DE60039913D1 - Methoden um die bindung einer cd8+ zelle an einen class i mhc zu inhibieren,unter verwendung eines modifizierten beta 2 microglobulins - Google Patents

Methoden um die bindung einer cd8+ zelle an einen class i mhc zu inhibieren,unter verwendung eines modifizierten beta 2 microglobulins

Info

Publication number
DE60039913D1
DE60039913D1 DE60039913T DE60039913T DE60039913D1 DE 60039913 D1 DE60039913 D1 DE 60039913D1 DE 60039913 T DE60039913 T DE 60039913T DE 60039913 T DE60039913 T DE 60039913T DE 60039913 D1 DE60039913 D1 DE 60039913D1
Authority
DE
Germany
Prior art keywords
mhc
class
microglobulin
binding
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60039913T
Other languages
English (en)
Inventor
Bent Karsten Jakobsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Avidex Ltd
Original Assignee
Avidex Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avidex Ltd filed Critical Avidex Ltd
Application granted granted Critical
Publication of DE60039913D1 publication Critical patent/DE60039913D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Jellies, Jams, And Syrups (AREA)
DE60039913T 1999-12-17 2000-12-15 Methoden um die bindung einer cd8+ zelle an einen class i mhc zu inhibieren,unter verwendung eines modifizierten beta 2 microglobulins Expired - Fee Related DE60039913D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9929993.5A GB9929993D0 (en) 1999-12-17 1999-12-17 Substances
PCT/GB2000/004828 WO2001044296A1 (en) 1999-12-17 2000-12-15 Methods of inhibiting the binding of a cd8+ t cell to a class i mhc employing a modified beta 2 microglobulin

Publications (1)

Publication Number Publication Date
DE60039913D1 true DE60039913D1 (de) 2008-09-25

Family

ID=10866607

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60039913T Expired - Fee Related DE60039913D1 (de) 1999-12-17 2000-12-15 Methoden um die bindung einer cd8+ zelle an einen class i mhc zu inhibieren,unter verwendung eines modifizierten beta 2 microglobulins

Country Status (7)

Country Link
US (1) US20030108547A1 (de)
EP (1) EP1244704B1 (de)
AT (1) ATE404586T1 (de)
AU (1) AU2199101A (de)
DE (1) DE60039913D1 (de)
GB (1) GB9929993D0 (de)
WO (1) WO2001044296A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002253283A1 (en) * 2001-03-19 2002-10-03 Isis Innovation Limited Mutated mhc molecules for use in immune suppression
GB0107628D0 (en) * 2001-03-27 2001-05-16 Avidex Ltd Substances
GB0115071D0 (en) * 2001-06-20 2001-08-15 Avidex Ltd Substances
US9809654B2 (en) 2002-09-27 2017-11-07 Vaccinex, Inc. Targeted CD1d molecules
GB2398300A (en) * 2003-02-17 2004-08-18 Isis Innovation Method and compositions for boosting immune response
CA2525696A1 (en) * 2003-05-19 2004-12-02 Japan Science And Technology Agency Control of function of intracellular ca ion
CA2678618C (en) 2007-02-21 2019-03-12 Vaccinex, Inc. Modulation of nkt cell activity with antigen-loaded cd1d molecules
KR20110137290A (ko) 2009-01-08 2011-12-22 알버트 아인슈타인 컬리지 오브 메디신 오브 예쉬바 유니버시티 세포벽 결합 세라미드 유사 당지질을 갖는 박테리아 백신 및 이의 용도
US9371352B2 (en) 2013-02-08 2016-06-21 Vaccinex, Inc. Modified glycolipids and methods of making and using the same
CN118027176A (zh) * 2024-03-27 2024-05-14 郑春杨 人β2-微球蛋白突变体

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK160944C (da) * 1986-01-16 1991-10-21 Novo Industri As Modificerede beta2-mikroglobuliner og farmaceutiske praeparater indeholdende disse
US5674681A (en) * 1994-12-06 1997-10-07 Rothenberg; Barry E. Methods to identify hemochromatosis
GB9722779D0 (en) * 1997-10-28 1997-12-24 Isis Innovation Human CD8 as an inhibitor of the cellular immune system
WO1999064597A1 (en) * 1998-06-10 1999-12-16 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services β2 MICROGLOBULIN FUSION PROTEINS AND HIGH AFFINITY VARIANTS

Also Published As

Publication number Publication date
WO2001044296A1 (en) 2001-06-21
ATE404586T1 (de) 2008-08-15
EP1244704B1 (de) 2008-08-13
AU2199101A (en) 2001-06-25
US20030108547A1 (en) 2003-06-12
GB9929993D0 (en) 2000-02-09
EP1244704A1 (de) 2002-10-02

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee