DE60104839D1 - Verbesserung der enantioselektivität bei reduktionen mit boranreagenzien - Google Patents

Verbesserung der enantioselektivität bei reduktionen mit boranreagenzien

Info

Publication number
DE60104839D1
DE60104839D1 DE60104839T DE60104839T DE60104839D1 DE 60104839 D1 DE60104839 D1 DE 60104839D1 DE 60104839 T DE60104839 T DE 60104839T DE 60104839 T DE60104839 T DE 60104839T DE 60104839 D1 DE60104839 D1 DE 60104839D1
Authority
DE
Germany
Prior art keywords
enantioselectivity
borohydride
boran
reductions
reagents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60104839T
Other languages
English (en)
Other versions
DE60104839T2 (de
Inventor
Karl Matos
A Corella
R Burkhardt
M Nettles
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF SE filed Critical BASF SE
Application granted granted Critical
Publication of DE60104839D1 publication Critical patent/DE60104839D1/de
Publication of DE60104839T2 publication Critical patent/DE60104839T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/143—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE60104839T 2000-04-20 2001-01-22 Verbesserung der enantioselektivität bei reduktionen mit boranreagenzien Expired - Lifetime DE60104839T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/553,264 US6218585B1 (en) 2000-04-20 2000-04-20 Increasing enatioselectivity in reductions with borane reagents
US553264 2000-04-20
PCT/US2001/002069 WO2001081277A1 (en) 2000-04-20 2001-01-22 Increasing enantioselectivity in reductions with borane reagents

Publications (2)

Publication Number Publication Date
DE60104839D1 true DE60104839D1 (de) 2004-09-16
DE60104839T2 DE60104839T2 (de) 2005-01-05

Family

ID=24208775

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60104839T Expired - Lifetime DE60104839T2 (de) 2000-04-20 2001-01-22 Verbesserung der enantioselektivität bei reduktionen mit boranreagenzien

Country Status (7)

Country Link
US (2) US6218585B1 (de)
EP (1) EP1274666B1 (de)
AT (1) ATE273258T1 (de)
AU (1) AU2001234510A1 (de)
DE (1) DE60104839T2 (de)
ES (1) ES2223784T3 (de)
WO (1) WO2001081277A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6218585B1 (en) * 2000-04-20 2001-04-17 Mine Safety Appliances Company Increasing enatioselectivity in reductions with borane reagents
FR2824830B1 (fr) * 2001-05-18 2003-07-04 Centre Nat Rech Scient Catalyseur pour reduction enantioselective de cetones
US7767833B2 (en) * 2004-08-12 2010-08-03 Sigma-Aldrich Co. Stabilized borane-tetrahydrofuran complex
US20080200672A1 (en) * 2005-08-30 2008-08-21 Margarita Ortiz-Marciales Highly enantioselective carbonyl reduction with borane catalyzed by chiral spiroborate esters derived from chiral beta-aminoalcohols
US7750168B2 (en) * 2006-02-10 2010-07-06 Sigma-Aldrich Co. Stabilized deuteroborane-tetrahydrofuran complex
MX2008010235A (es) * 2006-02-16 2008-10-23 Kotobuki Pharmaceutical Co Ltd Metodo para producir alcohol opticamente activo.
RU2009102149A (ru) * 2006-06-26 2010-08-10 Басф Се (De) Комплексы боран-простой эфир
US8013189B2 (en) * 2007-09-21 2011-09-06 Basf Se Accelerated amide and ester reductions with amine boranes and additives
US20100016484A1 (en) * 2008-07-18 2010-01-21 Basf Se Process for producing 1,3,2-dioxaborinane compounds
WO2017136254A1 (en) * 2016-02-04 2017-08-10 Merck Sharp & Dohme Corp. Methods of preparing hydroxylamine derivatives useful in the preparation of anti-infective agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4943635A (en) * 1987-08-27 1990-07-24 President & Fellows Of Harvard College Enantioselective reduction of ketones
US6048985A (en) * 1998-12-22 2000-04-11 Mine Safety Appliances Company Borane-tetrahydrofuran complex method of storing and reacting borane-tetrahydrofuran complex
US6218585B1 (en) * 2000-04-20 2001-04-17 Mine Safety Appliances Company Increasing enatioselectivity in reductions with borane reagents

Also Published As

Publication number Publication date
EP1274666B1 (de) 2004-08-11
WO2001081277A1 (en) 2001-11-01
EP1274666A1 (de) 2003-01-15
US20010047116A1 (en) 2001-11-29
ES2223784T3 (es) 2005-03-01
ATE273258T1 (de) 2004-08-15
US6610894B2 (en) 2003-08-26
DE60104839T2 (de) 2005-01-05
US6218585B1 (en) 2001-04-17
AU2001234510A1 (en) 2001-11-07

Similar Documents

Publication Publication Date Title
DE60104839D1 (de) Verbesserung der enantioselektivität bei reduktionen mit boranreagenzien
BR9910837A (pt) Catalizador para produção de acetato de vinila por reação de etileno, oxigênio e ácido acético, método para preparar um catalizador , e processo para produção de acetato de vinila
Gustafson et al. Chemoenzymatic dynamic kinetic resolution of secondary alcohols using an air‐and moisture‐stable iron racemization catalyst
US4623465A (en) Removal of combined organic substances from aqueous solutions
AU2003258238A1 (en) Method for processing data based on the data context
HUP0104295A2 (hu) Átmenetifémmel komplexet képező szerves anyag alkalmazása fehérítőkészítmény előállítására és eljárás szubsztrátum fehérítésére
AU2003277612A1 (en) Method of detecting gene mutation
PL336717A1 (en) Effective enantioselective addition reaction employing a zinc containing organic reagent
GB0002261D0 (en) Fluorescent detection method & reagent
GR3022924T3 (en) Enantioselective oxazaborolidine catalysts
ATE240259T1 (de) Verfahren zur herstellung von wasserstoff
YU49425B (sh) Postupak pripremanja katalizatora za proizvodnju vinil acetata
HUT65136A (en) Process for producing and using enantioselective oxazaborolidine catalysts
WO2003102585A3 (en) Biomolecular kinetics method using a flow-through microarray
DE50012832D1 (de) Halbleiterbauelement, elektronisches bauteil, sensorsystem und verfahren zur herstellung eines halbleiterbauelementes
Mayer et al. A genetically encodable ligand for transfer hydrogenation
ATE304711T1 (de) Messung von hydriden mit hilfe chemilumineszierender acridiniumverbindungen
IT1291356B1 (it) Processo per la rimozione di metalli pesanti
JPS63198999A (ja) リボフラビン連結検定法および材料
HUT65592A (en) Process for conducting chemical reactions with formaldehyde and for the production of aromatic azomethine
FI990283A0 (fi) alfa-olefiinin polymerointikatalysattorijärjestelmä ja sen käyttö alfa-olefiinien polymeroinnissa
DE60210065D1 (de) Katalysator für enantioselektive reduktion von ketonen
WO2002083983A3 (de) Bestimmung der beschleunigerkonzentration in phosphatierbäder
EP0173276A3 (de) Verfahren zur Bestimmung eines Substrats oder der Enzymwirksamkeit
GB0306267D0 (en) Process

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: BASF SE, 67063 LUDWIGSHAFEN, DE