DE50310674D1 - Verwendung von biologischen photorezeptoren als direkt lichtgesteuerte ionenkanäle - Google Patents

Verwendung von biologischen photorezeptoren als direkt lichtgesteuerte ionenkanäle

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Publication number
DE50310674D1
DE50310674D1 DE50310674T DE50310674T DE50310674D1 DE 50310674 D1 DE50310674 D1 DE 50310674D1 DE 50310674 T DE50310674 T DE 50310674T DE 50310674 T DE50310674 T DE 50310674T DE 50310674 D1 DE50310674 D1 DE 50310674D1
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DE
Germany
Prior art keywords
light
biological
photore
receptors
controlled ion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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DE50310674T
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English (en)
Inventor
Peter Hegemann
Georg Nagel
Ernst Bamberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
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Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
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Application granted granted Critical
Publication of DE50310674D1 publication Critical patent/DE50310674D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/405—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from algae
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/84—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving inorganic compounds or pH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/405—Assays involving biological materials from specific organisms or of a specific nature from algae
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Inorganic Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Radiation-Therapy Devices (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Magnetic Treatment Devices (AREA)
  • Photometry And Measurement Of Optical Pulse Characteristics (AREA)
DE50310674T 2002-04-11 2003-04-11 Verwendung von biologischen photorezeptoren als direkt lichtgesteuerte ionenkanäle Expired - Lifetime DE50310674D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10216005A DE10216005A1 (de) 2002-04-11 2002-04-11 Verwendung von biologischen Photorezeptoren als direkt lichtgesteuerte Ionenkanäle
PCT/EP2003/003799 WO2003084994A2 (de) 2002-04-11 2003-04-11 Verwendung von biologischen photorezeptoren als direkt lichtgesteuerte ionenkanäle

Publications (1)

Publication Number Publication Date
DE50310674D1 true DE50310674D1 (de) 2008-12-04

Family

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DE10216005A Ceased DE10216005A1 (de) 2002-04-11 2002-04-11 Verwendung von biologischen Photorezeptoren als direkt lichtgesteuerte Ionenkanäle
DE50310674T Expired - Lifetime DE50310674D1 (de) 2002-04-11 2003-04-11 Verwendung von biologischen photorezeptoren als direkt lichtgesteuerte ionenkanäle

Family Applications Before (1)

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DE10216005A Ceased DE10216005A1 (de) 2002-04-11 2002-04-11 Verwendung von biologischen Photorezeptoren als direkt lichtgesteuerte Ionenkanäle

Country Status (8)

Country Link
US (3) US7824869B2 (de)
EP (2) EP2055714B1 (de)
AT (1) ATE412063T1 (de)
AU (1) AU2003233968A1 (de)
DE (2) DE10216005A1 (de)
DK (1) DK1492881T3 (de)
ES (1) ES2315495T3 (de)
WO (1) WO2003084994A2 (de)

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US8926959B2 (en) 2005-07-22 2015-01-06 The Board Of Trustees Of The Leland Stanford Junior University System for optical stimulation of target cells
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US20190321651A1 (en) * 2005-07-22 2019-10-24 The Board Of Trustees Of The Leland Stanford Junior University System for Optical Stimulation of Target Cells
US10052497B2 (en) * 2005-07-22 2018-08-21 The Board Of Trustees Of The Leland Stanford Junior University System for optical stimulation of target cells
US20090093403A1 (en) 2007-03-01 2009-04-09 Feng Zhang Systems, methods and compositions for optical stimulation of target cells
US9274099B2 (en) 2005-07-22 2016-03-01 The Board Of Trustees Of The Leland Stanford Junior University Screening test drugs to identify their effects on cell membrane voltage-gated ion channel
US20070053996A1 (en) 2005-07-22 2007-03-08 Boyden Edward S Light-activated cation channel and uses thereof
AU2007247929A1 (en) * 2006-05-04 2007-11-15 Pennsylvania College Of Optometry Restoration of visual responses by In Vivo delivery of rhodopsin nucleic acids
EP1891976A1 (de) * 2006-08-23 2008-02-27 Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute for Biomedical Research Verwendung lichtempfindlicher Gene
WO2008086470A1 (en) * 2007-01-10 2008-07-17 The Board Of Trustees Of The Leland Stanford Junior University System for optical stimulation of target cells
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US8910638B2 (en) 2007-05-09 2014-12-16 Massachusetts Institute Of Technology Methods and apparatus for high-throughput neural screening
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CN102159713A (zh) 2008-05-20 2011-08-17 Eos神经科学公司 用于递送光敏蛋白的载体和使用方法
ES2606458T3 (es) 2008-05-29 2017-03-24 The Board Of Trustees Of The Leland Stanford Junior University Línea celular, sistema y procedimiento para el control óptico de mensajeros secundarios
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WO2010006049A1 (en) 2008-07-08 2010-01-14 The Board Of Trustees Of The Leland Stanford Junior University Materials and approaches for optical stimulation of the peripheral nervous system
NZ602416A (en) 2008-11-14 2014-08-29 Univ Leland Stanford Junior Optically-based stimulation of target cells and modifications thereto
WO2011116238A2 (en) 2010-03-17 2011-09-22 The Board Of Trustees Of The Leland Stanford Junior University. Light-sensitive ion-passing molecules
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US9453241B2 (en) 2010-05-04 2016-09-27 Wayne State University AAV-mediated subcellular targeting of heterologous rhodopsins in retinal ganglion cells
EP2609425A1 (de) 2010-08-23 2013-07-03 President and Fellows of Harvard College Optogenetische sonden zur messung des membranpotenzials
US9207237B2 (en) 2010-08-23 2015-12-08 President And Fellows Of Harvard College Systems, methods, and workflows for optogenetics analysis
WO2012032103A1 (en) * 2010-09-08 2012-03-15 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Mutant channelrhodopsin 2
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ES2716819T3 (es) * 2010-11-05 2019-06-17 Univ Leland Stanford Junior Opsinas quiméricas activadas por luz y métodos de uso de las mismas
CA2816968C (en) 2010-11-05 2019-11-26 The Board Of Trustees Of The Leland Stanford Junior University Optically-controlled cns dysfunction
EP2635111B1 (de) 2010-11-05 2018-05-23 The Board of Trustees of the Leland Stanford Junior University Stabilisierte opsin-proteine mit stufenfunktion und verwendungsverfahren dafür
CN106422081B (zh) 2010-11-05 2019-06-21 斯坦福大学托管董事会 用于光遗传学方法的光的上转换
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US20120214188A1 (en) * 2010-11-12 2012-08-23 Nathan Klapoetke Light-activated ion channel molecules and uses thereof
US8696722B2 (en) 2010-11-22 2014-04-15 The Board Of Trustees Of The Leland Stanford Junior University Optogenetic magnetic resonance imaging
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SI3693025T1 (sl) 2011-04-22 2022-04-29 The Regents Of The University Of California Virioni adeno-povezanega virusa z varianto kapsida in postopki za njihovo uporabo
US9163094B2 (en) 2011-09-27 2015-10-20 Massachusetts Institute Of Technology Light-activated fusion proteins and uses therefor
ES2801679T3 (es) 2011-11-12 2021-01-12 Massachusetts Inst Technology Canalrodopsinas para el control óptico de células
EP3524676A1 (de) 2011-12-16 2019-08-14 The Board of Trustees of The Leland Stanford Junior University Opsin-polypeptide und verfahren zu ihrer verwendung
AU2013222443B2 (en) 2012-02-21 2017-12-14 Circuit Therapeutics, Inc. Compositions and methods for treating neurogenic disorders of the pelvic floor
PT2822964T (pt) 2012-03-05 2018-11-29 Univ Wayne State Identificação de mutações de canalrodopsina (chop2) e métodos de utilização
AU2014227600B2 (en) 2013-03-15 2018-10-04 The Board Of Trustees Of The Leland Stanford Junior University Optogenetic control of behavioral state
US9636380B2 (en) 2013-03-15 2017-05-02 The Board Of Trustees Of The Leland Stanford Junior University Optogenetic control of inputs to the ventral tegmental area
CN105431046B (zh) 2013-04-29 2020-04-17 小利兰·斯坦福大学托管委员会 用于靶细胞中的动作电位的光遗传学调节的装置、系统和方法
US10307609B2 (en) 2013-08-14 2019-06-04 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for controlling pain
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Also Published As

Publication number Publication date
EP2055714A2 (de) 2009-05-06
US8202699B2 (en) 2012-06-19
ATE412063T1 (de) 2008-11-15
US20050202398A1 (en) 2005-09-15
US20130017597A1 (en) 2013-01-17
AU2003233968A8 (en) 2003-10-20
US8647870B2 (en) 2014-02-11
WO2003084994A2 (de) 2003-10-16
US20110086421A1 (en) 2011-04-14
EP1492881A2 (de) 2005-01-05
EP1492881B1 (de) 2008-10-22
AU2003233968A1 (en) 2003-10-20
ES2315495T3 (es) 2009-04-01
US7824869B2 (en) 2010-11-02
WO2003084994A3 (de) 2004-02-05
DK1492881T3 (da) 2009-02-16
DE10216005A1 (de) 2003-10-30
EP2055714A3 (de) 2009-08-12
EP2055714B1 (de) 2014-05-07

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