DE4219966A1 - Rotationally symmetrical filter with hydrophilic and hydrophobic filter media - used for filtering and degassing liquids e.g. sterile filtration of aq. solns. and cell culture media - Google Patents

Rotationally symmetrical filter with hydrophilic and hydrophobic filter media - used for filtering and degassing liquids e.g. sterile filtration of aq. solns. and cell culture media

Info

Publication number
DE4219966A1
DE4219966A1 DE4219966A DE4219966A DE4219966A1 DE 4219966 A1 DE4219966 A1 DE 4219966A1 DE 4219966 A DE4219966 A DE 4219966A DE 4219966 A DE4219966 A DE 4219966A DE 4219966 A1 DE4219966 A1 DE 4219966A1
Authority
DE
Germany
Prior art keywords
filter
hydrophilic
hydrophobic
housing
flat filter
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE4219966A
Other languages
German (de)
Other versions
DE4219966C2 (en
Inventor
Andreas Graus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vivascience AG
Original Assignee
Sartorius AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sartorius AG filed Critical Sartorius AG
Priority to DE9213434U priority Critical patent/DE9213434U1/de
Priority to DE4219966A priority patent/DE4219966C2/en
Publication of DE4219966A1 publication Critical patent/DE4219966A1/en
Application granted granted Critical
Publication of DE4219966C2 publication Critical patent/DE4219966C2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/08—Flat membrane modules
    • B01D63/087—Single membrane modules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D19/00—Degasification of liquids
    • B01D19/0031—Degasification of liquids by filtration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D29/00—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor
    • B01D29/01—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor with flat filtering elements
    • B01D29/012—Making filtering elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D29/00—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor
    • B01D29/01—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor with flat filtering elements
    • B01D29/05—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor with flat filtering elements supported
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D36/00—Filter circuits or combinations of filters with other separating devices
    • B01D36/001—Filters in combination with devices for the removal of gas, air purge systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
    • C12M37/02—Filters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
    • C12M37/04—Seals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)

Abstract

Filter has a first housing portion with a central inlet nozzle and a second housing portion with a central outlet nozzle, the housing portions enclosing a hydrophilic flat filter and a spaced hydrophobic flat filter. The hydrophilic filter is sealed between the edges of the housing portions, while the hydrophobic filter is an annular filter which surrounds the inner opening of the inlet nozzle and which covers venting openings in the first housing portion. Each housing portion (1,7) has an integrated permeable filter support (4.9) for the hydrophilic filter (10). The hydrophobic filter (5) is sealed at both edges (6) to a recessed annular surface of the first housing portion (1) in which the gas venting openings (3) are located. Pref. the hydrophobic filter (5) consists of a PTFE membrane having a non-woven permeable material facing the venting openings. USE/ADVANTAGE - The filter is useful for filtering and degassing liquids e.g. sterile filtration of aq. solns. and cell culture media. It has a simple design and low dead space and provides improved degassing even when in the inclined position.

Description

Die Erfindung betrifft einen weitgehend rotationssymme­ trisch aufgebauten Filter für Fluide mit einem zentralen Einlaßstutzen in einem ersten Gehäuseteil und einem zen­ tralen Auslaßstutzen in einem zweiten Gehäuseteil, die unter randseitiger Abdichtung ein hydrophiles Flachfilter und ein hydrophobes Flachfilter vom hydrophilen Flachfilter beabstandet zwischen sich einschließen, wobei das hydro­ phobe Flachfilter als Ringfilter um die innere Öffnung des Einlaßstutzens herum angeordnet ist und mehrere nach außen führende Entgasungsöffnungen im ersten Gehäuseteil abdeckt. Ein solches Filter ist bekannt durch die US-PS 41 13 627 und besteht aus mehr als zwei Gehäuseteilen. Zusätzlich zu den beiden, die Anschlußstutzen aufweisenden Gehäuseteile sind eingelagerte Gehäuseteile vorgesehen, die der Filter­ abstützung und der Befestigung des ringförmigen hydrophoben Filters in dem ersten Gehäuseteil dienen. Das hydrophile Flachfilter ist dabei nur einseitig durch eine Filter­ unterstützung abgestützt. Dieses aus mehreren Bauteilen bestehende Filter dient zur Flüssigkeitsfiltration und zur Entgasung der in der Flüssigkeit befindlichen Gasblasen. Das hydrophobe Flachfilter ist in dem ersten Gehäuseteil ringförmig durch eine zusätzlich eingebrachte Kunststoff­ masse eingesiegelt. The invention relates to a largely rotationally symmetrical tric filter for fluids with a central Inlet nozzle in a first housing part and a zen tralen outlet port in a second housing part, the a hydrophilic flat filter with an edge seal and a hydrophobic flat filter from the hydrophilic flat filter include spaced between them, the hydro phobe flat filter as a ring filter around the inner opening of the Inlet port is arranged around and several to the outside covers leading degassing openings in the first housing part. Such a filter is known from US-PS 41 13 627 and consists of more than two housing parts. In addition to the two housing parts with the connecting pieces embedded housing parts are provided, which the filter support and attachment of the annular hydrophobic Filters in the first housing part serve. The hydrophilic Flat filter is only one side through a filter support supported. This from several components existing filter is used for liquid filtration and Degassing of the gas bubbles in the liquid. The hydrophobic flat filter is in the first housing part ring-shaped due to an additional plastic mass sealed.  

Diese Einsiegelung läßt jedoch nur den kleinen Bereich um die jeweilige Entgasungsöffnung frei, d. h. auch die übrige Ringfläche ist von der Siegelungsmasse überdeckt, so daß dieser Bereich der hydrophoben Filterfläche nicht mehr für die Filtration zur Verfügung steht. Nachteilig bei diesem bekannten Filter ist auch, daß durch die Vielzahl der Bau­ teile nicht nur die Fertigung verteuert wird, sondern auch ein relativ großes Totvolumen im Filter selbst entsteht, welches sich nachteilig bei der Filtration kleiner Flüssig­ keitsmengen bzw. teuerer Flüssigkeiten bemerkbar macht.However, this sealing only leaves the small area the respective vent opening free, d. H. the rest too Ring surface is covered by the sealing compound, so that this area of the hydrophobic filter surface is no longer for the filtration is available. A disadvantage of this known filter is also that due to the variety of construction parts not only make production more expensive, but also there is a relatively large dead volume in the filter itself, which is disadvantageous in the filtration of small liquids quantities or expensive liquids.

Der Erfindung liegt daher die Aufgabe zugrunde, einen Filter der eingangs beschriebenen Bauart bezüglich seiner Gehäusekonfigurationen einfacher und mit geringem Tot­ volumen zu gestalten und die Entgasung auch bei Schräglage zu verbessern.The invention is therefore based on the object Filters of the type described above with regard to its Housing configurations easier and with less dead space volume and degassing even in an inclined position to improve.

Diese Aufgabe wird erfindungsgemäß dadurch gelöst, daß das erste und zweite randseitig miteinander verbundene Gehäuse­ teil je eine integrierte, drainierende Filterunterstützung für den hydrophilen Flachfilter aufweisen und das hydro­ phobe ringförmige Flachfilter an beiden Rändern auf einer gegenüber der Filterunterstützung für den hydrophilen Flachfilter zurückgesetzten Gehäuseringfläche des ersten Gehäuseteiles eingesiegelt ist, welche die Entgasungs­ öffnungen aufweist.This object is achieved in that the first and second housings connected to one another at the edge partly an integrated, draining filter support for the hydrophilic flat filter and the hydro phobe annular flat filter on both edges on one compared to the filter support for the hydrophilic Flat filter reset housing ring surface of the first Housing part is sealed, which the degassing has openings.

Durch die geringe Beabstandung des hydrophoben Flachfilters vom hydrophilen Flachfilter wird eine kleinvolumige Ge­ häusekammer mit geringem Totvolumen geschaffen, die be­ darfsweise auch noch zur Aufnahme eines zusätzlichen hydro­ philen Vorfilters dienen kann, der auf dem hydrophilen Flachfilter lose aufliegend angeordnet ist und dessen Rand am inneren Gehäuserand des einen Gehäuseteils durch geringe Übergröße radial fixiert ist. Due to the small spacing of the hydrophobic flat filter the hydrophilic flat filter becomes a small volume Ge Housing chamber with low dead volume created, the be may also be used to accommodate an additional hydro can serve phile pre-filter on the hydrophilic Flat filter is loosely arranged and the edge on the inner edge of the housing part by small Oversize is fixed radially.  

Durch die Zweiteiligkeit des Gehäuses wird eine einfache Herstellung beibehalten und durch die Anordnung eines ring­ förmigen hydrophoben Flachfilters mit mehreren über die Ringzone angeordneten Entgasungsöffnungen ist auch eine Entlüftung in Schräglage oder horizontaler Ausrichtung der beiden Anschlußstutzen gewährleistet bzw. sinkt die Filter­ leistung nur geringfügig ab. Durch die randseitige Ein­ siegelung des hydrophoben, ringförmigen Flachfilters wird praktisch zwischen diesen beiden randseitigen Siegelungs­ zonen in der Mitte eine ringförmig durchgehende hydrophobe Filterzone geschaffen, welche die verteilt angeordneten Entgasungsöffnungen überdeckt. Es bleibt also eine relativ große durchgehende hydrophobe Zone und Filterfläche er­ halten, die auf der Seite der Entgasungsöffnungen diese untereinander verbindet.The two-piece housing makes it simple Manufacture maintained and by arranging a ring shaped hydrophobic flat filter with several over the Degassing openings arranged in the ring zone is also a Ventilation in an inclined position or horizontal orientation of the The two connecting pieces guarantee or sink the filter performance only slightly. By the edge on sealing of the hydrophobic, ring-shaped flat filter practically between these two marginal sealing zones in the middle a continuous hydrophobic Filter zone created, which are distributed Degassing openings covered. So it remains a relative one large continuous hydrophobic zone and filter area keep that on the side of the vent holes this connects with each other.

Der Gegenstand der Erfindung ist in einem Ausführungs­ beispiel anhand der beiliegenden Zeichnung näher erläutert, welche einen Vertikalschnitt durch das zusammengefügte Filter zeigt.The object of the invention is in an embodiment example explained in more detail with reference to the accompanying drawing, which is a vertical section through the assembled Filter shows.

Das Filter besteht aus den beiden Gehäuseteilen 1 und 7, welche je einen Anschlußstutzen 2, 8, eine drainierende Filterunterstützung 4, 9 aus Kanälen und Rippen aufweisen und zwischen sich randseitig ein hydrophiles Flachfilter 10 leckdicht einschließen. Das hydrophile Flachfilter 10 ist dabei randseitig bei 11 zwischen den Gehäuseteilen 1, 7 eingeklemmt oder am Rand des Gehäuseteils 7 durch Heiß­ siegelung dichtend befestigt.The filter consists of the two housing parts 1 and 7 , which each have a connecting piece 2 , 8 , a draining filter support 4 , 9 made of channels and ribs and enclose a hydrophilic flat filter 10 between them at the edge in a leak-tight manner. The hydrophilic flat filter 10 is clamped at the edge at 11 between the housing parts 1 , 7 or fastened sealingly at the edge of the housing part 7 by heat sealing.

Beide Gehäuseteile sind bei 12 durch Ultraschallschweißung dauerhaft verbunden. Um den Einlaßstutzen 2 herum ist in einer Vertiefung des Gehäuseteils 1 in einer Gehäusering­ fläche 14 ein ringförmiges hydrophobes Flachfilter 5 an seinen beiden Rändern 6 eingesiegelt, so daß der mittlere Bereich ringförmig als Entgasungsfilter zur Verfügung steht. In diesem Bereich sind im Gehäuseteil 1 drei bis zehn Entgasungsöffnungen 3 angeordnet.Both housing parts are permanently connected at 12 by ultrasonic welding. Around the inlet port 2 is in a recess of the housing part 1 in a housing ring surface 14 an annular hydrophobic flat filter 5 sealed at its two edges 6 , so that the central region is available as a degassing filter. In this area, three to ten degassing openings 3 are arranged in the housing part 1 .

Die in den Einlaßstutzen 2 eingeführte Flüssigkeit wird über den Auslaßstutzen 8 über eine Vakuumpumpe durch das hydrophile Filter 10 und gegebenenfalls durch das aufge­ legte Vorfilter 13 gesaugt und die sich in der Flüssigkeit befindlichen Gasbestandteile oder angesaugten Gasvolumina haben die Möglichkeit, sich im Gehäuseraum 1′ zu sammeln und können das Gehäuse über das hydrophobe Flachfilter 5 und Entgasungsöffnungen 3 verlassen, ohne daß die Gefahr einer Kontamination besteht. Diese Entgasung wirkt auch, wenn die Filterflächen und damit der hydrophobe Flach­ filter 5 sich in einer Schräglage bzw. in vertikaler Ausrichtung befindet.The liquid introduced into the inlet port 2 is sucked through the outlet port 8 via a vacuum pump through the hydrophilic filter 10 and possibly through the pre-filter 13 and the gas components or gas volumes in the liquid have the possibility of becoming in the housing space 1 ' collect and can leave the housing via the hydrophobic flat filter 5 and degassing openings 3 without the risk of contamination. This degassing also works when the filter surfaces and thus the hydrophobic flat filter 5 is in an inclined position or in a vertical orientation.

Bei dem dargestellten Ausführungsbeispiel besteht das hydrophile Flachfilter 10 aus Celluloseacetat, hat eine Porengröße von 0,2 µm und eine Fläche von 22 cm2.In the exemplary embodiment shown, the hydrophilic flat filter 10 consists of cellulose acetate, has a pore size of 0.2 μm and an area of 22 cm 2 .

Das hydrophobe Flachfilter 5 besteht aus PTFE-Polyester-Vlies, hat eine Porengröße von 0,02 µm und eine Filter­ fläche von 1 cm2. Das Füllvolumen des Filters beträgt 3 ml und das Totvolumen 1 ml. Das Polyester-Vlies dient der Drainage und ist den Entgasungsöffnungen 3 zugewandt.The hydrophobic flat filter 5 is made of PTFE-polyester fleece, has a pore size of 0.02 µm and a filter area of 1 cm 2 . The filling volume of the filter is 3 ml and the dead volume is 1 ml. The polyester fleece serves for drainage and faces the degassing openings 3 .

Die Einheit dient der Sterilfiltration von wäßrigen Lö­ sungen und Zellkulturmedien. In letzteren sind oft hohe Serumanteile beinhaltet. Durch den optional integrierten Vorfilter ist die wirtschaftliche Filtration auch dieser kritischen Medien gewährleistet.The unit is used for the sterile filtration of aqueous solvents solutions and cell culture media. The latter are often high Serum levels included. Through the optionally integrated The pre-filter is the economical filtration critical media guaranteed.

Claims (3)

1. Rotationssymmetrisch aufgebauter Filter für Fluide mit einem zentralen Einlaßstutzen in einem ersten Gehäuse­ teil und einem zentralen Auslaßstutzen in einem zweiten Gehäuseteil, die unter randseitiger Abdichtung ein hydrophiles Flachfilter zwischen sich einschließen und ein hydrophobes Flachfilter vom hydrophilen Flachfilter beabstandet zwischen sich einschließen, wobei das hydro­ phobe Flachfilter als Ringfilter um die innere Öffnung des Einlaßstutzens herum angeordnet ist und mehrere nach außen führende Entgasungsöffnungen im ersten Ge­ häuseteil abdeckt, dadurch gekennzeichnet, daß das erste und zweite randseitig miteinander verbundene Gehäuse­ teil (1, 7) je eine integrierte, drainierende Filter­ unterstützung (4, 9) für den hydrophilen Flachfilter (10) aufweisen und das hydrophobe ringförmige Flachfilter (5) an beiden Rändern (6) auf einer gegenüber der Filter­ unterstützung (4) für den hydrophilen Flachfilter (10) zurückgesetzten Gehäuseringfläche des ersten Gehäuse­ teiles (1) eingesiegelt ist, welche die Entgasungs­ öffnungen (3) aufweist.1. Rotationally symmetrical filter for fluids with a central inlet connection in a first housing part and a central outlet connection in a second housing part, which include a hydrophilic flat filter between them under edge sealing and a hydrophobic flat filter spaced apart from the hydrophilic flat filter, with the hydro phobe flat filter is arranged as a ring filter around the inner opening of the inlet connector and covers several outwardly leading degassing openings in the first part of the housing, characterized in that the first and second edge-connected housing part ( 1 , 7 ) each have an integrated, draining filter support Have ( 4 , 9 ) for the hydrophilic flat filter ( 10 ) and the hydrophobic annular flat filter ( 5 ) on both edges ( 6 ) on a housing ringf that is set back compared to the filter support ( 4 ) for the hydrophilic flat filter ( 10 ) Surface of the first housing part ( 1 ) is sealed, which has the degassing openings ( 3 ). 2. Filter nach Anspruch 1, dadurch gekennzeichnet, daß das hydrophobe Flachfilter (5) aus einer PTFE-Membran mit einem Drainagevlies gebildet ist, wobei das Drainage­ vlies den Entgasungsöffnungen (3) zugewandt ist.2. Filter according to claim 1, characterized in that the hydrophobic flat filter ( 5 ) is formed from a PTFE membrane with a drainage fleece, the drainage fleece facing the degassing openings ( 3 ). 3. Filter nach Anspruch 1, dadurch gekennzeichnet, daß auf dem hydrophilen Flachfilter (10) ein hydrophiles Vor­ filter (13) lose aufliegend angeordnet ist, dessen Rand am inneren Gehäuserand des einen Gehäuseteils (1) durch geringe Übergröße radial fixiert ist.3. Filter according to claim 1, characterized in that on the hydrophilic flat filter ( 10 ) a hydrophilic pre filter ( 13 ) is loosely arranged, the edge of which is radially fixed by a small oversize on the inner housing edge of the one housing part ( 1 ).
DE4219966A 1991-07-26 1992-06-19 Rotationally symmetrical filter for fluids Expired - Lifetime DE4219966C2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE9213434U DE9213434U1 (en) 1991-07-26 1992-06-19
DE4219966A DE4219966C2 (en) 1991-07-26 1992-06-19 Rotationally symmetrical filter for fluids

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4124803 1991-07-26
DE4219966A DE4219966C2 (en) 1991-07-26 1992-06-19 Rotationally symmetrical filter for fluids

Publications (2)

Publication Number Publication Date
DE4219966A1 true DE4219966A1 (en) 1993-01-28
DE4219966C2 DE4219966C2 (en) 2001-10-11

Family

ID=6437073

Family Applications (1)

Application Number Title Priority Date Filing Date
DE4219966A Expired - Lifetime DE4219966C2 (en) 1991-07-26 1992-06-19 Rotationally symmetrical filter for fluids

Country Status (1)

Country Link
DE (1) DE4219966C2 (en)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19636006A1 (en) * 1996-09-05 1998-03-12 Sartorius Gmbh Filtration unit with pleated filter elements
DE19733021A1 (en) * 1997-07-31 1999-02-04 Sartorius Gmbh Filtration unit made of plastic and process for its production
DE19955636A1 (en) * 1999-11-20 2001-05-31 Ibs Filtran Kunststoff Metall Suction oil filter for engines or transmissions or automatic transmissions
WO2002018037A2 (en) * 2000-08-31 2002-03-07 Millipore Corporation Gas vent filter construction incorporating a hollow fiber membrane assembly
WO2002043841A2 (en) * 2000-12-01 2002-06-06 Millipore Corporation Chemical process system with multi-functional barrier filter
EP1219333A1 (en) * 2000-12-28 2002-07-03 Nipro Corporation Air trap for liquid circulation line
EP1520609A1 (en) * 2003-09-30 2005-04-06 Boehringer Ingelheim microParts GmbH Method and apparatus for separating and eliminating gas bubbles from liquids
EP2076322A1 (en) * 2006-09-22 2009-07-08 3M Innovative Properties Company Method of preventing filter media cracking when compressing two or more filter media layers
CN102940987A (en) * 2012-11-08 2013-02-27 凡嘉科技（无锡）有限公司 Disposable syringe filter structure
WO2019158480A1 (en) * 2018-02-19 2019-08-22 Sartorius Stedim Biotech Gmbh Media filtration device

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102012012543B4 (en) * 2012-06-26 2016-09-29 Mann+Hummel Gmbh A filter assembly

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4113627A (en) * 1976-01-28 1978-09-12 Filtertek, Inc. Process for making hermetically sealed filter units and filters made thereby
DE3202330C2 (en) * 1981-01-27 1986-05-07 Sartorius GmbH, 3400 Göttingen Essentially symmetrically constructed two-part filter housing made of plastic

Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19636006A1 (en) * 1996-09-05 1998-03-12 Sartorius Gmbh Filtration unit with pleated filter elements
DE19733021A1 (en) * 1997-07-31 1999-02-04 Sartorius Gmbh Filtration unit made of plastic and process for its production
WO1999006135A1 (en) * 1997-07-31 1999-02-11 Sartorius Ag Plastic filtration unit and method for producing the same
DE19733021C2 (en) * 1997-07-31 2002-05-29 Vivascience Ag Filtration unit made of plastic and process for its production
DE19955636A1 (en) * 1999-11-20 2001-05-31 Ibs Filtran Kunststoff Metall Suction oil filter for engines or transmissions or automatic transmissions
DE19955636C2 (en) * 1999-11-20 2001-10-18 Ibs Filtran Kunststoff Metall Suction oil filter for engines or transmissions or automatic transmissions
WO2002018037A3 (en) * 2000-08-31 2002-06-06 Millipore Corp Gas vent filter construction incorporating a hollow fiber membrane assembly
WO2002018037A2 (en) * 2000-08-31 2002-03-07 Millipore Corporation Gas vent filter construction incorporating a hollow fiber membrane assembly
WO2002043841A3 (en) * 2000-12-01 2003-02-27 Millipore Corp Chemical process system with multi-functional barrier filter
WO2002043841A2 (en) * 2000-12-01 2002-06-06 Millipore Corporation Chemical process system with multi-functional barrier filter
US6902671B2 (en) 2000-12-01 2005-06-07 Millipore Corporation Chemical process system with multi-functional barrier filter
EP1219333A1 (en) * 2000-12-28 2002-07-03 Nipro Corporation Air trap for liquid circulation line
US6669762B2 (en) 2000-12-28 2003-12-30 Nipro Corporation Air trap for liquid circulation line
EP1520609A1 (en) * 2003-09-30 2005-04-06 Boehringer Ingelheim microParts GmbH Method and apparatus for separating and eliminating gas bubbles from liquids
US7166147B2 (en) 2003-09-30 2007-01-23 Boehringer Ingelheim Microparts Gmbh Process and device for separating and exhausting gas bubbles from liquids
EP2076322A1 (en) * 2006-09-22 2009-07-08 3M Innovative Properties Company Method of preventing filter media cracking when compressing two or more filter media layers
EP2076322A4 (en) * 2006-09-22 2010-01-13 3M Innovative Properties Co Method of preventing filter media cracking when compressing two or more filter media layers
US8636151B2 (en) 2006-09-22 2014-01-28 3M Innovative Properties Company Method of preventing filter media cracking when compressing two or more filter media layers
CN102940987A (en) * 2012-11-08 2013-02-27 凡嘉科技（无锡）有限公司 Disposable syringe filter structure
WO2019158480A1 (en) * 2018-02-19 2019-08-22 Sartorius Stedim Biotech Gmbh Media filtration device
JP2021513872A (en) * 2018-02-19 2021-06-03 ザトーリウス ステディム ビオテーク ゲーエムベーハー Medium filtration device
US11877982B2 (en) 2018-02-19 2024-01-23 Sartorius Stedim Biotech Gmbh Media filtration device

Also Published As

Publication number Publication date
DE4219966C2 (en) 2001-10-11

Similar Documents

Publication Publication Date Title
EP1449553B1 (en) Filter for medical and laboratory purposes, in particular for blood analysis
WO2000048716A2 (en) Device for concentrating and/or purifying macromolecules ina solution and method for producing such a device
DE69728983T2 (en) Filter device for biological fluids with a leukocyte depleting medium
DE3803886C2 (en)
EP1154838B1 (en) Filter assembly for vacuum filtration
DE60019478T2 (en) Filter unit with a separately connectable filter cassette and filtration process
DE4219966C2 (en) Rotationally symmetrical filter for fluids
DE2110751A1 (en) Filter holder
EP0808633A2 (en) Liquid degassing device
EP0325712A1 (en) Disposable filter with a double supporting grid
DE10106950A1 (en) Filter element for fuels
WO2018072936A1 (en) Round filter element, in particular for gas filtration
EP0060346A2 (en) Pressure filter apparatus
EP3341105B1 (en) Fluid filter and filter insert for the same
DE102015215168B4 (en) Filter and filter housing
DE3205229C2 (en) Disposable filters
US4919805A (en) Vertical leaf filter flush
DE3200443C3 (en) Filtration device for flat filter cuts
DE102018009203B4 (en) Filter cartridge and filter device
EP3967662A1 (en) Filter cartridge and filter device
DE669974C (en) Fuel gap filter, especially for vehicle engines
DE19856723B4 (en) Filter insert for a fuel filter having an inlet and an outlet
EP1619382A2 (en) Fuel supply device
DE102012220250A1 (en) FLUIDIKMODUL FOR A CENTRIFUGAL FILTRATION AND METHOD FOR FILTERING A SAMPLE
DE3635728A1 (en) LIQUID FILTER, ESPECIALLY FOR FUELS

Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
D2 Grant after examination
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: VIVASCIENCE AG, 30625 HANNOVER, DE

8327 Change in the person/name/address of the patent owner

Owner name: SARTORIUS STEDIM BIOTECH GMBH, 37079 GOETTINGE, DE

8320 Willingness to grant licences declared (paragraph 23)
R071 Expiry of right
R071 Expiry of right