DE589780C - Process for the preparation of compounds of aspidinol silicine - Google Patents

Process for the preparation of compounds of aspidinol silicine

Info

Publication number
DE589780C
DE589780C DEB158603D DEB0158603D DE589780C DE 589780 C DE589780 C DE 589780C DE B158603 D DEB158603 D DE B158603D DE B0158603 D DEB0158603 D DE B0158603D DE 589780 C DE589780 C DE 589780C
Authority
DE
Germany
Prior art keywords
silicine
aspidinol
compounds
preparation
cinchonidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DEB158603D
Other languages
German (de)
Inventor
Dr Hans Hatzig
Dr Fritz Johannessohn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Priority to DEB158603D priority Critical patent/DE589780C/en
Application granted granted Critical
Publication of DE589780C publication Critical patent/DE589780C/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C07D453/04—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Description

Verfahren zur Herstellung von Verbindungen des Aspidinolfilicins Aspidinolfilicin stellt bekanntlich eine bei gewöhnlicher Temperatur feste Substand vor, die wegen ihrer klebrigen Eigenschaften sich ungelöst nur schlecht verarbeiten läßt und sich in dieser Form insbesondere nicht zur Herstellung . pharmazeutischer Verreibungen eignet.Process for the preparation of compounds of the aspidinol silicine Aspidinol silicine is known to represent a solid substance at ordinary temperature, which because of Their sticky properties are difficult to process and unresolved in this form especially not for production. pharmaceutical triturations suitable.

Es wurde nun gefunden, daß Aspidinolfilicin mit Cinchonidin und anderen Chininbasen Verbindungen eingeht, die schön pulverige Stoffe -vorstellen oder in diese Form übergeführt werden können.It has now been found that aspidinol silicine with cinchonidine and others Quinine bases form compounds that represent or contain powdery substances this form can be converted.

Beispiel ' i Teil Cinchonidin. und 2 Teile Aspidinolfilicin werden in etwa io Volumteilen Essigester gelöst.- Auf Zusatz von Ligroin fällt die neue Verbindung zunächst in harziger' Form aus. Beim Durchkneten des Fällungsproduktes mit der Lösung und nachfolgend mit frischem Ligroin geht das Harz in einen pulverigen Körper über, der leicht abgesaugt werden kann. Während Ligroin Aspidinolfilicin löst, wird die neue Verbindung durch. Ligroin in ihrer Zusammensetzung nicht verändert. Die wurmtreibende Wirkung der Verbindung entspricht je Gewichtseinheit etwa der des Aspidinolfilicins.Example 'i part cinchonidine. and 2 parts of aspidinol silicine dissolved in about 10 parts by volume of ethyl acetate. The addition of ligroin causes the new Compound initially in resinous form. When kneading the precipitation product with the solution and then with fresh ligroin, the resin turns into a powdery one Body over that can be easily aspirated. While ligroin aspidinol silicine solves, the new connection is through. Ligroin does not change its composition. The worming effect of the compound corresponds approximately to that per unit weight of aspidinol silicine.

In gleicher Weise wird aus i Teil Chinin (oder Conchinin oder Cinchonin) und 2 Teilen Aspidinolfilicin unter denselben Reaktionsbedingungen ein Körper erhalten, der in seinen Eigenschaften dem aus Cinchonidin erhaltenen völlig gleichartig ist. Die Menge Chininbase, die in den neuen Körpern enthalten ist, beträgt jeweils etwa 40 °/o.In the same way, i part becomes quinine (or conchinine or cinchonine) and 2 parts of aspidinol silicine obtained a body under the same reaction conditions, which is completely similar in its properties to those obtained from cinchonidine. The amount of quinine base contained in the new bodies is approximately each 40 ° / o.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung von Verbindungen des Aspidinolfilicins, dadurch gekennzeichnet, daß man Aspidinolfilicin oder seine Verbindungen nach den für die Herstellung von Salzen üblichen Methoden in Salze des Cinchonidins oder anderer Chininbasen überführt.PATENT CLAIM: Process for the preparation of compounds of aspidinol silicine, characterized in that aspidinol silicine or its compounds according to the for the preparation of salts common methods in salts of cinchonidine or other quinine bases transferred.
DEB158603D 1932-12-04 1932-12-04 Process for the preparation of compounds of aspidinol silicine Expired DE589780C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DEB158603D DE589780C (en) 1932-12-04 1932-12-04 Process for the preparation of compounds of aspidinol silicine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEB158603D DE589780C (en) 1932-12-04 1932-12-04 Process for the preparation of compounds of aspidinol silicine

Publications (1)

Publication Number Publication Date
DE589780C true DE589780C (en) 1933-12-15

Family

ID=7003985

Family Applications (1)

Application Number Title Priority Date Filing Date
DEB158603D Expired DE589780C (en) 1932-12-04 1932-12-04 Process for the preparation of compounds of aspidinol silicine

Country Status (1)

Country Link
DE (1) DE589780C (en)

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