DE60044620D1 - Amino-containing carrier matrices, use and preparation thereof - Google Patents

Amino-containing carrier matrices, use and preparation thereof

Info

Publication number
DE60044620D1
DE60044620D1 DE60044620T DE60044620T DE60044620D1 DE 60044620 D1 DE60044620 D1 DE 60044620D1 DE 60044620 T DE60044620 T DE 60044620T DE 60044620 T DE60044620 T DE 60044620T DE 60044620 D1 DE60044620 D1 DE 60044620D1
Authority
DE
Germany
Prior art keywords
amino
groups
monomers
monomer
support matrix
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60044620T
Other languages
German (de)
Inventor
Geir Fonnum
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cytiva Sweden AB
Original Assignee
GE Healthcare Bio Sciences AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GE Healthcare Bio Sciences AB filed Critical GE Healthcare Bio Sciences AB
Application granted granted Critical
Publication of DE60044620D1 publication Critical patent/DE60044620D1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/282—Porous sorbents
    • B01J20/285—Porous sorbents based on polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28042—Shaped bodies; Monolithic structures
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F212/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an aromatic carbocyclic ring
    • C08F212/02—Monomers containing only one unsaturated aliphatic radical
    • C08F212/04—Monomers containing only one unsaturated aliphatic radical containing one ring
    • C08F212/14—Monomers containing only one unsaturated aliphatic radical containing one ring substituted by heteroatoms or groups containing heteroatoms
    • C08F212/26—Nitrogen
    • C08F212/28—Amines
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00—Aspects relating to sorbent materials
    • B01J2220/80—Aspects related to sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J2220/82—Shaped bodies, e.g. monoliths, plugs, tubes, continuous beds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Polymerisation Methods In General (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Cephalosporin Compounds (AREA)
  • Polishing Bodies And Polishing Tools (AREA)

Abstract

A method for the manufacture of a support matrix exhibiting amino groups I, possibly in acylated form, comprising the step of polymerising one or more monovinyl monomers (monomer I) with one or more di- tri- or polyvinyl monomers (monomer II). The method is characterized in that that the polymerisation is run in the presence of one or more amino-(C0-10)hydrocarbon vinyl aromatic monomers possibly in acylated form (monomer III. <??>The preferred combination of monomers are ethyl vinyl benzene, divinyl benzene and amino styrene. <??>A support matrix comprising a polyvinyl backbone Ä(-CH2CH2)nÜ and amino groups or groups derived from said amino groups while retaining the nitrogen of the amino group, each of which groups being attached to said backbone via a link structure containing an arylene group. The matrix is charactetized in that each of said groups is directly attached via said nitrogen to said arylene group. <??>The use of the support matrix as defined in any one of claims 1-17, for solid phase synthesis, for instance of an oligo/poly-nucleotide or an oligo/polypeptide.
DE60044620T 1999-03-22 2000-03-22 Amino-containing carrier matrices, use and preparation thereof Expired - Lifetime DE60044620D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/273,513 US6335438B1 (en) 1999-03-22 1999-03-22 Method for the manufacture of amino group containing support matrices, support matrices prepared by the method, and use of the support matrices

Publications (1)

Publication Number Publication Date
DE60044620D1 true DE60044620D1 (en) 2010-08-12

Family

ID=23044247

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60015514T Expired - Lifetime DE60015514T2 (en) 1999-03-22 2000-03-22 AMINO GROUPS CONTAINING AMINO GROUPS, USE AND MANUFACTURE THEREOF
DE60044620T Expired - Lifetime DE60044620D1 (en) 1999-03-22 2000-03-22 Amino-containing carrier matrices, use and preparation thereof

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE60015514T Expired - Lifetime DE60015514T2 (en) 1999-03-22 2000-03-22 AMINO GROUPS CONTAINING AMINO GROUPS, USE AND MANUFACTURE THEREOF

Country Status (10)

Country Link
US (1) US6335438B1 (en)
EP (2) EP1171489B1 (en)
JP (1) JP4523176B2 (en)
AT (2) ATE472567T1 (en)
AU (2) AU773644B2 (en)
CA (1) CA2368019C (en)
DE (2) DE60015514T2 (en)
ES (1) ES2234575T3 (en)
NO (1) NO20014563L (en)
WO (1) WO2000056790A1 (en)

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* Cited by examiner, † Cited by third party
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FR2862976B1 (en) * 2003-11-28 2006-01-13 Commissariat Energie Atomique VERY LOW DENSITY POLYMER FOAMS AND METHOD OF MANUFACTURING THE SAME
WO2006004161A1 (en) * 2004-07-06 2006-01-12 Kyoto University Novel polyphenylacetylene derivatives
EP1789460B1 (en) * 2004-09-02 2013-01-09 Isis Pharmaceuticals, Inc. Polymeric beads for oligonucleotide synthesis
JP5113036B2 (en) * 2006-02-20 2013-01-09 独立行政法人科学技術振興機構 Hydrophilic carbon cluster
JP4970881B2 (en) * 2006-09-21 2012-07-11 日東電工株式会社 Carrier for solid phase synthesis
JP5097506B2 (en) 2007-11-05 2012-12-12 日東電工株式会社 Method for producing porous resin particles having a hydroxyl group
JP5438922B2 (en) * 2008-06-25 2014-03-12 日東電工株式会社 Method for producing nucleic acid
JP5276367B2 (en) * 2008-06-25 2013-08-28 日東電工株式会社 Porous resin beads and method for producing nucleic acid using the same
US9138308B2 (en) 2010-02-03 2015-09-22 Apollo Endosurgery, Inc. Mucosal tissue adhesion via textured surface
ES2623475T3 (en) 2010-05-11 2017-07-11 Allergan, Inc. Porogen compositions, methods for making them and uses
US20130109596A1 (en) 2011-09-26 2013-05-02 Life Technologies Corporation High efficiency, small volume nucleic acid synthesis
WO2014022657A1 (en) 2012-08-02 2014-02-06 Allergan, Inc. Mucosal tissue adhesion via textured surface
WO2014052724A1 (en) 2012-09-28 2014-04-03 Allergan, Inc. Porogen compositions, methods of making and uses
US10563240B2 (en) 2013-03-14 2020-02-18 Life Technologies Corporation High efficiency, small volume nucleic acid synthesis
CA3147259A1 (en) 2014-12-09 2016-06-16 Life Technologies Corporation High efficiency, small volume nucleic acid synthesis
US11612852B2 (en) 2020-05-28 2023-03-28 Palo Alto Research Center Incorporated Tunable, rapid uptake, aminopolymer aerogel sorbent for direct air capture of CO2
WO2022268932A1 (en) 2021-06-24 2022-12-29 Thermo Fisher Scientific Geneart Gmbh Systems and methods for single cell analysis
WO2023069599A1 (en) 2021-10-22 2023-04-27 Hongene Biotech Corporation Polymeric solid support for oligonucleotide synthesis

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1745717A1 (en) 1957-03-09 1970-01-29 Bayer Ag Process for the production of crosslinked copolymers with a sponge structure
US4275184A (en) * 1974-10-01 1981-06-23 Rhone-Poulenc Industries Ethylenic silicon compounds and thermoplastic elastomers obtained therefrom
FR2352547A1 (en) * 1976-05-25 1977-12-23 Viridis Ets NEW ANIONIC RESIN WITH HYPOCHOLESTEROLEMIANTE ACTION, ITS PREPARATION PROCESS AND THERAPEUTIC COMPOSITIONS CONTAINING IT
JPS54100489A (en) * 1978-01-26 1979-08-08 Asahi Chem Ind Co Ltd New basic crosslinked copolymer and its preparation
US4373071A (en) 1981-04-30 1983-02-08 City Of Hope Research Institute Solid-phase synthesis of polynucleotides
US4689359A (en) * 1985-08-22 1987-08-25 Eastman Kodak Company Composition formed from gelatin and polymer of vinyl monomer having a primary amine addition salt group
DE3643987A1 (en) * 1986-12-22 1988-06-23 Lohmann Therapie Syst Lts BASIC, ACTIVE SUBSTANCE-ADHESIVE ADHESIVE POLYMER, IN PARTICULAR FOR USE WITH BASIC ACTIVE SUBSTANCES, PROCESS FOR THEIR PRODUCTION AND THEIR USE
US5098960A (en) 1987-09-23 1992-03-24 Board Of Reagents, The University Of Texas System Methods and compositions for providing articles having improved biocompatibility characteristics
US5369012A (en) 1992-03-26 1994-11-29 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Method of making a membrane having hydrophilic and hydrophobic surfaces for adhering cells or antibodies by using atomic oxygen or hydroxyl radicals
EP0801082B1 (en) 1990-08-31 2003-04-09 Regents Of The University Of Minnesota Method for making graft resins for solid-phase peptide synthesis
AU668855B2 (en) * 1990-10-26 1996-05-23 Genta Incorporated Non-aromatic organic polymeric reagents for solid phase synthesis of oligomers
AU4544193A (en) 1992-06-25 1994-01-24 Microprobe Corporation Solid supports for nucleic acid hybridization assays

Also Published As

Publication number Publication date
CA2368019A1 (en) 2000-09-28
US6335438B1 (en) 2002-01-01
ES2234575T3 (en) 2005-07-01
ATE472567T1 (en) 2010-07-15
AU2004203549A1 (en) 2004-08-26
EP1433795A3 (en) 2004-12-01
WO2000056790A1 (en) 2000-09-28
EP1171489B1 (en) 2004-11-03
DE60015514D1 (en) 2004-12-09
CA2368019C (en) 2010-07-20
JP2002540231A (en) 2002-11-26
EP1433795B1 (en) 2010-06-30
EP1171489A1 (en) 2002-01-16
EP1433795A2 (en) 2004-06-30
JP4523176B2 (en) 2010-08-11
NO20014563D0 (en) 2001-09-20
NO20014563L (en) 2001-11-15
AU3314400A (en) 2000-10-09
AU773644B2 (en) 2004-05-27
DE60015514T2 (en) 2005-10-20
ATE281480T1 (en) 2004-11-15

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