DE3814910A1 - Process for the preparation of lipoid ethylcellulose gels and pharmaceutical, cosmetic and industrial use thereof - Google Patents
Process for the preparation of lipoid ethylcellulose gels and pharmaceutical, cosmetic and industrial use thereofInfo
- Publication number
- DE3814910A1 DE3814910A1 DE19883814910 DE3814910A DE3814910A1 DE 3814910 A1 DE3814910 A1 DE 3814910A1 DE 19883814910 DE19883814910 DE 19883814910 DE 3814910 A DE3814910 A DE 3814910A DE 3814910 A1 DE3814910 A1 DE 3814910A1
- Authority
- DE
- Germany
- Prior art keywords
- lipoid
- gels
- preparation
- cosmetic
- pharmaceutical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/342—Alcohols having more than seven atoms in an unbroken chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/54—Polymers characterized by specific structures/properties
- A61K2800/542—Polymers characterized by specific structures/properties characterized by the charge
- A61K2800/5422—Polymers characterized by specific structures/properties characterized by the charge nonionic
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Dispersion Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Abstract
Description
Die Herstellung lipoider Gele erfolgt im allgemeinen in der Form, daß bestimmte anorganische Gelbildner, wie beispielsweise hochdisperses Siliciumdioxid, in lipoiden Lösungsmitteln dispergiert werden. Ein anderes grundsätzliches Verfahren besteht darin, daß man Polymere wie etwa Polyethylen bei hoher Temperatur in Paraffin löst und dann einem Kälte schock unterwirft. Das dabei wieder erstarrte Poly ethylen bildet im Paraffin eine Matrix, die zu einem Gelzustand führt. Ein weiteres Verfahren zur Bildung lipoider Gele besteht darin, feste Wachse wie etwa Bienenwachs, in lipoiden Lösungsmitteln zu disper gieren. Lipoid gels are generally prepared in the form that certain inorganic gelling agents, such as highly disperse silicon dioxide, be dispersed in lipoid solvents. A another basic procedure is that polymers such as polyethylene at high Temperature dissolves in paraffin and then a cold subject to shock. The solidified poly again ethylene forms a matrix in the paraffin, which leads to a Gel state leads. Another method of education Lipoid gels consist of solid waxes such as Beeswax to disper in lipoid solvents yaw.
Es ist bisher nicht bekannt, daß man mit partial synthetischen Cellulosederivaten eine Gelbildung in lipoiden Lösungsmitteln vollziehen kann.It is not yet known that partial synthetic cellulose derivatives gelation in can perform lipoid solvents.
Überraschenderweise wurde gefunden, daß Alkylether der Cellulose, insbesondere Ethylcellulose, in Hydroxyl gruppen-haltigen, lipoiden Lösungsmitteln Gelsysteme bilden.Surprisingly, it was found that alkyl ethers cellulose, especially ethyl cellulose, in hydroxyl group-containing, lipoid solvents gel systems form.
Bei der Herstellung solcher Gele geht man im allgemeinen so vor, daß die Ethylcellulose bei Temperaturen bis zu etwa 150°C unter Rühren in lipoiden Lösungsmitteln gelöst wird. Als Lösungsmittel kommen beispielsweise in Betracht:In general, such gels are manufactured so that the ethyl cellulose at temperatures up to to about 150 ° C with stirring in lipoid solvents is solved. Examples of suitable solvents are: considered:
Die flüssigen, gesättigten Fettalkohole C8 bis C10 (z. B. LOROL C8, Henkel, LOROL C10, Henkel) oder der verzweigte Fettalkohol 2-Octyldodecanol (z. B. EUTANOL G, Henkel) oder der ungesättigte Fettalkohol Oleylalkohol (z. B. HD-EUTANOL, Henkel).The liquid, saturated fatty alcohols C 8 to C 10 (e.g. LOROL C8, Henkel, LOROL C10, Henkel) or the branched fatty alcohol 2-octyldodecanol (e.g. EUTANOL G, Henkel) or the unsaturated fatty alcohol oleyl alcohol (e.g. B. HD-EUTANOL, Henkel).
Als weitere Lösungsmittel sind Hydroxylgruppen-haltige
Fettsäureglyceride wie beispielsweise Rizinusöl (DAB 9)
oder etherische Öle oder Riechstoffe verwendbar. Den
so erhaltenen Gelen können zur Konsistenzverbesserung
andere lipoide Medien wie beispielsweise Fettsäure
glyceride oder Paraffine oder Fettsäureester (Wachse)
hinzugefügt werden. Die wie vorstehend beschriebenen
lipoiden Gele lassen sich als solche oder nach Ein
arbeitung von Wirkstoffen für pharmazeutische oder
kosmetische oder technische Zwecke verwenden.
Hydroxyl group-containing fatty acid glycerides such as castor oil (DAB 9) or essential oils or fragrances can be used as further solvents. To improve the consistency, other lipoid media such as, for example, fatty acid glycerides or paraffins or fatty acid esters (waxes) can be added to the gels thus obtained. The lipoid gels as described above can be used as such or after the incorporation of active ingredients for pharmaceutical or cosmetic or technical purposes.
Die folgenden Beispiele erläutern die Erfindung:The following examples illustrate the invention:
1 g bis 30 g Ethylcellulose werden in ca. 30 g Oleyl alkohol dispergiert, mit Oleylalkohol zu 100 g er gänzt und bei einer Temperatur von etwa 100°C bis zur vollständigen Lösung der Ethylcellulose gerührt. Nach dem Abkühlen werden transparente Gele erhalten.1 g to 30 g of ethyl cellulose are in about 30 g of oleyl alcohol dispersed with oleyl alcohol to 100 g complete and at a temperature of about 100 ° C to stirred to completely dissolve the ethyl cellulose. After cooling, transparent gels are obtained.
1 g bis 30 g Ethylcellulose werden in ca. 30 g 2-Octyl dodecanol dispergiert, mit 2-Octyldodecanol zu 100 g ergänzt und bei einer Temperatur von etwa 100°C bis zur vollständigen Auflösung der Ethyl cellulose gerührt. Nach dem Abkühlen werden leicht opaleszierende Gele erhalten.1 g to 30 g of ethyl cellulose are in about 30 g of 2-octyl dispersed dodecanol with 2-octyldodecanol 100 g supplemented and at a temperature of about 100 ° C until the ethyl has completely dissolved stirred cellulose. After cooling, become light Obtain opalescent gels.
1 g bis 15 g Ethylcellulose werden in ca. 30 g 2-Octyl dodecanol dispergiert, mit 2-Octyldodecanol zu 50 g ergänzt und bei einer Temperatur von etwa 100°C bis zur vollständigen Auflösung der Ethylcellulose gerührt. Die so erhaltene Lösung wird bei einer Temperatur von etwa 100°C mit 50 g flüssigem Paraffin, das auf die gleiche Temperatur erwärmt wurde, gemischt. Nach dem Abkühlen der Mischung wird ein transparentes Gel erhalten. 1 g to 15 g of ethyl cellulose are in about 30 g of 2-octyl dispersed dodecanol, with 2-octyldodecanol at 50 g added and at a temperature of about 100 ° C until the ethyl cellulose is completely dissolved touched. The solution thus obtained is at a Temperature of about 100 ° C with 50 g of liquid Paraffin that warms to the same temperature was mixed. After the mixture has cooled a transparent gel is obtained.
1. Ethylcellulose1. ethyl cellulose
R=-C₂H₅ oder -H
2. OleylalkoholR = -C₂H₅ or -H
2. Oleyl alcohol
CH₃(CH₂)₇CH=CH(CH₂)₇CH₂-OHCH₃ (CH₂) ₇CH = CH (CH₂) ₇CH₂-OH
3. 2-Octyldodecanol3. 2-octyldodecanol
Claims (5)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19883814910 DE3814910A1 (en) | 1988-05-03 | 1988-05-03 | Process for the preparation of lipoid ethylcellulose gels and pharmaceutical, cosmetic and industrial use thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19883814910 DE3814910A1 (en) | 1988-05-03 | 1988-05-03 | Process for the preparation of lipoid ethylcellulose gels and pharmaceutical, cosmetic and industrial use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3814910A1 true DE3814910A1 (en) | 1989-11-16 |
Family
ID=6353430
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19883814910 Withdrawn DE3814910A1 (en) | 1988-05-03 | 1988-05-03 | Process for the preparation of lipoid ethylcellulose gels and pharmaceutical, cosmetic and industrial use thereof |
Country Status (1)
Country | Link |
---|---|
DE (1) | DE3814910A1 (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0861657A2 (en) * | 1997-02-27 | 1998-09-02 | L'Oreal S.A. | Monohydric alcohol-free composition for topical use comprising solubilized ethylcellulose |
EP1604644A1 (en) * | 2004-05-19 | 2005-12-14 | Beiersdorf AG | Emulsion concentrate containing water-soluble and oil-soluble polymers |
US9168309B2 (en) | 2010-12-01 | 2015-10-27 | Omnis Biotechnology Inc. | Thixotropic compositions |
WO2018138744A1 (en) | 2017-01-24 | 2018-08-02 | Maria Desantis | Composition, device and method for conformational intra-tissue beta branchytherapy |
-
1988
- 1988-05-03 DE DE19883814910 patent/DE3814910A1/en not_active Withdrawn
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0861657A2 (en) * | 1997-02-27 | 1998-09-02 | L'Oreal S.A. | Monohydric alcohol-free composition for topical use comprising solubilized ethylcellulose |
EP0861657A3 (en) * | 1997-02-27 | 2000-07-05 | L'Oreal S.A. | Monohydric alcohol-free composition for topical use comprising solubilized ethylcellulose |
EP1604644A1 (en) * | 2004-05-19 | 2005-12-14 | Beiersdorf AG | Emulsion concentrate containing water-soluble and oil-soluble polymers |
US9168309B2 (en) | 2010-12-01 | 2015-10-27 | Omnis Biotechnology Inc. | Thixotropic compositions |
WO2018138744A1 (en) | 2017-01-24 | 2018-08-02 | Maria Desantis | Composition, device and method for conformational intra-tissue beta branchytherapy |
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Legal Events
Date | Code | Title | Description |
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8139 | Disposal/non-payment of the annual fee |