DE602005016479D1 - Lokale, vaskuläre Verabreichung von Cladribin in Kombination mit Rapamycin zur Vorbeugung von Restenose nach Gefässverletzungen - Google Patents

Lokale, vaskuläre Verabreichung von Cladribin in Kombination mit Rapamycin zur Vorbeugung von Restenose nach Gefässverletzungen

Info

Publication number
DE602005016479D1
DE602005016479D1 DE602005016479T DE602005016479T DE602005016479D1 DE 602005016479 D1 DE602005016479 D1 DE 602005016479D1 DE 602005016479 T DE602005016479 T DE 602005016479T DE 602005016479 T DE602005016479 T DE 602005016479T DE 602005016479 D1 DE602005016479 D1 DE 602005016479D1
Authority
DE
Germany
Prior art keywords
devices
agents
compounds
medical device
utilized
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE602005016479T
Other languages
German (de)
English (en)
Inventor
Robert Falotico
Tom Jay Parry
Jonathon Z Zhao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cordis Corp
Original Assignee
Cordis Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cordis Corp filed Critical Cordis Corp
Publication of DE602005016479D1 publication Critical patent/DE602005016479D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2420/00—Materials or methods for coatings medical devices
    • A61L2420/08—Coatings comprising two or more layers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Surgery (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Materials For Medical Uses (AREA)
  • Surgical Instruments (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Prostheses (AREA)
DE602005016479T 2004-02-18 2005-02-17 Lokale, vaskuläre Verabreichung von Cladribin in Kombination mit Rapamycin zur Vorbeugung von Restenose nach Gefässverletzungen Expired - Lifetime DE602005016479D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10/780,596 US7806924B2 (en) 2004-02-18 2004-02-18 Implantable structures for local vascular delivery of cladribine in combination with rapamycin for restenosis

Publications (1)

Publication Number Publication Date
DE602005016479D1 true DE602005016479D1 (de) 2009-10-22

Family

ID=34750452

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005016479T Expired - Lifetime DE602005016479D1 (de) 2004-02-18 2005-02-17 Lokale, vaskuläre Verabreichung von Cladribin in Kombination mit Rapamycin zur Vorbeugung von Restenose nach Gefässverletzungen

Country Status (6)

Country Link
US (1) US7806924B2 (https=)
EP (1) EP1570871B1 (https=)
JP (1) JP4846246B2 (https=)
AT (1) ATE442169T1 (https=)
CA (1) CA2497216C (https=)
DE (1) DE602005016479D1 (https=)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7611533B2 (en) 1995-06-07 2009-11-03 Cook Incorporated Coated implantable medical device
US7947015B2 (en) * 1999-01-25 2011-05-24 Atrium Medical Corporation Application of a therapeutic substance to a tissue location using an expandable medical device
US6955661B1 (en) 1999-01-25 2005-10-18 Atrium Medical Corporation Expandable fluoropolymer device for delivery of therapeutic agents and method of making
US8038708B2 (en) 2001-02-05 2011-10-18 Cook Medical Technologies Llc Implantable device with remodelable material and covering material
US7056338B2 (en) 2003-03-28 2006-06-06 Conor Medsystems, Inc. Therapeutic agent delivery device with controlled therapeutic agent release rates
DE60221287D1 (de) * 2001-11-08 2007-08-30 Atrium Medical Corp Intraluminale vorrichtung mit einer ein therapeutisches-mittel enthaltenden beschichtung
EP1610823B1 (en) 2003-03-28 2011-09-28 Innovational Holdings, LLC Implantable medical device with continuous agent concentration gradient
WO2005027996A2 (en) * 2003-09-15 2005-03-31 Atrium Medical Corporation Application of a therapeutic substance to a tissue location using an expandable medical device
WO2005027994A2 (en) * 2003-09-15 2005-03-31 Atrium Medical Corporation Application of a therapeutic substance to a tissue location using a porous medical device
US8021331B2 (en) * 2003-09-15 2011-09-20 Atrium Medical Corporation Method of coating a folded medical device
WO2005030091A2 (en) * 2003-09-25 2005-04-07 Scios Inc. Stents and intra-luminal prostheses containing map kinase inhibitors
US8652502B2 (en) 2003-12-19 2014-02-18 Cordis Corporation Local vascular delivery of trichostatin A alone or in combination with sirolimus to prevent restenosis following vascular injury
US20050249776A1 (en) * 2003-12-19 2005-11-10 Chen Chao C Coated aneurysmal repair device
US8747881B2 (en) 2003-12-19 2014-06-10 Cordis Corporation Intraluminal medical devices in combination with therapeutic agents
WO2006078320A2 (en) 2004-08-04 2006-07-27 Brookwood Pharmaceuticals, Inc. Methods for manufacturing delivery devices and devices thereof
US9012506B2 (en) 2004-09-28 2015-04-21 Atrium Medical Corporation Cross-linked fatty acid-based biomaterials
US9592324B2 (en) 2006-11-06 2017-03-14 Atrium Medical Corporation Tissue separating device with reinforced support for anchoring mechanisms
US9801982B2 (en) 2004-09-28 2017-10-31 Atrium Medical Corporation Implantable barrier device
US20060083768A1 (en) * 2004-09-28 2006-04-20 Atrium Medical Corporation Method of thickening a coating using a drug
US9000040B2 (en) 2004-09-28 2015-04-07 Atrium Medical Corporation Cross-linked fatty acid-based biomaterials
EP1811935B1 (en) 2004-09-28 2016-03-30 Atrium Medical Corporation Heat cured gel and method of making
US20060067977A1 (en) * 2004-09-28 2006-03-30 Atrium Medical Corporation Pre-dried drug delivery coating for use with a stent
US8312836B2 (en) 2004-09-28 2012-11-20 Atrium Medical Corporation Method and apparatus for application of a fresh coating on a medical device
US8367099B2 (en) 2004-09-28 2013-02-05 Atrium Medical Corporation Perforated fatty acid films
US9427423B2 (en) 2009-03-10 2016-08-30 Atrium Medical Corporation Fatty-acid based particles
US9278161B2 (en) 2005-09-28 2016-03-08 Atrium Medical Corporation Tissue-separating fatty acid adhesion barrier
AU2006304590A1 (en) 2005-10-15 2007-04-26 Atrium Medical Corporation Hydrophobic cross-linked gels for bioabsorbable drug carrier coatings
US20070116736A1 (en) * 2005-11-23 2007-05-24 Argentieri Dennis C Local vascular delivery of PI3 kinase inhibitors alone or in combination with sirolimus to prevent restinosis following vascular injury
US20070203564A1 (en) * 2006-02-28 2007-08-30 Boston Scientific Scimed, Inc. Biodegradable implants having accelerated biodegradation properties in vivo
US9492596B2 (en) 2006-11-06 2016-11-15 Atrium Medical Corporation Barrier layer with underlying medical device and one or more reinforcing support structures
US8142490B2 (en) * 2007-10-24 2012-03-27 Cordis Corporation Stent segments axially connected by thin film
WO2009085952A1 (en) 2007-12-20 2009-07-09 Brookwood Pharmaceuticals, Inc. Process for preparing microparticles having a low residual solvent volume
US20110038910A1 (en) 2009-08-11 2011-02-17 Atrium Medical Corporation Anti-infective antimicrobial-containing biomaterials
US20110301695A1 (en) * 2010-06-08 2011-12-08 Svelte Medical Systems, Inc. Optimum coatings for vascular stents
CA2802753C (en) 2010-06-21 2018-07-31 Zorion Medical, Inc. Bioabsorbable implants
US10322213B2 (en) 2010-07-16 2019-06-18 Atrium Medical Corporation Compositions and methods for altering the rate of hydrolysis of cured oil-based materials
US8986369B2 (en) 2010-12-01 2015-03-24 Zorion Medical, Inc. Magnesium-based absorbable implants
US9867880B2 (en) 2012-06-13 2018-01-16 Atrium Medical Corporation Cured oil-hydrogel biomaterial compositions for controlled drug delivery
EP2968730B1 (en) 2013-03-15 2019-01-09 Bitol Designs, LLC Occlusion resistant catheter and method of use
CN113384390B (zh) 2015-09-15 2023-08-22 萨维奇医疗股份有限公司 用于在组织腔中锚定护套的装置和方法
EP3565520B1 (en) 2017-01-06 2026-02-25 Palvella Therapeutics, Inc. Anhydrous compositions of mtor inhibitors and methods of use
CN107335100A (zh) * 2017-07-31 2017-11-10 首都医科大学附属北京安贞医院 一种冠状动脉旁路移植术预防桥血管再狭窄系统
US11000513B2 (en) 2018-07-02 2021-05-11 Palvella Therapeutics, Inc. Anhydrous compositions of mTOR inhibitors and methods of use
JP2024522808A (ja) * 2021-06-21 2024-06-21 パルヴェラ セラピューティクス、インク． ゴーリン症候群を治療するための方法および組成物

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA737247B (en) 1972-09-29 1975-04-30 Ayerst Mckenna & Harrison Rapamycin and process of preparation
US3959078A (en) 1973-05-18 1976-05-25 Midwest Research Institute Enzyme immobilization with a thermochemical-photochemical bifunctional agent
SU1088712A1 (ru) 1979-11-14 1984-04-30 Всесоюзный научно-исследовательский и испытательный институт медицинской техники Аппарат дл циркул рного сшивани кровеносных сосудов
US4366819A (en) 1980-11-17 1983-01-04 Kaster Robert L Anastomotic fitting
US4368736A (en) 1980-11-17 1983-01-18 Kaster Robert L Anastomotic fitting
US4917091A (en) 1982-06-24 1990-04-17 Unilink Ab Annular fastening means
SE431609B (sv) 1982-06-24 1984-02-20 Unilink Ab Kirurgiskt instrument for astadkommande av anastomos och festelement herfor
US4722906A (en) 1982-09-29 1988-02-02 Bio-Metric Systems, Inc. Binding reagents and methods
US4733665C2 (en) 1985-11-07 2002-01-29 Expandable Grafts Partnership Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft
US5234447A (en) 1990-08-28 1993-08-10 Robert L. Kaster Side-to-end vascular anastomotic staple apparatus
US5516781A (en) * 1992-01-09 1996-05-14 American Home Products Corporation Method of treating restenosis with rapamycin
US5350800A (en) 1993-01-19 1994-09-27 Medtronic, Inc. Method for improving the biocompatibility of solid surfaces
US5229172A (en) 1993-01-19 1993-07-20 Medtronic, Inc. Modification of polymeric surface by graft polymerization
US5308641A (en) 1993-01-19 1994-05-03 Medtronic, Inc. Biocompatibility of solid surfaces
US6099562A (en) 1996-06-13 2000-08-08 Schneider (Usa) Inc. Drug coating with topcoat
US6120536A (en) 1995-04-19 2000-09-19 Schneider (Usa) Inc. Medical devices with long term non-thrombogenic coatings
US5837313A (en) 1995-04-19 1998-11-17 Schneider (Usa) Inc Drug release stent coating process
US7611533B2 (en) * 1995-06-07 2009-11-03 Cook Incorporated Coated implantable medical device
EP1226796B1 (en) 1997-02-03 2005-06-01 Angioguard, Inc. Vascular filter
US6425898B1 (en) 1998-03-13 2002-07-30 Cordis Corporation Delivery apparatus for a self-expanding stent
US8029561B1 (en) 2000-05-12 2011-10-04 Cordis Corporation Drug combination useful for prevention of restenosis
US6153252A (en) 1998-06-30 2000-11-28 Ethicon, Inc. Process for coating stents
JP4898991B2 (ja) * 1998-08-20 2012-03-21 クック メディカル テクノロジーズ エルエルシー 被覆付植込式医療装置
CA2337565A1 (en) * 2000-02-25 2001-08-25 Cordis Corporation Use of cladribine on a stent to prevent restenosis
US7419678B2 (en) 2000-05-12 2008-09-02 Cordis Corporation Coated medical devices for the prevention and treatment of vascular disease
AU1129902A (en) * 2000-09-29 2002-04-08 Cordis Corp Coated medical devices
US7195640B2 (en) 2001-09-25 2007-03-27 Cordis Corporation Coated medical devices for the treatment of vulnerable plaque
US8652502B2 (en) * 2003-12-19 2014-02-18 Cordis Corporation Local vascular delivery of trichostatin A alone or in combination with sirolimus to prevent restenosis following vascular injury
US7306677B2 (en) * 2004-01-30 2007-12-11 Boston Scientific Corporation Clamping fixture for coating stents, system using the fixture, and method of using the fixture

Also Published As

Publication number Publication date
EP1570871B1 (en) 2009-09-09
CA2497216A1 (en) 2005-08-18
EP1570871A1 (en) 2005-09-07
CA2497216C (en) 2014-01-07
US20050182485A1 (en) 2005-08-18
JP4846246B2 (ja) 2011-12-28
ATE442169T1 (de) 2009-09-15
US7806924B2 (en) 2010-10-05
JP2005253959A (ja) 2005-09-22

Similar Documents

Publication Publication Date Title
DE602005016479D1 (de) Lokale, vaskuläre Verabreichung von Cladribin in Kombination mit Rapamycin zur Vorbeugung von Restenose nach Gefässverletzungen
DE602005022378D1 (de) Lokale, vaskuläre Verabreichung von 2-methoxyestradiol in Kombination mit Rapamycin zur Vorbeugung von Restenose nach Gefässverletzungen
EP2286848A3 (en) Local vascular delivery of mycophenolic acid in combination with rapamycin to prevent restenosis
EP1582225A3 (en) Drug delivery device
EP1591108A3 (en) Solution formulations of sirolimus and its analogs for CAD treatment
CA2490170A1 (en) Local vascular delivery of trichostatin a alone or in combination with sirolimus to prevent restenosis following vascular injury
EP1568387A3 (en) Radioprotective compound coating for medical devices
EP1723976A3 (en) Intraluminal medical devices in combination with therapeutic agents
EP3056229A3 (en) The local administration of a combination of rapamycin and 17 beta-estradiol for the treatment of vulnerable plaque
EP1974758A3 (en) Local vascular delivery of probucol alone or in combination with sirolimus to treat restenosis, vulnerable plaque, AAA and stroke
DE602005022515D1 (de) Lokale, vaskuläre Verabreichung von Etoposide in Kombination mit Rapamycin zur Vorbeugung von Restenose nach Gefässverletzungen
CA2467797A1 (en) Increased biocompatibility of implantable medical devices
EP1749545A3 (en) System for treating aneurysmal disease
US7906133B2 (en) Optimized dosing for drug coated stents
ATE339227T1 (de) Beschichtetes medizinsches implantat zur behandlung von gefässerkrankungen
CA2462479A1 (en) Modified delivery device for coated medical devices
ATE358505T1 (de) Beschichtete endovaskuläre vorrichtung
EP2042202A3 (en) Local vascular delivery of mTor inhibitors in combination with peroxisome proliferators-activated receptor stimulators
MXPA03006825A (es) Dispositivos vasculares revestidos.
US20030152609A1 (en) Devices and methods for reducing scar tissue formation
DE602005022645D1 (de) Implantierbare vaskuläre Vorrichtung zur Abgabe von Topotecan in Kombination mit Rapamycin
MX2010007571A (es) Endoprotesis eluyente con receptaculo de rapamicina.
EP2095833A3 (en) Layer-by-layer stereocomplexed polymers as drug depot carriers or coatings in medical devices
EP1586338A3 (en) The use of antioxidants to prevent oxidation and reduce drug degradation in drug eluting medical devices
AP2003002828A0 (en) Implantable device containing resorbable matrix material and anti-proliferative drugs for preventing or treating failure of hemodialysis vascular access and other vascular grafts.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition