DE50204608D1 - PROCESS FOR PREPARING BIPERIDES I - Google Patents

PROCESS FOR PREPARING BIPERIDES I

Info

Publication number
DE50204608D1
DE50204608D1 DE50204608T DE50204608T DE50204608D1 DE 50204608 D1 DE50204608 D1 DE 50204608D1 DE 50204608 T DE50204608 T DE 50204608T DE 50204608 T DE50204608 T DE 50204608T DE 50204608 D1 DE50204608 D1 DE 50204608D1
Authority
DE
Germany
Prior art keywords
biperiden
biperides
preparing
exo
endo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE50204608T
Other languages
German (de)
Inventor
Gerhard Kastner
Klaus Scheib
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorio Farmaceutico Sit Specialita' Igienico Terapeutiche Srl Mede
FARMACEUTICO S I T SPECIALITA
Original Assignee
Laboratorio Farmaceutico Sit Specialita' Igienico Terapeutiche Srl Mede
FARMACEUTICO S I T SPECIALITA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2001124452 external-priority patent/DE10124452A1/en
Priority claimed from DE2001124450 external-priority patent/DE10124450A1/en
Application filed by Laboratorio Farmaceutico Sit Specialita' Igienico Terapeutiche Srl Mede, FARMACEUTICO S I T SPECIALITA filed Critical Laboratorio Farmaceutico Sit Specialita' Igienico Terapeutiche Srl Mede
Priority to DE50204608T priority Critical patent/DE50204608D1/en
Application granted granted Critical
Publication of DE50204608D1 publication Critical patent/DE50204608D1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)

Abstract

The invention relates to a method for producing biperiden which is characterized in that an exo/endo mixture of 1-(bicyclo[2.2.1]hept-5-en-2-yl)-3-piperidino-1-propanone is reacted with an isomer ratio of the exo form to the endo form of at least 2.5:1 with diphenyl magnesium, an isomer mixture containing biperiden is obtained therefrom and biperiden is produced therefrom.
DE50204608T 2001-05-18 2002-05-17 PROCESS FOR PREPARING BIPERIDES I Expired - Lifetime DE50204608D1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE50204608T DE50204608D1 (en) 2001-05-18 2002-05-17 PROCESS FOR PREPARING BIPERIDES I

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE2001124452 DE10124452A1 (en) 2001-05-18 2001-05-18 Preparation of biperiden used for treating Parkinson's disease by reacting diphenylmagnesium and bicycloheptenenyl-substituted propanone of high exo/endo ratio
DE2001124450 DE10124450A1 (en) 2001-05-18 2001-05-18 Preparation of biperiden used for treating Parkinson's disease by reacting phenylmagnesium compound and bicycloheptenenyl-substituted propanone of high exo/endo ratio
PCT/EP2002/005498 WO2002094801A1 (en) 2001-05-18 2002-05-17 Method for producing biperiden i
DE50204608T DE50204608D1 (en) 2001-05-18 2002-05-17 PROCESS FOR PREPARING BIPERIDES I

Publications (1)

Publication Number Publication Date
DE50204608D1 true DE50204608D1 (en) 2006-03-02

Family

ID=26009342

Family Applications (1)

Application Number Title Priority Date Filing Date
DE50204608T Expired - Lifetime DE50204608D1 (en) 2001-05-18 2002-05-17 PROCESS FOR PREPARING BIPERIDES I

Country Status (12)

Country Link
US (1) US7034158B2 (en)
EP (1) EP1389193B1 (en)
JP (1) JP4338979B2 (en)
KR (1) KR100896836B1 (en)
CN (1) CN1281594C (en)
AT (1) ATE307124T1 (en)
BR (1) BRPI0209850B8 (en)
DE (1) DE50204608D1 (en)
DK (1) DK1389193T3 (en)
ES (1) ES2250678T3 (en)
IL (2) IL158932A0 (en)
WO (1) WO2002094801A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5861884B2 (en) * 2012-03-29 2016-02-16 荒川化学工業株式会社 Method for producing exo-type norbornene compound

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1005067B (en) * 1953-03-14 1957-03-28 Knoll Ag Process for the preparation of bicyclically substituted aminopropanols
US2789110A (en) 1953-03-14 1957-04-16 Knoll Ag Amino alcohols substituted by bicycloalkyl residues and a process of making same
JPH11189729A (en) 1997-12-26 1999-07-13 Chemiprokasei Kaisha Ltd Coloring matter-cum-ultraviolet stabilizer and polymer composition containing the same
DE10124451A1 (en) 2001-05-18 2002-11-21 Abbott Gmbh & Co Kg Preparation of biperiden used for treating Parkinson's disease, by reacting phenylmagnesium compound and bicycloheptenenyl-substituted propanone of high exo/endo ratio
DE10124449A1 (en) * 2001-05-18 2002-11-21 Abbott Gmbh & Co Kg Preparation of biperiden used for treating Parkinson's disease by reacting phenylmagnesium compound and bicycloheptenenyl substituted propanone of high exo/endo ratio

Also Published As

Publication number Publication date
CN1525963A (en) 2004-09-01
KR20040007578A (en) 2004-01-24
IL158932A (en) 2009-12-24
US20050176963A1 (en) 2005-08-11
BR0209850A (en) 2004-06-15
ATE307124T1 (en) 2005-11-15
ES2250678T3 (en) 2006-04-16
DK1389193T3 (en) 2006-03-06
EP1389193B1 (en) 2005-10-19
JP2004536068A (en) 2004-12-02
EP1389193A1 (en) 2004-02-18
JP4338979B2 (en) 2009-10-07
IL158932A0 (en) 2004-05-12
BRPI0209850B8 (en) 2021-05-25
CN1281594C (en) 2006-10-25
BRPI0209850B1 (en) 2018-05-15
US7034158B2 (en) 2006-04-25
WO2002094801A1 (en) 2002-11-28
KR100896836B1 (en) 2009-05-12

Similar Documents

Publication Publication Date Title
DE69200983D1 (en) Process for the production of hydrogen peroxide.
DE69204484D1 (en) Process for the production of hydrogen peroxide.
DE69407653T2 (en) Process for the production of hydrogen peroxide
ATE295153T1 (en) METHOD FOR PRODUCING MICROPARTICLES CONTAINING METOPROLOL
DE60109494D1 (en) PROCESS FOR PREPARING SALBUTAMOLISOMERS
ATE226931T1 (en) METHOD FOR PRODUCING PURE CIS-TRAMADOL
DE69415345D1 (en) METHOD FOR PRODUCING BISNORALDEHYDES FROM BISNORAL ALCOHOL
ATE337796T1 (en) METHOD FOR PRODUCING HYPERPOLARIZED 129XE
ATE281434T1 (en) METHOD FOR PRODUCING BENZOPERHYDROISOINDOLES
DE50204608D1 (en) PROCESS FOR PREPARING BIPERIDES I
DE50207388D1 (en) PROCESS FOR PREPARING BIPERIDES II
DE69605064T3 (en) Process for the production of hydrogen peroxide
ATE356215T1 (en) METHOD FOR PRODUCING 2,4-DIDESOXYHEXOSES AND 2,4,6-TRIDESOXYHEXOSES
ATE365726T1 (en) METHOD FOR PRODUCING BIPERIDES
DE69926223D1 (en) PROCESS FOR PRODUCING INTERMEDIATE PRODUCTS
ATE282594T1 (en) METHOD FOR PRODUCING (+)-TRANS-4-P-FLUOROPHENYL-3-HYDROXYMETHYL-1-METHYLPIPERIDINE
DE50110561D1 (en) Non-metallocene, process for producing the same and their use for the polymerisation of olefins
ATE339423T1 (en) METHOD FOR PRODUCING 4'-O-SUBSTITUTED 4'-DEMETHYL-1 DEOXYPODOPHYLLOTOXINE DERIVATIVES AND GEOMETRIC ISOMERS THEREOF, AND ANTICANCER PREPARATION CONTAINING SAME
DE50103009D1 (en) METHOD FOR PRODUCING 2-ALKYL-3-CHLORPHENOLS
ATE425143T1 (en) METHOD FOR PRODUCING INDOLES
DE60011463D1 (en) METHOD FOR PRODUCING 24 (S) -HYDROXYVITAMIN D2
ATE236851T1 (en) DEVICE FOR THE PHOTOACTIVATED PRODUCTION OF SINGLET OXYGEN AND METHOD FOR PRODUCING THE DEVICE
ATE184265T1 (en) METHOD FOR PRODUCING A ZEOLITE
DE50312447D1 (en) PROCESS FOR THE PREPARATION OF 4,6-DICHLOR-5-FLUORPYRIMIDINE
ATE325111T1 (en) METHOD FOR PRODUCING 15-PENTADECANOLIDE

Legal Events

Date Code Title Description
8364 No opposition during term of opposition