DE4012894A1 - Compsns. contg. carnitine and fish oil - for preventing and treating fat metabolism disorders, esp. hyperlipidaemia - Google Patents
Compsns. contg. carnitine and fish oil - for preventing and treating fat metabolism disorders, esp. hyperlipidaemiaInfo
- Publication number
- DE4012894A1 DE4012894A1 DE19904012894 DE4012894A DE4012894A1 DE 4012894 A1 DE4012894 A1 DE 4012894A1 DE 19904012894 DE19904012894 DE 19904012894 DE 4012894 A DE4012894 A DE 4012894A DE 4012894 A1 DE4012894 A1 DE 4012894A1
- Authority
- DE
- Germany
- Prior art keywords
- fish oil
- carnitine
- contg
- fish
- fat metabolism
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/60—Fish, e.g. seahorses; Fish eggs
Abstract
Description
Die Erfindung betrifft ein pharmazeutisches Mittel zur Behandlung von Störungen des Fettstoffwechsels, insbeson dere der Hyperlipidämie, auf der Grundlage von Fischöl und Carnitin.The invention relates to a pharmaceutical agent for Treatment of disorders of fat metabolism, in particular that of hyperlipidemia, based on fish oil and carnitine.
Arteriosklerose ist nach Herzkrankheiten und Krebserkran kungen eine der Haupttodesursachen bei Menschen. Ein Risikofaktor für die Erkrankung an Arteriosklerose ist eine erhöhte Menge an Serumlipiden und Lipoproteinen, so daß eine Senkung der Serumlipid- und Lipoproteinspiegel für die Therapie wichtig ist.Atherosclerosis is after heart disease and cancer crane one of the main causes of death in humans. A Risk factor for arteriosclerosis disease an increased amount of serum lipids and lipoproteins, causing a decrease in serum lipid and lipoprotein levels is important for therapy.
Als Lipidsenker kommen neben den seit langem bekannten Chemotherapeutika in neuerer Zeit Produkte zur Anwendung, die sich in natürlichen Materialien finden. In diesem Zusammenhang sind in erster Linie ungesättigte Fettsäuren zu nennen.As lipid-lowering agents come alongside those that have been known for a long time Chemotherapy drugs more recently products for use, that are found in natural materials. In this The connection is primarily unsaturated fatty acids to call.
Die EP-A-8 61 16 933 beschreibt ein pharmazeutisches Präparat zur Behandlung von Störungen des Fettstoffwech sels, das Knoblauchextrakt und Fischöl enthält. Mit diesem Präparat sollen bei Dosierungen von 2 bis 4 g pro Tag vorteilhafte Ergebnisse erzielt werden.EP-A-8 61 16 933 describes a pharmaceutical Preparation for the treatment of disorders of the fat metabolism sels, which contains garlic extract and fish oil. With this The preparation should be used at doses of 2 to 4 g per day advantageous results can be achieved.
Carnitin-(4-Amino-3-hydroxybuttersäuretrimethylbetain), das früher als Vitamin BT bezeichnet wurde, kommt in allen Geweben, insbesondere der quergestreiften Muskula tur vor. Es ist als Transportprotein von Acylgruppen am Fettstoffwechsel beteiligt. Carnitine (4-amino-3-hydroxybutyric acid trimethylbetaine), formerly known as vitamin B T , occurs in all tissues, especially the striated muscles. As a transport protein of acyl groups, it is involved in fat metabolism.
Überraschenderweise wurde nun gefunden, daß eine Kombination von Carnitin und Fischöl in der Lage ist, den Serumlipid- und Lipoproteinspiegel stark zu senken.Surprisingly, it has now been found that a combination of carnitine and fish oil is able to reduce the serum lipid and greatly lower lipoprotein levels.
Gegenstand der vorliegenden Erfindung ist daher ein pharmazeutisches Mittel, das Fischöl und Carnitin enthält. Dieses Mittel ist zur Behandlung von Störungen des Fett stoffwechsels und insbesondere der Hyperlipidämie brauch bar.The subject of the present invention is therefore a pharmaceutical agent containing fish oil and carnitine. This remedy is used to treat fat disorders metabolism and especially hyperlipidemia bar.
Fischöl, das erfindungsgemäß zur Anwendung kommen kann, ist in der EP-A-8 61 16 933 beschrieben. Auf diese Publi kation wird hiermit in vollem Umfang Bezug genommen.Fish oil, which can be used according to the invention, is described in EP-A-8 61 16 933. On this publi cation is hereby fully referred to.
Fischöl hat einen hohen Gehalt an C18 bis C22-Fettsäuren, insbesondere vom Omega-3-Typ. Dies gilt insbesondere für das Fischöl von Kaltwasserfischen.Fish oil has a high content of C 18 to C 22 fatty acids, especially of the omega-3 type. This applies in particular to the fish oil from cold water fish.
Vorzugsweise verwendet man daher Fischöl von Kaltwasser fischen, insbesondere Fischöl aus dem Fleisch von Lachsen, Heringen, Salmen, Forellen, Sardellen, Makrelen und/oder Sardinen sowie Lebertran, insbesondere von Dorschen.Fish oil from cold water is therefore preferably used fish, especially fish oil from salmon meat, Herring, salmon, trout, anchovy, mackerel and / or Sardines and cod liver oil, especially from cod.
Besonders bevorzugt enthält das Fischöl 15 bis 50 Gew.-%, insbesondere 20 bis 30 Gew.-% hochungesättigte Fettsäuren vom Omega-3-Typ. Zu derartigen Fettsäuren zählen Eico sapenteinsäure und Docosahexaensäure. Vorzugsweise setzt man Fischöl ein, das 10 bis 30 Gew.-%, insbesondere 15 bis 20 Gew.-% Eicosapentaensäure und 7 bis 20 Gew.-%, insbesondere 10 bis 15 Gew.-% Docosahexaensäure enthält.The fish oil particularly preferably contains 15 to 50 % by weight, in particular 20 to 30% by weight, of highly unsaturated fatty acids of the omega-3 type. Such fatty acids include eico sapentic acid and docosahexaenoic acid. Fish oil is preferably used which contains 10 to 30% by weight, in particular 15 to 20% by weight, of eicosapentaenoic acid and 7 to 20% by weight, in particular 10 to 15% by weight of docosahexaenoic acid.
Das Carnitin kann auch in Form eines pharmazeutisch ver träglichen Salzes, z. B. als Hydrochlorid, eingesetzt werden. Das Carnitin kommt vorzugweise als L-Carnitin zur Anwendung. The carnitine can also be in the form of a pharmaceutical ver inert salt, e.g. B. be used as hydrochloride. The carnitine is preferably used as L-carnitine.
Das Verhältnis von Fischöl zu Carnitin liegt im allgemeinen im Bereich von 1 : 2 bis 10 : 1, vorzugsweise im Bereich von 1 : 1 bis 5 : 1.The ratio of fish oil to carnitine is generally in the range of 1: 2 to 10: 1, preferably in the range of 1: 1 to 5: 1.
Das erfindungsgemäße Mittel wird insbesondere oral verab reicht. Geeignete Darreichungsformen sind Kapseln, Lösun gen, Dispersionen etc. Vorzugsweise wird das Mittel als Kapsel (Weich- oder Hartgelatine) verabreicht, die 500 bis 1000 mg, insbesondere 600 bis 800 mg, Fischöl und 200 bis 400 mg, insbesondere 200 bis 300 mg, Carnitin enthält. Das Mittel kann auch in zwei Teilen vorliegen, wobei die beiden Komponenten voneinander getrennt gleich zeitig oder nacheinander verabreicht werden können.The agent according to the invention is administered orally in particular enough. Suitable dosage forms are capsules, solutions conditions, dispersions etc. The agent is preferably used as Capsule (soft or hard gelatin) administered, the 500th up to 1000 mg, especially 600 to 800 mg, fish oil and 200 to 400 mg, especially 200 to 300 mg, carnitine contains. The agent can also be in two parts, the two components being the same separately from each other can be administered early or sequentially.
Die Herstellung der erfindungsgemäßen Mittel erfolgt in üblicher Weise durch Zusammengeben oder getrennte Formulierung der beiden Komponenten, gegebenenfalls unter Verwendung üblicher Zusätze und Hilfsstoffe.The agents according to the invention are produced in the usual way by combining or separate Formulation of the two components, if necessary under Use of common additives and auxiliary substances.
Die Dosierung des erfindungsgemäßen Mittels liegt im allgemeinen im Bereich von 1 bis 10 Gramm pro Tag bei Erwachsenen, wobei Fischöl und Carnitin in den genannten Mengenanteilen vorliegen.The dosage of the agent according to the invention is generally in the range of 1 to 10 grams per day Adults, with fish oil and carnitine in the above Quantities are available.
Das nachfolgende Beispiel erläutert die Erfindung.The following example explains the invention.
Jeweils 200 mg Carnitin werden mit jeweils 400, 500 und 600 mg Heringsöl, Sardinenöl und Lachsöl in eine Weich gelatinekapsel gefüllt.Each 200 mg of carnitine with 400, 500 and 600 mg of herring oil, sardine oil and salmon oil in a soft filled gelatin capsule.
Claims (7)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19904012894 DE4012894C2 (en) | 1990-04-23 | 1990-04-23 | Pharmaceutical agent for the treatment of disorders of the fat metabolism |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19904012894 DE4012894C2 (en) | 1990-04-23 | 1990-04-23 | Pharmaceutical agent for the treatment of disorders of the fat metabolism |
Publications (2)
Publication Number | Publication Date |
---|---|
DE4012894A1 true DE4012894A1 (en) | 1991-10-24 |
DE4012894C2 DE4012894C2 (en) | 1998-11-12 |
Family
ID=6404903
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19904012894 Expired - Lifetime DE4012894C2 (en) | 1990-04-23 | 1990-04-23 | Pharmaceutical agent for the treatment of disorders of the fat metabolism |
Country Status (1)
Country | Link |
---|---|
DE (1) | DE4012894C2 (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19503993A1 (en) * | 1995-02-08 | 1996-08-14 | Johann Friedrich Dr Med Desaga | Enteral product contg n-3-fatty acid or deriv and medium chain length tri:glyceride |
EP0780124A1 (en) * | 1995-12-21 | 1997-06-25 | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. | Pharmaceutical composition comprising L-carnitine or an alkanoyl L-carnitine in combination with a polyunsaturated fatty acid of the omega-3 series for the prevention and the treatment of lipid metabolism disorders |
DE10214005A1 (en) * | 2002-03-27 | 2003-10-09 | Volker Bartz | Orally administered dietetic, nutritional supplement or medicament composition, useful as hypolipemic agent, comprising mixture of pectin and/or guar powder with eicosapentaenoic and docosahexaenoic acids |
ES2208131A1 (en) * | 2002-03-27 | 2004-06-01 | Volker Bartz | Orally administered dietetic, nutritional supplement or medicament composition, useful as hypolipemic agent, comprising mixture of pectin and/or guar powder with eicosapentaenoic and docosahexaenoic acids |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3721137A1 (en) * | 1987-06-26 | 1989-01-05 | Dietl Hans | Fat emulsion for intravenous use |
DE3726299A1 (en) * | 1987-06-26 | 1989-02-23 | Dietl Hans | Fat emulsion for intravenous use |
-
1990
- 1990-04-23 DE DE19904012894 patent/DE4012894C2/en not_active Expired - Lifetime
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3721137A1 (en) * | 1987-06-26 | 1989-01-05 | Dietl Hans | Fat emulsion for intravenous use |
DE3726299A1 (en) * | 1987-06-26 | 1989-02-23 | Dietl Hans | Fat emulsion for intravenous use |
Non-Patent Citations (2)
Title |
---|
DE-Z: WEBER, P.C. * |
SCHACKY, v.C: HochunggesättigteFettsäuren vom w-3-Typ, Nr. 1/2, 126.Jg., 1986, S.4-7 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19503993A1 (en) * | 1995-02-08 | 1996-08-14 | Johann Friedrich Dr Med Desaga | Enteral product contg n-3-fatty acid or deriv and medium chain length tri:glyceride |
EP0780124A1 (en) * | 1995-12-21 | 1997-06-25 | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. | Pharmaceutical composition comprising L-carnitine or an alkanoyl L-carnitine in combination with a polyunsaturated fatty acid of the omega-3 series for the prevention and the treatment of lipid metabolism disorders |
DE10214005A1 (en) * | 2002-03-27 | 2003-10-09 | Volker Bartz | Orally administered dietetic, nutritional supplement or medicament composition, useful as hypolipemic agent, comprising mixture of pectin and/or guar powder with eicosapentaenoic and docosahexaenoic acids |
ES2208131A1 (en) * | 2002-03-27 | 2004-06-01 | Volker Bartz | Orally administered dietetic, nutritional supplement or medicament composition, useful as hypolipemic agent, comprising mixture of pectin and/or guar powder with eicosapentaenoic and docosahexaenoic acids |
Also Published As
Publication number | Publication date |
---|---|
DE4012894C2 (en) | 1998-11-12 |
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Legal Events
Date | Code | Title | Description |
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OM8 | Search report available as to paragraph 43 lit. 1 sentence 1 patent law | ||
8110 | Request for examination paragraph 44 | ||
8127 | New person/name/address of the applicant |
Owner name: GIELSDORF, WERNER, DR., 89346 BIBERTAL, DE |
|
D2 | Grant after examination | ||
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: REDINOMEDICA AG, 80538 MUENCHEN, DE |
|
8327 | Change in the person/name/address of the patent owner |
Owner name: REDINOMEDICA AG, 33649 BIELEFELD, DE |
|
8327 | Change in the person/name/address of the patent owner |
Owner name: SFS INTERNATIONAL LTD., CLONMEL, TIPPERARY, IE |