DE60136730D1 - Methode zur behandlung von krebs mit dithiocarbamat-derivaten - Google Patents

Methode zur behandlung von krebs mit dithiocarbamat-derivaten

Info

Publication number
DE60136730D1
DE60136730D1 DE60136730T DE60136730T DE60136730D1 DE 60136730 D1 DE60136730 D1 DE 60136730D1 DE 60136730 T DE60136730 T DE 60136730T DE 60136730 T DE60136730 T DE 60136730T DE 60136730 D1 DE60136730 D1 DE 60136730D1
Authority
DE
Germany
Prior art keywords
cancer
treatment
dithiocarbamate
tetraethylthiuram disulfide
dithiocarbamate derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60136730T
Other languages
German (de)
English (en)
Inventor
Thomas Preston Kennedy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Utah
Original Assignee
University of Utah
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/679,932 external-priority patent/US6706759B1/en
Application filed by University of Utah filed Critical University of Utah
Application granted granted Critical
Publication of DE60136730D1 publication Critical patent/DE60136730D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/242—Gold; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/245—Bismuth; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/26—Iron; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/32—Manganese; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/34—Copper; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/36—Arsenic; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/38—Silver; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE60136730T 2000-10-05 2001-10-04 Methode zur behandlung von krebs mit dithiocarbamat-derivaten Expired - Lifetime DE60136730D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/679,932 US6706759B1 (en) 1998-09-08 2000-10-05 Method of treating cancer using dithiocarbamate derivatives
US09/735,205 US6548540B2 (en) 1998-09-08 2000-12-12 Method of treating cancer using dithiocarbamate derivatives
PCT/US2001/031142 WO2002028349A2 (en) 2000-10-05 2001-10-04 Method of treating cancer using dithiocarbamate derivatives

Publications (1)

Publication Number Publication Date
DE60136730D1 true DE60136730D1 (de) 2009-01-08

Family

ID=27102340

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60136730T Expired - Lifetime DE60136730D1 (de) 2000-10-05 2001-10-04 Methode zur behandlung von krebs mit dithiocarbamat-derivaten

Country Status (8)

Country Link
US (3) US6548540B2 (https=)
EP (1) EP1328267B1 (https=)
JP (1) JP4268801B2 (https=)
AT (1) ATE415158T1 (https=)
AU (2) AU9661001A (https=)
CA (1) CA2424761A1 (https=)
DE (1) DE60136730D1 (https=)
WO (1) WO2002028349A2 (https=)

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US20050096304A1 (en) * 1998-09-08 2005-05-05 David White Method of treating cancer using dithiocarbamate derivatives
US20060142621A1 (en) * 2003-01-29 2006-06-29 Tiekink Edward R T Bismuth dithiocarbamate compounds and uses thereof
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US20100227920A1 (en) * 2008-09-29 2010-09-09 The Regents Of The University Of California Aldehyde dehydrogenase inhibitors as novel depigmenting agents
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CN103992289B (zh) * 2014-05-22 2016-04-06 河南全宇制药股份有限公司 取代噻唑烷氨荒酸铋配合物及其用途
US10722480B2 (en) 2015-01-06 2020-07-28 Tokyo University Of Science Foundation Agent for controlling cells constituting cancer microenvironment or inflammatory microenvironment
EP3311843A1 (en) * 2016-10-13 2018-04-25 Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts Compositions comprising dithiocarbamate and cyclodextrin
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WO2019010231A1 (en) * 2017-07-05 2019-01-10 Duke University APPARATUS AS TARGETED PRODRUGS FOR PROSTATE CANCER AND METHODS OF MAKING AND USING THE SAME
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EP3636285A1 (en) 2018-10-08 2020-04-15 Palacky University, Olomouc Molecular complex assembly particles comprising bis-r1,r2-dithiocarbamate-metal complex and a ligand, method of preparation and use thereof
US10494394B1 (en) 2018-11-29 2019-12-03 King Fahd University Of Petroleum And Minerals Synthesis, x-ray structures and cytotoxic behavior of platinum (II) complexes of dithiocarbamates
CN111349033A (zh) * 2018-12-20 2020-06-30 杜剑平 基于双硫仑结构的衍生物广谱抗肿瘤药物及其制备方法
CN109432072A (zh) * 2018-12-29 2019-03-08 广州中医药大学(广州中医药研究院) 一种双硫仑-金属有机框架复合物及其制备方法和应用
CN110917182A (zh) * 2019-12-30 2020-03-27 广州医科大学 双硫仑在制备防治nlrp3炎症小体相关疾病的药物中的应用
CN112022815B (zh) * 2020-08-19 2022-05-10 四川大学 一种水相制备高Cu(DTC)2载药量抗肿瘤蛋白纳米药物的方法
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Also Published As

Publication number Publication date
EP1328267A4 (en) 2006-03-22
US20070232692A1 (en) 2007-10-04
CA2424761A1 (en) 2002-04-11
EP1328267B1 (en) 2008-11-26
US20030229064A1 (en) 2003-12-11
AU9661001A (en) 2002-04-15
US20010016600A1 (en) 2001-08-23
EP1328267A2 (en) 2003-07-23
AU2001296610B2 (en) 2006-06-29
WO2002028349A2 (en) 2002-04-11
US6548540B2 (en) 2003-04-15
WO2002028349A3 (en) 2002-07-11
ATE415158T1 (de) 2008-12-15
JP2004525079A (ja) 2004-08-19
JP4268801B2 (ja) 2009-05-27

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