DE602005014141D1 - Medikamente zur behandlung oder prävention fibrotischer krankheiten - Google Patents
Medikamente zur behandlung oder prävention fibrotischer krankheitenInfo
- Publication number
- DE602005014141D1 DE602005014141D1 DE602005014141T DE602005014141T DE602005014141D1 DE 602005014141 D1 DE602005014141 D1 DE 602005014141D1 DE 602005014141 T DE602005014141 T DE 602005014141T DE 602005014141 T DE602005014141 T DE 602005014141T DE 602005014141 D1 DE602005014141 D1 DE 602005014141D1
- Authority
- DE
- Germany
- Prior art keywords
- medicaments
- prevention
- treatment
- fibrotic diseases
- fibrotic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04030768 | 2004-12-24 | ||
PCT/EP2005/057006 WO2006067168A1 (en) | 2004-12-24 | 2005-12-21 | Medicaments for the treatment or prevention of fibrotic diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602005014141D1 true DE602005014141D1 (de) | 2009-06-04 |
Family
ID=35809691
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602005014141T Expired - Fee Related DE602005014141D1 (de) | 2004-12-24 | 2005-12-21 | Medikamente zur behandlung oder prävention fibrotischer krankheiten |
Country Status (10)
Country | Link |
---|---|
US (2) | US20060154939A1 (de) |
EP (1) | EP1830842B1 (de) |
JP (1) | JP2008525371A (de) |
AR (1) | AR052841A1 (de) |
AT (1) | ATE429221T1 (de) |
CA (1) | CA2591084A1 (de) |
DE (1) | DE602005014141D1 (de) |
ES (1) | ES2326276T3 (de) |
TW (1) | TW200635595A (de) |
WO (1) | WO2006067168A1 (de) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
EP1992344A1 (de) | 2007-05-18 | 2008-11-19 | Institut Curie | P38 Alpha als therapeutisches Target für Erkrankungen, die mit einer FGFR3- Mutation assoziiert sind |
EP2167465A1 (de) * | 2007-06-12 | 2010-03-31 | Boehringer Ingelheim International GmbH | Indolinonderivate und deren verwendung bei der behandlung von krankheiten wie krebs |
CA2731919A1 (en) | 2008-07-29 | 2010-02-04 | Boehringer Ingelheim International Gmbh | New compounds |
US10450295B2 (en) | 2013-08-09 | 2019-10-22 | Acclaim BioMed USA LLC | Method of using an indolinone molecule and derivatives for inhibiting liver fibrosis and hepatitis |
EP3394048B1 (de) * | 2015-12-24 | 2020-03-11 | Respivert Limited | Indolinonen verbindungen und deren verwendung zur behandlung von fibrotischen erkrankungen |
EP3426649B1 (de) * | 2016-03-08 | 2020-07-22 | Respivert Limited | Indolederivate und ihre verwendung als protein kinase hemmer |
CN114732910A (zh) | 2017-10-05 | 2022-07-12 | 弗尔康医疗公司 | P38激酶抑制剂降低dux4和下游基因表达以用于治疗fshd |
US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6043254A (en) * | 1998-04-03 | 2000-03-28 | Boehringer Ingelheim Pharma Kg | Indolinones having kinase-inhibiting activity |
US6169106B1 (en) * | 1998-04-15 | 2001-01-02 | Boehringer Ingelheim Pharma Kg | Indolinones having kinase inhibitory activity |
US6319918B1 (en) * | 1998-06-04 | 2001-11-20 | Boehringer Ingelheim Pharma Kg | Substituted indolinones with kinase inhibitory activity |
US6762180B1 (en) * | 1999-10-13 | 2004-07-13 | Boehringer Ingelheim Pharma Kg | Substituted indolines which inhibit receptor tyrosine kinases |
EP1311277A4 (de) * | 2000-07-18 | 2004-08-25 | Joslin Diabetes Center Inc | Methoden zur fibrose-modulation |
DE10117204A1 (de) * | 2001-04-06 | 2002-10-10 | Boehringer Ingelheim Pharma | In 6-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
DE10237423A1 (de) * | 2002-08-16 | 2004-02-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verwendung von LCK-Inhibitoren für die Behandlung von immunologischen Erkrankungen |
PE20060777A1 (es) * | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
-
2005
- 2005-12-20 US US11/275,225 patent/US20060154939A1/en not_active Abandoned
- 2005-12-21 WO PCT/EP2005/057006 patent/WO2006067168A1/en active Application Filing
- 2005-12-21 DE DE602005014141T patent/DE602005014141D1/de not_active Expired - Fee Related
- 2005-12-21 JP JP2007547505A patent/JP2008525371A/ja not_active Withdrawn
- 2005-12-21 EP EP05823645A patent/EP1830842B1/de not_active Not-in-force
- 2005-12-21 ES ES05823645T patent/ES2326276T3/es active Active
- 2005-12-21 AT AT05823645T patent/ATE429221T1/de not_active IP Right Cessation
- 2005-12-21 CA CA002591084A patent/CA2591084A1/en not_active Abandoned
- 2005-12-22 AR ARP050105466A patent/AR052841A1/es not_active Application Discontinuation
- 2005-12-23 TW TW094146422A patent/TW200635595A/zh unknown
-
2008
- 2008-05-12 US US12/118,992 patent/US20090048267A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
ES2326276T3 (es) | 2009-10-06 |
CA2591084A1 (en) | 2006-06-29 |
US20090048267A1 (en) | 2009-02-19 |
ATE429221T1 (de) | 2009-05-15 |
TW200635595A (en) | 2006-10-16 |
EP1830842A1 (de) | 2007-09-12 |
AR052841A1 (es) | 2007-04-04 |
EP1830842B1 (de) | 2009-04-22 |
WO2006067168A1 (en) | 2006-06-29 |
JP2008525371A (ja) | 2008-07-17 |
US20060154939A1 (en) | 2006-07-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |