DE3808141A1 - Composition for controlling migraine - Google Patents
Composition for controlling migraineInfo
- Publication number
- DE3808141A1 DE3808141A1 DE19883808141 DE3808141A DE3808141A1 DE 3808141 A1 DE3808141 A1 DE 3808141A1 DE 19883808141 DE19883808141 DE 19883808141 DE 3808141 A DE3808141 A DE 3808141A DE 3808141 A1 DE3808141 A1 DE 3808141A1
- Authority
- DE
- Germany
- Prior art keywords
- composition according
- extract
- acid
- plant
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
Die Erfindung betrifft ein Mittel zur Bekämpfung von Migräne.The invention relates to an agent for combating Migraine.
Unter Migräne wird ein in Anfällen auftretender, heftiger, meist einseitiger (Hemikromie) Kopfschmerz bei gleichzeitiger starker Überregbarkeit der Sinnes organe verstanden. Er beruht auf Gefäßstörungen im Gehirn (Gefäßverkrampfungen, Gefäßerweiterungen und Ödem um die Gefäße). Zu den Begleiterscheinungen der Migräne gehören Übelkeit, Erbrechen, Widerwillen gegen Speiseaufnahme, Speichelfluß.Migraines are a type of violent, mostly one-sided (hemicromia) headache with simultaneous strong excitability of the senses organs understood. It is based on vascular disorders in the Brain (vascular spasms, vasodilation and Edema around the vessels). On the side effects of Migraines include nausea, vomiting, reluctance to Food intake, salivation.
Die eigentlichen Ursachen der Migräne sind unbekannt. Bei Frauen besteht eine gewisse Beziehung zur inneren Sekretion, außerdem können allergische Ursachen eine Rolle spielen. Nicht selten ist jedoch auch die Anlage zur Migräne vererbt. The actual causes of the migraines are unknown. In women there is a certain relationship with the inner one Secretion, moreover, allergic causes can be one Role-play. However, the system is also not uncommon inherited to migraines.
Die Behandlung von Migräne besteht heute in der Regel in einer Beeinflussung des Stoffwechsels und in Ent spannung durch Bindegewebsmassage. Ferner sind auch spezifische chemische Mittel bekannt.The treatment of migraines usually exists today in influencing metabolism and in Ent tension through connective tissue massage. Furthermore, too specific chemical agents known.
Die Erfinder haben sich zum Ziel gesetzt, ein Mittel gegen die Migräne zu entwickeln bzw. finden, welches ein Naturheilmittel ist und trotzdem eine hohe Wirksam keit besitzt.The inventors set themselves the goal of being a means to develop or find which migraine is a natural remedy and is still highly effective possesses.
Zur Lösung dieser Aufgabe führt, daß das Mittel das Alkaloid-Trigonellin bzw. Trigonellin-Säure enthält.To solve this problem, the means that the Contains alkaloid trigonelline or trigonellic acid.
Das Trigonellin kann künstlich hergestellt werden. Bevorzugt wird aber ein Extrakt aus Pflanzen der Unter familie Trigonella und hier insbesondere aus Bockshorn klee (Trigonella foenum graecum). Dieser Extrakt kann in besonders wirkungsvoller Weise aus dem Samen des Bockshornklees gewonnen werden, indem man den Samen aufquellen läßt und damit mit Wasser extrahiert.The trigonelline can be manufactured artificially. However, an extract from plants of the sub is preferred Trigonella family and here especially from fenugreek clover (Trigonella foenum graecum). This extract can in a particularly effective way from the seed of the Fenugreek can be obtained by looking at the seeds can swell and extracted with water.
Die Substanz bewirkt eine Erweiterung und Entkrampfung der Blutgefäße, so daß beispielsweise eine bessere Ver sorgung des Gehirns mit Sauerstoff und Nährstoffen stattfindet. Auf diese Weise wird einer Migräne wirksam vorgebeugt.The substance causes enlargement and relaxation the blood vessels, so that, for example, a better ver supplying the brain with oxygen and nutrients takes place. In this way, a migraine is effective leaning forward.
Daß der Bockshornklee eine sehr ausgeprägte heilende Wirkung aufweist, wird bereits in Lehrbüchern beschrie ben. Als Beispiel wird auf das Lehrbuch der biologi schen Heilmittel von Gerhard Madaus, Band 2, Seiten 1362 bis 1368 verwiesen. Ferner auch auf das Buch "Heilpflanzen-Lexikon für Ärzte und Apotheker" von Privatdozent Dr. med. Hans Braun, 3. erweiterte Auf lage, Gustav Fischer Verlag, Stuttgart und New York 178, Seite 219. That fenugreek is a very pronounced healing Is already described in textbooks ben. As an example, the textbook of biologi remedies by Gerhard Madaus, volume 2, pages Referred to 1362 to 1368. Also on the book "Medicinal plants lexicon for doctors and pharmacists" by Privatdozent Dr. med. Hans Braun, 3rd expanded Auf location, Gustav Fischer Verlag, Stuttgart and New York 178, page 219.
Dort wird der Gebrauch von Bockshornklee in Form von heißen Breiumschlägen oder als Tee für den inneren Gebrauch angegeben. In der DE-OS 32 25 056 wird der zerkleinerte Samen von Bockshornklee zur Verbesserung der Leberfunktion bzw. der protektiven Wirkung auf die Leber und/oder zur Absenkung von Blutalkoholwerten in oral verabreichbaren Arzneimittel-Zubereitungen er wähnt. Allerdings war seine Wirkung als Gegenmittel für die Migräne bisher unbekannt.There the use of fenugreek in the form of are called poultices or as tea for the inside Use specified. In DE-OS 32 25 056 the crushed fenugreek seeds for improvement the liver function or the protective effect on the Liver and / or to lower blood alcohol levels in orally administrable pharmaceutical preparations thinks. However, its effect was an antidote to the migraine so far unknown.
Im Rahmen der vorliegenden Erfindung wird ein Trigo nellin bevorzugt, welches Coffearin, N-Methylnicotinyl-3-Carboxyl Betainsäure und N-Methyl pyridin-3-Carboxyl Betainsäure enthält. Weiterhin können steroidale Glycoside und/oder Proteine mit einem hohen Anteil an Lysin und Tryptophan vorhanden sein, ebenso galaktoseartige Mucilago. Weiterhin sollte dem Extrakt ein Alkohol und ein Konservierungsmittel zuge geben werden. Hierdurch erhält man ein Breitspektrum tonikum.In the context of the present invention, a trigo nellin preferred, which coffearin, N-methylnicotinyl-3-carboxyl betaine acid and N-methyl contains pyridine-3-carboxyl betaine acid. Farther can contain steroidal glycosides and / or proteins with a high levels of lysine and tryptophan are present, also galactose-like mucilago. Furthermore, the Extract an alcohol and a preservative will give. This gives you a broad spectrum tonic.
Das Trigonellin kann andererseits auch mit einem weiteren wäßrigen Bockshornklee-Extrakt gemischt werden, wodurch nicht nur seine Wirkung verbessert, sondern auch sein Wirkungsspektrum verbreitert wird.The trigonelline, on the other hand, can also be used with a another aqueous fenugreek extract mixed which not only improves its effectiveness, but also its spectrum of activity is broadened.
Als Darreichungsform bietet sich einmal eine Lösung in Tropfflaschen an. Das Mittel kann aber auch in Kapseln verpackt werden. In diesen Fällen dient es zur oralen Einnahme. Ferner ist selbstverständlich auch daran gedacht, das Mittel als Tee zu verabreichen. Andere Möglichkeiten sind denkbar und sollen von dem Erfindungsgedanken umfaßt werden. As a dosage form, there is a solution in Dropper bottles. The remedy can also be in capsules be packed. In these cases it is used for oral Ingestion. Furthermore, of course, is also there thought to administer the agent as tea. Other Possibilities are conceivable and should be of that Invention ideas are included.
Für die kapselierte Form wird in der Regel auf die Anteile Alkohol und Nipastat verzichtet. Stattdessen wird die vitaminisierte Form von Riboflavin, Nicotin amid, Calciumpantothenat und Folsäure angeboten.The encapsulated form is usually based on the Alcohol and nipastat portions waived. Instead becomes the vitaminized form of riboflavin, nicotine amide, calcium pantothenate and folic acid are offered.
Eine bevorzugte Zusammensetzung ist insbesondere in der Europäischen Patentanmeldung 87 106 650.2 zu finden.A preferred composition is particularly in the To find European patent application 87 106 650.2.
Claims (11)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19883808141 DE3808141A1 (en) | 1988-03-11 | 1988-03-11 | Composition for controlling migraine |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19883808141 DE3808141A1 (en) | 1988-03-11 | 1988-03-11 | Composition for controlling migraine |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3808141A1 true DE3808141A1 (en) | 1989-09-21 |
Family
ID=6349489
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19883808141 Withdrawn DE3808141A1 (en) | 1988-03-11 | 1988-03-11 | Composition for controlling migraine |
Country Status (1)
Country | Link |
---|---|
DE (1) | DE3808141A1 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996022774A2 (en) * | 1995-01-26 | 1996-08-01 | Ashbury Research Corporation | Combinational drugs for treating migraine and other illnesses, comprising sesquiterpene lactones and b-complex vitamins |
WO2021004913A1 (en) * | 2019-07-05 | 2021-01-14 | Société des Produits Nestlé S.A. | Compositions and methods using trigonelline and high protein for preventing or treating conditions or disorders in skeletal muscle |
WO2021004919A1 (en) * | 2019-07-05 | 2021-01-14 | Société des Produits Nestlé S.A. | Compositions and methods using trigonelline and vitamins for preventing or treating conditions or disorders in skeletal muscle |
-
1988
- 1988-03-11 DE DE19883808141 patent/DE3808141A1/en not_active Withdrawn
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996022774A2 (en) * | 1995-01-26 | 1996-08-01 | Ashbury Research Corporation | Combinational drugs for treating migraine and other illnesses, comprising sesquiterpene lactones and b-complex vitamins |
WO1996022774A3 (en) * | 1995-01-26 | 1996-09-26 | Ashbury Research Corp | Combinational drugs for treating migraine and other illnesses, comprising sesquiterpene lactones and b-complex vitamins |
WO2021004913A1 (en) * | 2019-07-05 | 2021-01-14 | Société des Produits Nestlé S.A. | Compositions and methods using trigonelline and high protein for preventing or treating conditions or disorders in skeletal muscle |
WO2021004919A1 (en) * | 2019-07-05 | 2021-01-14 | Société des Produits Nestlé S.A. | Compositions and methods using trigonelline and vitamins for preventing or treating conditions or disorders in skeletal muscle |
CN113993546A (en) * | 2019-07-05 | 2022-01-28 | 雀巢产品有限公司 | Compositions and methods for preventing or treating skeletal muscle conditions or disorders using trigonelline and vitamins |
CN114072147A (en) * | 2019-07-05 | 2022-02-18 | 雀巢产品有限公司 | Compositions and methods for preventing or treating skeletal muscle disorders or disorders using trigonelline and high protein |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8139 | Disposal/non-payment of the annual fee |