DE60106901D1 - Vorrichtung zur Elektroporation unter kontinuierlichen Steuerung der Zellendurchlässigkeit - Google Patents

Vorrichtung zur Elektroporation unter kontinuierlichen Steuerung der Zellendurchlässigkeit

Info

Publication number
DE60106901D1
DE60106901D1 DE60106901T DE60106901T DE60106901D1 DE 60106901 D1 DE60106901 D1 DE 60106901D1 DE 60106901 T DE60106901 T DE 60106901T DE 60106901 T DE60106901 T DE 60106901T DE 60106901 D1 DE60106901 D1 DE 60106901D1
Authority
DE
Germany
Prior art keywords
electroporation device
device under
under continuous
continuous control
electrodes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60106901T
Other languages
English (en)
Other versions
DE60106901T2 (de
Inventor
Damijan Miklavcic
Lluis Mir
Eberhard Neumann
Bertil Persson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Igea SRL
Original Assignee
Igea SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Igea SRL filed Critical Igea SRL
Publication of DE60106901D1 publication Critical patent/DE60106901D1/de
Application granted granted Critical
Publication of DE60106901T2 publication Critical patent/DE60106901T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/02—Electrical or electromagnetic means, e.g. for electroporation or for cell fusion

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Electromagnetism (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
  • X-Ray Techniques (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Hybrid Cells (AREA)
DE60106901T 2000-04-21 2001-04-20 Vorrichtung zur Elektroporation unter kontinuierlichen Steuerung der Zellendurchlässigkeit Expired - Lifetime DE60106901T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT2000TO000390A IT1320187B1 (it) 2000-04-21 2000-04-21 Dispositivo e metodo di elettro-porazione che fornisce un segnalemodulato sotto il controllo continuo della elettro-permeabilizzazione
ITTO000390 2000-04-21
PCT/IT2001/000195 WO2001081532A1 (en) 2000-04-21 2001-04-20 Electroporation device and method, delivering a modulated signal under continuous control of cell electropermeabilization

Publications (2)

Publication Number Publication Date
DE60106901D1 true DE60106901D1 (de) 2004-12-09
DE60106901T2 DE60106901T2 (de) 2005-11-10

Family

ID=11457686

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60106901T Expired - Lifetime DE60106901T2 (de) 2000-04-21 2001-04-20 Vorrichtung zur Elektroporation unter kontinuierlichen Steuerung der Zellendurchlässigkeit

Country Status (8)

Country Link
US (1) US7306940B2 (de)
EP (1) EP1274830B1 (de)
AT (1) ATE281513T1 (de)
AU (1) AU2001258728A1 (de)
DE (1) DE60106901T2 (de)
ES (1) ES2232621T3 (de)
IT (1) IT1320187B1 (de)
WO (1) WO2001081532A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2873385B1 (fr) * 2004-07-23 2006-10-27 Centre Nat Rech Scient Cnrse Surveillance et controle d'une electroporation
DE102007005909A1 (de) 2007-02-01 2008-08-14 Amaxa Ag Verfahren zur Kontrolle eines mit Elektroden versehenen Behältnissen
DE102008008614A1 (de) 2008-02-12 2009-08-13 Leibniz-Institut für Plasmaforschung und Technologie e.V. Plama-Gerät zur selektiven Behandlung elektroporierter Zellen
US9616245B2 (en) 2009-03-16 2017-04-11 Rajah Vijay Kumar Method of treating cells with drug and radiation according to proton density
DE102009028462A1 (de) 2009-08-11 2011-03-24 Leibniz-Institut für Plasmaforschung und Technologie e.V. Vorrichtung und Verfahren zur Behandlung von lebenden Zellen mittels eines Plasmas
US10131900B2 (en) * 2010-12-15 2018-11-20 Old Dominion University Research Foundation Electroporation-induced electrosensitization
BR112018004278B1 (pt) 2015-09-04 2022-05-03 Rutgers, The State University Of New Jersey Sistema para eletroporação de uma célula biológica, e método para eletroporação de células biológicas em uma solução tampão
ITUB20160311A1 (it) * 2016-01-18 2017-07-18 Rise Tech S R L Elettrodo flessibile per l'applicazione di un campo elettrico al corpo umano
JP7158820B2 (ja) * 2016-10-26 2022-10-24 ロレアル エレクトロポレーションデバイスおよびエレクトロポレーションデバイスを制御するための方法
WO2018144814A1 (en) 2017-02-03 2018-08-09 Infinitesimal Llc Electroporation system with micromanipulator and probe
US11045648B2 (en) 2017-11-14 2021-06-29 Boston Scientific Scimed, Inc. Irreversible electroporation through a combination of substance injection and electrical field application
US11364070B2 (en) 2018-01-23 2022-06-21 Boston Scientific Scimed, Inc. Enhanced needle array and therapies for tumor ablation
JP7401555B2 (ja) 2019-03-15 2023-12-19 ボストン サイエンティフィック サイムド，インコーポレイテッド 選択的細胞アブレーションのための時間多重化波形
US12558144B2 (en) 2019-03-15 2026-02-24 Boston Scientific Scimed, Inc. Waveform generator and control for selective cell ablation
CN114945338A (zh) 2019-10-15 2022-08-26 波士顿科学国际有限公司 用于消融系统的控制系统和用户界面
US11992260B2 (en) 2020-03-31 2024-05-28 Boston Scientific Scimed, Inc. Smart probe identification for ablation modalities
EP3915633A1 (de) 2020-05-29 2021-12-01 Imec VZW Steuerung der elektroporation von zellen
IT202000031379A1 (it) 2020-12-18 2022-06-18 Curaleaf International Ltd Formulazione farmaceutica topica e metodo per il trattamento delle sindromi associate a dolore pelvico cronico

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE131081T1 (de) * 1988-01-21 1995-12-15 Massachusetts Inst Technology Molekültransport durch gewebe mit der verwendung von elektroporation.
US5749847A (en) * 1988-01-21 1998-05-12 Massachusetts Institute Of Technology Delivery of nucleotides into organisms by electroporation
US5134070A (en) * 1990-06-04 1992-07-28 Casnig Dael R Method and device for cell cultivation on electrodes
WO2000020554A1 (en) * 1998-10-08 2000-04-13 Astrazeneca Ab Microfabricated cell injector
US6300108B1 (en) * 1999-07-21 2001-10-09 The Regents Of The University Of California Controlled electroporation and mass transfer across cell membranes
US6403348B1 (en) * 1999-07-21 2002-06-11 The Regents Of The University Of California Controlled electroporation and mass transfer across cell membranes

Also Published As

Publication number Publication date
EP1274830B1 (de) 2004-11-03
ITTO20000390A1 (it) 2001-10-21
AU2001258728A1 (en) 2001-11-07
US7306940B2 (en) 2007-12-11
EP1274830A1 (de) 2003-01-15
ES2232621T3 (es) 2005-06-01
WO2001081532A1 (en) 2001-11-01
US20040039327A1 (en) 2004-02-26
DE60106901T2 (de) 2005-11-10
ATE281513T1 (de) 2004-11-15
ITTO20000390A0 (it) 2000-04-21
IT1320187B1 (it) 2003-11-26

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