DE60023862D1 - NIKROMASSSTABGUE DEVICE FOR CHEMICAL ANALYSIS - Google Patents

NIKROMASSSTABGUE DEVICE FOR CHEMICAL ANALYSIS

Info

Publication number
DE60023862D1
DE60023862D1 DE60023862T DE60023862T DE60023862D1 DE 60023862 D1 DE60023862 D1 DE 60023862D1 DE 60023862 T DE60023862 T DE 60023862T DE 60023862 T DE60023862 T DE 60023862T DE 60023862 D1 DE60023862 D1 DE 60023862D1
Authority
DE
Germany
Prior art keywords
flow
liquid
channel
reaction chamber
flow channel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60023862T
Other languages
German (de)
Other versions
DE60023862T2 (en
Inventor
S Rossier
Frederic Reymond
H Girault
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ecole Polytechnique Federale de Lausanne EPFL
Original Assignee
Ecole Polytechnique Federale de Lausanne EPFL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ecole Polytechnique Federale de Lausanne EPFL filed Critical Ecole Polytechnique Federale de Lausanne EPFL
Publication of DE60023862D1 publication Critical patent/DE60023862D1/en
Application granted granted Critical
Publication of DE60023862T2 publication Critical patent/DE60023862T2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0672—Integrated piercing tool
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B01L2300/165—Specific details about hydrophobic, oleophobic surfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0688—Valves, specific forms thereof surface tension valves, capillary stop, capillary break
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves

Abstract

The invention relates to an apparatus for performing chemical assays in an aqueous medium. The apparatus contains a reaction chamber(s) and a liquid in-flow channel connected to each chamber. The flow of liquid through the fluid in-flow channel to the reaction chamber is controlled by the presence of a hydrophobic inner surface on the walls of the in-flow channel. Under normal conditions fluid will not flow through the channel. However, application of an external force pushes the liquid through said channel into the reaction chamber. The invention is applicable to the monitoring of many different molecular interactions, in particular molecular recognition between an immobilised affinity partner and a species in solution, such as immunoglobulin/antigen interaction, DNA hybridisation, haptamer-protein interaction, drug and virus detection, high throughput screening of synthetic molecules and for determining the concentration and reaction kinetics of target species.
DE60023862T 1999-03-29 2000-03-28 MICROMASSETTE DEVICE FOR CHEMICAL ANALYSIS Expired - Fee Related DE60023862T2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9907249.8A GB9907249D0 (en) 1999-03-29 1999-03-29 Chemical assay apparatus
GB9907249 1999-03-29
PCT/EP2000/002887 WO2000058724A1 (en) 1999-03-29 2000-03-28 Microscale total analysis system

Publications (2)

Publication Number Publication Date
DE60023862D1 true DE60023862D1 (en) 2005-12-15
DE60023862T2 DE60023862T2 (en) 2006-07-27

Family

ID=10850602

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60023862T Expired - Fee Related DE60023862T2 (en) 1999-03-29 2000-03-28 MICROMASSETTE DEVICE FOR CHEMICAL ANALYSIS

Country Status (7)

Country Link
EP (1) EP1166103B1 (en)
JP (1) JP2002540425A (en)
AT (1) ATE309534T1 (en)
AU (1) AU4292700A (en)
DE (1) DE60023862T2 (en)
GB (1) GB9907249D0 (en)
WO (1) WO2000058724A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10126798A1 (en) 2001-06-01 2002-12-19 Nanotype Gmbh Highly parallel determination of analytes, useful e.g. for diagnostic detection of proteins, by immobilization then contacting with surface carrying specific probes
US7179423B2 (en) 2001-06-20 2007-02-20 Cytonome, Inc. Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system
US7211442B2 (en) 2001-06-20 2007-05-01 Cytonome, Inc. Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system
EP1407257A4 (en) * 2001-06-20 2004-11-24 Cytonome Inc Microfabricated separation device employing a virtual wall for interfacing fluids
WO2003000418A2 (en) * 2001-06-20 2003-01-03 Cytonome, Inc. Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system
JP3877572B2 (en) * 2001-08-09 2007-02-07 オリンパス株式会社 Fine channel device and method of using the same
EP1314479A3 (en) * 2001-11-24 2004-03-24 GeSIM Gesellschaft für Silizium-Mikrosysteme mbH Device for the transfer of liquid samples
GB0226160D0 (en) 2002-11-08 2002-12-18 Diagnoswiss Sa Apparatus for dispensing a sample in electrospray mass spectrometers
DE102004013161B4 (en) * 2004-03-17 2008-04-10 microTec Gesellschaft für Mikrotechnologie mbH Microfluidic chip
JP2006226752A (en) * 2005-02-16 2006-08-31 Matsushita Electric Ind Co Ltd Plate for bio-sample discrimination device
JP5175778B2 (en) * 2009-03-11 2013-04-03 株式会社東芝 Liquid feeding device
WO2011160015A2 (en) 2010-06-17 2011-12-22 Abaxis, Inc. Rotors for immunoassays
DE102011001550A1 (en) * 2011-03-25 2012-09-27 Friz Biochem Gesellschaft Für Bioanalytik Mbh Device useful e.g. for promoting and blending reagents, comprises at least one reaction cell with at least a cavity exhibiting an aperture for carrying reagents, at least one reagent reservoir and at least one piston
CN112877191A (en) * 2021-02-22 2021-06-01 西安交通大学 Anti-pollution consumable material and method for performing CRISPR molecular diagnosis by using same

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06105261B2 (en) * 1984-03-05 1994-12-21 株式会社東芝 Concentration gradient measuring device
US5017473A (en) * 1987-05-26 1991-05-21 Becton, Dickinson And Company Homogeneous chemiluminescence immunoassay using a light absorbing material
US5281540A (en) * 1988-08-02 1994-01-25 Abbott Laboratories Test array for performing assays
US5624850A (en) * 1994-06-06 1997-04-29 Idetek, Inc. Immunoassays in capillaries
US5585069A (en) * 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
US5766962A (en) * 1995-12-22 1998-06-16 Universal Healthwatch, Inc. Device for collecting and testing samples
WO1998049344A1 (en) * 1997-04-28 1998-11-05 Lockheed Martin Energy Research Corporation Method and apparatus for analyzing nucleic acids

Also Published As

Publication number Publication date
DE60023862T2 (en) 2006-07-27
ATE309534T1 (en) 2005-11-15
WO2000058724A1 (en) 2000-10-05
AU4292700A (en) 2000-10-16
GB9907249D0 (en) 1999-05-26
EP1166103A1 (en) 2002-01-02
EP1166103B1 (en) 2005-11-09
JP2002540425A (en) 2002-11-26

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee