DE59900775D1 - UNSATURATED 14.15-CYCLOPROPANO ANDROSTANES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE COMPOUNDS - Google Patents

UNSATURATED 14.15-CYCLOPROPANO ANDROSTANES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE COMPOUNDS

Info

Publication number
DE59900775D1
DE59900775D1 DE59900775T DE59900775T DE59900775D1 DE 59900775 D1 DE59900775 D1 DE 59900775D1 DE 59900775 T DE59900775 T DE 59900775T DE 59900775 T DE59900775 T DE 59900775T DE 59900775 D1 DE59900775 D1 DE 59900775D1
Authority
DE
Germany
Prior art keywords
compounds
cyclopropano
androstanes
unsaturated
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE59900775T
Other languages
German (de)
Inventor
Sven Ring
Sigfrid Schwarz
Walter Elger
Birgitt Schneider
Guenter Kaufmann
Lothar Sobek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Jenapharm GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jenapharm GmbH and Co KG filed Critical Jenapharm GmbH and Co KG
Application granted granted Critical
Publication of DE59900775D1 publication Critical patent/DE59900775D1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Described are new, unsaturated 14,15-cyclopropano-androstanes of general formula (I) and their pharmaceutically acceptable salts, a process for their production and pharmaceutical preparations that contain these compounds. The compounds are characterized by hormonal (gestagenic and/or androgenic) activity and may be used for hormone replacement therapy.
DE59900775T 1998-06-22 1999-06-18 UNSATURATED 14.15-CYCLOPROPANO ANDROSTANES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE COMPOUNDS Expired - Fee Related DE59900775D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19827523A DE19827523A1 (en) 1998-06-22 1998-06-22 New unsaturated 14,15-cyclopropano-androstanes useful in fertility control and for treating e.g. hypogonadism, endometriosis or mammary carcinoma
PCT/DE1999/001794 WO1999067275A1 (en) 1998-06-22 1999-06-18 Unsaturated 14,15-cyclopropanoandrostanes, method for the production thereof and pharmaceutical preparations containing said compounds

Publications (1)

Publication Number Publication Date
DE59900775D1 true DE59900775D1 (en) 2002-03-14

Family

ID=7871498

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19827523A Withdrawn DE19827523A1 (en) 1998-06-22 1998-06-22 New unsaturated 14,15-cyclopropano-androstanes useful in fertility control and for treating e.g. hypogonadism, endometriosis or mammary carcinoma
DE59900775T Expired - Fee Related DE59900775D1 (en) 1998-06-22 1999-06-18 UNSATURATED 14.15-CYCLOPROPANO ANDROSTANES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE COMPOUNDS

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE19827523A Withdrawn DE19827523A1 (en) 1998-06-22 1998-06-22 New unsaturated 14,15-cyclopropano-androstanes useful in fertility control and for treating e.g. hypogonadism, endometriosis or mammary carcinoma

Country Status (10)

Country Link
US (1) US6534490B1 (en)
EP (1) EP1090028B1 (en)
JP (1) JP3541008B2 (en)
AT (1) ATE212352T1 (en)
AU (1) AU5278799A (en)
DE (2) DE19827523A1 (en)
DK (1) DK1090028T3 (en)
ES (1) ES2172343T3 (en)
PT (1) PT1090028E (en)
WO (1) WO1999067275A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19959696A1 (en) * 1999-12-08 2001-06-21 Jenapharm Gmbh Unsaturated 14,15-cyclopropano-androstanes, processes for their preparation and pharmaceutical compositions containing these compounds
DE19959697A1 (en) 1999-12-08 2001-06-21 Jenapharm Gmbh 14,15-Cyclopropanosteroids of the 19-norandrostane series, process for their preparation and pharmaceutical compositions containing these compounds
WO2002092618A1 (en) * 2001-05-15 2002-11-21 Schering Ag 17 alpha-hydroxy-4-androstene-3-one and the 14, 15-methylene-derivatives thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3262949A (en) * 1956-11-13 1966-07-26 Syntex Corp 7-methyl androstane compounds
US3007945A (en) 1957-04-02 1961-11-07 Olin Mathieson Process and intermediates for preparing 6-dehydromethyltestosterone
US3194803A (en) 1960-04-28 1965-07-13 Searle & Co Process and intermediates for the manufacture of 3-keto-delta4, 6 steroids
US3624111A (en) 1966-03-30 1971-11-30 Syntex Corp 18-lower alkyl androstenes
US3968132A (en) * 1974-12-23 1976-07-06 Schering Corporation (17R)-Spiro-[androstane-17,1'-cyclobutan]-2'-ones, methods for their manufacture and intermediates useful therein
DE2558088C2 (en) 1975-12-19 1985-05-30 Schering AG, 1000 Berlin und 4709 Bergkamen Process for the preparation of 4-androstene-3,17-dione derivatives
DD293591A5 (en) * 1988-12-02 1991-09-05 Jenapharm,De PROCESS FOR THE PREPARATION OF 17 ALPHA-ETHYNYL-17BETA-HYDROXYANDROST-4-EN-3-ON
DE19537626A1 (en) 1995-10-10 1997-04-17 Jenapharm Gmbh Steroids with a 14, 15 methylene group

Also Published As

Publication number Publication date
EP1090028B1 (en) 2002-01-23
PT1090028E (en) 2002-07-31
ES2172343T3 (en) 2002-09-16
WO1999067275A1 (en) 1999-12-29
AU5278799A (en) 2000-01-10
JP2002518517A (en) 2002-06-25
ATE212352T1 (en) 2002-02-15
JP3541008B2 (en) 2004-07-07
EP1090028A1 (en) 2001-04-11
DK1090028T3 (en) 2002-04-29
US6534490B1 (en) 2003-03-18
DE19827523A1 (en) 1999-12-23

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: SCHERING AG, 13353 BERLIN, DE

8327 Change in the person/name/address of the patent owner

Owner name: BAYER SCHERING PHARMA AG, 13353 BERLIN, DE

8327 Change in the person/name/address of the patent owner

Owner name: BAYER SCHERING PHARMA AKIENGESELLSCHAFT, 13353, DE

8339 Ceased/non-payment of the annual fee