DE518215C - Process for obtaining all of the oxyanthraquinone derivatives in the free state from corresponding drugs - Google Patents

Process for obtaining all of the oxyanthraquinone derivatives in the free state from corresponding drugs

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Publication number
DE518215C
DE518215C DEST45395D DEST045395D DE518215C DE 518215 C DE518215 C DE 518215C DE ST45395 D DEST45395 D DE ST45395D DE ST045395 D DEST045395 D DE ST045395D DE 518215 C DE518215 C DE 518215C
Authority
DE
Germany
Prior art keywords
oxyanthraquinone
derivatives
obtaining
free state
corresponding drugs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DEST45395D
Other languages
German (de)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
WALTHER STRAUB DR DR
Original Assignee
WALTHER STRAUB DR DR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by WALTHER STRAUB DR DR filed Critical WALTHER STRAUB DR DR
Priority to DEST45395D priority Critical patent/DE518215C/en
Application granted granted Critical
Publication of DE518215C publication Critical patent/DE518215C/en
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C46/00—Preparation of quinones
    • C07C46/10—Separation; Purification; Stabilisation; Use of additives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)

Description

Verfahren zur Gewinnung der gesamten Oxyanthrachinonderivate in freiem Zustande aus entsprechenden Drogen Die Oxyanthrachinonderivate, wie Emodin usw., sind in den entsprechenden Drogen teils in freier, teils in gebundener Form enthalten. Die freien Substanzen sind in organischen Lösungsmitteln, wie Äther und chlorierten Iohlenwasserstoffen, z. B. Chloroform, Trichloräthylen usw., gut löslich, die gebundenen dagegen in diesen Lösungsmitteln unlöslich. Erschöpft man zum Beispiel in einem geeigneten Extraktionsapparate trockene Rinde @-on Rharnus frangulae mit trockenem Äther. so erhält man bis zur vollständigen Erschöpfung insgesamt q.,2°/" freie Oxyanthrachinone. Wird dagegen die Rinde vor der Extraktion mit Äther mit 2°/oiger Schwefelsäure behandelt, danach die Schwefelsäure neutralisiert und die Rinde wieder getrocknet, so erhält man bei der Extraktion mit trockenem Äther nunmehr i i,o8 °lQ. Die Droge enthält also i i,o8°f0- 4,2°0 - 6,88 °J" Oxyanthrachinone in gebundener Form.Process for obtaining all of the oxyanthraquinone derivatives in the free state from corresponding drugs The oxyanthraquinone derivatives, such as emodin, etc., are contained in the corresponding drugs partly in free, partly in bound form. The free substances are in organic solvents such as ethers and chlorinated hydrocarbons, e.g. B. chloroform, trichlorethylene, etc., readily soluble, the bound, however, insoluble in these solvents. For example, one exhausts dry bark @ -on Rharnus frangulae with dry ether in a suitable extraction apparatus. Thus a total of q.2% of free oxyanthraquinones is obtained up to complete exhaustion. If, on the other hand, the bark is treated with ether with 2% sulfuric acid before the extraction, then the sulfuric acid is neutralized and the bark is dried again, one obtains with the Extraction with dry ether is now 10.8 ° 1Q. The drug thus contains 10.8 ° F0-4.2 ° 0 - 6.88 ° J "oxyanthraquinones in bound form.

Es hat sich nun gezeigt, daß die Spaltung auch ohne Säurebehandlung allein schon durch Wasser erfolgt, und daß dazu selbst die Benutzung eines wassergesättigten, organischen Extraktionsmittels ausreicht.It has now been shown that the cleavage takes place even without acid treatment is done by water alone, and that even the use of a water-saturated, organic extractant is sufficient.

B e i s p i e 1. In einem Soxhletschen Extraktionsapparat werden i o g Droge, z. B. Cortex frangulae, in -der Weise Extrahiert, daß in dem den Äther enthaltenden unteren Sammelgefäß eine Bodenschicht von Wasser enthalten ist, etwa im Verhältnis von 5 Volumprozent des zu verwendenden Äthers. Extrahiert man auf diese Weise die Cortex frangulae, so gewinnt man in einem Arbeitsgang io,9 0`o Oxyanthrachinone in fast reiner Form ohne merkliche Verunreinigung mit den wasserlöslichen Beistoffen, wie Zucker, Gerbstoff, fremde Säuren usw. In gleicher Weise läßt sich statt Äther ein anderes mit Wasser wenig mischbares, organisches Extraktionsmittel verwenden, wie z. B. gechlorte Ilohlenwasserstoffe (Chloroform, Trichloräthylen usw.l.EXAMPLE 1. In a Soxhlet extraction apparatus i o g drug, e.g. B. Cortex frangulae, extracted in such a way that in which the ether containing lower collecting vessel contains a bottom layer of water, for example in the ratio of 5 percent by volume of the ether to be used. One extracts on In this way, the cortex frangulae, one obtains 10.9 0`o oxyanthraquinones in one operation in almost pure form without noticeable contamination with the water-soluble co-formulants, like sugar, tannin, foreign acids, etc. In the same way, instead of ether use another organic extractant that is difficult to mix with water, such as B. chlorinated hydrocarbons (chloroform, trichlorethylene, etc.)

Claims (1)

PATENTANSPRUCH: Verfahren zur Gewinnung der gesamten Oxyanthrachinondernvate in freiem Zustande aus entsprechenden Drogen, dadurch gekennzeichnet, daß in einem Arbeitsgange die trockenen Drogen mit feuchten, organischen Lösungsmitteln, die sich mit Wasser nicht unbeschränkt mischen, wie Äther, Chloroform, Trichloräthylen, bis zur vollständigen Erschöpfung extrahiert werden.PATENT CLAIM: Process for obtaining the entire oxyanthraquinone derivatives in the free state from corresponding drugs, characterized in that in one Work the dry drugs with moist, organic solvents that do not mix unlimitedly with water, such as ether, chloroform, trichlorethylene, can be extracted until completely exhausted.
DEST45395D 1929-02-06 1929-02-06 Process for obtaining all of the oxyanthraquinone derivatives in the free state from corresponding drugs Expired DE518215C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DEST45395D DE518215C (en) 1929-02-06 1929-02-06 Process for obtaining all of the oxyanthraquinone derivatives in the free state from corresponding drugs

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEST45395D DE518215C (en) 1929-02-06 1929-02-06 Process for obtaining all of the oxyanthraquinone derivatives in the free state from corresponding drugs

Publications (1)

Publication Number Publication Date
DE518215C true DE518215C (en) 1931-02-13

Family

ID=7464884

Family Applications (1)

Application Number Title Priority Date Filing Date
DEST45395D Expired DE518215C (en) 1929-02-06 1929-02-06 Process for obtaining all of the oxyanthraquinone derivatives in the free state from corresponding drugs

Country Status (1)

Country Link
DE (1) DE518215C (en)

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