DE60137226D1 - Verfahren zur rna-spaltung - Google Patents
Verfahren zur rna-spaltungInfo
- Publication number
- DE60137226D1 DE60137226D1 DE60137226T DE60137226T DE60137226D1 DE 60137226 D1 DE60137226 D1 DE 60137226D1 DE 60137226 T DE60137226 T DE 60137226T DE 60137226 T DE60137226 T DE 60137226T DE 60137226 D1 DE60137226 D1 DE 60137226D1
- Authority
- DE
- Germany
- Prior art keywords
- bulge
- rna
- clearing
- target molecule
- helix
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 3
- 238000003776 cleavage reaction Methods 0.000 abstract 2
- 230000007017 scission Effects 0.000 abstract 2
- 108010042946 splicing endonuclease Proteins 0.000 abstract 1
- 102000010448 tRNA-splicing endonucleases Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
Landscapes
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20843200P | 2000-05-31 | 2000-05-31 | |
PCT/IB2001/001189 WO2001092463A2 (en) | 2000-05-31 | 2001-05-30 | Method of rna cleavage |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60137226D1 true DE60137226D1 (de) | 2009-02-12 |
Family
ID=22774580
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60137226T Expired - Lifetime DE60137226D1 (de) | 2000-05-31 | 2001-05-30 | Verfahren zur rna-spaltung |
Country Status (7)
Country | Link |
---|---|
US (1) | US20040023239A1 (de) |
EP (1) | EP1303597B1 (de) |
JP (1) | JP2003534789A (de) |
AT (1) | ATE419347T1 (de) |
AU (1) | AU2001274428A1 (de) |
DE (1) | DE60137226D1 (de) |
WO (1) | WO2001092463A2 (de) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8512945B2 (en) * | 2000-05-31 | 2013-08-20 | Glauco P. Tocchini-Valentini | Method of RNA cleavage and recombination |
CA2520415A1 (en) | 2003-03-27 | 2004-10-14 | Ptc Therapeutics, Inc. | Methods of identifying compounds that target trna splicing endonuclease and uses of said compounds as anti-proliferative agents |
CA2520510A1 (en) | 2003-03-27 | 2004-10-14 | Ptc Therapeutics, Inc. | Methods of identifying compounds that target trna splicing endonuclease and uses of said compounds as anti-fungal agents |
US20050053985A1 (en) * | 2003-07-02 | 2005-03-10 | Ptc Therapeutics, Inc. | RNA processing protein complexes and uses thereof |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5869248A (en) * | 1994-03-07 | 1999-02-09 | Yale University | Targeted cleavage of RNA using ribonuclease P targeting and cleavage sequences |
AU2601495A (en) * | 1994-05-23 | 1995-12-18 | Indiana University Foundation | Sequence-specific endonucleases, and preparation and use of same |
-
2001
- 2001-05-30 JP JP2002500657A patent/JP2003534789A/ja active Pending
- 2001-05-30 AU AU2001274428A patent/AU2001274428A1/en not_active Abandoned
- 2001-05-30 US US10/296,574 patent/US20040023239A1/en not_active Abandoned
- 2001-05-30 EP EP01940942A patent/EP1303597B1/de not_active Expired - Lifetime
- 2001-05-30 WO PCT/IB2001/001189 patent/WO2001092463A2/en active Application Filing
- 2001-05-30 AT AT01940942T patent/ATE419347T1/de not_active IP Right Cessation
- 2001-05-30 DE DE60137226T patent/DE60137226D1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US20040023239A1 (en) | 2004-02-05 |
EP1303597A2 (de) | 2003-04-23 |
ATE419347T1 (de) | 2009-01-15 |
WO2001092463A3 (en) | 2003-01-09 |
AU2001274428A1 (en) | 2001-12-11 |
JP2003534789A (ja) | 2003-11-25 |
WO2001092463A2 (en) | 2001-12-06 |
EP1303597B1 (de) | 2008-12-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |