DE60104839D1 - Verbesserung der enantioselektivität bei reduktionen mit boranreagenzien - Google Patents

Verbesserung der enantioselektivität bei reduktionen mit boranreagenzien

Info

Publication number
DE60104839D1
DE60104839D1 DE60104839T DE60104839T DE60104839D1 DE 60104839 D1 DE60104839 D1 DE 60104839D1 DE 60104839 T DE60104839 T DE 60104839T DE 60104839 T DE60104839 T DE 60104839T DE 60104839 D1 DE60104839 D1 DE 60104839D1
Authority
DE
Germany
Prior art keywords
enantioselectivity
borohydride
boran
reductions
reagents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60104839T
Other languages
English (en)
Other versions
DE60104839T2 (de
Inventor
Karl Matos
A Corella
R Burkhardt
M Nettles
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF SE filed Critical BASF SE
Publication of DE60104839D1 publication Critical patent/DE60104839D1/de
Application granted granted Critical
Publication of DE60104839T2 publication Critical patent/DE60104839T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/143—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
DE60104839T 2000-04-20 2001-01-22 Verbesserung der enantioselektivität bei reduktionen mit boranreagenzien Expired - Lifetime DE60104839T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US553264 2000-04-20
US09/553,264 US6218585B1 (en) 2000-04-20 2000-04-20 Increasing enatioselectivity in reductions with borane reagents
PCT/US2001/002069 WO2001081277A1 (en) 2000-04-20 2001-01-22 Increasing enantioselectivity in reductions with borane reagents

Publications (2)

Publication Number Publication Date
DE60104839D1 true DE60104839D1 (de) 2004-09-16
DE60104839T2 DE60104839T2 (de) 2005-01-05

Family

ID=24208775

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60104839T Expired - Lifetime DE60104839T2 (de) 2000-04-20 2001-01-22 Verbesserung der enantioselektivität bei reduktionen mit boranreagenzien

Country Status (7)

Country Link
US (2) US6218585B1 (de)
EP (1) EP1274666B1 (de)
AT (1) ATE273258T1 (de)
AU (1) AU2001234510A1 (de)
DE (1) DE60104839T2 (de)
ES (1) ES2223784T3 (de)
WO (1) WO2001081277A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6218585B1 (en) * 2000-04-20 2001-04-17 Mine Safety Appliances Company Increasing enatioselectivity in reductions with borane reagents
FR2824830B1 (fr) * 2001-05-18 2003-07-04 Centre Nat Rech Scient Catalyseur pour reduction enantioselective de cetones
US7767833B2 (en) * 2004-08-12 2010-08-03 Sigma-Aldrich Co. Stabilized borane-tetrahydrofuran complex
US20080200672A1 (en) * 2005-08-30 2008-08-21 Margarita Ortiz-Marciales Highly enantioselective carbonyl reduction with borane catalyzed by chiral spiroborate esters derived from chiral beta-aminoalcohols
US7750168B2 (en) * 2006-02-10 2010-07-06 Sigma-Aldrich Co. Stabilized deuteroborane-tetrahydrofuran complex
MX2008010235A (es) * 2006-02-16 2008-10-23 Kotobuki Pharmaceutical Co Ltd Metodo para producir alcohol opticamente activo.
DE602007008564D1 (en) * 2006-06-26 2010-09-30 Basf Se Boranetherkomplexe
US8013189B2 (en) * 2007-09-21 2011-09-06 Basf Se Accelerated amide and ester reductions with amine boranes and additives
US20100016484A1 (en) * 2008-07-18 2010-01-21 Basf Se Process for producing 1,3,2-dioxaborinane compounds
EP3411359B1 (de) * 2016-02-04 2021-10-13 Merck Sharp & Dohme Corp. Verfahren zur herstellung von hydroxylaminderivaten, die in der herstellung von infektionsschutzmitteln nützlich sind

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4943635A (en) * 1987-08-27 1990-07-24 President & Fellows Of Harvard College Enantioselective reduction of ketones
US6048985A (en) * 1998-12-22 2000-04-11 Mine Safety Appliances Company Borane-tetrahydrofuran complex method of storing and reacting borane-tetrahydrofuran complex
US6218585B1 (en) * 2000-04-20 2001-04-17 Mine Safety Appliances Company Increasing enatioselectivity in reductions with borane reagents

Also Published As

Publication number Publication date
US6218585B1 (en) 2001-04-17
ES2223784T3 (es) 2005-03-01
US6610894B2 (en) 2003-08-26
AU2001234510A1 (en) 2001-11-07
DE60104839T2 (de) 2005-01-05
WO2001081277A1 (en) 2001-11-01
EP1274666B1 (de) 2004-08-11
US20010047116A1 (en) 2001-11-29
ATE273258T1 (de) 2004-08-15
EP1274666A1 (de) 2003-01-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: BASF SE, 67063 LUDWIGSHAFEN, DE