DE3880566T2 - Verfahren zur Isomerisierung von trans-2-Methylspiro-(1,3-oxathiolan-5,3')-chinuklidin oder Säureadditionsalzen davon. - Google Patents

Verfahren zur Isomerisierung von trans-2-Methylspiro-(1,3-oxathiolan-5,3')-chinuklidin oder Säureadditionsalzen davon.

Info

Publication number
DE3880566T2
DE3880566T2 DE88110895T DE3880566T DE3880566T2 DE 3880566 T2 DE3880566 T2 DE 3880566T2 DE 88110895 T DE88110895 T DE 88110895T DE 3880566 T DE3880566 T DE 3880566T DE 3880566 T2 DE3880566 T2 DE 3880566T2
Authority
DE
Germany
Prior art keywords
methylspiro
oxathiolane
quinuclidine
isomerization
trans
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE88110895T
Other languages
English (en)
Other versions
DE3880566D1 (de
Inventor
Takahiro Ishihara Sangyo Haga
Toru Ishihara Sangyo Koyanagi
Kazutoshi Ishihara Sangyo Hara
Masaru Ishihara Sangyo K Maeda
Itaru Ishihara Sangy Shigehara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ishihara Sangyo Kaisha Ltd
Daiichi Sankyo Co Ltd
Original Assignee
Ishihara Sangyo Kaisha Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP62172451A external-priority patent/JP2529576B2/ja
Priority claimed from JP62202170A external-priority patent/JP2529577B2/ja
Priority claimed from JP63007020A external-priority patent/JPH0816111B2/ja
Application filed by Ishihara Sangyo Kaisha Ltd filed Critical Ishihara Sangyo Kaisha Ltd
Publication of DE3880566D1 publication Critical patent/DE3880566D1/de
Application granted granted Critical
Publication of DE3880566T2 publication Critical patent/DE3880566T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D497/20—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE88110895T 1987-07-10 1988-07-07 Verfahren zur Isomerisierung von trans-2-Methylspiro-(1,3-oxathiolan-5,3')-chinuklidin oder Säureadditionsalzen davon. Expired - Lifetime DE3880566T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP62172451A JP2529576B2 (ja) 1987-07-10 1987-07-10 トランス型２−メチルスピロ（１，３−オキサチオラン−５，３▲’▼）キヌクリジンの異性化方法
JP18011987 1987-07-21
JP62202170A JP2529577B2 (ja) 1987-08-13 1987-08-13 トランス型２−メチルスピロ（１，３−オキサチオラン−５，３▲’▼）キヌクリジン又はこれらの酸付加塩の異性化方法
JP63007020A JPH0816111B2 (ja) 1987-07-21 1988-01-18 トランス型２−メチルスピロ（１，３−オキサチオラン−５，３’）キヌクリジン又はこれらの酸付加塩の異性化方法

Publications (2)

Publication Number Publication Date
DE3880566D1 DE3880566D1 (de) 1993-06-03
DE3880566T2 true DE3880566T2 (de) 1993-12-09

Family

ID=27454612

Family Applications (1)

Application Number Title Priority Date Filing Date
DE88110895T Expired - Lifetime DE3880566T2 (de) 1987-07-10 1988-07-07 Verfahren zur Isomerisierung von trans-2-Methylspiro-(1,3-oxathiolan-5,3')-chinuklidin oder Säureadditionsalzen davon.

Country Status (5)

Country Link
US (1) US4861886A (de)
EP (1) EP0298491B1 (de)
CA (1) CA1331183C (de)
DE (1) DE3880566T2 (de)
ES (1) ES2054739T3 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5571918A (en) * 1994-05-19 1996-11-05 Ishihara Sangyo Kaisha Ltd. Method for producing 2-methylspiro(1,3-oxathiolane-5,3')quinuclidine
JP4447685B2 (ja) * 1999-01-14 2010-04-07 第一三共株式会社 皮膚乾燥症治療剤
US8080663B2 (en) * 2007-04-04 2011-12-20 Apotex Pharmachem Inc Process for the preparation of 2-methylspiro(1,3-oxathiolane-5,3′)quiniclidine
US8143400B2 (en) * 2008-01-10 2012-03-27 Apotex Pharmachem Inc. Process for the preparation and purification of cis-2-methylspiro(1,3-oxathiolane-5,3′)quiniclidine hydrochloride
US8450487B2 (en) 2010-06-08 2013-05-28 Apicore, Llc Process for the preparation of cis-2-methylspiro (1,3-oxathiolane 5-3′) quinuclidine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4054582A (en) * 1976-07-06 1977-10-18 Eli Lilly And Company Process for converting cis-hexahydrodibenzo[b,d]pyran-9-ones to trans-hexahydrodibenzo[b,d]-pyran-9-ones
US4473703A (en) * 1981-03-30 1984-09-25 Sumitomo Chemical Company, Limited Method of epimerization of alkyl chrysanthemate
US4855290A (en) * 1985-05-10 1989-08-08 State Of Israel, Represented By Prime Minister's Office, Israel Institute For Biological Research Derivatives of quinuclidine

Also Published As

Publication number Publication date
EP0298491A1 (de) 1989-01-11
EP0298491B1 (de) 1993-04-28
DE3880566D1 (de) 1993-06-03
ES2054739T3 (es) 1994-08-16
US4861886A (en) 1989-08-29
CA1331183C (en) 1994-08-02

Similar Documents

Publication Publication Date Title
DE3889393T2 (de) Verfahren zur Herstellung von 2,2,6,6-Tetramethyl-4-piperidylaminen.
DE3852381D1 (de) Verfahren zur Herstellung von para-Ethylphenol.
ATE58529T1 (de) Verfahren zur herstellung von 2,2,6,6,-tetraalkyl-4-piperidylamine.
ATE60583T1 (de) Verfahren zur herstellung von 2,2,6,6-tetraalkyl- 4-piperidylaminen.
DE3672942D1 (de) Verfahren zur herstellung von tetrafluorbenzoesaeure.
DE68906562T2 (de) Verfahren zur Kristallisierung von Bisphenol-A-phenol-Addukt.
DE3879049T2 (de) Verfahren zur Herstellung von Penizillan-Säurederivaten.
DE3850230T2 (de) Verfahren zur Herstellung von Alkylthioethylaminsalzen.
DE3880566T2 (de) Verfahren zur Isomerisierung von trans-2-Methylspiro-(1,3-oxathiolan-5,3')-chinuklidin oder Säureadditionsalzen davon.
ATE59634T1 (de) Verfahren zur herstellung von dialkyldisulfiden.
DE68920948D1 (de) Verfahren zur Racemisierung von Tetrahydrfuran-2-carbonsäure.
ATE88709T1 (de) Verfahren zur isomerisierung von trans-2methylspiro-(1,3-oxathiolan-5,3')-chinuklidin oder saeureadditionsalzen davon.
DE3885542D1 (de) Verfahren zur Herstellung von Bisphenol-bisacrylaten.
DE3883186T2 (de) Verfahren zur Herstellung von Zinksalz der Salizylsäureverbindung.
ATE49222T1 (de) Verfahren zur herstellung von elastischen formkoerpern.
DE3851376D1 (de) Verfahren zur Herstellung von Triphendioxazinverbindungen.
DE68922361D1 (de) Verfahren zur Herstellung von 2,6-Naphthalendicarbonsäure.
DE68909118T2 (de) Verfahren zur Ausscheidung von 2,6-Dimethylnaphthalin.
DE3881103T2 (de) Verfahren zur Herstellung von 1,3,2-Oxazaphosphorinan.
DE59007620D1 (de) Verfahren zur Herstellung von 3-Methylchinolin-8-carbonsäure.
DE3862402D1 (de) Verfahren zur herstellung von 2,3,5,6-tetrafluorbenzoesaeure.
DE68905413T2 (de) Verfahren zur Herstellung von Alkalimetallsalz von 2,3,6,7-Naphthalintetracarbonsäure.
DE69020091D1 (de) Verfahren zur Herstellung von 2-Trifluormethyl-4-hydroxybenzoesäure.
DE68905673T2 (de) Verfahren zur Ausscheidung von 2,6-Dimethylnaphthalin.
ATE77363T1 (de) Verfahren zur herstellung von dichlorbernsteinsaeuredialkylestern.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: ISHIHARA SANGYO KAISHA LTD., OSAKA, JP SNOW BRAND

8327 Change in the person/name/address of the patent owner

Owner name: ISHIHARA SANGYO KAISHA LTD., OSAKA, JP DAIICHI PHA

8327 Change in the person/name/address of the patent owner

Owner name: DAIICHI SANKYO CO., LTD., TOKYO, JP

Owner name: ISHIHARA SANGYO KAISHA LTD., OSAKA, JP