DE60123960D1 - System und verfahren zum optimieren des gewebebarrieretransfers von verbindungen - Google Patents

System und verfahren zum optimieren des gewebebarrieretransfers von verbindungen

Info

Publication number
DE60123960D1
DE60123960D1 DE60123960T DE60123960T DE60123960D1 DE 60123960 D1 DE60123960 D1 DE 60123960D1 DE 60123960 T DE60123960 T DE 60123960T DE 60123960 T DE60123960 T DE 60123960T DE 60123960 D1 DE60123960 D1 DE 60123960D1
Authority
DE
Germany
Prior art keywords
methods
transfer
tissue barrier
throughput
barrier transfer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60123960T
Other languages
English (en)
Other versions
DE60123960T2 (de
Inventor
J Cima
Hongming Chen
Richard Gyory
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Transform Pharmaceuticals Inc
Original Assignee
Transform Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Transform Pharmaceuticals Inc filed Critical Transform Pharmaceuticals Inc
Application granted granted Critical
Publication of DE60123960D1 publication Critical patent/DE60123960D1/de
Publication of DE60123960T2 publication Critical patent/DE60123960T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B01L3/50255—Multi-well filtration
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N13/00—Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
DE60123960T 2000-07-14 2001-07-13 System und verfahren zum optimieren des gewebebarrieretransfers von verbindungen Expired - Lifetime DE60123960T2 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US21837700P 2000-07-14 2000-07-14
US218377P 2000-07-14
US22032400P 2000-07-24 2000-07-24
US220324P 2000-07-24
US24089100P 2000-10-16 2000-10-16
US240891P 2000-10-16
PCT/US2001/022167 WO2002006518A1 (en) 2000-07-14 2001-07-13 System and method for optimizing tissue barrier transfer of compounds

Publications (2)

Publication Number Publication Date
DE60123960D1 true DE60123960D1 (de) 2006-11-30
DE60123960T2 DE60123960T2 (de) 2007-04-26

Family

ID=27396536

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60123960T Expired - Lifetime DE60123960T2 (de) 2000-07-14 2001-07-13 System und verfahren zum optimieren des gewebebarrieretransfers von verbindungen

Country Status (9)

Country Link
US (2) US6758099B2 (de)
EP (1) EP1301619B1 (de)
JP (1) JP2004504585A (de)
AT (1) ATE342959T1 (de)
AU (2) AU2001277887B2 (de)
DE (1) DE60123960T2 (de)
ES (1) ES2273873T3 (de)
IL (2) IL153468A0 (de)
WO (1) WO2002006518A1 (de)

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US6852526B2 (en) 2000-07-14 2005-02-08 Transform Pharmaceuticals, Inc. Transdermal assay with magnetic clamp
US20080182293A1 (en) * 2000-07-14 2008-07-31 Transform Pharmaceuticals, Inc. Computerized control of high-throughput transdermal experimental processing and digital analysis of comparative samples
IL153468A0 (en) 2000-07-14 2003-07-06 Transform Pharmaceuticals Inc System and method for optimizing tissue barrier transfer of compounds
US7172859B2 (en) * 2000-07-14 2007-02-06 Transform Pharmaceuticals, Inc. System and method for optimizing tissue barrier transfer of compounds
US20040023841A1 (en) * 2001-08-23 2004-02-05 Samir Mitragotri Combinatorial method for rapid screening of drug delivery formulations
UA80957C2 (en) * 2001-11-01 2007-11-26 Sciclone Pharmaceuticals Inc Method of administering a thymosin alpha 1 peptide
US6855332B2 (en) * 2002-07-03 2005-02-15 Lyfjathroun Hf. Absorption promoting agent
JP2006516047A (ja) * 2002-10-28 2006-06-15 トランスフォーム・ファーマシューティカルズ・インコーポレイテッド マグネットクランプを備えた経皮アッセイ
US6908760B2 (en) * 2002-10-28 2005-06-21 Transform Pharmaceuticals, Inc. Raised surface assay plate
US7449307B2 (en) 2002-10-28 2008-11-11 Transform Pharmaceuticals, Inc. Raised surface assay plate
WO2004068107A2 (en) * 2003-01-21 2004-08-12 Transform Pharmaceuticals, Inc Apparatus and method for transcellular testing
CA2467131C (en) * 2003-05-13 2013-12-10 Becton, Dickinson & Company Method and apparatus for processing biological and chemical samples
US20070269379A1 (en) * 2003-07-23 2007-11-22 Samir Mitragotri Penetration Enhancer Combinations for Transdermal Delivery
US20050065062A1 (en) * 2003-09-24 2005-03-24 3M Innovative Properties Company Method of formulating a pharmaceutical composition
US7635452B2 (en) * 2003-09-24 2009-12-22 3M Innovative Properties Company System, kit, and method for measuring membrane diffusion
US6844545B1 (en) * 2003-10-10 2005-01-18 Perseptive Biosystems, Inc. MALDI plate with removable insert
US20050265902A1 (en) * 2004-05-27 2005-12-01 Ellen Chen Industry standard multi-well plates with increased capacity and efficiency per well
US20100239655A1 (en) * 2004-12-09 2010-09-23 Georgia Levis Taurine-based compositions and therapeutic methods
US7856263B2 (en) * 2005-04-22 2010-12-21 Travanti Pharma Inc. Transdermal systems for the delivery of therapeutic agents including granisetron using iontophoresis
US20080152592A1 (en) * 2006-12-21 2008-06-26 Bayer Healthcare Llc Method of therapeutic drug monitoring
US20100210932A1 (en) * 2007-03-20 2010-08-19 Bayer Healthcare Llc Method of analyzing an analyte
EP2205967B1 (de) * 2007-10-17 2013-05-01 Syneron Medical Ltd. Überprüfung der auflösungsrate
TWI398307B (zh) * 2009-07-09 2013-06-11 Chan Li Machinery Co Ltd Detection and screening device and its detection and screening method
US8491927B2 (en) * 2009-12-02 2013-07-23 Nimble Epitech, Llc Pharmaceutical composition containing a hypomethylating agent and a histone deacetylase inhibitor
ES2647361T3 (es) * 2010-01-07 2017-12-21 Alkermes Pharma Ireland Limited Profármacos de sales de amonio cuaternario
EP3030646A4 (de) * 2013-08-07 2017-03-22 Agency For Science, Technology And Research Verfahren, vorrichtungen und systeme für zell- und gewebekultur
KR102354954B1 (ko) 2016-04-04 2022-01-24 오메자 엘엘씨 어유 국소 조성물
WO2018002673A1 (en) 2016-07-01 2018-01-04 N4 Pharma Uk Limited Novel formulations of angiotensin ii receptor antagonists
FI127408B (en) 2016-09-29 2018-05-15 Nanoform Finland Oy Device, method and equipment for solubility testing
EP3399313A1 (de) * 2017-05-03 2018-11-07 Galderma Research & Development Vorrichtung und verfahren zur messung der diffusion einer verbindung über einer membran
US20210072231A1 (en) * 2019-09-09 2021-03-11 Board Of Regents, The University Of Texas System Methods and apparatus for high-throughput screening for testing permeability and retention of compounds across biological barriers
CN113567690A (zh) * 2020-04-28 2021-10-29 深圳迎凯生物科技有限公司 孵育组件、孵育装置和自动分析装置
DE102021114585A1 (de) 2021-06-07 2022-12-08 Leica Microsystems Cms Gmbh Mikrotiterplatte, Komponenten hierfür, Probentisch, Mikroskop und entsprechendes Verfahren

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Also Published As

Publication number Publication date
DE60123960T2 (de) 2007-04-26
ATE342959T1 (de) 2006-11-15
AU2001277887B2 (en) 2006-09-14
ES2273873T3 (es) 2007-05-16
IL153468A (en) 2008-07-08
US6758099B2 (en) 2004-07-06
EP1301619A4 (de) 2005-06-01
EP1301619A1 (de) 2003-04-16
IL153468A0 (en) 2003-07-06
US20020025509A1 (en) 2002-02-28
AU7788701A (en) 2002-01-30
JP2004504585A (ja) 2004-02-12
EP1301619B1 (de) 2006-10-18
US20040087007A1 (en) 2004-05-06
WO2002006518A1 (en) 2002-01-24

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Legal Events

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8364 No opposition during term of opposition