DE602004014500D1 - Aromatische verbindungen als aldolase inhibitoren - Google Patents
Aromatische verbindungen als aldolase inhibitorenInfo
- Publication number
- DE602004014500D1 DE602004014500D1 DE602004014500T DE602004014500T DE602004014500D1 DE 602004014500 D1 DE602004014500 D1 DE 602004014500D1 DE 602004014500 T DE602004014500 T DE 602004014500T DE 602004014500 T DE602004014500 T DE 602004014500T DE 602004014500 D1 DE602004014500 D1 DE 602004014500D1
- Authority
- DE
- Germany
- Prior art keywords
- phosphate
- group
- ring
- attached
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000001390 Fructose-Bisphosphate Aldolase Human genes 0.000 title abstract 3
- 108010068561 Fructose-Bisphosphate Aldolase Proteins 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title abstract 3
- 150000001491 aromatic compounds Chemical class 0.000 title 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 239000010452 phosphate Substances 0.000 abstract 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 3
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 abstract 3
- 150000001299 aldehydes Chemical class 0.000 abstract 2
- 244000045947 parasite Species 0.000 abstract 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 abstract 2
- NTCCNERMXRIPTR-UHFFFAOYSA-N 2-hydroxy-1-naphthaldehyde Chemical class C1=CC=CC2=C(C=O)C(O)=CC=C21 NTCCNERMXRIPTR-UHFFFAOYSA-N 0.000 abstract 1
- 241000283973 Oryctolagus cuniculus Species 0.000 abstract 1
- 230000002141 anti-parasite Effects 0.000 abstract 1
- 239000003096 antiparasitic agent Substances 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000824 cytostatic agent Substances 0.000 abstract 1
- 230000001085 cytostatic effect Effects 0.000 abstract 1
- 230000030609 dephosphorylation Effects 0.000 abstract 1
- 238000006209 dephosphorylation reaction Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 230000034659 glycolysis Effects 0.000 abstract 1
- 125000001165 hydrophobic group Chemical group 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 210000003205 muscle Anatomy 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 230000002269 spontaneous effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/12—Esters of phosphoric acids with hydroxyaryl compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0308042A FR2857012B1 (fr) | 2003-07-02 | 2003-07-02 | Nouveaux composes aromatiques inhibiteurs des aldolases, procede de synthese et applications |
PCT/FR2004/001664 WO2005012313A2 (fr) | 2003-07-02 | 2004-06-29 | Composes aromatiques inhibiteurs des aldolases |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602004014500D1 true DE602004014500D1 (de) | 2008-07-31 |
Family
ID=33522687
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602004014500T Expired - Lifetime DE602004014500D1 (de) | 2003-07-02 | 2004-06-29 | Aromatische verbindungen als aldolase inhibitoren |
Country Status (9)
Country | Link |
---|---|
US (2) | US7470821B2 (de) |
EP (1) | EP1641807B1 (de) |
JP (1) | JP2007516184A (de) |
AT (1) | ATE398625T1 (de) |
CA (1) | CA2531102A1 (de) |
DE (1) | DE602004014500D1 (de) |
ES (1) | ES2309555T3 (de) |
FR (1) | FR2857012B1 (de) |
WO (1) | WO2005012313A2 (de) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006078774A2 (en) * | 2005-01-19 | 2006-07-27 | The Trustees Of The University Of Pennsylvania | Regulation of autophagy and cell survival |
US8318233B2 (en) * | 2010-03-26 | 2012-11-27 | Corn Products Development Inc | Emulsions useful in beverages |
EP4410822A1 (de) * | 2021-11-02 | 2024-08-07 | Spiber Inc. | Verestertes protein und verfahren zu seiner herstellung |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4436736A (en) * | 1982-03-29 | 1984-03-13 | Union Carbide Corporation | Methods for controlling pests with substituted phenyl thio(thiono)phosphates and the thio(thiono)phosphates |
WO1999024442A1 (en) * | 1997-11-12 | 1999-05-20 | Ariad Pharmaceuticals, Inc. | Novel signal transduction inhibitors, compositions containing them |
-
2003
- 2003-07-02 FR FR0308042A patent/FR2857012B1/fr not_active Expired - Fee Related
-
2004
- 2004-06-29 WO PCT/FR2004/001664 patent/WO2005012313A2/fr active IP Right Grant
- 2004-06-29 JP JP2006518266A patent/JP2007516184A/ja active Pending
- 2004-06-29 DE DE602004014500T patent/DE602004014500D1/de not_active Expired - Lifetime
- 2004-06-29 CA CA002531102A patent/CA2531102A1/fr not_active Abandoned
- 2004-06-29 EP EP04767508A patent/EP1641807B1/de not_active Expired - Lifetime
- 2004-06-29 AT AT04767508T patent/ATE398625T1/de not_active IP Right Cessation
- 2004-06-29 ES ES04767508T patent/ES2309555T3/es not_active Expired - Lifetime
- 2004-06-29 US US10/562,251 patent/US7470821B2/en not_active Expired - Fee Related
-
2008
- 2008-11-06 US US12/291,141 patent/US20090137532A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
FR2857012B1 (fr) | 2006-02-03 |
ES2309555T3 (es) | 2008-12-16 |
US20070043002A1 (en) | 2007-02-22 |
US7470821B2 (en) | 2008-12-30 |
ATE398625T1 (de) | 2008-07-15 |
WO2005012313A3 (fr) | 2005-06-09 |
CA2531102A1 (fr) | 2005-02-10 |
WO2005012313A2 (fr) | 2005-02-10 |
EP1641807A2 (de) | 2006-04-05 |
US20090137532A1 (en) | 2009-05-28 |
JP2007516184A (ja) | 2007-06-21 |
EP1641807B1 (de) | 2008-06-18 |
FR2857012A1 (fr) | 2005-01-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US5358952A (en) | O6 -substituted guanine compounds and methods for depleting O6 -alkylguanine-DNA alkyltransferase levels | |
BRPI0417687A (pt) | derivados de benzenossulfonilamino-piridin-2-ila e compostos relacionados como inibidores de 11-beta-hidroxiesteróide desidrogenase tipo 1 (11-beta-hsd-1) para o tratamento de diabetes e obesidade | |
BR0012646A (pt) | Composto, análogo de oligonucleotìdeo ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso de um análogo de oligonucleotìdeo | |
MY152176A (en) | Amino phosphate derivative and s1p receptor modulator having same as an active ingredient | |
BRPI0515628A (pt) | composto de 2-morfolina-4-pirimidona | |
BRPI0510305A (pt) | composto ou um sal do mesmo, pródroga ou um sal da mesma, agente farmacêutico, método de produção do composto ou um sal do mesmo, inibidor de metaloproteinase de matriz ou um sal do mesmo ou uma pródroga do mesmo, método de inibir uma metaloproteinase de matriz, e, uso de um composto ou de um sal do mesmo ou de uma pródroga do mesmo | |
MA28460B1 (fr) | Composition fongicides contenant un derive de pyridylethylbenzamide et un compose capable d'inhiber la biosynthese des sterols | |
BRPI0506613A (pt) | composição e método de controle curativo ou preventivo de fungos fitopatogênicos de safras | |
BRPI0418031A (pt) | inibidores de quinase fosfonato-substituìdos | |
EP1775283A4 (de) | 3-aminobenzamid-verbindung und hemmer der aktivität des vanilloid-rezeptors 1 (vr1) | |
MY139461A (en) | Condensed furan compounds | |
MA31594B1 (fr) | Composes organiques | |
Muthuraju et al. | Cholinesterase inhibitors ameliorate spatial learning deficits in rats following hypobaric hypoxia | |
NO20090951L (no) | Nytt eukalyptusekstrakt, fremgangsmate for fremstilling og terapeutiske anvendelser derav | |
WO2004096287A3 (en) | Inosine monophosphate dehydrogenase inhibitory phosphonate compounds | |
ATE398625T1 (de) | Aromatische verbindungen als aldolase inhibitoren | |
BRPI0506619A (pt) | composição e método de controle curativo ou preventivo de fungos fitopatogênicos de safras | |
BR0311136A (pt) | composto ou um sal, enanciÈmero, diaestereÈmero ou éster hidrolisável in vivo ou mistura dos mesmos farmaceuticamente aceitável, composição, e, método para inibir a atividade de fator letal (lf) liberado de bactérias em um mamìfero | |
MY158069A (en) | Tricyclic compound and pharmaceutical use thereof | |
WO2017190116A1 (en) | Synthetic ligands that modulate the activity of the rhlr quorum sensing receptor | |
TW200420554A (en) | A intra-airway administrating preparation | |
Suk et al. | Phosphonoxins: rational design and discovery of a potent nucleotide anti-Giardia agent | |
Wu et al. | Ethyl octylphosphonofluoridate and analogs: optimized inhibitors of neuropathy target esterase | |
WO2005075460A3 (en) | Pyrrolopyrimidine derivatives for treating proliferative diseases | |
BRPI0713369A2 (pt) | composição fungicida e método para controle de doenças de planta |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |