DE3728852C2 - Medicines for tumor therapy - Google Patents

Medicines for tumor therapy

Info

Publication number
DE3728852C2
DE3728852C2 DE3728852A DE3728852A DE3728852C2 DE 3728852 C2 DE3728852 C2 DE 3728852C2 DE 3728852 A DE3728852 A DE 3728852A DE 3728852 A DE3728852 A DE 3728852A DE 3728852 C2 DE3728852 C2 DE 3728852C2
Authority
DE
Germany
Prior art keywords
tumor therapy
medicines
lysino
norleucine
mono
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3728852A
Other languages
German (de)
Other versions
DE3728852A1 (en
Inventor
Wilhelm Hoerrmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to DE3728852A priority Critical patent/DE3728852C2/en
Priority to CH3152/88A priority patent/CH680189A5/de
Priority to GB8820188A priority patent/GB2209120B/en
Publication of DE3728852A1 publication Critical patent/DE3728852A1/en
Application granted granted Critical
Publication of DE3728852C2 publication Critical patent/DE3728852C2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Description

Der Gegenstand der Erfindung betrifft Arzneimittel mit über­ raschender therapeutischer Wirkung enthaltend als Wirkstoffe Lysino-norleucin oder Mono- oder Di-hydroxy-lysino-norleucine der Formeln (a)-(c):
The subject matter of the invention relates to medicinal products with surprising therapeutic effects containing as active ingredients lysino-norleucine or mono- or di-hydroxy-lysino-norleucine of the formulas (a) - (c):

oder pharmazeutisch annehmbare Verbindungen hiervon. or pharmaceutically acceptable compounds thereof.  

Die genannten Verbindungen sind als solche bekannt, wie auch die Verfahren zu ihrer Herstellung.The compounds mentioned are known as such, as well the processes for their manufacture.

Neu jedoch und Gegenstand dieser Erfindung ist, daß diese Substanzen, gegebenenfalls zusammen mit üblichen Trägern und/oder Hilfsmitteln, überraschen­ derweise wirksame Arzneimittel sind bei schwerwiegenden Tumor­ erkrankungen, die bisher nicht oder nur wenig beeinflusst werden können.New however and subject of this invention is that these substances, if any surprise with usual carriers and / or aids Such drugs are effective for severe tumors diseases that have so far been little or no influence can.

Die erfindungsgemäßen Wirkstoffe werden in der für Aminosäuren charakteristischen Weise und Dosierung zugeführt. Als Richtlinie gelten 25-250 mg pro Kilogramm Körpergewicht und Tag, und zwar pro Verbindung.The active compounds according to the invention are used for amino acids characteristic way and dosage supplied. As a guideline apply 25-250 mg per kilogram of body weight and day, and per connection.

Claims (1)

Arzneimittel zur Tumortherapie, dadurch gekennzeichnet, daß als Wirkstoffe Lysino-norleucin oder Mono- oder Di-lysino-norleu­ cine mit folgenden Formeln enthalten sind:
oder pharmazeutisch annehmbare Verbindungen hiervon.Medicinal product for tumor therapy, characterized in that it contains lysino-norleucine or mono- or di-lysino-norleu cine with the following formulas:
or pharmaceutically acceptable compounds thereof.
DE3728852A 1987-08-28 1987-08-28 Medicines for tumor therapy Expired - Fee Related DE3728852C2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
DE3728852A DE3728852C2 (en) 1987-08-28 1987-08-28 Medicines for tumor therapy
CH3152/88A CH680189A5 (en) 1987-08-28 1988-08-19
GB8820188A GB2209120B (en) 1987-08-28 1988-08-25 Drugs containing lysine or hydroxylysine derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3728852A DE3728852C2 (en) 1987-08-28 1987-08-28 Medicines for tumor therapy

Publications (2)

Publication Number Publication Date
DE3728852A1 DE3728852A1 (en) 1989-03-09
DE3728852C2 true DE3728852C2 (en) 2003-06-18

Family

ID=6334743

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3728852A Expired - Fee Related DE3728852C2 (en) 1987-08-28 1987-08-28 Medicines for tumor therapy

Country Status (3)

Country Link
CH (1) CH680189A5 (en)
DE (1) DE3728852C2 (en)
GB (1) GB2209120B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3744542B4 (en) * 1987-12-30 2004-06-03 Hoerrmann, Wilhelm, Dr. Pharmaceutical use of L-δ-hydroxylysine

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3538619A1 (en) * 1984-11-05 1986-05-07 Wilhelm Dr. 8127 Iffeldorf Hoerrmann MEDICINAL PRODUCTS CONTAINING ISOMERS OF HYDROXYPROLIN
DE3718889A1 (en) * 1987-06-05 1988-12-22 Behringwerke Ag METHOD FOR PRODUCING A SOLUTION OF HIGH SPECIFIC VOLUME ACTIVITY FROM A PROTEIN WITH TISSUE PLASMINOGEN ACTIVATOR (T-PA) ACTIVITY, SOLUTION, CONTAINING PROTEIN WITH T-PA ACTIVITY AND USE OF THE SOLUTION AND IN THE HUMAN VITALIZE

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR6588M (en) * 1967-10-11 1968-12-30
FR2587900B1 (en) * 1985-10-01 1988-10-07 Morelle Jean BASIC FATTY-AMINO ACID ASSOCIATIONS WITH EMOLLIENT, EMULSIFIING AND ANTIOXIDANT PROPERTIES FOR COSMETICS, DERMATOLOGY AND FOOD

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3538619A1 (en) * 1984-11-05 1986-05-07 Wilhelm Dr. 8127 Iffeldorf Hoerrmann MEDICINAL PRODUCTS CONTAINING ISOMERS OF HYDROXYPROLIN
DE3718889A1 (en) * 1987-06-05 1988-12-22 Behringwerke Ag METHOD FOR PRODUCING A SOLUTION OF HIGH SPECIFIC VOLUME ACTIVITY FROM A PROTEIN WITH TISSUE PLASMINOGEN ACTIVATOR (T-PA) ACTIVITY, SOLUTION, CONTAINING PROTEIN WITH T-PA ACTIVITY AND USE OF THE SOLUTION AND IN THE HUMAN VITALIZE

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHAITOW, L.: Amino Acids in Therapy, Thorsons Publ. Ltd., New York 1985, S. 52-55 *

Also Published As

Publication number Publication date
GB2209120B (en) 1992-01-15
DE3728852A1 (en) 1989-03-09
GB2209120A (en) 1989-05-04
GB8820188D0 (en) 1988-09-28
CH680189A5 (en) 1992-07-15

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
8304 Grant after examination procedure
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee
8370 Indication of lapse of patent is to be deleted
8339 Ceased/non-payment of the annual fee