DE602006015195D1 - Verbesserungen der proteinproduktion oder in zusammenhang damit - Google Patents

Verbesserungen der proteinproduktion oder in zusammenhang damit

Info

Publication number
DE602006015195D1
DE602006015195D1 DE602006015195T DE602006015195T DE602006015195D1 DE 602006015195 D1 DE602006015195 D1 DE 602006015195D1 DE 602006015195 T DE602006015195 T DE 602006015195T DE 602006015195 T DE602006015195 T DE 602006015195T DE 602006015195 D1 DE602006015195 D1 DE 602006015195D1
Authority
DE
Germany
Prior art keywords
cells
sialic acid
present
relates
producing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602006015195T
Other languages
English (en)
Inventor
Gilbert Gorr
Heike Launhardt
Christian Stemmer
Franco Marta Rodriguez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eleva GmbH
Original Assignee
Greenovation Biotech GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Greenovation Biotech GmbH filed Critical Greenovation Biotech GmbH
Publication of DE602006015195D1 publication Critical patent/DE602006015195D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8245—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified carbohydrate or sugar alcohol metabolism, e.g. starch biosynthesis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
DE602006015195T 2005-07-12 2006-07-12 Verbesserungen der proteinproduktion oder in zusammenhang damit Active DE602006015195D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69824605P 2005-07-12 2005-07-12
PCT/EP2006/006831 WO2007006570A2 (en) 2005-07-12 2006-07-12 Improvements in or relating to protein production

Publications (1)

Publication Number Publication Date
DE602006015195D1 true DE602006015195D1 (de) 2010-08-12

Family

ID=37547026

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602006015195T Active DE602006015195D1 (de) 2005-07-12 2006-07-12 Verbesserungen der proteinproduktion oder in zusammenhang damit

Country Status (10)

Country Link
US (1) US7741539B2 (de)
JP (1) JP2009501011A (de)
AT (1) ATE472605T1 (de)
AU (1) AU2006268851B2 (de)
CA (1) CA2614998C (de)
DE (1) DE602006015195D1 (de)
DK (1) DK1904636T3 (de)
ES (1) ES2348857T3 (de)
PT (1) PT1904636E (de)
WO (1) WO2007006570A2 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0015031B1 (pt) * 1999-10-26 2017-05-30 Plant Res Int B V método para prover uma planta transgênica capaz de expressar um anticorpo com galactosilação terminal e método para obtenção de uma glicoproteína desejada ou fragmento funcional da mesma
GB2377446B (en) * 2001-07-13 2005-06-29 Lars Erik Berglund Expression of cobalamin binding proteins in transgenic plants
CA2549932C (en) * 2002-12-20 2013-08-20 Greenovation Biotech Gmbh Production of heterologous glycosylated proteins in bryophyte cells
EP2224009B1 (de) * 2006-02-09 2012-10-31 Medicago Inc. Synthese von Sialinsäure in Pflanzen
CA2788992A1 (en) 2010-02-24 2011-09-01 Merck Sharp & Dohme Corp. Method for increasing n-glycosylation site occupancy on therapeutic glycoproteins produced in pichia pastoris
US20130323803A1 (en) * 2011-02-04 2013-12-05 North Carolina State University Methods and compositions for the production of extremophile enzymes from green microalgae and cyanobacteria
US20140115728A1 (en) 2012-10-24 2014-04-24 A. Joseph Tector Double knockout (gt/cmah-ko) pigs, organs and tissues
GB201308120D0 (en) * 2013-05-06 2013-06-12 Baden Wuerttemberg Stiftung Gmbh Recombinant protein and method for its production
US9932599B2 (en) 2015-03-02 2018-04-03 Synthetic Genomics, Inc. Regulatory elements from labyrinthulomycetes microorganisms
EP3271453B1 (de) 2015-03-17 2021-09-08 eleva GmbH Glykosylierte lysosomale proteine, verfahren zur herstellung und verwendungen
US10584347B2 (en) 2016-03-16 2020-03-10 Conagen Inc. Production of proteins in labyrinthulomycetes
WO2018085273A1 (en) 2016-11-01 2018-05-11 Synthetic Genomics, Inc. Expression of modified glycoproteins and glycopeptides
US10633454B2 (en) 2016-11-01 2020-04-28 Conagen Inc. Expression of modified glycoproteins and glycopeptides

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000052135A2 (en) * 1999-03-02 2000-09-08 Human Genome Sciences, Inc. Engineering intracellular sialylation pathways
DE19947290A1 (de) 1999-10-01 2001-04-19 Greenovation Pflanzenbiotechno Verfahren zur Herstellung proteinöser Substanzen
BRPI0015031B1 (pt) * 1999-10-26 2017-05-30 Plant Res Int B V método para prover uma planta transgênica capaz de expressar um anticorpo com galactosilação terminal e método para obtenção de uma glicoproteína desejada ou fragmento funcional da mesma
US20050260729A1 (en) 2004-03-17 2005-11-24 Hamilton Stephen R Method of engineering a cytidine monophosphate-sialic acid synthetic pathway in fungi and yeast
CA2549932C (en) 2002-12-20 2013-08-20 Greenovation Biotech Gmbh Production of heterologous glycosylated proteins in bryophyte cells
JP2006333701A (ja) * 2003-01-15 2006-12-14 Kazuhito Fujiyama 動物型糖鎖をもつ糖タンパク質の生産方法
WO2004071177A2 (en) * 2003-02-11 2004-08-26 Arizona Board Of Regents, Acting For And On Behalf Of, Arizona State University Sialylation of glycoproteins in plants
DE60326716D1 (de) * 2003-08-11 2009-04-30 Greenovation Biotech Gmbh Promoter Sequenzen aus Moos und dessen Verwendung

Also Published As

Publication number Publication date
JP2009501011A (ja) 2009-01-15
CA2614998C (en) 2015-03-17
US7741539B2 (en) 2010-06-22
AU2006268851A1 (en) 2007-01-18
WO2007006570A2 (en) 2007-01-18
PT1904636E (pt) 2010-09-14
ATE472605T1 (de) 2010-07-15
DK1904636T3 (da) 2010-10-18
WO2007006570A3 (en) 2007-07-19
ES2348857T3 (es) 2010-12-03
CA2614998A1 (en) 2007-01-18
AU2006268851B2 (en) 2011-06-30
US20080201804A1 (en) 2008-08-21

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