DE60138532D1 - Kristall - Google Patents
KristallInfo
- Publication number
- DE60138532D1 DE60138532D1 DE60138532T DE60138532T DE60138532D1 DE 60138532 D1 DE60138532 D1 DE 60138532D1 DE 60138532 T DE60138532 T DE 60138532T DE 60138532 T DE60138532 T DE 60138532T DE 60138532 D1 DE60138532 D1 DE 60138532D1
- Authority
- DE
- Germany
- Prior art keywords
- lbd
- har
- ligand binding
- hpr
- androgen receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0005689.5A GB0005689D0 (en) | 2000-03-09 | 2000-03-09 | Crystal |
PCT/IB2001/000475 WO2001066599A1 (en) | 2000-03-09 | 2001-03-09 | Crystal |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60138532D1 true DE60138532D1 (de) | 2009-06-10 |
Family
ID=9887287
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60138532T Expired - Lifetime DE60138532D1 (de) | 2000-03-09 | 2001-03-09 | Kristall |
Country Status (9)
Country | Link |
---|---|
US (1) | US20030167999A1 (de) |
EP (1) | EP1265927B1 (de) |
JP (1) | JP2003525948A (de) |
AT (1) | ATE430163T1 (de) |
AU (1) | AU2001250557A1 (de) |
DE (1) | DE60138532D1 (de) |
ES (1) | ES2326516T3 (de) |
GB (2) | GB0005689D0 (de) |
WO (1) | WO2001066599A1 (de) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7235367B2 (en) * | 2000-07-12 | 2007-06-26 | Genetics Institute, Llc. | Method using crystal structure of estrogen receptor-β complex |
JP4447826B2 (ja) * | 2002-06-03 | 2010-04-07 | 武田薬品工業株式会社 | 変異アンドロゲン受容体、それを発現する癌細胞、それらの作出方法およびそれらの用途 |
WO2006117592A1 (en) * | 2005-04-29 | 2006-11-09 | Inserm | Methods of modulating nuclear receptors |
SG11201500184TA (en) * | 2012-07-27 | 2015-04-29 | Aragon Pharmaceuticals Inc | Methods and compositions for determining resistance to androgen receptor therapy |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69636677D1 (de) * | 1995-12-13 | 2006-12-14 | Univ California | Kristalle der mit einem Ligand komplexierten Ligandenbindedomäne des Schilddrüsenhormonrezeptors |
AU775928B2 (en) * | 1999-10-14 | 2004-08-19 | Bristol-Myers Squibb Company | Crystallographic structure of the androgen receptor ligand binding domain |
-
2000
- 2000-03-09 GB GBGB0005689.5A patent/GB0005689D0/en not_active Ceased
-
2001
- 2001-03-09 AU AU2001250557A patent/AU2001250557A1/en not_active Abandoned
- 2001-03-09 WO PCT/IB2001/000475 patent/WO2001066599A1/en active Application Filing
- 2001-03-09 JP JP2001565763A patent/JP2003525948A/ja active Pending
- 2001-03-09 AT AT01923873T patent/ATE430163T1/de not_active IP Right Cessation
- 2001-03-09 US US10/220,981 patent/US20030167999A1/en not_active Abandoned
- 2001-03-09 ES ES01923873T patent/ES2326516T3/es not_active Expired - Lifetime
- 2001-03-09 GB GB0214799A patent/GB2373505A/en not_active Withdrawn
- 2001-03-09 DE DE60138532T patent/DE60138532D1/de not_active Expired - Lifetime
- 2001-03-09 EP EP01923873A patent/EP1265927B1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
GB2373505A (en) | 2002-09-25 |
GB0005689D0 (en) | 2000-05-03 |
US20030167999A1 (en) | 2003-09-11 |
AU2001250557A1 (en) | 2001-09-17 |
ES2326516T3 (es) | 2009-10-14 |
EP1265927A1 (de) | 2002-12-18 |
JP2003525948A (ja) | 2003-09-02 |
GB0214799D0 (en) | 2002-08-07 |
WO2001066599A1 (en) | 2001-09-13 |
EP1265927B1 (de) | 2009-04-29 |
ATE430163T1 (de) | 2009-05-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |