DE602005025735D1 - Mesoporöse beschichtungen für medizinische implantate mit katalysator - Google Patents

Mesoporöse beschichtungen für medizinische implantate mit katalysator

Info

Publication number
DE602005025735D1
DE602005025735D1 DE602005025735T DE602005025735T DE602005025735D1 DE 602005025735 D1 DE602005025735 D1 DE 602005025735D1 DE 602005025735 T DE602005025735 T DE 602005025735T DE 602005025735 T DE602005025735 T DE 602005025735T DE 602005025735 D1 DE602005025735 D1 DE 602005025735D1
Authority
DE
Germany
Prior art keywords
catalyst
medical implants
mesoporous coatings
mesoporous
coatings
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005025735T
Other languages
English (en)
Inventor
Jan Weber
Tom Holman
Tracee Eidenschink
John Jianhua Chen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boston Scientific Ltd Barbados
Original Assignee
Boston Scientific Ltd Barbados
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston Scientific Ltd Barbados filed Critical Boston Scientific Ltd Barbados
Publication of DE602005025735D1 publication Critical patent/DE602005025735D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16Biologically active materials, e.g. therapeutic substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08Materials for coatings
    • A61L31/082Inorganic materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/146Porous materials, e.g. foams or sponges
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067Means for introducing or releasing pharmaceutical products into the body
    • A61F2250/0068Means for introducing or releasing pharmaceutical products into the body the pharmaceutical product being in a reservoir
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606Coatings

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
DE602005025735T 2004-01-20 2005-01-19 Mesoporöse beschichtungen für medizinische implantate mit katalysator Active DE602005025735D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/759,605 US20050159805A1 (en) 2004-01-20 2004-01-20 Functional coatings and designs for medical implants
PCT/US2005/001437 WO2005072788A2 (en) 2004-01-20 2005-01-19 Functional coatings and designs for medical implants

Publications (1)

Publication Number Publication Date
DE602005025735D1 true DE602005025735D1 (de) 2011-02-17

Family

ID=34749720

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005025735T Active DE602005025735D1 (de) 2004-01-20 2005-01-19 Mesoporöse beschichtungen für medizinische implantate mit katalysator

Country Status (4)

Country Link
US (1) US20050159805A1 (de)
EP (1) EP1722836B1 (de)
DE (1) DE602005025735D1 (de)
WO (1) WO2005072788A2 (de)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7713297B2 (en) 1998-04-11 2010-05-11 Boston Scientific Scimed, Inc. Drug-releasing stent with ceramic-containing layer
US7727221B2 (en) 2001-06-27 2010-06-01 Cardiac Pacemakers Inc. Method and device for electrochemical formation of therapeutic species in vivo
CA2609687C (en) * 2005-05-24 2014-04-22 Inspire M.D Ltd. Stent apparatuses for treatment via body lumens and methods of use
US20070038176A1 (en) * 2005-07-05 2007-02-15 Jan Weber Medical devices with machined layers for controlled communications with underlying regions
DE102005032604A1 (de) * 2005-07-13 2007-01-18 Gfe Medizintechnik Gmbh Resorbierbares, in den Körper einsetzbares medizinisches Element, insbesondere resorbierbares Implantat
US20070027530A1 (en) * 2005-07-26 2007-02-01 Medtronic Vascular, Inc. Intraluminal device, catheter assembly, and method of use thereof
WO2007047420A2 (en) 2005-10-13 2007-04-26 Synthes (U.S.A.) Drug-impregnated encasement
US20070112421A1 (en) * 2005-11-14 2007-05-17 O'brien Barry Medical device with a grooved surface
US20070154466A1 (en) * 2005-12-30 2007-07-05 Jan Weber Internal medical devices containing peroxide-converting catalysts
US8840660B2 (en) 2006-01-05 2014-09-23 Boston Scientific Scimed, Inc. Bioerodible endoprostheses and methods of making the same
US8089029B2 (en) 2006-02-01 2012-01-03 Boston Scientific Scimed, Inc. Bioabsorbable metal medical device and method of manufacture
US20070224235A1 (en) 2006-03-24 2007-09-27 Barron Tenney Medical devices having nanoporous coatings for controlled therapeutic agent delivery
US8187620B2 (en) 2006-03-27 2012-05-29 Boston Scientific Scimed, Inc. Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents
US8048150B2 (en) 2006-04-12 2011-11-01 Boston Scientific Scimed, Inc. Endoprosthesis having a fiber meshwork disposed thereon
US20070264303A1 (en) * 2006-05-12 2007-11-15 Liliana Atanasoska Coating for medical devices comprising an inorganic or ceramic oxide and a therapeutic agent
US8815275B2 (en) 2006-06-28 2014-08-26 Boston Scientific Scimed, Inc. Coatings for medical devices comprising a therapeutic agent and a metallic material
JP2009542359A (ja) 2006-06-29 2009-12-03 ボストン サイエンティフィック リミテッド 選択的被覆部を備えた医療装置
US8052743B2 (en) 2006-08-02 2011-11-08 Boston Scientific Scimed, Inc. Endoprosthesis with three-dimensional disintegration control
JP2010503469A (ja) * 2006-09-14 2010-02-04 ボストン サイエンティフィック リミテッド 薬物溶出性皮膜を有する医療デバイス
EP2076296A2 (de) 2006-09-15 2009-07-08 Boston Scientific Scimed, Inc. Endoprothese mit einstellbaren oberflächenfunktionen
WO2008034013A2 (en) 2006-09-15 2008-03-20 Boston Scientific Limited Medical devices and methods of making the same
ES2357661T3 (es) * 2006-09-15 2011-04-28 Boston Scientific Scimed, Inc. Endoprótesis bioerosionables con capas inorgánicas bioestables.
CA2663250A1 (en) 2006-09-15 2008-03-20 Boston Scientific Limited Bioerodible endoprostheses and methods of making the same
US8057534B2 (en) 2006-09-15 2011-11-15 Boston Scientific Scimed, Inc. Bioerodible endoprostheses and methods of making the same
CA2663762A1 (en) 2006-09-18 2008-03-27 Boston Scientific Limited Endoprostheses
US7981150B2 (en) 2006-11-09 2011-07-19 Boston Scientific Scimed, Inc. Endoprosthesis with coatings
CA2668765A1 (en) * 2006-11-16 2008-05-29 Boston Scientific Limited Stent with differential timing of abluminal and luminal release of a therapeutic agent
US20080140179A1 (en) * 2006-12-12 2008-06-12 Ladisa John F Apparatus and method for minimizing flow disturbances in a stented region of a lumen
ES2506144T3 (es) 2006-12-28 2014-10-13 Boston Scientific Limited Endoprótesis bioerosionables y procedimiento de fabricación de las mismas
US8431149B2 (en) 2007-03-01 2013-04-30 Boston Scientific Scimed, Inc. Coated medical devices for abluminal drug delivery
US8070797B2 (en) 2007-03-01 2011-12-06 Boston Scientific Scimed, Inc. Medical device with a porous surface for delivery of a therapeutic agent
US8067054B2 (en) 2007-04-05 2011-11-29 Boston Scientific Scimed, Inc. Stents with ceramic drug reservoir layer and methods of making and using the same
US20080251391A1 (en) * 2007-04-12 2008-10-16 Boston Scientific Scimed, Inc. Methods and systems for applying therapeutic agent to a medical device
JP2010524653A (ja) * 2007-04-25 2010-07-22 ボストン サイエンティフィック サイムド,インコーポレイテッド 治療薬放出用医療機器及びその製造方法
US7976915B2 (en) 2007-05-23 2011-07-12 Boston Scientific Scimed, Inc. Endoprosthesis with select ceramic morphology
US9265636B2 (en) * 2007-05-25 2016-02-23 C. R. Bard, Inc. Twisted stent
US7942926B2 (en) 2007-07-11 2011-05-17 Boston Scientific Scimed, Inc. Endoprosthesis coating
US8002823B2 (en) 2007-07-11 2011-08-23 Boston Scientific Scimed, Inc. Endoprosthesis coating
JP2010533563A (ja) 2007-07-19 2010-10-28 ボストン サイエンティフィック リミテッド 吸着抑制表面を有する内部人工器官
US20090028785A1 (en) * 2007-07-23 2009-01-29 Boston Scientific Scimed, Inc. Medical devices with coatings for delivery of a therapeutic agent
US8815273B2 (en) 2007-07-27 2014-08-26 Boston Scientific Scimed, Inc. Drug eluting medical devices having porous layers
US7931683B2 (en) 2007-07-27 2011-04-26 Boston Scientific Scimed, Inc. Articles having ceramic coated surfaces
US8221822B2 (en) 2007-07-31 2012-07-17 Boston Scientific Scimed, Inc. Medical device coating by laser cladding
EP2185103B1 (de) 2007-08-03 2014-02-12 Boston Scientific Scimed, Inc. Überzug für ein medizinprodukt mit vergrösserter oberfläche
US8052745B2 (en) 2007-09-13 2011-11-08 Boston Scientific Scimed, Inc. Endoprosthesis
US20090076591A1 (en) * 2007-09-19 2009-03-19 Boston Scientific Scimed, Inc. Stent Design Allowing Extended Release of Drug and/or Enhanced Adhesion of Polymer to OD Surface
US9247973B2 (en) 2007-09-28 2016-02-02 DePuy Synthes Products, Inc. Anti-microbial implant
US8216632B2 (en) 2007-11-02 2012-07-10 Boston Scientific Scimed, Inc. Endoprosthesis coating
US7938855B2 (en) 2007-11-02 2011-05-10 Boston Scientific Scimed, Inc. Deformable underlayer for stent
US20090118821A1 (en) * 2007-11-02 2009-05-07 Boston Scientific Scimed, Inc. Endoprosthesis with porous reservoir and non-polymer diffusion layer
US8029554B2 (en) 2007-11-02 2011-10-04 Boston Scientific Scimed, Inc. Stent with embedded material
US20090118812A1 (en) * 2007-11-02 2009-05-07 Boston Scientific Scimed, Inc. Endoprosthesis coating
US7833266B2 (en) 2007-11-28 2010-11-16 Boston Scientific Scimed, Inc. Bifurcated stent with drug wells for specific ostial, carina, and side branch treatment
US8920491B2 (en) 2008-04-22 2014-12-30 Boston Scientific Scimed, Inc. Medical devices having a coating of inorganic material
WO2009132176A2 (en) 2008-04-24 2009-10-29 Boston Scientific Scimed, Inc. Medical devices having inorganic particle layers
US7998192B2 (en) 2008-05-09 2011-08-16 Boston Scientific Scimed, Inc. Endoprostheses
US8236046B2 (en) 2008-06-10 2012-08-07 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
EP2303350A2 (de) 2008-06-18 2011-04-06 Boston Scientific Scimed, Inc. Endoprothesen-beschichtung
US7951193B2 (en) 2008-07-23 2011-05-31 Boston Scientific Scimed, Inc. Drug-eluting stent
US7985252B2 (en) 2008-07-30 2011-07-26 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
US8382824B2 (en) 2008-10-03 2013-02-26 Boston Scientific Scimed, Inc. Medical implant having NANO-crystal grains with barrier layers of metal nitrides or fluorides
US8758287B2 (en) 2008-11-12 2014-06-24 Marv Enterprises, LLC Utilization of stents for the treatment of blood borne carcinomas
US8231980B2 (en) 2008-12-03 2012-07-31 Boston Scientific Scimed, Inc. Medical implants including iridium oxide
US9763697B2 (en) 2008-12-16 2017-09-19 DePuy Synthes Products, Inc. Anti-infective spinal rod with surface features
EP2403546A2 (de) 2009-03-02 2012-01-11 Boston Scientific Scimed, Inc. Selbstpufferende medizinische implantate
US8071156B2 (en) 2009-03-04 2011-12-06 Boston Scientific Scimed, Inc. Endoprostheses
US8287937B2 (en) 2009-04-24 2012-10-16 Boston Scientific Scimed, Inc. Endoprosthese
US8668732B2 (en) 2010-03-23 2014-03-11 Boston Scientific Scimed, Inc. Surface treated bioerodible metal endoprostheses
TWI590843B (zh) 2011-12-28 2017-07-11 信迪思有限公司 膜及其製造方法
EP3010560B1 (de) 2013-06-21 2020-01-01 DePuy Synthes Products, Inc. Folien und verfahren zur herstellung
AU2017368072B2 (en) * 2016-11-29 2021-10-07 Bnnt, Llc Boron nitride nanotube materials for cryopumps and other large volume configurations

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2547744B1 (fr) * 1983-06-27 1988-05-20 Interox Procede et appareil pour la production de produits gazeux par decomposition de liquides
US5477864A (en) * 1989-12-21 1995-12-26 Smith & Nephew Richards, Inc. Cardiovascular guidewire of enhanced biocompatibility
GB9418937D0 (en) * 1994-09-20 1994-11-09 Isis Innovation Opening and filling carbon nanotubes
US6683783B1 (en) * 1997-03-07 2004-01-27 William Marsh Rice University Carbon fibers formed from single-wall carbon nanotubes
US5902475A (en) * 1997-04-08 1999-05-11 Interventional Technologies, Inc. Method for manufacturing a stent
DE19916086B4 (de) 1998-04-11 2004-11-11 Inflow Dynamics Inc. Implantierbare Prothese, insbesondere Gefäßprothese (Stent)
US7713297B2 (en) * 1998-04-11 2010-05-11 Boston Scientific Scimed, Inc. Drug-releasing stent with ceramic-containing layer
US6245104B1 (en) * 1999-02-28 2001-06-12 Inflow Dynamics Inc. Method of fabricating a biocompatible stent
US6217607B1 (en) * 1998-10-20 2001-04-17 Inflow Dynamics Inc. Premounted stent delivery system for small vessels
US6325825B1 (en) * 1999-04-08 2001-12-04 Cordis Corporation Stent with variable wall thickness
US6280466B1 (en) * 1999-12-03 2001-08-28 Teramed Inc. Endovascular graft system
JP4091728B2 (ja) * 2000-03-27 2008-05-28 京セラ株式会社 生体インプラント材とその製法
DE10026540A1 (de) 2000-05-27 2001-11-29 Gfe Met & Mat Gmbh Gegenstand, insbesondere Implantat
US6699525B2 (en) * 2001-04-16 2004-03-02 The Board Of Trustees Of Western Michigan University Method of forming carbon nanotubes and apparatus therefor
US7527804B2 (en) * 2001-04-27 2009-05-05 Vivoxid Oy Method for improvement of soft tissue attachment and implants making use of said method
US7168605B2 (en) * 2001-09-18 2007-01-30 Boston Scientific Scimed, Inc. Microtubes for therapeutic delivery
WO2003070662A1 (en) * 2002-02-22 2003-08-28 Hte Aktiengesellschaft The High Throughput Experimentation Company Decomposable monolithic ceramic materials having an at least bimodal pore distribution and active metal centers located in the pores
US7162308B2 (en) * 2002-11-26 2007-01-09 Wilson Greatbatch Technologies, Inc. Nanotube coatings for implantable electrodes
DE502004010042D1 (de) * 2003-05-16 2009-10-22 Cinv Ag Verfahren zur beschichtung von substraten mit kohlenstoffbasiertem material

Also Published As

Publication number Publication date
WO2005072788A2 (en) 2005-08-11
EP1722836B1 (de) 2011-01-05
US20050159805A1 (en) 2005-07-21
EP1722836A2 (de) 2006-11-22
WO2005072788A3 (en) 2005-11-24

Similar Documents

Publication Publication Date Title
DE602005025735D1 (de) Mesoporöse beschichtungen für medizinische implantate mit katalysator
BRPI0909908A2 (pt) implante de válvula cardíaca
DE502007004174D1 (de) Markerkomposit für medizinische Implantate
BRPI0817437A2 (pt) Implante cirúrgico com um recurso antirretrocesso
DE602006010476D1 (de) Implantierbares Herzdiagnosesystem
BRPI0810555A2 (pt) Implante dentário
DK2298237T3 (da) Hjerteprotese
FR2893255B1 (fr) Site medical implantable atraumatique de construction simplifiee
ATE533518T1 (de) Resorbierbare polyetherester zur herstellung von medizinischen implantaten
ZA200806510B (en) Heterobicyclic sulfonamide derivatives for the treatment of diabetes
BRPI0919626A2 (pt) implante dental
EP1883444A4 (de) Selbstreinigender katheter für die klinische implantation
DE602006003922D1 (de) Chirurgisches Implantat
EP2081520A4 (de) Medizinische implantate
BRPI0817964A2 (pt) Implante cirúrgico
FR2913196B1 (fr) Implant oculaire accomodatif
DK2344086T3 (da) Ortopædisk protese
EP1960447A4 (de) Biokompatible chirurgische zusammensetzungen
GB0618930D0 (en) Medical implant
EP1857494A4 (de) Hydrogel zur medizinischen verwendung
BRPI0820052A2 (pt) conjunto de válvula de coração mecânica implantável
CY2016019I2 (el) Θεραπευτικη αγωγη της σκληρυνσης κατα πλακας (ms) me campath-1h
EP2091480A4 (de) System zur behandlung von herzgewebe
EP1948246A4 (de) Stammzellenfaktor-therapie für gewebeverletzungen
GB2435425B (en) Medical wound healing treatment