DE60042552D1 - METABOLIC MANIPULATION OF THE PRODUCTION OF AMINO ACIDS - Google Patents

METABOLIC MANIPULATION OF THE PRODUCTION OF AMINO ACIDS

Info

Publication number
DE60042552D1
DE60042552D1 DE60042552T DE60042552T DE60042552D1 DE 60042552 D1 DE60042552 D1 DE 60042552D1 DE 60042552 T DE60042552 T DE 60042552T DE 60042552 T DE60042552 T DE 60042552T DE 60042552 D1 DE60042552 D1 DE 60042552D1
Authority
DE
Germany
Prior art keywords
production
amino acids
metabolic manipulation
metabolic
manipulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60042552T
Other languages
German (de)
Inventor
John P Rayapati
Corey M Crafton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Archer Daniels Midland Co
Original Assignee
Archer Daniels Midland Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Archer Daniels Midland Co filed Critical Archer Daniels Midland Co
Application granted granted Critical
Publication of DE60042552D1 publication Critical patent/DE60042552D1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/01—Preparation of mutants without inserting foreign genetic material therein; Screening processes therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
DE60042552T 1999-08-02 2000-08-02 METABOLIC MANIPULATION OF THE PRODUCTION OF AMINO ACIDS Expired - Lifetime DE60042552D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14637999P 1999-08-02 1999-08-02
PCT/US2000/020979 WO2001009286A1 (en) 1999-08-02 2000-08-02 Metabolic engineering of amino acid production

Publications (1)

Publication Number Publication Date
DE60042552D1 true DE60042552D1 (en) 2009-08-27

Family

ID=22517109

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60042552T Expired - Lifetime DE60042552D1 (en) 1999-08-02 2000-08-02 METABOLIC MANIPULATION OF THE PRODUCTION OF AMINO ACIDS

Country Status (12)

Country Link
US (2) US7323321B2 (en)
EP (1) EP1200553B1 (en)
JP (3) JP2003506030A (en)
KR (1) KR100815041B1 (en)
CN (1) CN1367823A (en)
AU (1) AU779019B2 (en)
BR (1) BR0012963B1 (en)
CA (1) CA2380613C (en)
DE (1) DE60042552D1 (en)
MX (1) MXPA02001174A (en)
NZ (1) NZ516893A (en)
WO (1) WO2001009286A1 (en)

Families Citing this family (19)

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Publication number Priority date Publication date Assignee Title
DE10063314A1 (en) * 2000-12-20 2002-07-04 Degussa New nucleotide sequences coding for the ilvE gene
BR0304860A (en) * 2002-11-11 2004-08-31 Ajinomoto Kk Method for producing a target substance by use of a bacterium belonging to the genus Escherichia
AR058584A1 (en) 2005-12-22 2008-02-13 Takeda Pharmaceutical METASTININE DERIVATIVES AND USE OF THE SAME
RU2451748C1 (en) 2008-03-03 2012-05-27 Глобал Био-Чем Текнолоджи Груп Компани Лимитед Recombinant dna and method of obtaining l-lysine
DE102010003419B4 (en) 2010-03-30 2019-09-12 Evonik Degussa Gmbh Process for the fermentative production of L-ornithine
US20130109596A1 (en) 2011-09-26 2013-05-02 Life Technologies Corporation High efficiency, small volume nucleic acid synthesis
JP6136930B2 (en) * 2011-11-02 2017-05-31 味の素株式会社 Protein secretory production
IN2014CN04039A (en) 2011-11-02 2015-10-23 Ajinomoto Kk
CN102604881B (en) * 2012-03-31 2013-12-18 福建省麦丹生物集团有限公司 Engineering bacterium for producing L-isoleucine and application thereof
US10563240B2 (en) 2013-03-14 2020-02-18 Life Technologies Corporation High efficiency, small volume nucleic acid synthesis
KR101720836B1 (en) * 2014-08-05 2017-04-03 씨제이제일제당 (주) Feedback-resistant acetohydroxy acid synthase variants and a method of producing L-valine using the same
LT3557262T (en) 2014-12-09 2022-11-10 Life Technologies Corporation High efficiency, small volume nucleic acid synthesis
PE20171663A1 (en) * 2015-02-17 2017-11-15 Ajinomoto Kk PRODUCTION SYSTEM AND PRODUCTION METHOD FOR ORGANIC COMPOUNDS OR MICROORGANISMS
US11021697B2 (en) 2017-07-11 2021-06-01 Cj Cheiljedang Corporation Acetohydroxy acid synthase variant, microorganism comprising the same, and method of producing L-branched-chain amino acid using the same
KR101996129B1 (en) * 2017-07-11 2019-07-04 씨제이제일제당 (주) Acetohydroxy acid synthase variant, microorganism comprising thereof, and method of producing L-branced-chained amino acid using the same
WO2019118548A1 (en) * 2017-12-15 2019-06-20 Archer Daniels Midland Company Engineered strains of corynebacteria
SG11202001730TA (en) * 2018-03-27 2020-03-30 Cj Cheiljedang Corp A novel promoter and a method for producing l-amino acid using the same
WO2020051420A1 (en) 2018-09-07 2020-03-12 Archer Daniels Midland Company Engineered strains of corynebacteria
KR102147381B1 (en) * 2019-11-22 2020-08-24 씨제이제일제당 주식회사 Novel acetohydroxy acid synthase variant and microorganism comprising thereof

Family Cites Families (28)

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US370057A (en) * 1887-09-20 Machine for packing cube sugar in boxes
US2979439A (en) * 1958-11-04 1961-04-11 Kyowa Hakko Kogyo Kk Method of producing l-lysine by fermentation
GB1118719A (en) 1966-03-14 1968-07-03 Kyowa Hakko Kogyo Kk Process for producing l-lysine by fermentation
IT1045451B (en) * 1966-03-23 1980-05-10 Ajinomoto Kk METHOD FOR RECOVERING LYSINE FROM FERMENTATION BROTH
GB1180104A (en) * 1966-06-15 1970-02-04 Ajinomoto Kk Method of Producing L-Lysine.
JPS4828078B1 (en) * 1969-03-20 1973-08-29
JPS5544597B1 (en) * 1969-06-09 1980-11-13
JPS5610036B1 (en) * 1969-07-23 1981-03-05
US3825472A (en) * 1972-04-27 1974-07-23 Ajinomoto Kk Method of producing l-lysine by fermentation
JPS4981586A (en) 1972-12-12 1974-08-06
JPS579796B2 (en) * 1974-03-15 1982-02-23
JPS539394A (en) * 1976-07-09 1978-01-27 Kyowa Hakko Kogyo Co Ltd Preparation of l-lysine by fermentation
JPS56160997A (en) * 1980-05-16 1981-12-11 Ajinomoto Co Inc Preparation of l-lysine by fermenaition method
JPS58893A (en) * 1981-06-25 1983-01-06 Ajinomoto Co Inc Preparation of l-isoleucine by fermentation
US5236831A (en) * 1981-12-29 1993-08-17 Kiowa Hakko Kogyo Co., Ltd. Amino acid synthesis in corynebacteria using E. coli genes
US4601983A (en) * 1983-06-15 1986-07-22 Ajinomoto Co., Inc. Coryneform bacteria carrying recombinant plasmids and their use in the fermentative production of L-threonine and L-isoleucine
DE3585052D1 (en) * 1984-06-29 1992-02-13 Ajinomoto Kk METHOD FOR PRODUCING L-ISOLEUCIN BY FERMENTATION.
EP0205849B1 (en) * 1985-05-13 1991-12-04 Toray Industries, Inc. Process for producing l-threonine by fermentation
DE3619111A1 (en) * 1986-06-06 1987-12-17 Degussa METHOD FOR THE FERMENTATIVE PRODUCTION OF L-ISOLEUCIN FROM D, L- (ALPHA) -HYDROXYBURYRATE
JPH0644872B2 (en) * 1987-01-14 1994-06-15 三井東圧化学株式会社 Method for producing L-threonine by fermentation method
US5188948A (en) * 1987-04-16 1993-02-23 Ajinomoto Co., Inc. Process for producing L-valine by fermentation
US6261825B1 (en) * 1989-04-10 2001-07-17 Regents Of The University Of Minnesota Production of amino acids using auxotrophic mutants of methylotrophic bacillus
JP2876739B2 (en) * 1990-08-03 1999-03-31 味の素株式会社 Production method of L-lysine by fermentation method
DE69116964T2 (en) * 1990-09-18 1996-10-02 Kyowa Hakko Kogyo Kk Process for the preparation of L-valine
DE69534592T2 (en) * 1994-03-04 2006-08-10 Ajinomoto Co., Inc. PROCESS FOR THE PREPARATION OF L-LYSINE
DE69535643D1 (en) * 1994-08-19 2007-12-27 Ajinomoto Kk Process for the fermentative production of L-lysine and L-glutamic acid
JP3704737B2 (en) * 1995-03-30 2005-10-12 味の素株式会社 Method for producing L-leucine
DE19547361A1 (en) * 1995-12-19 1997-06-26 Degussa Process for the production of L-amino acids by fermentation

Also Published As

Publication number Publication date
JP2010022374A (en) 2010-02-04
CA2380613A1 (en) 2001-02-08
US7323321B2 (en) 2008-01-29
NZ516893A (en) 2003-02-28
CN1367823A (en) 2002-09-04
KR20020033749A (en) 2002-05-07
WO2001009286A1 (en) 2001-02-08
CA2380613C (en) 2014-03-25
BR0012963A (en) 2002-04-23
JP5319489B2 (en) 2013-10-16
MXPA02001174A (en) 2002-07-30
US20080090272A1 (en) 2008-04-17
EP1200553A1 (en) 2002-05-02
EP1200553B1 (en) 2009-07-15
JP2006280383A (en) 2006-10-19
US7635579B2 (en) 2009-12-22
JP2003506030A (en) 2003-02-18
US20060154345A1 (en) 2006-07-13
KR100815041B1 (en) 2008-03-18
AU6617400A (en) 2001-02-19
AU779019B2 (en) 2005-01-06
BR0012963B1 (en) 2013-09-24

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