DE3891468T1 - AETHYL ESTER OF 6-BROM-5-HYDROXY-4-DIMETHYLAMINOMETHYL-1-METHYL-2-PHENYLTHIOMETHYLINDOL-3-CARBONIC ACID OF MONOHYDRATE HYDROGEN CHLORIDE, METHOD FOR ITS PRODUCTION OF INTERMEDIATE CLEANING - Google Patents

AETHYL ESTER OF 6-BROM-5-HYDROXY-4-DIMETHYLAMINOMETHYL-1-METHYL-2-PHENYLTHIOMETHYLINDOL-3-CARBONIC ACID OF MONOHYDRATE HYDROGEN CHLORIDE, METHOD FOR ITS PRODUCTION OF INTERMEDIATE CLEANING

Info

Publication number
DE3891468T1
DE3891468T1 DE883891468T DE3891468T DE3891468T1 DE 3891468 T1 DE3891468 T1 DE 3891468T1 DE 883891468 T DE883891468 T DE 883891468T DE 3891468 T DE3891468 T DE 3891468T DE 3891468 T1 DE3891468 T1 DE 3891468T1
Authority
DE
Germany
Prior art keywords
phenylthiomethylindol
brom
dimethylaminomethyl
hydroxy
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE883891468T
Other languages
German (de)
Other versions
DE3891468C2 (en
Inventor
Galina Vasilevna Grineva
Ellina Grigorevna Persina
Alexej Nikolaevic Grinev
Grigorij Nikolaevic Persin
Fedor Aleksandrovic Trofimov
Nina Gavrilovna Cyskova
Nadezda Sergeevna Bogdanova
Irina Sergeevna Nikolaeva
Svetlana Alekseevna Zotova
Zinaida Michailovna Sachascik
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Le Ni Skij I Epidemiologii I M
NI SKIJ I MEDICINSKOJ RADIOLOG
VNI SKIJ CHIMIKO FARMACEVTICES
Original Assignee
Le Ni Skij I Epidemiologii I M
NI SKIJ I MEDICINSKOJ RADIOLOG
VNI SKIJ CHIMIKO FARMACEVTICES
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Le Ni Skij I Epidemiologii I M, NI SKIJ I MEDICINSKOJ RADIOLOG, VNI SKIJ CHIMIKO FARMACEVTICES filed Critical Le Ni Skij I Epidemiologii I M
Publication of DE3891468T1 publication Critical patent/DE3891468T1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
DE883891468T 1989-01-12 1989-01-12 AETHYL ESTER OF 6-BROM-5-HYDROXY-4-DIMETHYLAMINOMETHYL-1-METHYL-2-PHENYLTHIOMETHYLINDOL-3-CARBONIC ACID OF MONOHYDRATE HYDROGEN CHLORIDE, METHOD FOR ITS PRODUCTION OF INTERMEDIATE CLEANING Pending DE3891468T1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/SU1988/000272 WO1990008135A1 (en) 1989-01-12 1989-01-12 Ethyl ester 6-bromine-5-hydroxy-4-dimethyl-aminomethyl-1-methyl-2-phenylthiomethyl indole-3-carboxylic acid hydrochloride monohydrate, method of obtaining it and a pharmaceutical preparation of antiviral, interferon inducing and immunomodulating action based on it

Publications (1)

Publication Number Publication Date
DE3891468T1 true DE3891468T1 (en) 1991-02-21

Family

ID=21617367

Family Applications (2)

Application Number Title Priority Date Filing Date
DE3891468A Expired - Fee Related DE3891468C2 (en) 1989-01-12 1989-01-12 Ethyl ester of 6-bromo-5-hydroxy-4-dimethylaminomethyl-1-methyl-2-phenylthiomethylindole-3-carboxylic acid monohydrate hydrochloride, process for its preparation and pharmaceutical preparation with antiviral, interferon-inducing and immunomodulating action on its basis
DE883891468T Pending DE3891468T1 (en) 1989-01-12 1989-01-12 AETHYL ESTER OF 6-BROM-5-HYDROXY-4-DIMETHYLAMINOMETHYL-1-METHYL-2-PHENYLTHIOMETHYLINDOL-3-CARBONIC ACID OF MONOHYDRATE HYDROGEN CHLORIDE, METHOD FOR ITS PRODUCTION OF INTERMEDIATE CLEANING

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE3891468A Expired - Fee Related DE3891468C2 (en) 1989-01-12 1989-01-12 Ethyl ester of 6-bromo-5-hydroxy-4-dimethylaminomethyl-1-methyl-2-phenylthiomethylindole-3-carboxylic acid monohydrate hydrochloride, process for its preparation and pharmaceutical preparation with antiviral, interferon-inducing and immunomodulating action on its basis

Country Status (10)

Country Link
US (1) US5198552A (en)
BE (1) BE1003341A4 (en)
CH (1) CH678726A5 (en)
DE (2) DE3891468C2 (en)
DK (1) DK15490A (en)
FR (1) FR2650504B1 (en)
GB (1) GB2234510B (en)
NL (1) NL9000265A (en)
SE (1) SE465462B (en)
WO (1) WO1990008135A1 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3891468C2 (en) * 1989-01-12 1994-02-24 Vni Skij Chimiko Farmacevtices Ethyl ester of 6-bromo-5-hydroxy-4-dimethylaminomethyl-1-methyl-2-phenylthiomethylindole-3-carboxylic acid monohydrate hydrochloride, process for its preparation and pharmaceutical preparation with antiviral, interferon-inducing and immunomodulating action on its basis
US5945425A (en) 1994-04-29 1999-08-31 G.D. Searle & Co. Method of using (H+ /K+)ATPase inhibitors as antiviral agents
CN100361975C (en) * 2003-01-04 2008-01-16 沈阳药科大学 Novel 5-hydroxy-3-carboxylate indoles derivant and method for preparing the same
CN1560035A (en) 2004-03-12 2005-01-05 沈阳药科大学 5-hydroxylic indole-3-carboxylic ester kind derivantion
CN100519523C (en) * 2004-03-12 2009-07-29 沈阳药科大学 5-hydroxyindole-3-carboxylate derivative and its use
CN100364975C (en) * 2005-04-26 2008-01-30 武汉大学 Medication for anti virus of respiratory tract and application
CN1316968C (en) * 2005-09-30 2007-05-23 青岛大学 Application of indole-2,3-diketone in preparing medication for antivirus or immunopotenfiator
US8329689B2 (en) 2006-05-23 2012-12-11 Alexandre Vasilievich Ivachtchenko Substituted indoles and a method for the production and use thereof
CN101070319B (en) * 2007-05-29 2012-04-18 沈阳中海生物技术开发有限公司 Crystal state of anti-hepatitis-B-virus compound and its preparing method and use
CN103189354A (en) 2010-07-16 2013-07-03 格林代克斯联合股份公司 Derivatives of 1,4-dihydropyridine possessing antiviral efficacy
CN102786462B (en) * 2011-05-18 2016-08-31 中国医学科学院药物研究所 Arbidol hydrochloride crystal B-type and preparation method are applied with in medicine and health product
CN102786461B (en) * 2011-05-18 2016-08-31 中国医学科学院药物研究所 Arbidol hydrochloride crystalline substance E type and preparation method are applied with in medicine and health product
CN102351778A (en) * 2011-08-17 2012-02-15 湖北华龙生物制药有限公司 Preparation method of arbidol hydrochloride
EP2578218A1 (en) 2011-10-06 2013-04-10 Grindeks, A Joint Stock Company Antiviral efficacy of disodium 2,6-dimethyl-1,4-dihydropyridine-3,5-bis(carbonyloxyacetate) and its derivatives
CN104193669B (en) * 2014-08-01 2016-12-07 大连理工大学 One class Abiduoer analog or its salt, its preparation method and application
CN106083691B (en) * 2016-08-22 2018-11-27 山东罗欣药业集团恒欣药业有限公司 A kind of preparation method of arbidol HCl monohydrate
WO2021209563A1 (en) 2020-04-16 2021-10-21 Som Innovation Biotech, S.A. Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus
CN111533677A (en) * 2020-05-13 2020-08-14 大连万福制药有限公司 Method for synthesizing arbidol hydrochloride intermediate
CN116003308B (en) * 2022-12-27 2023-09-29 石家庄中硕制药有限公司 Abidol crystallization process
CN117586173A (en) * 2023-11-29 2024-02-23 石家庄中硕制药有限公司 Preparation method of arbidol

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4124702A (en) * 1971-07-06 1978-11-07 Merck & Co., Inc. Polynucleotides active as inducers of interferon production in living animal cells
US4215137A (en) * 1978-06-26 1980-07-29 Sterling Drug Inc. Method of alleviating diseases by cell-mediated immune modulation
US4619942A (en) * 1982-04-08 1986-10-28 University Of North Carolina Inhibition of Respiratory Syncytial virus-induced cell fusion by amidino compounds
US5079257A (en) * 1986-04-17 1992-01-07 Speckamp Willem N Indoloquinone compounds
WO1988005432A1 (en) * 1987-01-23 1988-07-28 Yoshitomi Pharmaceutical Industries, Ltd. 5-hydroxyindole-3-carboxamide compound and medicinal use thereof
JPS63188665A (en) * 1987-01-30 1988-08-04 Yoshitomi Pharmaceut Ind Ltd 5-hydroxyindole-3-carboxylic acid ester compound
DE3891468C2 (en) * 1989-01-12 1994-02-24 Vni Skij Chimiko Farmacevtices Ethyl ester of 6-bromo-5-hydroxy-4-dimethylaminomethyl-1-methyl-2-phenylthiomethylindole-3-carboxylic acid monohydrate hydrochloride, process for its preparation and pharmaceutical preparation with antiviral, interferon-inducing and immunomodulating action on its basis

Also Published As

Publication number Publication date
DK15490A (en) 1991-07-20
BE1003341A4 (en) 1992-03-03
DE3891468C2 (en) 1994-02-24
GB9020370D0 (en) 1990-11-21
FR2650504A1 (en) 1991-02-08
GB2234510A (en) 1991-02-06
DK15490D0 (en) 1990-01-19
NL9000265A (en) 1991-09-02
FR2650504B1 (en) 1993-12-24
SE465462B (en) 1991-09-16
SE9000282D0 (en) 1990-01-26
CH678726A5 (en) 1991-10-31
WO1990008135A1 (en) 1990-07-26
GB2234510B (en) 1992-03-25
US5198552A (en) 1993-03-30
SE9000282L (en) 1991-07-27

Similar Documents

Publication Publication Date Title
DE3891468T1 (en) AETHYL ESTER OF 6-BROM-5-HYDROXY-4-DIMETHYLAMINOMETHYL-1-METHYL-2-PHENYLTHIOMETHYLINDOL-3-CARBONIC ACID OF MONOHYDRATE HYDROGEN CHLORIDE, METHOD FOR ITS PRODUCTION OF INTERMEDIATE CLEANING
ATE33494T1 (en) 1,8-NAPHTHYRIDE DERIVATIVES AND PROCESS FOR THEIR PRODUCTION.
DE69631305D1 (en) Process for the production of polylactic acid
DE69224562D1 (en) Process for the production of steel bars for cold working
AT363195B (en) METHOD FOR PRODUCING N-SUBSTITUTED 9,10-DIHYDROLYSIC ACID ESTERS
DE69233106D1 (en) Process for the production of single-stranded "stem-loop" DNS
DE69122936D1 (en) Process for the production of sialic acid
FI98067C (en) Novel alkylenediammonium diclavulanate derivatives, process for their preparation as well as their use for the purification of calvulanic acid
DE69513138D1 (en) Process for the production of nickel-based superalloys
DE69225702T2 (en) Process for the production of compact cleaning agents
DE69004648D1 (en) Process for the preparation of alpha-hydroxycarboxylic acid amides.
DE69004582T2 (en) Process for the preparation of alpha-hydroxycarboxylic acid amide.
DE69208208D1 (en) METHOD FOR PRODUCING PURIFIED NAPHTHALEDICARBONIC ACID DIMETHYLESTER
DE69029078D1 (en) METHOD FOR THE CONTINUOUS PRODUCTION OF ELASTIC POLYESTERS
DE59001820D1 (en) METHOD FOR THE PRODUCTION OF INDOLCARBONIC ACID DERIVATIVES.
DE69519799D1 (en) METHOD FOR THE PRODUCTION OF [S, S] -ETHYLENE DIAMINE-N, N'-DIBERONIC ACID
ATE189220T1 (en) METHOD FOR PRODUCING 7-(3-AMINO- AND 3-AMINOMETHYL-1-PYRROLIDINYL)-3-QUINOLOONE CARBOXYLIC ACIDS AND NAPHTHYRIDONE CARBOXYLIC ACIDS
DE69113323D1 (en) Process for the preparation of alpha-hydroxycarboxylic acid amides.
DE69418054T2 (en) Process for the production of carbonic acid diesters
DE69221024D1 (en) Process for the preparation of ascorbic acid esters or erythorbic acid esters
DE59308496D1 (en) Improved process for the production of R / S-gamma-lipoic acid or R / S-alpha-lipoic acid
DE59205377D1 (en) Microbiological process for the production of 5-hydroxypyrazine carboxylic acid
DE69509822D1 (en) Process for the preparation of ascorbic acid derivatives
DE69122550D1 (en) Process for the production of fatty acid
DE69218736T2 (en) New process for the production of 4-amino-5-hexenoic acid