DE3865863D1 - - Google Patents

Info

Publication number
DE3865863D1
DE3865863D1 DE88730061T DE3865863T DE3865863D1 DE 3865863 D1 DE3865863 D1 DE 3865863D1 DE 88730061 T DE88730061 T DE 88730061T DE 3865863 T DE3865863 T DE 3865863T DE 3865863 D1 DE3865863 D1 DE 3865863D1
Authority
DE
Germany
Prior art keywords
radical
hydrogen atom
alkyl radical
image
bond
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE88730061T
Other languages
German (de)
Inventor
Dr. Eckhard W-1000 Berlin 44 De Ottow
Prof. Dr. Rudolf W-1000 Berlin 39 De Wiechert
Dr. Guenter W-1000 Berlin 15 De Neef
Dr. Sybille W-1000 Berlin 31 De Beier
Dr. Walter W-1000 Berlin 33 De Elger
Dr. David Andrew W-1000 Berlin 28 De Henderson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Priority to DE88730061T priority Critical patent/DE3865863D1/de
Application granted granted Critical
Publication of DE3865863D1 publication Critical patent/DE3865863D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0057—Nitrogen and oxygen
    • C07J71/0063—Nitrogen and oxygen at position 2(3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only
    • C07J71/0047—Nitrogen only at position 2(3)

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Separation By Low-Temperature Treatments (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • External Artificial Organs (AREA)

Abstract

New 19,11 beta -bridged steroids of the general formula I <IMAGE> (I) where R1 stands for a methyl or ethyl radical, R2 for a hydrogen or chlorine atom or a C1-C4-alkyl radical, B and G, which are the same or different, respectively for a hydrogen atom, a C1-C4-alkyl radical or, together, for a second bond between the carbon atoms 6 and 7, B and R2 together for a methylene or an ethylene group, Z for the radical of a pentagonal or hexagonal ring, which is possibly substituted and possibly unsaturated, V stands for a possibly substituted carbocyclic or heterocyclic aryl radical, the ring A for <IMAGE> a) M and N together meaning a second bond or M a hydrogen atom and N a hydroxy group, X means an oxygen atom, two hydrogen atoms or a hydroxyimino grouping N DIFFERENCE OH, R3 and D, which are the same or different, respectively a hydrogen atom, a nitrile radical or a C1-C4-alkyl radical or, together, a methylene or ethylene group, E a hydrogen atom or a C1-C4-alkyl radical, D and E together meaning a second bond between carbon atoms 1 and 2 or together a methylene group <IMAGE> b) or <IMAGE> c) with R11 in the meaning of a hydrogen atom or a C1-C8-alkyl radical, are described as well as their pharmaceutically tolerated addition salts with acids. The new compounds possess valuable pharmacological properties.
DE88730061T 1987-03-18 1988-03-11 Expired - Lifetime DE3865863D1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE88730061T DE3865863D1 (en) 1987-03-18 1988-03-11

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19873708942 DE3708942A1 (en) 1987-03-18 1987-03-18 19.11SS-BRIDGED STEROIDS, THEIR PRODUCTION AND THEIR PHARMACEUTICAL PREPARATIONS CONTAINING THEM
DE88730061T DE3865863D1 (en) 1987-03-18 1988-03-11

Publications (1)

Publication Number Publication Date
DE3865863D1 true DE3865863D1 (en) 1991-12-05

Family

ID=6323462

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19873708942 Withdrawn DE3708942A1 (en) 1987-03-18 1987-03-18 19.11SS-BRIDGED STEROIDS, THEIR PRODUCTION AND THEIR PHARMACEUTICAL PREPARATIONS CONTAINING THEM
DE88730061T Expired - Lifetime DE3865863D1 (en) 1987-03-18 1988-03-11

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE19873708942 Withdrawn DE3708942A1 (en) 1987-03-18 1987-03-18 19.11SS-BRIDGED STEROIDS, THEIR PRODUCTION AND THEIR PHARMACEUTICAL PREPARATIONS CONTAINING THEM

Country Status (19)

Country Link
US (1) US5095129A (en)
EP (1) EP0283428B1 (en)
JP (1) JP2588267B2 (en)
CN (3) CN1033033C (en)
AT (1) ATE69055T1 (en)
AU (1) AU628015B2 (en)
CA (1) CA1326015C (en)
DD (1) DD273262A5 (en)
DE (2) DE3708942A1 (en)
ES (1) ES2040373T3 (en)
FI (1) FI101883B (en)
GR (1) GR3003362T3 (en)
HU (2) HU206368B (en)
IE (1) IE62480B1 (en)
IL (1) IL85773A (en)
NZ (1) NZ223924A (en)
PT (1) PT87007B (en)
WO (1) WO1988007051A1 (en)
ZA (1) ZA881962B (en)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5446178A (en) * 1987-03-18 1995-08-29 Schering Aktiengesellschaft Process for preparing 19,11β-bridged steroids
DE3832303A1 (en) * 1988-09-20 1990-04-12 Schering Ag 11SS-PHENYL-14SSH STEROIDS
DE3917274A1 (en) * 1989-05-24 1990-11-29 Schering Ag 9 (ALPHA) -HYDROXY-19, 11 (BETA) -BRIDGED STEROIDS, THEIR PRODUCTION AND THEIR PHARMACEUTICAL PREPARATIONS CONTAINING THEM
DE3921059A1 (en) * 1989-06-23 1991-01-10 Schering Ag 11 (BETA) -ARYL-4-ESTRENE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A MEDICINAL PRODUCT
DD289541A5 (en) * 1989-08-04 1991-05-02 ��@�K@�������������@�K@��������������@��������k�� PROCESS FOR THE PREPARATION OF 11BETA-ARYL-16 ALPHA, 17 ALPH-CYCLOHEXANOESTRA-4,9-DIENES
DE4038128A1 (en) * 1990-11-27 1992-06-04 Schering Ag 8-EN-19, 11 (BETA) BRIDGED STEROIDS, THEIR PRODUCTION AND THEIR PHARMACEUTICAL PREPARATIONS CONTAINING THEM
US5439913A (en) * 1992-05-12 1995-08-08 Schering Aktiengesellschaft Contraception method using competitive progesterone antagonists and novel compounds useful therein
DE4235220A1 (en) * 1992-10-13 1994-06-16 Schering Ag Gestagen effective 19,11ß-bridged 4-estrene
DE4413184A1 (en) * 1994-04-12 1995-10-19 Schering Ag 10.11-C¶3¶-bridged steroids
DE4413185A1 (en) * 1994-04-12 1995-10-19 Schering Ag 11beta, 19-bridged 13alpha alkyl steroids
DE4417880A1 (en) * 1994-05-18 1995-11-23 Schering Ag 19,11beta-bridged 18-nor steroids, process for their preparation, medicinal products containing these steroids and their use in the manufacture of medicinal products
US5639598A (en) * 1994-05-19 1997-06-17 The Trustees Of The University Of Pennsylvania Method and kit for identification of antiviral agents capable of abrogating HIV Vpr-Rip-1 binding interactions
US5780220A (en) * 1994-05-19 1998-07-14 Trustees Of The University Of Pennsylvania Methods and compositions for inhibiting HIV replication
DE4424222C1 (en) * 1994-07-09 1995-09-14 Metallgesellschaft Ag Stable solns of methyl lithium
DE4434488A1 (en) * 1994-09-14 1996-03-21 Schering Ag Steroid esters and amides, processes for their preparation and their pharmaceutical use
US5521166A (en) * 1994-12-19 1996-05-28 Ortho Pharmaceitical Corporation Antiprogestin cyclophasic hormonal regimen
ZA9510926B (en) 1994-12-23 1996-07-03 Schering Ag Compounds with progesterone-antagonistic and antiestrogenic action to be used together for female contraception
IL118974A (en) * 1995-08-17 2001-09-13 Akzo Nobel Nv 11-(substituted phenyl)-estra-4,9-diene derivatives, their preparation and pharmaceutical compositions containing them
DE19652408C2 (en) * 1996-12-06 2002-04-18 Schering Ag Steroid esters, processes for their preparation and their use in the manufacture of medicinal products
US6090798A (en) * 1997-12-19 2000-07-18 Alcon Laboratories, Inc. Treatment of GLC1A glaucoma with glucocorticoid antagonists
GB0000313D0 (en) * 2000-01-10 2000-03-01 Astrazeneca Uk Ltd Formulation
SI3263112T1 (en) 2006-10-24 2020-10-30 Allergan Pharmaceuticals International Limited Compositions and methods for suppressing endometrial proliferations
TWI539953B (en) 2008-04-28 2016-07-01 瑞波若斯治療學公司 Compositions and methods for treating breast cancer
WO2011119194A1 (en) 2010-03-22 2011-09-29 Repros Therapeutics Inc. Compositions and methods for non-toxic delivery of antiprogestins
WO2011150209A1 (en) 2010-05-26 2011-12-01 Corcept Therapeutics, Inc. Treatment of muscular dystrophy
CN103555806B (en) * 2013-11-16 2015-05-13 江南大学 Method for synthesizing 7alpha-hydroxy-androstenone by efficient utilization of colletotrichum lini
CN107530435A (en) 2015-03-02 2018-01-02 科赛普特治疗学股份有限公司 Use glucocorticoid receptor antagonists and Somatostatin in Treating ACTH secreting type tumours
KR102495223B1 (en) 2015-03-30 2023-02-01 코어셉트 쎄라퓨틱스 인코포레이티드 Use of a glucocorticoid receptor antagonist in combination with a glucocorticoid for the treatment of adrenal insufficiency
CA2994422A1 (en) 2015-08-13 2017-02-16 Corcept Therapeutics, Inc. Method for differentially diagnosing acth-dependent cushing's syndrome
SG11201806101SA (en) 2016-01-19 2018-08-30 Corcept Therapeutics Inc Differential diagnosis of ectopic cushing's syndrome
EP3641780A4 (en) 2017-06-20 2021-02-24 Corcept Therapeutics, Inc. Methods of treating neuroepithelial tumors using selective glucocorticoid receptor modulators
AU2021400069A1 (en) 2020-12-18 2023-07-06 Instil Bio (Uk) Limited Processing of tumor infiltrating lymphocytes

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA8231B (en) * 1981-01-09 1982-11-24 Roussel Uclaf New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained
FR2522328B1 (en) * 1982-03-01 1986-02-14 Roussel Uclaf NEW PRODUCTS DERIVED FROM THE STRUCTURE 3-CETO 4,9 19-NOR STEROIDS, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICAMENTS
FR2576025B1 (en) * 1985-01-14 1987-01-23 Roussel Uclaf NOVEL SUBSTITUTED STEROIDS IN POSITION 10, THEIR PROCESS AND THE PREPARATION INTERMEDIATES, THEIR APPLICATION AS MEDICAMENTS, THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Also Published As

Publication number Publication date
EP0283428B1 (en) 1991-10-30
FI894364A0 (en) 1989-09-15
DE3708942A1 (en) 1988-09-29
NZ223924A (en) 1991-12-23
CN1135488A (en) 1996-11-13
IE880793L (en) 1988-09-18
HU210532A9 (en) 1995-04-28
ES2040373T3 (en) 1993-10-16
FI101883B1 (en) 1998-09-15
AU1420988A (en) 1988-10-10
PT87007A (en) 1988-04-01
US5095129A (en) 1992-03-10
ZA881962B (en) 1988-09-08
CN1057770C (en) 2000-10-25
GR3003362T3 (en) 1993-02-17
PT87007B (en) 1992-06-30
HU206368B (en) 1992-10-28
ATE69055T1 (en) 1991-11-15
FI101883B (en) 1998-09-15
IL85773A0 (en) 1988-09-30
CN1033033C (en) 1996-10-16
HU911518D0 (en) 1991-11-28
IE62480B1 (en) 1995-02-08
CA1326015C (en) 1994-01-11
CN88102162A (en) 1988-11-23
EP0283428A1 (en) 1988-09-21
CN1080267C (en) 2002-03-06
AU628015B2 (en) 1992-09-10
IL85773A (en) 1994-01-01
DD273262A5 (en) 1989-11-08
JP2588267B2 (en) 1997-03-05
WO1988007051A1 (en) 1988-09-22
CN1141926A (en) 1997-02-05
JPH02503194A (en) 1990-10-04

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: SCHERING AG, 13353 BERLIN, DE

8330 Complete renunciation