DE3836519C2 - Use of a pharmaceutical preparation based on Calendula officinalis for the treatment of psoriasis - Google Patents

Description

The present invention relates to the use of a pharmaceutical preparation based on Calendula officinalis.

The use of Calendula officinalis in pharmaceutical preparations and in cosmetics is already known.

So far, either Calendula officinalis or the marigold flowers (Flores Calendulae) or the marigold herb (Herba Calendulae) or Calendula oil, d. H. a fat oil extract from the Flowers of Calendula officinalis or in shape of alcoholic extracts and flower infusions used (Hagers manual of pharmaceutical Praxis, by P.H. List and L. Hörhammer, third  Volume, page 603 ff., Berlin, Heidelberg, New York, 1972 and Römpps chemistry lexicon, 8th edition, Stuttgart, 1985, page 577).

In case of using Flores Calendulae are collected at the heyday, dried, whole or partially decayed Flower heads used, and earlier at Scrofulosis and cancer, as beauty products as well internally similar in inflammatory processes Arnica, in the form of ointments for the treatment of Sores and poorly healing ulcers, in the Dentistry, in homeopathy for cracked, fresh and old injuries and ulcers cruris, in folk medicine as Diaphoreticum, Diureticum, Antispasmodicum, Anthelminticum, Laxans, Emmenagogum and Abortivum, furthermore at Liver disease and typhoid fever.

Herba Calendulae was used in folk medicine earlier as a sweaty agent, for lifting metabolism and used as a wound dressing.

Calendula oil is a reddish yellow oil Herbal smell, which is used in skin cosmetics Promotion of epithelial formation, formerly also for Therapy of inflammatory processes of the skin and Mucous membranes are used has been.

In the form of alcoholic extracts and Flower infusions became Calendula officinalis Envelopes and applied in ointments.

DE-OS 35 40 635 is already a cosmetic cal means known, characterized by  is that there is at least one in a fat carrier Substance with a reddening effect, at least with an oil-soluble plant extract slimming effect from u. a. Marigold and at least one volatile organopolysiloxane contains.

From DE-OS 19 31 467 is an ointment for Treatment of congestion of the lymphatic system known, characterized by a content of various active ingredients, including u. a. one Concentrate Calendulae, preferably in one Quantity from 1.2 to 4.0%.

DE-OS 34 32 793 is a cosmetic Known preparation, in particular for Serve aftercare of seborrhea and acne and which is optionally dried Marigolds can be used preferably in an amount of 10-40 Parts by weight.

From Czetsch-Lindenwald: Vegetable Pharmaceutical preparations, South German pharmacists newspaper, Stuttgart, 1945, page 115 is already a calendula ointment known from fresh Flowers is made. Also from R. Hänsel, H. Haas: Therapy with phytopharmaceuticals, Springer, Berlin 1983, pages 268-270 and R.F. White: Textbook of phytotherapy, Hippocrates, Stuttgart 1985, pages 423, 409 and 410 it is already known that the whole flower heads with the green goblet in pharmacy be used.

P.H. List and P.C. Schmidt: Technology  herbal medicinal preparations, Wiss. Verlagsgesellschaft mbH Stuttgart, 1984, pages 92, 93, 36, 37, 226 and 227 describe this so-called "enfleurage á chaud" process, at which melted fats, e.g. Belly Vaseline, used for the extraction.

Milking fats are ointment-like Preparations (including emulsions) that are used as Lubricant between the hands of the milker and serve the cow udder.

All pharmaceuticals used so far Preparations based on calendula officinalis have the disadvantage that they Skin diseases, especially psoriasis none or at least not the desired effect exhibit.

It is an object of the present invention therefore, a pharmaceutical preparation too create that successful in psoriasis can be used.

This object is achieved by a pharmaceutical preparation solved as Active ingredient left fresh from the cut Basket inflorescences from Calendula officinalis contains.

Preferably the end product is the following Process used:

• a) 500 g of milking fat as an ointment base are heated to the melting point,  
• b) then 100-400 g fresh cut, d. H. before a maximum of 2 Hours cut, externally dry inflorescence from Calendula officinalis in the straight Milking fat that has become liquid is entered and the mixture to distribute the Basket inflorescences stirred,
• c) then the mixture at Room temperature 24-36 hours ditched,
• d) then the mixture is again until heated to the melting point, the Milk-soaked basket inflorescences separated and by means of a Passier sieve pressed out and so obtained pressed product is with the liquid mixture combined and in this spread by stirring while the press residue (press cake) is discarded
• e) finally the mixture filtered and that as a filtrate final product obtained in portions bottled and at room temperature cooled down.

Calendula officinalis medicina is preferred used. But it can also be calendula officinalis fl. pl. or Calendula officinalis L. be used.

The milking fat used can  made of pure petroleum jelly (white or yellow Vaseline), but preferably 99.4 % By weight of petroleum jelly and 0.6% by weight of benzoates long chain fatty amines from palm kernel and Coconut fats, mainly dodecylammonium benzoates and tetradecylbenzoates.

The applicable milking greases should preferably be odorless and tasteless be and stay, good gliding and have an even, soft ointment texture, do not melt below 40 ° C, completely in ether be soluble and neutral against litmus respond, essentially no reducing organic substances and no saponifiable fats and contain resins as well as after two months Storage at ordinary room temperature still appear unchanged and as much germicidal as possible Have properties.

One can also be used Mixture of 70% by weight yellow petroleum jelly, 20% by weight Paraffin oil and 10% by weight paraffin. Can also be used according to the invention Emulsions with 30-50 wt .-% water.

Preferably that Milking fat to be used, bactericidal additives included, such as those above mentioned benzoates of long-chain fatty amines Palm kernel and coconut fats.

The weight ratio is preferably Milking fat for Calendula officinalis 500 for 150-200. Optimal results are achieved when the weight ratio of milking fat to calendula  officinalis is 500 to 175.

The pharmaceutical preparation is according to the invention used to treat psoriasis. Fungal diseases, Eczema, eczema, seborrhea and acne be treated.

The following is a production example of the preparation used according to the invention described:

In a 2 liter reaction flask equipped with a magnetic stirrer and thermometer, was 1 kg Milking grease entered and melted (49 ° C) heated. Thereupon, 350 g became external dry basket inflorescences from Calendula officinalis medicina half a year ago Hour had been cut into the liquid Milking fat has entered and the mixture stirred to distribute the basket inflorescences. The mixture was then added to Room temperature left for 30 hours. Then the mixture was again up to the melting point heated, the milking fat soaked basket inflorescences separated and by means of a strainer and a passierholz pressed out and so obtained pressed product with the liquid mixture combined and distributed in this by stirring. The press residue (press cake) was discarded. Finally, the mixture was mixed using a sterile filter and the filtrate in portions in sterile 300 g plastic jars bottled and through to room temperature Let it cool down.  

Toxic side effects of pharmaceutical No preparation has been observed. In extremely rare cases can be a Marigold allergy occur, leading to temporarily suspend treatment can.

The average dosage is approximately 0.8 g per dm ^{2 of} skin. The skin areas to be treated are preferably treated twice a day (morning and evening) and after each washing of the affected areas.

Claims (1)

Use of a pharmaceutical preparation, ent The basket remains fresh as an active ingredient inflorescences of Calendula officinalis with milking fat as an ointment base for the treatment of psoriasis.