DE60014375D1 - Uebergangsmetallkomplexe der vii-nebengruppe mit multidentaten aminopolycarboxylat-liganden und ein kit zu deren herstellung - Google Patents

Uebergangsmetallkomplexe der vii-nebengruppe mit multidentaten aminopolycarboxylat-liganden und ein kit zu deren herstellung

Info

Publication number
DE60014375D1
DE60014375D1 DE60014375T DE60014375T DE60014375D1 DE 60014375 D1 DE60014375 D1 DE 60014375D1 DE 60014375 T DE60014375 T DE 60014375T DE 60014375 T DE60014375 T DE 60014375T DE 60014375 D1 DE60014375 D1 DE 60014375D1
Authority
DE
Germany
Prior art keywords
multidentate
ligands
compound
formula
ligand
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60014375T
Other languages
English (en)
Other versions
DE60014375T2 (de
Inventor
M Dyszlewski
Roger Alberto
E Bugaj
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Inc
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Application granted granted Critical
Publication of DE60014375D1 publication Critical patent/DE60014375D1/de
Publication of DE60014375T2 publication Critical patent/DE60014375T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0476—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from monodendate ligands, e.g. sestamibi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE60014375T 1999-06-29 2000-06-28 Uebergangsmetallkomplexe der vii-nebengruppe mit multidentaten aminopolycarboxylat-liganden und ein kit zu deren herstellung Expired - Fee Related DE60014375T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14098999P 1999-06-29 1999-06-29
US140989P 1999-06-29
PCT/US2000/017813 WO2001000637A1 (en) 1999-06-29 2000-06-28 Group (vii) transition-metal complexes with multidentate aminopolycarboxylate ligands and a kit for producing them

Publications (2)

Publication Number Publication Date
DE60014375D1 true DE60014375D1 (de) 2004-11-04
DE60014375T2 DE60014375T2 (de) 2005-12-01

Family

ID=22493669

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60014375T Expired - Fee Related DE60014375T2 (de) 1999-06-29 2000-06-28 Uebergangsmetallkomplexe der vii-nebengruppe mit multidentaten aminopolycarboxylat-liganden und ein kit zu deren herstellung

Country Status (10)

Country Link
EP (1) EP1192166B1 (de)
JP (1) JP2003503415A (de)
AT (1) ATE277939T1 (de)
AU (1) AU6488900A (de)
CA (1) CA2377018A1 (de)
CZ (1) CZ20014603A3 (de)
DE (1) DE60014375T2 (de)
ES (1) ES2223559T3 (de)
HU (1) HUP0301779A3 (de)
WO (1) WO2001000637A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6359119B1 (en) * 2000-05-24 2002-03-19 Mallinckrodt Inc. Formulation of Tc and Re carbonyl complexes using stannous ion as the reductant for pertechnetate and perrhenate
DE60326465D1 (de) * 2002-09-03 2009-04-16 Univ Zuerich Herstellung von m(co)3-komplexen durch festphasentechniken durch metal-unterstützte trennung vom festen träger
EP1644050B1 (de) 2003-04-15 2010-06-09 Mallinckrodt Inc. Bifunktionale tridentate pyrazolyl-enthaltende liganden für re-, tc- und mn- tricarbonyl-komplexe
US7682601B2 (en) 2003-04-15 2010-03-23 Mallinckrodt Inc. Bifunctional tridentate pyrazolyl containing ligands for re and tc tricarbonyl complexes
DE602004024879D1 (de) 2003-04-29 2010-02-11 Univ Zuerich AN EINEM BIOMOLEKÜL GEBUNDENEN N epsilon- UND/ODER N alpha DERIVATISIERTEM UND ORGANISCH-GESCHÜTZTEM L-HISTIDIN ZUR HOCH-EFFIZIENTER MARKIERUNG MIT (M(H2O)3(CO)3)+ MITTELS FAC KOORDINIERUNG
US8986650B2 (en) 2005-10-07 2015-03-24 Guerbet Complex folate-NOTA-Ga68
US8926945B2 (en) 2005-10-07 2015-01-06 Guerbet Compounds comprising a biological target recognizing part, coupled to a signal part capable of complexing gallium
GB0623482D0 (en) 2006-11-24 2007-01-03 Mallinckrodt Inc Technetium-99m (l) tricarbonyl complexes with tridentate chelators for myocardium imaging

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0600992B1 (de) * 1991-08-29 2000-09-20 Mallinckrodt Medical, Inc. Verwendung von gentisinsäure oder gentisylalkohol zur stabilisierung von radio-markierten peptiden und proteinen
EP0879606A1 (de) * 1997-04-25 1998-11-25 Paul Scherrer Institut Verfahren zur Herstellung von facial Metall Tricarbonyl Verbindungen und ihre Anwendung zur Markierung von Biosubstraten
DE19860289C2 (de) * 1998-12-21 2003-11-13 Schering Ag Neue Chelatoren sowie deren Tricarbonyl-Komplexe mit Technetium und Rhenium

Also Published As

Publication number Publication date
HUP0301779A3 (en) 2008-01-28
WO2001000637A1 (en) 2001-01-04
CZ20014603A3 (cs) 2002-11-13
EP1192166A1 (de) 2002-04-03
ATE277939T1 (de) 2004-10-15
ES2223559T3 (es) 2005-03-01
AU6488900A (en) 2001-01-31
HUP0301779A2 (hu) 2003-08-28
CA2377018A1 (en) 2001-01-04
EP1192166B1 (de) 2004-09-29
DE60014375T2 (de) 2005-12-01
JP2003503415A (ja) 2003-01-28

Similar Documents

Publication Publication Date Title
Moerlein et al. The chemistry of gallium and indium as related to radiopharmaceutical production
Halfen et al. Synthetic Analogs of Nitrite Adducts of Copper Proteins: Characterization and Interconversion of Dicopper (I, I) and-(I, II) Complexes Bridged Only by NO2
Jurisson et al. New oxotechnetium (V) complexes of N, N'-ethylenebis (acetylacetone imine), N, N'-ethylenebis (salicylideneamine), and o-phenylenebis (salicylideneamine). X-ray structures of the complexes of N, N'-ethylenebis (acetylacetone imine) and N, N'-ethylenebis (salicylideneamine)
EP2922830B1 (de) Synthese von imidazo(1,2-a)pyrazin-4-ium-salzen zur synthese von 1,4,7-triazacyclononan (tacn) und n- und/oder c-funktionalisierten derivaten davon
Boatman et al. An anionic equivalent of the Friedel-Crafts cycloacylation
DE60014375D1 (de) Uebergangsmetallkomplexe der vii-nebengruppe mit multidentaten aminopolycarboxylat-liganden und ein kit zu deren herstellung
Thomas et al. Technetium radiopharmaceutical development. 2. Preparation, characterization, and synthetic utility of the oxotetrahalotechnetate (V) species TcOX4-(X= chloro, bromo, iodo)
Taylor et al. Reduction of nitrate by monomeric molybdenum (V) complexes in dimethylformamide
Murase et al. Synthesis and characterization of copper (II), nickel (II), and cobalt (II) binuclear complexes with a new tricyclic octadentate ligand, 1, 5, 8, 12, 15, 19, 22, 26-octaazatricyclo [17.9. 2.25, 15] dotriacontane (tcoa): trapping of carbon dioxide in a neutral aqueous solution
Baumann et al. Reactions of coordinated dinitrogen. 18. Formation of ammonia and hydrazine from the reactions of acids with bis (dinitrogen) complexes of molybdenum. Identification and isolation of intermediates. Possible analogy with the hydrazine-forming property of nitrogenase
EP0441953B1 (de) Kerne für technetium-radioarzneimittel
Komiya et al. Isolation of a zerovalent iron dinitrogen complex with 1, 2-bis (diethylphosphino) ethane ligands
WO2001089586A3 (en) Tc and re carbonyl complexes for pertechnetate and perrhenate
Clarke et al. The chemistry of technetium: Toward improved diagnostic agents
US5589576A (en) Cores for technetium radiopharmaceuticals
Hoshino et al. A novel family of binuclear cobalt (II) complexes with face-to-face bis (cyclidene) ligands: structural characterization, unusual reactions with dioxygen, and a distinctive host-guest complexation with a bridging ligand
Luneva et al. A Novel Mixed‐Valence Tetranuclear Vii/Viii Complex Isolated from 3, 5‐Di‐tert‐Butylcatechol/Vanadium (ii)/Sodium Methoxide System for Dinitrogen Reduction
Mach et al. Synthesis, characterization and biodistribution of neutral and lipid-soluble 99mTc-PAT-HM and 99mTc-TMR for brain imaging
Lapouyade et al. Primary and tertiary amines as catalysts of hydrogen transfer in the photocyclization of 1, 1-diarylethylenes
Roy et al. Coordination chemistry of f-block elements with imine acids. Part IV. Synthetic and chiroptical studies on lanthanide (III) complexes of imine acids derived from L-alanine, L-valine, L-tyrosine and L-glutamic acid
US7731936B2 (en) Metal complexes based on tetrathiol ligands and their use in nuclear medical diagnostics and endoradionuclide therapy and method for producing said metal complexes
Halime et al. Functionalization of porphyrins: towards the synthesis of bifunctional chelates for bismuth coordination
Riché et al. Tc (IV) Cl4 (PPh3) 2 and Tc (III) Cl3 (CH3CN)(PPh3) 2 as precursors of trans dioxo technetium (V) complexes with chelating amines and tetraazamacrocycles
US6124440A (en) Cores for technetium radiopharmaceuticals
Ghosh et al. Osmium azo oxime chemistry. Facial tris chelate and trinuclear OsMOs species

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee