DE430883C - Process for the preparation of water-soluble, complex antimony compounds of the quinoline series - Google Patents
Process for the preparation of water-soluble, complex antimony compounds of the quinoline seriesInfo
- Publication number
- DE430883C DE430883C DEF57451D DEF0057451D DE430883C DE 430883 C DE430883 C DE 430883C DE F57451 D DEF57451 D DE F57451D DE F0057451 D DEF0057451 D DE F0057451D DE 430883 C DE430883 C DE 430883C
- Authority
- DE
- Germany
- Prior art keywords
- water
- soluble
- preparation
- antimony compounds
- quinoline series
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229940058905 antimony compound for treatment of leishmaniasis and trypanosomiasis Drugs 0.000 title claims description 3
- 150000001463 antimony compounds Chemical class 0.000 title claims description 3
- 238000000034 method Methods 0.000 title claims description 3
- 125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 title claims 2
- 239000003513 alkali Substances 0.000 claims description 3
- 150000003839 salts Chemical class 0.000 claims description 3
- FAWGZAFXDJGWBB-UHFFFAOYSA-N antimony(3+) Chemical compound [Sb+3] FAWGZAFXDJGWBB-UHFFFAOYSA-N 0.000 claims description 2
- 150000002927 oxygen compounds Chemical class 0.000 claims description 2
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 229910000410 antimony oxide Inorganic materials 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- VTRUBDSFZJNXHI-UHFFFAOYSA-N oxoantimony Chemical compound [Sb]=O VTRUBDSFZJNXHI-UHFFFAOYSA-N 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- YPMOSINXXHVZIL-UHFFFAOYSA-N sulfanylideneantimony Chemical compound [Sb]=S YPMOSINXXHVZIL-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- HIVLDXAAFGCOFU-UHFFFAOYSA-N ammonium hydrosulfide Chemical compound [NH4+].[SH-] HIVLDXAAFGCOFU-UHFFFAOYSA-N 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- MCJGNVYPOGVAJF-UHFFFAOYSA-N quinolin-8-ol Chemical class C1=CN=C2C(O)=CC=CC2=C1 MCJGNVYPOGVAJF-UHFFFAOYSA-N 0.000 description 1
- 150000003248 quinolines Chemical class 0.000 description 1
- 235000011121 sodium hydroxide Nutrition 0.000 description 1
- 150000004763 sulfides Chemical class 0.000 description 1
- 125000000542 sulfonic acid group Chemical group 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/90—Antimony compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
Description
Verfahren zur Darstellung von in Wasser löslichen, komplexen Antimonverbindungen der Chinolinreihe, Es wurde gefunden, (laß die Alkali- oder Erdalkalisalze von 8-Oxychinolinstilfosüuren bei der Behandlung mit Sauerstoffverbindungen des dreiwertigen Antimons in wasserlösliche komplexe Antinionverbindungen übergehen. Die Bildung derartiger Verbindungen ist überraschend, denn es war eher zu erwarten, daß das Antimonoxyd niit dein `ulfonsäurerest unter Entstehung wasserunlGslicher Antinionsalze reagieren Würde.Process for the preparation of water-soluble, complex antimony compounds of the quinoline series, It was found (leave the alkali or alkaline earth salts of 8-oxyquinoline stilfosuures when treated with oxygen compounds of the trivalent antimony into water-soluble ones skip complex anti-ion compounds. The formation of such compounds is surprising, because it was rather to be expected that the antimony oxide with your sulfonic acid residue would react with the formation of water-insoluble antinionic salts.
Die neuen Verbindungen stellen hervorragend spezifisch wirkende 'Mittel dar. Ihre w iißrigeti Lösungen sind ohne Reizwirkung. Beispiel i.The new compounds are excellent specific agents Their aqueous solutions are not irritating. Example i.
2o Gewichtsteile 8-Oxycliinolin-5-stilfosäure und 3,6 Ge«'ichtsteile Ätznatron werden zusammen in Zoo Gewichtsteilen Wasser gelöst und unter Zusatz von 13 Gewichtsteilen Antiinonoxyd einige Zeit erhitzt. Nach fast völliger Lösung des Antimonoxydes wird filtlfiert und das Filtrat eingedampft. Es hinterbleibt ein gelblichweißes Pulver, das in Wasser mit gelber Farbe und fast neutraler Reaktion löslich ist. Aus der wäßrigen Lösung wird durch Schwefelammonium orangerotes Schwefelantimon ausgefällt.20 parts by weight of 8-oxycliinoline-5-stilfonic acid and 3.6 parts by weight Caustic soda are dissolved together in zoo parts by weight of water and with the addition of 13 parts by weight of antiinone oxide heated for some time. After almost complete solution of the Antimony oxide is filtered off and the filtrate is evaporated. What remains is a yellowish white Powder that is soluble in water with a yellow color and almost neutral reaction. Sulfur ammonium turns the aqueous solution into orange-red sulfur antimony failed.
Beispiel Eine neutrale wäßrige Lösung der 8-Oxycliinolinelistilfosätire (Journ. für praktische Chemie, N. F. 41 [18901, Seite 4o) wird finit überschüssigem Aiitimonhydroxyd [- Sb (OH),] einige Zeit erhitzt. Dann v ird filtriert und das klare Filtrat in Alkohol getropft. Es fällt ein gelber Körper aus, der nach dein Absaugen und Trocknen sich leicht ii, Wasser finit schwach saurer Reaktion löst. Die Lösung gibt mit Alkalisulfiden einen orangefarbenen Niederschlag von Schwefelantimon. Der Antiniongehalt der Verbindung beträgt etwa 9 Prozent.EXAMPLE A neutral aqueous solution of the 8-oxycliinolinelistilfosätire (Journ. For practical chemistry, NF 41 [18901, page 40) is heated for some time with excess aluminum hydroxide [- Sb (OH),]. Then it is filtered and the clear filtrate is added dropwise to alcohol. A yellow body precipitates out, which after being sucked off and dried easily dissolves in water with a finite, weakly acidic reaction. With alkali sulfides, the solution gives an orange-colored precipitate of sulfur antimony. The antinion content of the compound is about 9 percent.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEF57451D DE430883C (en) | 1924-11-29 | 1924-11-29 | Process for the preparation of water-soluble, complex antimony compounds of the quinoline series |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEF57451D DE430883C (en) | 1924-11-29 | 1924-11-29 | Process for the preparation of water-soluble, complex antimony compounds of the quinoline series |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE430883C true DE430883C (en) | 1926-06-23 |
Family
ID=7108276
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DEF57451D Expired DE430883C (en) | 1924-11-29 | 1924-11-29 | Process for the preparation of water-soluble, complex antimony compounds of the quinoline series |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE430883C (en) |
-
1924
- 1924-11-29 DE DEF57451D patent/DE430883C/en not_active Expired
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