DE3814910A1 - Process for the preparation of lipoid ethylcellulose gels and pharmaceutical, cosmetic and industrial use thereof - Google Patents

Process for the preparation of lipoid ethylcellulose gels and pharmaceutical, cosmetic and industrial use thereof

Info

Publication number
DE3814910A1
DE3814910A1 DE19883814910 DE3814910A DE3814910A1 DE 3814910 A1 DE3814910 A1 DE 3814910A1 DE 19883814910 DE19883814910 DE 19883814910 DE 3814910 A DE3814910 A DE 3814910A DE 3814910 A1 DE3814910 A1 DE 3814910A1
Authority
DE
Germany
Prior art keywords
lipoid
gels
preparation
cosmetic
pharmaceutical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19883814910
Other languages
German (de)
Inventor
Theodor Prof Dr Eckert
Josef Brinkmann
Doris Panreck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to DE19883814910 priority Critical patent/DE3814910A1/en
Publication of DE3814910A1 publication Critical patent/DE3814910A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/042—Gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/342—Alcohols having more than seven atoms in an unbroken chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/731—Cellulose; Quaternized cellulose derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/54—Polymers characterized by specific structures/properties
    • A61K2800/542—Polymers characterized by specific structures/properties characterized by the charge
    • A61K2800/5422—Polymers characterized by specific structures/properties characterized by the charge nonionic

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)

Abstract

A process for the preparation of lipoid ethylcellulose gels is described. The gels are obtained by dissolving ethylcellulose in hydroxyl group-containing lipoid solvents, preferably in fatty alcohols or castor oil. Other lipoid media such as triglycerides or paraffins or fatty esters (waxes) can be added to the solutions. The use of the preparations thus obtained is described for pharmaceutical or cosmetic or industrial purposes.

Description

Die Herstellung lipoider Gele erfolgt im allgemeinen in der Form, daß bestimmte anorganische Gelbildner, wie beispielsweise hochdisperses Siliciumdioxid, in lipoiden Lösungsmitteln dispergiert werden. Ein anderes grundsätzliches Verfahren besteht darin, daß man Polymere wie etwa Polyethylen bei hoher Temperatur in Paraffin löst und dann einem Kälte­ schock unterwirft. Das dabei wieder erstarrte Poly­ ethylen bildet im Paraffin eine Matrix, die zu einem Gelzustand führt. Ein weiteres Verfahren zur Bildung lipoider Gele besteht darin, feste Wachse wie etwa Bienenwachs, in lipoiden Lösungsmitteln zu disper­ gieren. Lipoid gels are generally prepared in the form that certain inorganic gelling agents, such as highly disperse silicon dioxide, be dispersed in lipoid solvents. A another basic procedure is that polymers such as polyethylene at high Temperature dissolves in paraffin and then a cold subject to shock. The solidified poly again ethylene forms a matrix in the paraffin, which leads to a Gel state leads. Another method of education Lipoid gels consist of solid waxes such as Beeswax to disper in lipoid solvents yaw.  

Es ist bisher nicht bekannt, daß man mit partial­ synthetischen Cellulosederivaten eine Gelbildung in lipoiden Lösungsmitteln vollziehen kann.It is not yet known that partial synthetic cellulose derivatives gelation in can perform lipoid solvents.

Überraschenderweise wurde gefunden, daß Alkylether der Cellulose, insbesondere Ethylcellulose, in Hydroxyl­ gruppen-haltigen, lipoiden Lösungsmitteln Gelsysteme bilden.Surprisingly, it was found that alkyl ethers cellulose, especially ethyl cellulose, in hydroxyl group-containing, lipoid solvents gel systems form.

Bei der Herstellung solcher Gele geht man im allgemeinen so vor, daß die Ethylcellulose bei Temperaturen bis zu etwa 150°C unter Rühren in lipoiden Lösungsmitteln gelöst wird. Als Lösungsmittel kommen beispielsweise in Betracht:In general, such gels are manufactured so that the ethyl cellulose at temperatures up to to about 150 ° C with stirring in lipoid solvents is solved. Examples of suitable solvents are: considered:

Die flüssigen, gesättigten Fettalkohole C8 bis C10 (z. B. LOROL C8, Henkel, LOROL C10, Henkel) oder der verzweigte Fettalkohol 2-Octyldodecanol (z. B. EUTANOL G, Henkel) oder der ungesättigte Fettalkohol Oleylalkohol (z. B. HD-EUTANOL, Henkel).The liquid, saturated fatty alcohols C 8 to C 10 (e.g. LOROL C8, Henkel, LOROL C10, Henkel) or the branched fatty alcohol 2-octyldodecanol (e.g. EUTANOL G, Henkel) or the unsaturated fatty alcohol oleyl alcohol (e.g. B. HD-EUTANOL, Henkel).

Als weitere Lösungsmittel sind Hydroxylgruppen-haltige Fettsäureglyceride wie beispielsweise Rizinusöl (DAB 9) oder etherische Öle oder Riechstoffe verwendbar. Den so erhaltenen Gelen können zur Konsistenzverbesserung andere lipoide Medien wie beispielsweise Fettsäure­ glyceride oder Paraffine oder Fettsäureester (Wachse) hinzugefügt werden. Die wie vorstehend beschriebenen lipoiden Gele lassen sich als solche oder nach Ein­ arbeitung von Wirkstoffen für pharmazeutische oder kosmetische oder technische Zwecke verwenden.
Hydroxyl group-containing fatty acid glycerides such as castor oil (DAB 9) or essential oils or fragrances can be used as further solvents. To improve the consistency, other lipoid media such as, for example, fatty acid glycerides or paraffins or fatty acid esters (waxes) can be added to the gels thus obtained. The lipoid gels as described above can be used as such or after the incorporation of active ingredients for pharmaceutical or cosmetic or technical purposes.

BeispieleExamples

Die folgenden Beispiele erläutern die Erfindung:The following examples illustrate the invention:

Beispiel 1example 1

1 g bis 30 g Ethylcellulose werden in ca. 30 g Oleyl­ alkohol dispergiert, mit Oleylalkohol zu 100 g er­ gänzt und bei einer Temperatur von etwa 100°C bis zur vollständigen Lösung der Ethylcellulose gerührt. Nach dem Abkühlen werden transparente Gele erhalten.1 g to 30 g of ethyl cellulose are in about 30 g of oleyl alcohol dispersed with oleyl alcohol to 100 g complete and at a temperature of about 100 ° C to stirred to completely dissolve the ethyl cellulose. After cooling, transparent gels are obtained.

Beispiel 2Example 2

1 g bis 30 g Ethylcellulose werden in ca. 30 g 2-Octyl­ dodecanol dispergiert, mit 2-Octyldodecanol zu 100 g ergänzt und bei einer Temperatur von etwa 100°C bis zur vollständigen Auflösung der Ethyl­ cellulose gerührt. Nach dem Abkühlen werden leicht opaleszierende Gele erhalten.1 g to 30 g of ethyl cellulose are in about 30 g of 2-octyl dispersed dodecanol with 2-octyldodecanol 100 g supplemented and at a temperature of about 100 ° C until the ethyl has completely dissolved stirred cellulose. After cooling, become light Obtain opalescent gels.

Beispiel 3Example 3

1 g bis 15 g Ethylcellulose werden in ca. 30 g 2-Octyl­ dodecanol dispergiert, mit 2-Octyldodecanol zu 50 g ergänzt und bei einer Temperatur von etwa 100°C bis zur vollständigen Auflösung der Ethylcellulose gerührt. Die so erhaltene Lösung wird bei einer Temperatur von etwa 100°C mit 50 g flüssigem Paraffin, das auf die gleiche Temperatur erwärmt wurde, gemischt. Nach dem Abkühlen der Mischung wird ein transparentes Gel erhalten. 1 g to 15 g of ethyl cellulose are in about 30 g of 2-octyl dispersed dodecanol, with 2-octyldodecanol at 50 g added and at a temperature of about 100 ° C until the ethyl cellulose is completely dissolved touched. The solution thus obtained is at a Temperature of about 100 ° C with 50 g of liquid Paraffin that warms to the same temperature was mixed. After the mixture has cooled a transparent gel is obtained.  

FormelnFormulas

1. Ethylcellulose1. ethyl cellulose

R=-C₂H₅ oder -H
2. OleylalkoholR = -C₂H₅ or -H
2. Oleyl alcohol

CH₃(CH₂)₇CH=CH(CH₂)₇CH₂-OHCH₃ (CH₂) ₇CH = CH (CH₂) ₇CH₂-OH

3. 2-Octyldodecanol3. 2-octyldodecanol

Claims (5)

1. Verfahren zur Herstellung lipoider Gele unter Verwendung von Ethylcellulose und Hydroxyl­ gruppen-haltigen, lipoiden Lösungsmitteln.1. Process for making lipoid gels below Use of ethyl cellulose and hydroxyl group-containing, lipoid solvents. 2. Verfahren zur Herstellung lipoider Gele unter Verwendung von Ethylcellulose und Fettalkoholen wie Decylalkohol (z. B. LOROL C 10, Henkel) oder Oleylalkohol (z. B. HD-EUTANOL, Henkel) oder 2-Octyldodecanol (z. B. EUTANOL G, Henkel) oder Rizinusöl (DAB 9). 2. Process for making lipoid gels below Use of ethyl cellulose and fatty alcohols such as decyl alcohol (e.g. LOROL C 10, Henkel) or oleyl alcohol (e.g. HD-EUTANOL, Henkel) or 2-octyldodecanol (e.g. EUTANOL G, Henkel) or castor oil (DAB 9).   3. Verfahren zur Herstellung lipoider Gele nach Anspruch 1 und 2 unter Zusatz anderer lipoider Medien.3. Process for the preparation of lipoid gels Claims 1 and 2 with the addition of other lipoids Media. 4. Verfahren zur Herstellung lipoider Gele nach Anspruch 1 bis 3 unter Zusatz von Fettsäure­ glyceriden oder Paraffinen oder Fettsäureestern (Wachse).4. Process for the preparation of lipoid gels Claims 1 to 3 with the addition of fatty acid glycerides or paraffins or fatty acid esters (Waxes). 5. Verwendung von Zubereitungen nach Anspruch 1 bis 4 unter Einarbeitung von Wirkstoffen für pharmazeutische oder kosmetische oder technische Zwecke.5. Use of preparations according to claim 1 to 4 with the incorporation of active ingredients for pharmaceutical or cosmetic or technical Purposes.
DE19883814910 1988-05-03 1988-05-03 Process for the preparation of lipoid ethylcellulose gels and pharmaceutical, cosmetic and industrial use thereof Withdrawn DE3814910A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE19883814910 DE3814910A1 (en) 1988-05-03 1988-05-03 Process for the preparation of lipoid ethylcellulose gels and pharmaceutical, cosmetic and industrial use thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19883814910 DE3814910A1 (en) 1988-05-03 1988-05-03 Process for the preparation of lipoid ethylcellulose gels and pharmaceutical, cosmetic and industrial use thereof

Publications (1)

Publication Number Publication Date
DE3814910A1 true DE3814910A1 (en) 1989-11-16

Family

ID=6353430

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19883814910 Withdrawn DE3814910A1 (en) 1988-05-03 1988-05-03 Process for the preparation of lipoid ethylcellulose gels and pharmaceutical, cosmetic and industrial use thereof

Country Status (1)

Country Link
DE (1) DE3814910A1 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0861657A2 (en) * 1997-02-27 1998-09-02 L'Oreal S.A. Monohydric alcohol-free composition for topical use comprising solubilized ethylcellulose
EP1604644A1 (en) * 2004-05-19 2005-12-14 Beiersdorf AG Emulsion concentrate containing water-soluble and oil-soluble polymers
US9168309B2 (en) 2010-12-01 2015-10-27 Omnis Biotechnology Inc. Thixotropic compositions
WO2018138744A1 (en) 2017-01-24 2018-08-02 Maria Desantis Composition, device and method for conformational intra-tissue beta branchytherapy

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0861657A2 (en) * 1997-02-27 1998-09-02 L'Oreal S.A. Monohydric alcohol-free composition for topical use comprising solubilized ethylcellulose
EP0861657A3 (en) * 1997-02-27 2000-07-05 L'Oreal S.A. Monohydric alcohol-free composition for topical use comprising solubilized ethylcellulose
EP1604644A1 (en) * 2004-05-19 2005-12-14 Beiersdorf AG Emulsion concentrate containing water-soluble and oil-soluble polymers
US9168309B2 (en) 2010-12-01 2015-10-27 Omnis Biotechnology Inc. Thixotropic compositions
WO2018138744A1 (en) 2017-01-24 2018-08-02 Maria Desantis Composition, device and method for conformational intra-tissue beta branchytherapy

Similar Documents

Publication Publication Date Title
DE69600017T2 (en) Use of amphiphilic compounds as thickeners in non-aqueous media and the compositions thus produced
DE69534287T2 (en) Biodegradable quaternary hair treatment products
EP0521981B1 (en) Process for manufacturing oil-in-water creams
EP0085882A2 (en) Antimycotic tampons with high release of active agent
EP0214568B1 (en) Oil-in-water emulsion
DE68903887T2 (en) TRANSPARENT COSMETIC EMULSION.
EP0058887B1 (en) Antifungal compositions with a higher rate of the drug release as a stick
JPS62234540A (en) Gelated emulsion and o/w emulsion obtained from said emulsion
DE2455287C3 (en) Use of water-in-oil emulsifiers
CA1209922A (en) Emulsion-type composition for external use
PL184695B1 (en) Sterile ophtalmic dropable gelly preparation and method of obtaining same
DE3333639A1 (en) PREPARATION OF NITROESTERS FOR CORONARY THERAPY
DE1467907B2 (en) METHOD FOR MANUFACTURING SOFT GELATINE CAPSULES
CH681427A5 (en)
DE3814910A1 (en) Process for the preparation of lipoid ethylcellulose gels and pharmaceutical, cosmetic and industrial use thereof
EP0452758A2 (en) Hydrocarbon rich gels
KR20140067975A (en) Oily gel composition
EP0514435B1 (en) Alcoholic aqueous gel-type phospholipid composition, its use and topical preparations containing it
EP0479121A1 (en) Skin treatment compositions containing beta-phosphatidyl choline derivatives
DE69736985T2 (en) BIOLOGICAL ACTIVE COMPOSITION
DE2063896A1 (en) Ointment bases based on triglycerides of saturated medium-chain fatty acids and processes for their production
DE68906513T2 (en) PHARMACEUTICAL PREPARATIONS FOR DICLOFENAC.
CN114712261A (en) Nano-liposome containing ceramide-like extract and preparation method and application thereof
EP1014939B1 (en) Encapsulation of water insoluble active substances with an amphiphilic character
DE2913040C2 (en) Cosmetic products

Legal Events

Date Code Title Description
8139 Disposal/non-payment of the annual fee