DE60123830T2 - ANTIMICROBIAL WIPES - Google Patents

Description

Technical area

The The present invention relates to an antimicrobial wipe which especially for hygienic cleaning of surfaces, such as hard surfaces in the household or in ward or hospital environments or the surface the skin or textile surfaces, is provided. The wipe contains an antimicrobial active Mixture of anionic surfactant and acid in combination with a special solvents and shows improved hygienic cleaning performance.

Background of the invention and state of the art

For the application on surfaces, like hard surfaces in the household or in ward or hospital environments or the surface the skin or textile surfaces, intended cleaning compositions generally include one or more surfactants and optionally one or more antimicrobial Active ingredients and / or solvents.

Such surfaces are common contaminated with bacteria and other microorganisms Risk for human health, especially if they are near food present, represent.

The Biological effectiveness of surfactants is certain with some Exceptions are minor and it is therefore common to the compositions to add a separate antimicrobial agent.

The Antimicrobial effectiveness of organic acids is known in the literature. Organic acids are used in cleaning products to provide antimicrobial efficacy However, in general, adequate supplies do not suffice Measure Bacteria killing, especially when used in formulations at relatively low levels available.

Some surfactants have been found to enhance the effects of organic acids. US 4,975,217 discloses a synergistic germicidal activity for combinations of organic acid and surfactants when used as active ingredients in germicidal products applied directly to the skin. Lemon / maleic acid in combination with anionic surfactant is particularly preferred.

WO 98/55096 discloses that improved germ reduction and improved residue efficacy can be obtained in a skin cleansing antimicrobial wipe comprising a mixture of an anionic surfactant and a proton donating agent (such as organic acid) through the addition of another antimicrobial agent such as TRICLOSAN ^TM , impregnated.

US Pat. No. 6,015,763 discloses a detergent impregnated cloth comprising a flexible porous substrate and a cleaner formulation. The cleanser formulation comprises an anionic surfactant, N-methyl-2-pyrrolidone and an antimicrobial preservative which may be an acidic compound such as nalidic acid and other quinolone carboxylic acids.

The Authors of the present invention have found that a wipe, the antimicrobial mixture of anionic surfactant and acid contains in combination with a solvent, which represents an N-alkylpyrrolidone derivative, superior cleaning performance shows, especially with regard to the removal of grease and excellent hygiene performance.

The Wipes according to the invention are especially suitable for the hygienic cleaning of surfaces, such as hard surfaces in the Household and in ward or hospital environments or the surface of the Skin or textile surfaces. Surprisingly Make the required amount of bactericide for this Application type without requiring the addition of any others antibacterial agents, such as those described in WO 98/55096 are ready.

WHERE 95/21238 describes an acidic microemulsion or acidic all-purpose cleaner for hard Surfaces, the lather, lime scale and fat removed, which one anionic surfactant, at least one organic acid, such as a mono-, di- or tricarboxylic and an N-alkyl-2-pyrrolidone. The product is intended around on a surface sprayed to be followed by that is wiped. There is no mention of antimicrobial effectiveness.

US 5,470,508 discloses an aqueous oil removal / degreasing composition containing higher alkyl pyrrolidone such as N-octyl pyrrolidone, anionic surfactant and water.

GB 2 230 791 refers to a propylene glycol based solvent such as propylene glycol t-butyl ether, in combination with N-methyl-2-pyrrolidone for the removal of grease and paint from metallic surfaces such as automotive parts.

WHERE 98/55569 and WO 98/55570 relates to aqueous hard surface cleaners with improved residue removal and reduced filming / streaking. The compositions include a mixture of anionic surfactants, an anionic solvent, such as an alkylene glycol ether, and preferably include 1-alkyl-2-pyrrolidone for the distribution of fragrance oils and other insoluble ones organic materials in the compositions. The compositions are at a pH greater than Buffered with a nitrogen-containing buffer.

EP 0 598 257 describes a water-based solution for recovering paint from spray booths with an N-alkylpyrrolidone, preferably N-methylpyrrolidone, a surfactant, preferably nonionic, and an alkylene glycol monoalkyl ether, such as tripropylene glycol monomethyl ether.

EP 0 273 594 discloses a disposable semi-wiping wipe for dabbing or finely cleaning bath or kitchen debris containing a liquid detergent composition comprising anionic or nonionic surfactant, one or more solvents for oil and soils such as N-methylpyrrolidone and ethylene or propylene glycol ethers and sufficient Hydroxide compound to produce a composition pH of 8 to 12.

EP 0 690 906 describes a multiple surface cleaner for the removal of fat residues comprising an amine oxide or quaternary ammonium salt surfactant and a polar organic compound of defined water solubility, such as certain of the propylene glycol ethers and N-alkylpyrrolidones.

US 5,332,526 provides an environmentally safe paint stripping composition comprising N-methyl-2-pyrrolidone and lower alkyl ethers of propylene glycol and dipropylene glycol.

none from the above The prior art discloses the combination of components that wipes of the present invention as defined below and the improved surface cleaning and the improved performance that is available or suggests this in front.

Brief description of the invention

• (i) mindestens ein anionisches Tensid,
• (ii) mindestens eine Säure, und
• (iii) ein Lösungsmittel, das ein N-Alkylpyrrolidonderivat darstellt,

wobei die Säure eine Carbonsäure darstellt, ausgewählt aus Caprylsäure, Propionsäure, Azelainsäure, Capronsäure, Hydroxybenzoesäure, Salicylsäure, Äpfelsäure, Maleinsäure, Fumarsäure, Bernsteinsäure, Glutarsäure, Adipinsäure, Weinsäure und Gemischen davon.The present invention provides an antimicrobial wipe suitable for sanitizing surfaces comprising a substrate containing an aqueous composition having a pH of between 3.0 and 6.0, comprising:

• (i) at least one anionic surfactant,
• (ii) at least one acid, and
• (iii) a solvent which is an N-alkylpyrrolidone derivative,

wherein the acid is a carboxylic acid selected from caprylic, propionic, azelaic, caproic, hydroxybenzoic, salicylic, malic, maleic, fumaric, succinic, glutaric, adipic, tartaric and mixtures thereof.

Description of the invention in detail

Product form and constituent parts

The Wipes according to the invention are especially for hygienic cleaning of hard surfaces suitable. With "hard Surfaces "are those surfaces meant typically in the home or in ward or hospital environments occurrences and the for microbial contamination are susceptible. Close examples Toilet installation parts, toilet applications (toilets, bidets, Shower cabins, baths and bath applications), wall and floor surfaces and those surfaces, those with kitchen environments and other environments associated with food preparation are connected.

The Wipes according to the invention are also with washing or Personal care applications usable where an antimicrobial effect is desired, such as hygienic Protective removal products for Textiles or hygiene products for the skin, like antimicrobial cleansing products.

With "wipe" is a disposable substrate, like a porous one or absorbent wipe or cloth meant with the aqueous Composition was treated as defined above Ingredients (i), (ii) and (iii) (hereinafter referred to as the "inventive composition"), so that the composition of the invention in or on the substrate prior to its use by the consumer is incorporated.

These Product form is particularly advantageous as it ensures safe and convenient hygienic One-step cleaning disinfection of surfaces by the user without required dilution or spraying allowed.

typically, the wipe is absorbed by absorbing the composition of the invention formed the substrate to form a wet wipe. A Batch of wipes can then into a container be opened if necessary and if necessary sealed, sealed enough to allow evaporation of any Prevent components from the composition. The composition of the invention will be with the desired Weight impregnated on one or both sides of the substrate, which made of any woven or non-woven fibers, fiber blend or foam of sufficient moisture resistance and absorption capacity, to maintain an effective amount of the composition can.

preferred Materials used to form the substrate generally include all Nonwoven materials having sufficient liquid absorption capacity, around the watery Composition according to the invention to contain and leave the same in use.

explanatory examples for Suitable nonwoven materials close fibers more naturally Origin, such as viscose, cellulose, or synthetic origin, such as Polypropylene or polyester, a. Particularly suitable are mixtures of these materials, such as viscose / polyester, viscose / polypropylene and cellulose / polyester.

Possibly can one or more latex binders are added. These latex binders can typically one or more monomers selected from acrylic acid styrene-2-ethylhexyl ester, butyl acrylate, methyl methacrylate, ethyl acrylate, methyl acrylate, Include acrylonitrile and vinyl acetate.

The Materials can to fabrics using technologies generally in the field are known, such as carding, draining, moisturizing, air laying and extrusion.

sheet can using technologies known in the art are, like needling, stitching, Hydroentanglement, chemical bonding, thermal bonding, spunbonding and meltblowing.

A commercially available example of a suitable material used to form the substrate is Akena VPE ^™ from Orlandi (a viscose / polyester material available in various specific gravities ranging from 40 grams / m ² to 150 grams / m ² vary).

Other examples of commercially available include Tecnojet C500 ^™, a spun-laced material containing 70% viscose and 30% polyester of a specific weight of 50 grams / m ^2, available from TECNOFIBRA, Tecnojet A 1000 ^™, a material containing 100 % Viscose having a specific gravity of 100 grams / m ² available from Tecnofibra and Hydraspun 8579 ^™ , a nonwoven fabric made from a blend of cellulose and synthetic fibers having a specific gravity of 48 grams / m ² .

The compositions of the present invention will typically have ingredient percentages (by weight) as follows:
Surfactant: 0.1 to 2%, preferably about 0.3%
Acid: 0.1 to 2.0%, preferably 0.4 to 0.8%
N-alkylpyrrolidone derivative: 0.05 to 2%, preferably 0.2 to 0.6%
Water: at least 80%, preferably at least 90%.

In a wipe according to the invention is the weight ratio the composition of the invention to substrate suitably in the range of 1: 1 to 6: 1 and preferably 1: 1 to 4: 1, more preferably 2: 1 to 3: 1.

compositions

The Ingredients of the compositions of the invention are further described below as follows:

water

The Compositions of the invention are watery Compositions preferably having relatively low levels Contain active ingredients. Typically, the main ingredient is water, usually with a share of at least 50%, preferably at least 80%, more preferably at least 90% by weight, based on the Total weight, is present. The use of distilled or demineralized water is preferred, but is for the invention is not essential.

surfactant

The Compositions of the invention contain a surfactant that is anionic in nature.

suitable anionic surfactants for use herein include alkyl sulfates, alkyl sulfonates, Alkylarylsulfonates, alkylalkoxylated sulfates or mixtures thereof one.

alkyl sulfates are particularly preferred.

Suitable alkyl sulfate surfactants for use herein are represented by the formula RSO ₄ M wherein R represents a hydrocarbon group suitably a straight or branched alkyl group containing from 6 to 20 carbon atoms or an alkylphenyl group containing from 6 to 18 carbon atoms in the alkyl group can. Preferably, R is a straight or branched alkyl radical containing from 6 to 20 carbon atoms. M is hydrogen or a cation such as an alkali metal cation (e.g., sodium, potassium, lithium, calcium and magnesium) or ammonium or substituted ammonium (e.g., methyl, dimethyl, trimethylammonium and quaternary ammonium cations such as tetramethylammonium and dimethylpiperidinium cations and quaternary ammonium cations derived from alkylamines such as ethylamine, diethylamine, triethylamine, and mixtures thereof).

An example of a commercially available branched alkyl sulfate is DACPON 27-23 AL ^™ from CONDEA. This material may be prepared as a branched, substantially C ₁₂ / C ₁₃ sodium alkyl sulfate of the formula (R ₁ ) CH (R ₂ ) -OSO ₃ Na, wherein R _{1 is} C _1-4 alkyl and R _{2 is} C _8-11 Alkyl is described.

An example of a commercially available linear alkyl sulfate is EMPICOL LX28 ^™ from Albright & Wilson. This material can be used as R-OSO ₃ Na where R is C _10-16 alkyl, mainly C _12-14 alkyl, are described.

Suitable alkyl sulfonates for use herein include water-soluble salts or acids of the formula RSO ₃ M wherein R is a linear or branched, saturated or unsaturated C ₆ -C ₂₀ alkyl group, preferably a C ₈ -C ₁₈ alkyl group, and more preferably a C ₁₀ -C ₁₆ alkyl group and M represents hydrogen or a cation such as those listed above for alkyl sulfate surfactants.

An example of a commercially available C ₁₄ -C ₁₆ alkyl sulfonate is HOSTAPUR ^™ SAS from Hoechst.

Suitable alkylarylsulfonates for use herein include water-soluble salts or acids of the formula RSO ₃ M, wherein R is an aryl group, preferably a benzyl group substituted with a linear or branched saturated or unsaturated C ₆ -C ₂₀ alkyl group, preferably a C ₈ - C ₁₈ alkyl group, and more preferably a C ₁₀ -C ₁₆ alkyl group; and M represents hydrogen or a cation such as that listed above for the alkyl sulfate surfactants.

Examples of commercially available alkylaryl sulfonates are the alkyl benzene sulfonates available from Albright & Wilson under the tradename NANSA ^™ .

Suitable alkyl alkoxylated sulfate surfactants for use herein are of the formula RO (A) m SO ₃ M wherein R is an unsubstituted C ₆ -C ₂₀ alkyl or hydroxyalkyl group having a C ₆ -C ₂₀ alkyl moiety, preferably a C ₈ -C ₁₈ alkyl group. alkyl or hydroxyalkyl, more preferably C ₁₀ -C ₁₆ represents alkyl or hydroxyalkyl, a is an ethoxy or propoxy unit, m is greater than zero, typically between 0.5 and 6, more preferably between 0.5 and 3, and m is H or a Cation as stated above for alkyl sulfate surfactants.

An example of a commercially available alkyl alkoxylated sulfate surfactant is EMPICOL ESA 70 ^™ from Albright & Wilson. This material can be used as RO- (CH ₂ CH ₂ O) SO ₃ Na where R is C _10-16 alkyl, mainly C _12-14 alkyl, are described.

acid

The Compositions of the invention contain an acid, which is organic in nature, and is selected from caprylic acid, propionic acid, azelaic acid, caproic, hydroxy benzoic acid, Salicylic acid, malic acid, maleic acid, fumaric acid, succinic acid, glutaric acid, adipic acid, tartaric acid and Mixtures thereof.

Especially preferred are mixtures of dicarboxylic acids, in particular mixtures, including adipic, Glutaric and succinic acid. These mixtures are preferred to be commercially available. Typical commercially available Mixtures include 30-35 % Adipic acid, 45-50 % Glutaric acid and 10-18 % Succinic acid. Such a mixture is available as SOKALAN DCS from BASF. Another suitable mixture is available as RADIMIX from Radici.

The Use of substantially pure acids is not excluded however, these have limited commercial availability.

N-alkylpyrrolidone derivative

The Compositions of the invention contain an N-alkylpyrrolidone derivative.

suitable N-alkylpyrrolidone derivatives are N- (n-alkyl) -pyrrolidones wherein the alkyl group is 6 to 20, preferably 8 to 14 carbon atoms.

preferred N-alkylpyrrolidone derivatives are N- (n-octyl) -2-pyrrolidone, N- (n-decyl) -2-pyrrolidone, N- (n-dodecyl) -2-pyrrolidone and N- (n-tetradecyl) -2-pyrrolidone.

Particularly preferred is N- (n-octyl) -2-pyrrolidone, commercially available as SURFADONE LP-100 ^™ from International Specialty Products, Inc.

PH value

The Compositions of the invention have a pH between 3.0 and 6.0, preferably 3.5 to 4.5.

It It is believed that the relatively low pH of the composition in achieving both the cleansing and the antimicrobial Synergies demonstrated by the composition of the invention be important. However, below pH 3.0 surface damage may occur. The most preferred pH is around 3.8.

A soluble in water Base, such as an alkali metal hydroxide (typically sodium hydroxide), is generally used to lower the pH required To regulate the level.

Optional components

The Compositions of the invention can other optional ingredients contain their cleaning performance support and maintain the physical and chemical stability of the product.

Examples shut down a: further solvents, Perfumes, colorants and dyes, other hygiene agents, foam control agents, viscosity modifiers Means and mixtures thereof.

A preferred optional ingredient for inclusion in the compositions of the invention is another solvent which can be characterized by the general formula R ₁ -O- (EO) _m - (PO) _n -R ₂ where R ₁ and R _{2 are} independently C _{2 -6} represent alkyl or hydrogen, but not both hydrogen, m and n are independently 0-5, EO represents an ethyleneoxy group and PO represents a propyleneoxy group.

A preferred example of such another solvent is propylene glycol n-butyl ether, sold by Dow Chemical Company as Dowanol PnB ^™ . Other suitable materials include Dowanol PM ^™ and Dowanol DPnB ^™ , both also commercially available from Dow Chemical Company.

Of the Proportion of further solvent in the compositions of the invention (based on the weight of the total weight) is appropriate in the range of 0.05 to 5%, preferably 0.1 to 3%, more preferably 0.2 to 5%.

The The invention will now be illustrated by the following non-limiting examples explains wherein all percentages are by weight based on total weight unless otherwise stated.

Examples

example 1

A liquid formulation was prepared with ingredients as shown in the table below:

An antimicrobial wipe was formed by impregnating a substrate with the above liquid formulation. The substrate was made with a specific gravity of 50 grams / m ² in the spun-lace process (Akena VPE 50 from Orlandi). The weight ratio of liquid formulation to the substrate was 2.6: 1.

The Disinfecting performance was achieved by separating the liquid formulation from the substrate after 24 hours of impregnation time and rating the same on bacterial activity using the in the European Standard EN 1276 described methodology. This describes a test procedure and the requirements for the minimum bacterial Effectiveness of a disinfecting composition. The liquid formulation passed this test with heavy dirt with 5 minutes contact time, which is at least logarithm 5 killing against the bacterial test strains P. aeruginosa, E. coli, S. aureus and Ent. hirae yields.

Example 2 & 3

Examples 2 and 3 (compositions of the invention) and Comparative Examples A and B (no compositions according to the invention) have been produced.

Each composition was used to impregnate an antimicrobial wipe to produce a substrate with the particulate composition. The substrate was made by the spun-lace method, comprising viscose / polyester at a ratio of 70:30 with a specific gravity of 50 grams / m ² . In each case, the weight ratio of composition to substrate was 2.6: 1.

The compositions were evaluated for their cleaning performance on greasy soil. The table below shows the components of the compositions used and the results of the evaluation of the cleaning performance:

It It can be seen that Examples 2 & 3 are both Comparative Example A and Comparative Example B with respect to are superior in their cleaning performance of greasy soil.

Claims (6)

Antimicrobial wipe that for the hygienic Cleaning surfaces which comprises a substrate which is an aqueous composition with a pH between 3.0 and 6.0, comprising: (I) at least one anionic surfactant, (ii) at least one acid, and (Iii) a solvent, which represents an N-alkylpyrrolidone derivative, the acid being a carboxylic acid represents selected from caprylic acid, propionic acid, azelaic acid, caproic, hydroxy benzoic acid, Salicylic acid, malic acid, maleic acid, fumaric acid, succinic acid, glutaric acid, adipic acid, tartaric acid and Mixtures thereof. The wipe of claim 1, wherein the anionic surfactant from alkyl sulfates, alkyl sulfonates, alkylaryl sulfonates, alkyl alkoxylated Sulfates or mixtures thereof is selected. A wipe according to claims 1 or 2, wherein the N-alkylpyrrolidone derivative from N- (n-octyl) -2-pyrrolidone, N- (n-decyl) -2-pyrrolidone, N- (n-dodecyl) -2-pyrrolidone and N- (n-tetradecyl) -2-pyrrolidone is selected. A wipe according to any one of claims 1 to 3, wherein the composition has a pH between 3.5 and 4.5. A wipe according to any one of claims 1 to 4, wherein the aqueous composition includes another solvent of the general formula R ₁ -O- (EO) _m - (PO) _n -R ₂ wherein R ₁ and R _{2 are} independently C _2-6 - But not both are hydrogen, m and n are independently 0-5, EO represents an ethyleneoxy group and PO represents a propyleneoxy group. A wipe according to any one of claims 1 to 5, wherein the weight ratio of aqueous Composition to substrate in the range of 1: 1 to 4: 1.