JP (1) | JP2009517403A (https=) |
| AT (1) | ATE499098T1 (https=) |
| AU (1) | AU2006318226A1 (https=) |
| CA (1) | CA2630900A1 (https=) |
| DE (1) | DE602006020335D1 (https=) |
| ES (1) | ES2361566T3 (https=) |
| WO (1) | WO2007062413A2 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY164077A (en) * | 1999-05-13 | 2017-11-30 | Pharma Mar Sa | Compositions and uses of et743 for treating cancer |
| EP1365808B1 (en) * | 2000-11-06 | 2011-01-19 | Pharma Mar, S.A. | Compositions for antitumour treatment containing ecteinascidin 743 |
| GB0117402D0 (en) * | 2001-07-17 | 2001-09-05 | Pharma Mar Sa | New antitumoral derivatives of et-743 |
| CA2545054A1 (en) * | 2003-11-14 | 2005-06-02 | Pharma Mar, S.A. | Combination therapy comprising the use of et-743 and paclitaxel for treating cancer |
| DK1827500T3 (da) * | 2004-10-26 | 2009-08-31 | Pharma Mar Sa | Pegyleret liposomal doxorubicin i kombination med ecteinescidin 743 |
| RS50510B (sr) | 2004-10-29 | 2010-03-02 | Pharma Mar S.A., Sociedad Unipersonal | Formulacije koje sadrže ekteinascidin i disaharid |
| GB0522082D0 (en) * | 2005-10-31 | 2005-12-07 | Pharma Mar Sa | Formulations |
| WO2009047752A1 (en) * | 2007-10-09 | 2009-04-16 | Ramot At Tel-Aviv University Ltd. | Breast cancer therapy |
| US9486449B2 (en) | 2007-10-09 | 2016-11-08 | Malka COHEN-ARMON | Cancer therapy |
| JP2011500046A (ja) * | 2007-10-19 | 2011-01-06 | ファルマ・マール・ソシエダード・アノニマ | Ｅｔ−７４３治療のための予後分子マーカー |
| US8871765B2 (en) | 2010-07-27 | 2014-10-28 | Cadila Healthcare Limited | Substituted 4-(4-fluoro-3-(piperazine-1-carbonyl)benzyl)phthalazin-1(2H)-one derivatives as poly (ADP-ribose) polymerase-1 inhibitors |
| ES2595240T3 (es) | 2012-07-09 | 2016-12-28 | Lupin Limited | Derivados de tetrahidroquinazolinona como inhibidores de PARP |
| PL2938598T3 (pl) | 2012-12-31 | 2017-05-31 | Cadila Healthcare Limited | Podstawione pochodne ftalazyn-1 (2H)-onu jako selektywne inhibitory polimerazy-1 poli(ADP-rybozy) |
| CN106853252B (zh) * | 2015-12-09 | 2020-03-13 | 江苏恒瑞医药股份有限公司 | 曲贝替定药物组合物及其制备方法 |
| CN108368059B (zh) * | 2016-04-18 | 2022-02-01 | 深圳市塔吉瑞生物医药有限公司 | 一种取代的酞嗪酮化合物及其药物组合物 |
| KR20180097876A (ko) * | 2017-02-24 | 2018-09-03 | 주식회사 온코크로스 | 1,5-이소퀴놀린디올을 포함하는 피부 노화 방지 및 주름 개선용 조성물 |
| HRP20231233T1 (hr) | 2017-04-27 | 2024-01-19 | Pharma Mar, S.A. | Antitumorski spojevi |
| EP3960177A1 (en) * | 2020-08-26 | 2022-03-02 | Anturec Pharmaceuticals GmbH | Composition comprising ttf-ngr for use in treating soft-tissue sarcoma |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6635677B2 (en) * | 1999-08-13 | 2003-10-21 | Case Western Reserve University | Methoxyamine combinations in the treatment of cancer |
| EP1365808B1 (en) * | 2000-11-06 | 2011-01-19 | Pharma Mar, S.A. | Compositions for antitumour treatment containing ecteinascidin 743 |
| WO2004105700A2 (en) * | 2003-05-28 | 2004-12-09 | Guildford Pharmaceuticals, Inc. | Compounds, methods and pharmaceutical compositions for inhibiting parp |
| GB0317466D0 (en) * | 2003-07-25 | 2003-08-27 | Univ Sheffield | Use |
| US20050187172A1 (en) * | 2003-12-23 | 2005-08-25 | Masferrer Jaime L. | Combination of a Cox-2 inhibitor and a DNA topoisomerase I inhibitor for treatment of neoplasia |
| PE20060285A1 (es) * | 2004-03-30 | 2006-05-08 | Aventis Pharma Inc | Piridonas sustituidas como inhibidores de pol(adp-ribosa)-polimerasa (parp) |
-
2006
- 2006-11-27 DE DE602006020335T patent/DE602006020335D1/de active Active
- 2006-11-27 AT AT06840026T patent/ATE499098T1/de not_active IP Right Cessation
- 2006-11-27 JP JP2008542534A patent/JP2009517403A/ja active Pending
- 2006-11-27 US US12/094,744 patent/US20090170860A1/en not_active Abandoned
- 2006-11-27 AU AU2006318226A patent/AU2006318226A1/en not_active Abandoned
- 2006-11-27 CA CA002630900A patent/CA2630900A1/en not_active Abandoned
- 2006-11-27 WO PCT/US2006/061254 patent/WO2007062413A2/en not_active Ceased
- 2006-11-27 EP EP06840026A patent/EP1962843B1/en active Active
- 2006-11-27 ES ES06840026T patent/ES2361566T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP1962843A2 (en) | 2008-09-03 |
| JP2009517403A (ja) | 2009-04-30 |
| CA2630900A1 (en) | 2007-05-31 |
| EP1962843B1 (en) | 2011-02-23 |
| EP1962843A4 (en) | 2009-08-12 |
| WO2007062413A2 (en) | 2007-05-31 |
| WO2007062413A3 (en) | 2007-12-27 |
| ATE499098T1 (de) | 2011-03-15 |
| ES2361566T3 (es) | 2011-06-20 |
| US20090170860A1 (en) | 2009-07-02 |
| AU2006318226A1 (en) | 2007-05-31 |
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