DE60143845D1 - Methode zur Identifizierung BAKTERIELLE DNS - Google Patents
Methode zur Identifizierung BAKTERIELLE DNSInfo
- Publication number
- DE60143845D1 DE60143845D1 DE60143845T DE60143845T DE60143845D1 DE 60143845 D1 DE60143845 D1 DE 60143845D1 DE 60143845 T DE60143845 T DE 60143845T DE 60143845 T DE60143845 T DE 60143845T DE 60143845 D1 DE60143845 D1 DE 60143845D1
- Authority
- DE
- Germany
- Prior art keywords
- receptor protein
- bacterial dna
- unmethylated cpg
- cpg sequence
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108020000946 Bacterial DNA Proteins 0.000 title abstract 4
- 239000002299 complementary DNA Substances 0.000 abstract 3
- 102000005962 receptors Human genes 0.000 abstract 3
- 108020003175 receptors Proteins 0.000 abstract 3
- 108020004414 DNA Proteins 0.000 abstract 2
- 102000008235 Toll-Like Receptor 9 Human genes 0.000 abstract 2
- 108010060818 Toll-Like Receptor 9 Proteins 0.000 abstract 2
- 108091034117 Oligonucleotide Proteins 0.000 abstract 1
- 102000002689 Toll-like receptor Human genes 0.000 abstract 1
- 108020000411 Toll-like receptor Proteins 0.000 abstract 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 1
- 238000010171 animal model Methods 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 210000002865 immune cell Anatomy 0.000 abstract 1
- 238000011813 knockout mouse model Methods 0.000 abstract 1
- 210000002540 macrophage Anatomy 0.000 abstract 1
- 230000004043 responsiveness Effects 0.000 abstract 1
- 239000000523 sample Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000219652A JP2002034565A (ja) | 2000-07-19 | 2000-07-19 | 細菌ｄｎａを特異的に認識する受容体タンパク質 |
| PCT/JP2001/004731 WO2002006482A1 (fr) | 2000-07-19 | 2001-06-05 | Protéine réceptrice reconnaissant spécifiquement un adn bactérien |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60143845D1 true DE60143845D1 (de) | 2011-02-24 |
Family
ID=18714395
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60143845T Expired - Lifetime DE60143845D1 (de) | 2000-07-19 | 2001-06-05 | Methode zur Identifizierung BAKTERIELLE DNS |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7507872B2 (de) |
| EP (1) | EP1302541B1 (de) |
| JP (1) | JP2002034565A (de) |
| AT (1) | ATE495256T1 (de) |
| CA (1) | CA2385302C (de) |
| DE (1) | DE60143845D1 (de) |
| WO (1) | WO2002006482A1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003035695A2 (en) * | 2001-07-26 | 2003-05-01 | Tanox, Inc. | Agents that activate or inhibit toll-like receptor 9 |
| DE50207801D1 (de) | 2002-09-18 | 2006-09-21 | Sirs Lab Gmbh | Verfahren zum Nachweis prokaryontischer DNA |
| WO2004070344A2 (en) * | 2003-02-04 | 2004-08-19 | Bayer Healthcare Ag | Method of screening for agents which modulate the activity of tlr9 |
| US8163506B2 (en) | 2003-06-17 | 2012-04-24 | Meiji Co., Ltd. | Use of toll-like receptor-expressing cells |
| EP2415481A3 (de) * | 2004-02-19 | 2012-04-18 | Coley Pharmaceutical Group, Inc. | Immunstimulatorische Virale RNA-Oligonucleotide |
| JP4848358B2 (ja) * | 2004-03-05 | 2011-12-28 | ジルス−ラプ ゲーエムベーハー | 非メチル化ＣｐＧモチーフを含むＤＮＡに特異的に結合するタンパク質を用いて原核生物ＤＮＡの濃縮または分離のうち少なくともいずれか一方を行う方法 |
| US20090041808A1 (en) | 2004-12-09 | 2009-02-12 | Osaka University | Detection/Measurement Of Malaria Infection Disease Utilizing Natural Immunity By Hemozoin Induction, Screening Of Preventative Or Therapeutic Medicine For Malaria Infection Disease, And Regulation Of Natural Immunity Induction |
| US20090137024A1 (en) * | 2007-11-28 | 2009-05-28 | Canon U.S. Life Sciences, Inc. | Method of Separating Target DNA from Mixed DNA |
| EP2990419B1 (de) * | 2013-04-22 | 2019-09-18 | The University of Tokyo | Präventives oder therapeutisches mittel für entzündungskrankheit |
| US10956145B2 (en) * | 2019-01-22 | 2021-03-23 | Saudi Arabian Oil Company | System and method for determining dynamic dependencies for enterprise it change management, simulation and rollout |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| PT1798288E (pt) * | 1997-05-07 | 2009-12-23 | Schering Corp | Proteínas receptoras humanas semelhantes a toll, reagentes e métodos relacionados |
| CA2323929C (en) * | 1998-04-03 | 2004-03-09 | University Of Iowa Research Foundation | Methods and products for stimulating the immune system using immunotherapeutic oligonucleotides and cytokines |
| US20020012660A1 (en) * | 1999-03-04 | 2002-01-31 | Alan Colman | Method of preparing a somatic cells for nuclear transfer |
| GB0001704D0 (en) | 2000-01-25 | 2000-03-15 | Glaxo Group Ltd | Protein |
| US20030083244A1 (en) * | 2000-04-26 | 2003-05-01 | Vernet Corine A.M. | Novel proteins and nucleic acids encoding same |
| MXPA02011618A (es) * | 2000-05-25 | 2003-03-10 | Schering Corp | Proteinas de receptor de humano, reactivos y metodos relacionados. |
| WO2002022809A2 (en) | 2000-09-15 | 2002-03-21 | Coley Pharmaceutical Gmbh | PROCESS FOR HIGH THROUGHPUT SCREENING OF CpG-BASED IMMUNO-AGONIST/ANTAGONIST |
| AU2001296235A1 (en) * | 2000-10-12 | 2002-04-22 | Hyseq, Inc. | Novel nucleic acids and polypeptides |
-
2000
- 2000-07-19 JP JP2000219652A patent/JP2002034565A/ja active Pending
-
2001
- 2001-06-05 AT AT01934545T patent/ATE495256T1/de not_active IP Right Cessation
- 2001-06-05 EP EP01934545A patent/EP1302541B1/de not_active Expired - Lifetime
- 2001-06-05 CA CA002385302A patent/CA2385302C/en not_active Expired - Lifetime
- 2001-06-05 US US10/088,567 patent/US7507872B2/en not_active Expired - Lifetime
- 2001-06-05 WO PCT/JP2001/004731 patent/WO2002006482A1/ja active Application Filing
- 2001-06-05 DE DE60143845T patent/DE60143845D1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002006482A1 (fr) | 2002-01-24 |
| ATE495256T1 (de) | 2011-01-15 |
| EP1302541B1 (de) | 2011-01-12 |
| EP1302541A4 (de) | 2005-06-15 |
| CA2385302A1 (en) | 2002-01-24 |
| EP1302541A1 (de) | 2003-04-16 |
| JP2002034565A (ja) | 2002-02-05 |
| US20030124655A1 (en) | 2003-07-03 |
| CA2385302C (en) | 2009-08-25 |
| US7507872B2 (en) | 2009-03-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60143845D1 (de) | Methode zur Identifizierung BAKTERIELLE DNS | |
| DE60228758D1 (de) | Immunisierung gegen chlamydia tracheomatis | |
| PT1219711E (pt) | Vacina de lawsonia intracellularis | |
| ATE470673T1 (de) | Impfstoffe mit lawsoniaintrazellularis- untereinheit | |
| DE60220578D1 (de) | Methode und Reagenzien zur Analyse der Nukleotidsequenz von Nukleinsäuren | |
| Aboagye-Antwi et al. | Experimental swap of Anopheles gambiae's assortative mating preferences demonstrates key role of X-chromosome divergence island in incipient sympatric speciation | |
| ATE440861T1 (de) | Immunisierung gegen chlamydia pneumoniae | |
| Raszek et al. | Use of genomic tools to improve cattle health in the context of infectious diseases | |
| Guedes et al. | A comparative in silico linear B-cell epitope prediction and characterization for South American and African Trypanosoma vivax strains | |
| Garzón-Ospina et al. | Inferring natural selection signals in Plasmodium vivax-encoded proteins having a potential role in merozoite invasion | |
| ATE450545T1 (de) | Impfstoff mit lawsonia intracellularis- untereinheit | |
| AR020092A1 (es) | Una cepa aislada de virus de hepatitis, acido nucleico aislado que codifica un polipeptido de la cepa, vector que comprende dicho acido nucleico, sistemavector huesped para la produccion del polipeptido, el polipeptido, metodo para su produccion, metodo para obtener anticuerpos contra el polipeptido | |
| Rengaraj et al. | Expression analysis of cytosolic DNA-sensing pathway genes in the intestinal mucosal layer of necrotic enteritis-induced chicken | |
| Volkening et al. | Viral proteogenomic and expression profiling during productive replication of a skin-tropic herpesvirus in the natural host | |
| ZA200602107B (en) | Piroplasmid vaccine | |
| Coff et al. | Draft genome of the bluefin tuna blood fluke, Cardicola forsteri | |
| Feng et al. | Comparative epigenomics reveals host diversity of the Trichinella epigenomes and their effects on differential parasitism | |
| Pinard-van Der Laan et al. | Genetics and genomics of immunity and disease traits in poultry species | |
| Ifeonu et al. | Annotated draft genome sequences of three species of Cryptosporidium: C. meleagridis isolate UKMEL1, C. baileyi isolate TAMU-09Q1, and C. hominis isolates TU502_2012 and UKH1 | |
| Volkening et al. | Viral proteogenomic and expression profiling during fully productive replication of a skin-tropic herpesvirus in the natural host | |
| EP1237114A3 (de) | Verfahren zum Entwerfen von Gensonden und Informationsverarbeitungsvorrichtung | |
| George et al. | Genomic Characterization of Alphacoronavirus from Mops Condylurus Bats, Nigeriagenomic Characterization of Alphacoronavirus from Mops Condylurus Bats, Nigeria | |
| Rinaldi et al. | Trematode Genomics and Proteomics | |
| WO2014011023A1 (en) | A method for identifying epinephelus lanceolatus | |
| Rodriguez | Applications of Metagenomics and Viral Genomics to Investigating Diseases of Livestock |